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Rufino Mondejar,Jose Manuel Garcia-Moreno,Rocio Rubio,Francisca Solano,Mercedes Delgado,Begona Garcia-Bravo,Juan Jose Rios-Martin,Amalia Martinez-Mir,Miguel Lucas 대한신경과학회 2014 Journal of Clinical Neurology Vol.10 No.1
Background Lipoid proteinosis (LP) is a rare autosomal recessive disorder characterized bya hoarse voice, variable scarring, and infiltration of the skin and mucosa. This disease is associated with mutations of the gene encoding extracellular matrix protein 1 (ECM1). Case Report This was a clinical and molecular study of a new case of LP with a severe phenotype. A 35-year-old female born to nonconsanguineous parents developed dermatologicaland extracutaneous symptoms in her 9th month of life. The neurological abnormalities of thedisease began to appear at the age of 19 years. Computed tomography revealed cranial calcifications. Conclusions The diagnosis of LP was confirmed by histopathological findings and direct sequencing of ECM1. A new homozygous nonsense mutation was identified in exon 7 of ECM1, c.1076G>A (p.Trp359*). This mutation was not detected in 106 chromosomes of healthy individuals with a similar demographic origin. Microsatellite markers around ECM1 were used to construct the haplotype in both the parents and the patient. Reports on genotype-phenotype correlations in LP point to a milder phenotype in carriers of missense mutations in the Ecm1a isoform, whereas mutations in the Ecm1b isoform are thought to be associated with more severe phenotypes. The present findings in a Spanish patient carrying a truncating mutation in exon 7 revealed complete dermatological and neurological manifestations.
Feedback Control Based on a Sequential Observer-predictor for Systems with Unknown Actuator Delay
David Fernando Novella-Rodríguez,Juan Carlos Tudon-Martínez,Rocio Jasmin Vazquez-Guerra,Juan Francisco Márquez-Rubio 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.9
The present work is devoted to the stabilization of linear systems with input delay, where the delay value can be arbitrarily long with respect to the system response. The time-delay is considered unknown or incorrectly modeled. A sequential observer with variable time-delays is designed in order to predict the system states before the delay occurs. The delays in the sequential observer-predictor are updated by means of a delay estimation in order to obtain an accurate state prediction. The stability of the closed-loop system and the convergence of the observers are analyzed by considering the separation principle. Numerical simulations are performed to evaluate the proposed sequential observer-controller under different scenarios.