複合 韓藥劑 淸籬滋坎湯의 抗癌效果 및 作用機轉 糾明

Cho, Kyung-Sam,Kim, Si-Young,Park, Jai-Kyung,Choi, Seung-Hoon,Chung, Se-Young,Yoon, Hwi-Joong 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Kyung Sam Cho¹Si Young Kim¹, Jai Kyung Park²,Seung Hoon Choi³,Se Young Chung⁴, Hwi Joong Yoon¹¹College of Medicine, ²East-West Medical Research Institute, ³College of Oriental Medicine, ⁴College of Pharmacology, Kyung Hee University,Seoul, Korea. The Anti-cancer Effect of Oriental Medicine Chung-Ri-Ja-Gam-Tang in the Mouse with Metastatic Lung Cancer. Proceedings of International Symposium on East-West Medicine, Seoul. 231-243, 1999.-The oriental medicine Chung-Ri-Ja-Gam-Tang is an herbal medicine which has been used for pulmonary diseases and known as having immune stimulatory effects. It has been known effective in lung cancer. So we studied the effects and the mechanisms of this herbal medicine it the mouse with metastatic lung cancer. The metastatic lung cancer of the mouse was produced with melnoma cell line(B16BL/6).5×10□/mouse tumor cells were injected intravenously to the CDF1 mouse via tail vein. The mice were divided 4 groups. The first group was treated with 50mg/kg extract of Chung-Ri-Ja-Gam-Tang per oral for 10 days after cancer cell injection, second group treated with saline after cancer cell injection, the third group with medicine without cancer cell, and the last group with saline only. After 10 days treatments some of the mice were scarificed and the lung and spleen was removed. The survival duration, weight change, the number of metastatic cancer nodule of the lung, the NK cell activity, the capacity of cytokines(INF-γ,INF-α,IL-2) production and the proliferation activities of mouse lymphocytes were measured. The surival times of the group 1 mice were longer and the weight loss was less than the group 2 significantly. The number of the metastatic nodule of the lung were decresed in the group 1 than the group 2. The production of INF-γ,was increase in group 2 than group 3 and 4, IL-2 production was increased in group 1 than group 2,3,4 significantly. There was no difference in TNF- α production and proliferation activity of lymphocyte in each group. The NK cell activity was significantly increased in group 1 than group 2,3,4. We conclude that the Chung-Ri-Ja-Gam-Tang has the effect of increasing the NK cell activity of the CDF1 mouse with metastatic lung cancer(B16BL/6). And it is suggested that the increased production of the IL-2 is the mechanisms of enhanced NK cell activity.

20대 젊은 환자의 고관절 질환에 시행한 Biplane Inter-trochanteric Osteotomy의 경험 : 예비보고 Preliminary Report

조덕연,이중명,김태훈 대한고관절학회 1990 Hip and Pelvis Vol.2 No.1

이중혈류유발 심폐소생술이 심정지를 유발한 개의 단기 생존율에 미치는 영향

황성오,조준휘,강구현,김성환,문중범,이강현,이승환,윤정한,최경훈,홍은석 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3

Background and Objectives: We previously reported that, compared with standard cardiopulmonary resuscitation(S-CPR), better hemodynamic effects could be achieved by simultaneous sterno-thoracic cardiopulmonary resuscitation(SST-CPR) in which we compressed the sternum and constricted the thorax circumferentially during the systolic period by using a device. This study was designed to assess whether SST-CPR, compared with S-CPR, improve the survival rate of dogs with cardiac arrest. Subjects and methods: Twenty-five mongrel dogs(19∼31㎏) were enrolled in this study. After four minutes of ventricular fibrillation induced by an AC current, animals were randomized to resuscitate with either S-CPR(n=13) or SST-CPR(n=12). Epinephrine(1 ㎎) was injected into the right atrium every three minutes after the beginning of CPR. Defibrillation was attempted after 6 minutes of CPR. Standard advanced cardiac life support was started if defibrillation was not successful. Results: SST-CPR resulted in significantly(p<0.001) higher systolic arterial pressure(91±47 vs 47±24 ㎜ Hg), diastolic pressure(43±24 vs 17±10 ㎜ Hg), coronary perfusion pressure(35±25 vs 13±9㎜ Hg), and end tidal CO2 tension(9±4 vs 3±2 ㎜ Hg). Two of 13 animals(15 %) resuscitated with S-CPR and six of 12 animals(50%) resuscitated with SST-CPR survived until 12 hours after cardiac arrest(p<0.05). Donclusion: SST-CPR, compared with S-CPR, improves the short-term survival rate in canine cardiac arrest.

2차원 벡터 공정능력지수 Cр와 Cрк의 근사 신뢰영역

박병선,이충훈,조중재 한국품질경영학회 2002 품질경영학회지 Vol.30 No.4

In this paper we study two vector-valued process capability indices C_p = (C_px, C_py) and C_pR = (C_pRx, C_pRy) considering process capability indices C_p and C_pR' First, we derive two asymptotic distributions of plug-in estimators C_p∧ = (C_px∧, C_py∧) and C_pR∧=(C_pRx∧, C_pRy∧) under some proper conditions. Second, we examine the performance of asymptotic confidence regions of our process capability indices C_p = (C_px, C_py) and C_pR = (C_pRx, C_pRy) under BN(μ_x, μ_y, σ^2_x, σ^2_y, ρ)

성인 급성 골수성 백혈병에서 6-Thioguanine, Cytarabine, Doxorubicin(TAD) 3제 복합화학요법의 효과 : 최종보고

최환석,윤휘중,우인숙,박지훈,김정희,김시영,조경삼 大韓血液學會 1995 大韓血液學會誌 Vol.30 No.2

SOL-GEL法에 依한 LAS系 結晶化유리의 製造에 있어서 租成比유리의 特性에 미치는 影響

김봉걸,양중식,조훈성,권창오,박경호 慶熙大學校 材料科學技術硏究所 1990 材料科學技術硏究論集 Vol.3 No.-

The purpose of this study is to investigate into the physical properties of Li₂O-Al₂O₃-nSiO₂ (LAnS) system of crystallized glass prepared by sol-gel method according to the composition ratio of LAnS. In order to find the crystallization temperature as well as the state of crystalline, differential thermal analysis and X-ray diffraction analysis were examined. The results obtained are as follows : 1. Gelling time became longer as increasing the composition ratio of SiO₂ and also found that it became faster as increasing the additive amount of water. Also, additive amount of water required for the gellation was above four times of the theoretical amount of water required hydrolysis. 2. Surface area and mean pore size became larger as increasing the composition ratio of SiO₂ and for LA4S dried gel, surface area was 331.1m^(2)/g, mean pore size distributed about 5nm and 30-50nm. 3. The crystallization temperature is high as increasing the composition ratio of SiO₂ and for LA4S, crystallization temperature is 800℃. Also, LA4S formed at 800℃ for the crystalline phase of β-eucryptite and at 900℃ for crystalline phase of β-spodumene.

심초음파로 결정된 응급 심낭천자술의 천자부위

김성환,황성오,이강현,조준휘,강구현,문중범,이승환,윤정한,최경훈,김영식 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3

Background: The aim of this study was to determine whether the conventional subcostal approach is suitable for emergency pericardiocentesis in patients with cardiac tamponade or impending cardiac tamponade. Methods: This study was a prospective, observational study conducted at the emergency department of a tertiary hospital, Patients who had symptomatic pericardial effusion and who needed emergency pericardiocentesis in the emergency department were included in this study. We measured the epicardium-to-pericardium distance at the subcostal, parasternal, and apical area with two-dimensional echocardiography to determine the appropriate puncture site for pericardiocentesis. An epicardium-to-pericardium distance of more than 1.0 cm was considered as the primary safety factor in determining the Puncture site for pericardiocentesis. The skin-to-pericardium distance was considered as secondary safety factor. Results: Ninety-five consecutive patients(55 males and 40 females; total mean age: 53 year old) with cardiac tamponade or impending cardiac tamponade were enrolled in this study. The puncture site for pericardiocentesis, as determined by echocardiography, was the subcostal area in 43 patients(45%), the apical area in 40 patients(42%), the left parasternal area In 11 patients(12%), and the right parastemal area in one patient(1%). Pericardiocentesis failed in 2 patients(2%) with the subcostal approach and in one patient(1%) with the apical approach. The average epicardium-to-pericardium distance was 31 ±21 mm in patients with the subcostal approach and 21±8 mm in patients with other approaches. There were no differences in the amount of pericardial fluid and in the intraperical pressure among patient groups according to puncture site. There were two procedure related complications: a puncture of the right ventricle with the subcostal approach and a ventricular tachycardia with the apical approach.

한국인 관상동맥의 변화양상에 대한 형태학적 연구

권태정,이상용,이한영,고영창,권기석,조재홍,김태공,김유훈,조갑래,서중석,이원태 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-

A proposal for a novel staging system in renal pelvicaliceal urothelial carcinomas

Cho, Kang Su,Cho, Dae Sung,Choi, Young Deuk,Hong, Sung Joon,Kim, Se Joong,Cho, Nam Hoon Elsevier 2007 Human pathology Vol.38 No.11

<P><B>Summary</B></P><P>Renal caliceal urothelial carcinomas, which have characteristic microanatomies in which the tumor directly interfaces to the renal parenchyma without intervening muscle propria, are often overstaged using the existing staging system. Relying on our analysis of 150 renal caliceal and/or pelvic urothelial carcinomas, we propose a novel staging scheme based on the extent of invasion relative to the corticomedullary junction (CMJ). Tumors were classified as category pT2 when renal parenchymal invasion was present within the CMJ and where the renal papillae and medulla were dominant. Tumors going over the CMJ were classified as pT3 with the proposed new scheme. It is very important to exclude pagetoid spread along the collecting ducts/ducts of Bellini to evaluate true invasion into the renal parenchyma. Using this revised staging scheme, 38.5% of tumors that were previously classified as pT3 were reclassified into the pT2 or pT1 groups. On multivariate Cox proportional hazard regression analysis, the extent of CMJ invasion and peripelvic fat invasion were the most significant prognostic indicators (<I>P</I> < .001, HR, 9.308; <I>P</I> = .016, HR, 2.538, respectively). In the new scheme, pT3 tumors showed a tendency to be classified toward the pT4 stage, whereas pT2 tumors were classified closer to the pT1 stage than to the pT3 (pT3 vs pT4, <I>P</I> = .0127; pT3 vs pT2, <I>P</I> < .0001). Renal parenchymal invasion beyond the CMJ has a strong prognostic impact for renal caliceal carcinomas. Using this new staging scheme, we can more precisely evaluate the level of tumor invasion.</P>

Extraction of Docosahexaenoic Acid (DHA) from Lyophilized Thraustochitrium sp.

CHO, JOONG-HOON,HEO, GWI-SUK,YANG, JI-WON 한국미생물 · 생명공학회 1996 Journal of microbiology and biotechnology Vol.6 No.5

Solvent extraction, soxhlet method, and supercritical fluid extraction were considered, respectively, as the method of choice for the recovery of DHA from lyophilized Thraustochitrium sp., and the results of corresponding extraction were compared. Supercritical fluid extraction seem to be the most appropriate process with respect to time, process simplicity, and extractant intoxicity.