http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Cordyceps militaris alleviates non-alcoholic fatty liver disease in ob/ob mice
Ha-Neul Choi,Yang-Hee Jang,Min-Joo Kim,Min Jeong Seo,Byoung Won Kang,Yong Kee Jeong3,,Jung-In Kim 대한지역사회영양학회 2014 Nutrition Research and Practice Vol.8 No.2
BACKGROUND/OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is becoming an important public health problem as metabolic syndrome and type 2 diabetes have become epidemic. In this study we investigated the protective effect of Cordyceps militaris (C. militaris) against NAFLD in an obese mouse model. MATERIALS/METHODS: Four-week-old male ob/ob mice were fed an AIN-93G diet or a diet containing 1% C. militaris water extract for 10 weeks after 1 week of adaptation. Serum glucose, insulin, free fatty acid (FFA), alanine transaminase (ALT), and proinflammatory cytokines were measured. Hepatic levels of lipids, glutathione (GSH), and lipid peroxide were determined. RESULTS: Consumption of C. militaris significantly decreased serum glucose, as well as homeostasis model assessment for insulin resistance (HOMA-IR), in ob/ob mice. In addition to lowering serum FFA levels, C. militaris also significantly decreased hepatic total lipids and triglyceride contents. Serum ALT activities and tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels were reduced by C. militaris. Consumption of C. militaris increased hepatic GSH and reduced lipid peroxide levels. CONCLUSIONS: These results indicate that C. militaris can exert protective effects against development of NAFLD, partly by reducing inflammatory cytokines and improving hepatic antioxidant status in ob/ob mice.
Carnosine Promotes Exhaustive Swimming Capacity in Mice
Jong-Soo Kim, Ki Nam Lee, Jin-Joo Hue, Jun-Hyeong Kim, Bong Soo Kang, Sang Yoon Nam, Young Won Yun, Jae-Hwang Jeong2, Beom Jun Lee 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.1
To investigate the effect of carnosine on exhaustive exercise, swimming tests were conducted weekly with loads corresponding to 5% of body weight attached to the tails of mice, and the swimming time to exhaustion was measured. Eighty male ICR mice were divided into four groups, to which carnosine was administered at doses of 0 (control), 10, 50, and 250 mg/kg/day, respectively, for a period of four weeks. At the end of swimming exercise challenges, serum biochemistry, oxidative stress enzyme activity, and antioxidant enzyme activity in tissues were determined. Treatment with 250 mg/kg carnosine resulted in a significant increase in swimming times to exhaustion, compared to the control group in the first (P<0.01) and third week (P<0.05). Significantly lower serum lactate levels were observed after the swimming exercise in the carnosine-treated groups (10 and 250 mg/kg), compared with the control (P<0.01). Malondialdehyde levels in the liver (10 and 50 mg/kg carnosine treated groups) and skeletal muscle (250 mg/kg carnosine treated group) were significantly lower, compared with the control (P<0.05). Significantly lower protein carbonyl levels in skeletal muscle were observed in the 50 and 250 mg/kg carnosine treated groups, compared with the control (P<0.01). Superoxide dismutase and glutathione peroxidase activities in skeletal muscle did not differ significantly among the groups. These results indicate that carnosine may improve swimming exercise capacity by attenuating production of lactate and reducing oxidative stress in mice.
Analysis of Crud on Thick Oxide Layer Formed on Zirconium Alloy Cladding
Joo Young Park,Kyung Tae Kim,Jeong Won Kim,Oh Hyun Kwon 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.2
It has been known that as oxide layer (ZrO2) forms on the nuclear fuel cladding during irradiation in nuclear power plants, the corrosion kinetics are influenced by various parameters such as chemical environments. One of those environments, crud deposition driven by coolant chemistry has an adverse effect on the formation of oxide (ZrO2) and leads to increase thickness of the layer. In this study, crud formation was performed through loop experiment equipment on the surface of intentionally-made oxide layer (ZrO2) on cladding tubes and then the composition and characteristics of cruds were examined for the investigation of nuclear power plant environment. As a result, various cruds in composition and microstructure were formed depending on the exquisite methods and conditions such as metal ion concentration.
Electro-Emission Deposition of endo-Fullerenes on Copper Surface from Carbon Nanopeapod
Jeong Won Kang,Ho Jung Hwang,Hoong Joo Lee,Jun Ha Lee,Ki Ryang Byun 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.45 No.1
This paper demonstrates that carbon nanotube peapods can be applied to a nano-electro-emitter when encapsulated endo-fullerenes are electro-emitted from the carbon nanotube under applied external electric elds. Our molecular dynamics simulations showed that the C60 molecules were easily electro-emitted from the carbon nanotube when the applied electric elds were above 0.1 V/ whereas they were occasionally electro-emitted from the carbon nanotube when the applied electric elds were below 0.05 V/A. When the applied electric elds were 0.05 to 0.09 V/A, the initial congurations, the initial velocities, and the number of encapsulated C60 molecules were found to aect the electro-emission of C60 molecules as much as the applied electric elds did.
Comparing levels of perfluorinated compounds in processed marine products
Jeong, Yu-Jin,Bang, Sunah,Kim, Jihyun,Chun, Su-Hyun,Choi, Seogyeong,Kim, Jinhye,Chung, Myung-Sub,Kang, Gil Jin,Kang, Young-Woon,Kim, Junghoan,Kho, Younglim,Joo, Yongsung,Lee, Kwang-Won Elsevier 2019 Food and chemical toxicology Vol.126 No.-
<P><B>Abstract</B></P> <P>Perfluorinated compounds (PFCs) are widely distributed in nature and have many applications due to their unique chemical and physicochemical properties. While, PFCs are present in soil, water, and air, their pathway for entry into the human body is circumstantially via contaminated food. The demand for seafood has been increasing. In this study, we investigated via LC-MS/MS, the content of 19 different types of PFCs in 302 samples belonging to five different categories of the typical South Korean seafood. The highest levels of PFOA, PFTrDA, PFOS, and PFPeA were found in dried seafood, canned and salted seafood, processed fish food, and seasoned laver, respectively. The levels of PFOA and PFOS were compared on the basis of various criteria including the nomenclature, biological classification, and habitat of the source of seafood. High levels of PFOA and PFOS were detected in anchovy, sea squirt, and mackerel based on the nomenclature of raw seafood, in crustaceans based on the biological classification, and in demersal organisms based on the habitat. The human intake values of PFOA and PFOS from the processed marine products in South Korea were lower than the tolerable daily intake, indicating that the consumption of these processed seafood poses no immediate harm.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Method validation of each food base was performed. </LI> <LI> 19 types of PFCs showed different patterns in 5 processed seafoods. </LI> <LI> The main cause of the detected levels of PFOA and PFOS was fish species. </LI> <LI> Dry process and characteristics of PFCs affect their levels in dried seafood. </LI> <LI> The levels of PFOA and PFOS were higher in demersal fish than in pelagic fish. </LI> </UL> </P>
Joo, Jeong In,Yun, Jong Won S. Karger AG 2011 Cellular physiology and biochemistry Vol.27 No.3
<P>Different responses to a high fat diet (HFD) can occur even within a group of animals with the same genetic background, such as obesity-prone (OP) or obesity-resistant (OR) phenotypes, on the same feeding. To explain these phenotypes, we performed an analysis of gene expression differences in brown (BAT) and white adipose tissue (WAT) of OP and OR rats. Microarray analysis of transcripts revealed that 91 and 53 genes showed significant differences in expression between the BAT and WAT gene, respectively. Surprisingly, a majority of these genes were significantly down-regulated in adipose tissues in response to HFD feeding. K-means clustering of the expression levels of these genes identified 4 distinct groupings of genes with significant expression levels. Only a limited number of genes were significantly regulated in adipose tissues in response to HFD feeding, whereas expression levels of a large number of genes differed significantly between OP and OR rat. Our observations support that distinct discrepancies exist in gene-expression regulations in adipose tissues, and that alteration likely resulted from significant differences in genes encoding metabolic enzymes. To the best of our knowledge, this study provided the first direct comparison of gene-expression changes between OP and OR rats.</P><P>Copyright © 2011 S. Karger AG, Basel</P>