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Hierarchical Transmission Algorithm combined coding method in the T-DMB system
Jongtae Bae,Minhyuk Kim,Suksoon Choi,Taedoo Park,Namsoo Kim,Jiwon Jung 대한전자공학회 2008 ITC-CSCC :International Technical Conference on Ci Vol.2008 No.7
T-DMB (Terrestrial Digital Multimedia Broadcasting) system, is based on the Eureka-147 standard, provides various multimedia data services. However TDMB needs more various services and higher throughput while maintaining reception. Therefore, this paper proposes advanced T-DMB system using the unequal error protection system, hierarchical multi level modulation and various coding scheme which is used for recent wireless communication, while maintaining backward compatibility. As the simulation results, proposed advanced T-DMB system has coding gain of 2~6㏈ compared to conventional T-DMB.
Core degradation simulation of the PHEBUS FPT3 experiment using COMPASS code
Bae, Jun Ho,Son, Dong Gun,Kim, Jongtae,Park, Rae Joon,Park, Jong Hwa,Kim, Dong Ha,Song, Jin Ho,Podowski, Michael Z. Elsevier 2017 Nuclear engineering and design Vol.320 No.-
<P><B>Abstract</B></P> <P>As a part of the integrated severe accident code development project in Korea, KAERI (Korea Atomic Energy Research Institute) has been developing a stand-alone severe accident analysis code, COMPASS (COre Meltdown Progression Accident Simulation Software), which simulates the in-vessel severe accident phenomena including the core heat up, material melting and relocation, corium behavior in the lower plenum, and vessel failure. For the purpose of COMPASS code validation, a numerical simulation was conducted for the PHEBUS FPT3 experiment, which is an integrated severe accident experiment, initiated in 1988 by IRSN. In the COMPASS code, the core and surrounding structure in a test section consist of a two-dimensional node system, and the mass and energy equations are established for the main component in the core and surrounding structures. The temperature evolution of the core and surrounding structure at various locations of the test section are pursued and compared with the experimental data as well as the numerical results of the MELCOR code. The hydrogen generation rate and final mass distribution are compared among the experimental data and the numerical results of COMPASS and MELCOR. Generally, the COMPASS and MELCOR codes predicted the temperature evolution and hydrogen generation rate during the experiment well. In addition, COMPASS predicted a slightly smaller mass relocation compared with the experimental data, whereas MELCOR has a larger mass relocation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A severe accident analysis code, COMPASS, has been developed in Korea. </LI> <LI> A numerical simulation of the PHEBUS FPT3 experiment was conducted by using COMPASS. </LI> <LI> COMPASS code well predicts the experimental data of PHEBUS FPT3. </LI> </UL> </P>
Bae, Soo Hyeon,Park, Wan-Su,Han, Seunghoon,Park, Gab-jin,Lee, Jongtae,Hong, Taegon,Jeon, Sangil,Yim, Dong-Seok The Korean Society of Pharmacology 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.3
It was recently reported that the $C_{max}$ and AUC of rosuvastatin increases when it is coadministered with telmisartan and cyclosporine. Rosuvastatin is known to be a substrate of OATP1B1, OATP1B3, NTCP, and BCRP transporters. The aim of this study was to explore the mechanism of the interactions between rosuvastatin and two perpetrators, telmisartan and cyclosporine. Published (cyclosporine) or newly developed (telmisartan) PBPK models were used to this end. The rosuvastatin model in Simcyp (version 15)'s drug library was modified to reflect racial differences in rosuvastatin exposure. In the telmisartan-rosuvastatin case, simulated rosuvastatin $C_{maxI}/C_{max}$ and $AUC_I/AUC$ (with/without telmisartan) ratios were 1.92 and 1.14, respectively, and the $T_{max}$ changed from 3.35 h to 1.40 h with coadministration of telmisartan, which were consistent with the aforementioned report ($C_{maxI}/C_{max}$: 2.01, $AUC_I/AUC$:1.18, $T_{max}:5h{\rightarrow}0.75h$). In the next case of cyclosporine-rosuvastatin, the simulated rosuvastatin $C_{maxI}/C_{max}$ and $AUC_I/AUC$ (with/without cyclosporine) ratios were 3.29 and 1.30, respectively. The decrease in the $CL_{int,BCRP,intestine}$ of rosuvastatin by telmisartan and cyclosporine in the PBPK model was pivotal to reproducing this finding in Simcyp. Our PBPK model demonstrated that the major causes of increase in rosuvastatin exposure are mediated by intestinal BCRP (rosuvastatin-telmisartan interaction) or by both of BCRP and OATP1B1/3 (rosuvastatin-cyclosporine interaction).
Physiologically-based pharmacokinetic predictions of intestinal BCRP
Soo Hyeon Bae,Wan-Su Park,Seunghoon Han,Gab-jin Park,Jongtae Lee,Taegon Hong,Sangil Jeon,Dong-Seok Yim 대한생리학회-대한약리학회 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.3
It was recently reported that the Cmax and AUC of rosuvastatin increases when it is coadministered with telmisartan and cyclosporine. Rosuvastatin is known to be a substrate of OATP1B1, OATP1B3, NTCP, and BCRP transporters. The aim of this study was to explore the mechanism of the interactions between rosuvastatin and two perpetrators, telmisartan and cyclosporine. Published (cyclosporine) or newly developed (telmisartan) PBPK models were used to this end. The rosuvastatin model in Simcyp (version 15)’s drug library was modified to reflect racial differences in rosuvastatin exposure. In the telmisartan–rosuvastatin case, simulated rosuvastatin CmaxI/Cmax and AUCI/AUC (with/without telmisartan) ratios were 1.92 and 1.14, respectively, and the Tmax changed from 3.35 h to 1.40 h with coadministration of telmisartan, which were consistent with the aforementioned report (CmaxI/Cmax: 2.01, AUCI/AUC:1.18, Tmax: 5 h → 0.75 h). In the next case of cyclosporine–rosuvastatin, the simulated rosuvastatin CmaxI/Cmax and AUCI/AUC (with/without cyclosporine) ratios were 3.29 and 1.30, respectively. The decrease in the CLint,BCRP, intestine of rosuvastatin by telmisartan and cyclosporine in the PBPK model was pivotal to reproducing this finding in Simcyp. Our PBPK model demonstrated that the major causes of increase in rosuvastatin exposure are mediated by intestinal BCRP (rosuvastatin–telmisartan interaction) or by both of BCRP and OATP1B1/3 (rosuvastatin–cyclosporine interaction).
An Efficient Design Methodology of Serial Concatenate Coding Scheme for CATV Transmission System
Minhyuk Kim,Jongtae Bae,Suksoon Choi,Taedoo Park,Namsoo Kim,Jiwon Jung 대한전자공학회 2008 ITC-CSCC :International Technical Conference on Ci Vol.2008 No.7
This paper describes the design methodology of serial concatenate of extended RS code, trellis coded modulation with 64-/256-QAM, based upon testing and characterization of cable systems. In implementing the cable modem, there are some problems to fabricate and fitting on FPGA chip. First, many clocks are needed in implementing cable modem because of different code rate and different modulation types. To reduce the number of clocks, we use the two memories, which are different clock speed for reading and writing data. Second, this system lost the bit-synchronization and framesynchronization in decoder, the system recognizes that all data is error. This paper solves the problems by using simple 5-stage registers and unique sync-word. Based on solutions for about problems, the cable modem is fabricated on FPGA chip name as Vertex Ⅱ pro xc2vp30-5 by Xilinx, and we confirmed the effectiveness of the results.
An Efficient Implementation of LDPC Decoder with Partial Parallel Algorithm for DVB-S2 System
Suksoon Choi1,Minhyuk Kim,Jongtae Bae,Taedoo Park,Namsoo Kim,Jiwon Jung 대한전자공학회 2008 ITC-CSCC :International Technical Conference on Ci Vol.2008 No.7
In this paper, we investigate the encoding and decoding method of the irregular LDPC (Low Density Parity Check) codes that offer diverse coding rates from 1/2 to 9/10 defined in the Digital Video Broadcasting (DVB-S2) standard. We study the efficient memory assignment and the implementing method in the LDPC codes.
Hybrid ARQ System using the Cross Layer Coding
Taedoo Park,Minhyuk Kim,Jongtae Bae,Seoksoon Choi,Namsoo Kim,Jiwon Jung 대한전자공학회 2008 ITC-CSCC :International Technical Conference on Ci Vol.2008 No.7
Hybrid automatic repeat request (H-ARQ) system using the cross layer coding suitable for future mobile communication and radio data communication system. In this paper introduce cross layer coding and HARQ type, proposed H-ARQ system using cross layer coding methods. Simulate BER performance and Throughput. And we suggest that according to channel condition suitable H-ARQ type.
A Study on MPE-FEC decoding base on LLR method in DVB-SSP system
Namsoo Kim,Minhyuk Kim,Jongtae Bae,Seoksoon Choi,Taedoo Park,Jiwon Jung 대한전자공학회 2008 ITC-CSCC :International Technical Conference on Ci Vol.2008 No.7
In this paper, we described DVB-SSP system for mobility. The DVB-SSP for mobility system used cross layer scheme which is consist of e-RS(erasure Reed-Solomon), virtual interleaver and LDPC. Erasure data for e-RS decoding is detected by CRC check in conventional DVB-SSP system. However, this paper proposed erasure data detecting method by LLR value of LDPC. It is called LLR method. Through the simulation results, we know that the performance of LLR method is better than conventional CRC method as 0.2㏈.
Han, Seunghoon,Jeon, Sangil,Hong, Taegon,Lee, Jongtae,Bae, Soo Hyeon,Park, Wan-su,Park, Gab-jin,Youn, Sunil,Jang, Doo Yeon,Kim, Kyung-Soo,Yim, Dong-Seok Dove Medical Press 2015 Drug design, development and therapy Vol.9 No.-
<P>No wholly successful weight-control drugs have been developed to date, despite the tremendous demand. We present an exposure–response model of sibutramine mesylate that can be applied during clinical development of other weight-control drugs. Additionally, we provide a model-based evaluation of sibutramine efficacy. Data from a double-blind, randomized, placebo-controlled, multicenter study were used (N=120). Subjects in the treatment arm were initially given 8.37 mg sibutramine base daily, and those who lost <2 kg after 4 weeks’ treatment were escalated to 12.55 mg. The duration of treatment was 24 weeks. Drug concentration and body weight were measured predose and at 4 weeks, 8 weeks, and 24 weeks after treatment initiation. Exposure and response to sibutramine, including the placebo effect, were modeled using NONMEM 7.2. An asymptotic model approaching the final body weight was chosen to describe the time course of weight loss. Extent of weight loss was described successfully using a sigmoidal exposure–response relationship of the drug with a constant placebo effect in each individual. The placebo effect was influenced by subjects’ sex and baseline body mass index. Maximal weight loss was predicted to occur around 1 year after treatment initiation. The difference in mean weight loss between the sibutramine (daily 12.55 mg) and placebo groups was predicted to be 4.5% in a simulation of 1 year of treatment, with considerable overlap of prediction intervals. Our exposure–response model, which included the placebo effect, is the first example of a quantitative model that can be used to predict the efficacy of weight-control drugs. Similar approaches can help decision-making during clinical development of novel weight-loss drugs.</P>