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MODAL CHARACTERISTIC ANALYSIS OF THE APR1400 NUCLEAR REACTOR INTERNALS FOR SEISMIC ANALYSIS
Park, Jong-Beom,Choi, Youngin,Lee, Sang-Jeong,Park, No-Cheol,Park, Kyoung-Su,Park, Young-Pil,Park, Chan-Il Korean Nuclear Society 2014 Nuclear Engineering and Technology Vol.46 No.5
Reactor internals are sensitive to dynamic loads such as earthquakes and flow induced vibration. Thus, it is essential to identify the dynamic characteristics to evaluate the seismic integrity of the structures. However, a full-sized system is too large to perform modal experiments, making it difficult to extract data on its modal characteristics. In this research, we constructed a finite element model of the APR1400 reactor internals to identify their modal characteristics. The commercial reactor was selected to reflect the actual boundary conditions. Our FE model was constructed based on scale-similarity analysis and fluid-structure interaction investigations using a fabricated scaled-down model.
Current Status of Industrial Waste Generation and Symbiosis Network in Gyeongsangbuk-do, South Korea
Jong-Hun Park,In-Gyung Jung,Jae-Gun Seo,Sang-Hyoun Kim 한국폐기물자원순환학회 2015 한국폐기물자원순환학회 학술대회 Vol.2015 No.05
This work aimed to analyze current status of by-products generation and industrial symbiosis network in Gyeongsangbuk-do, South Korea. Manufacturing sector of the province mainly consists of electronics, machinery, steel, metal-working industries. Gumi and Pohang have the 1st and 2nd largest worker population in the manufacturing sector. 21,950.7 ton/d of waste is generated from the industries in 2011, of which 82.2% is recycled. The industrial waste, which is not recycled, is mainly composed of sludge cake from domestic wastewater treatment plants, waste plastic, incinerator ash, and slag. Pohang is the largest generating city of both total and the non-recycled industrial waste in the province, and most of the waste is from Pohang steel industrial park. Symbiosis map in Pohang steel industrial park shows that most of the current material symbiosis in the industrial park is for waste refractories and slag.
Park, Jong Il,Han, sang seop,Jeong, Tae Cheon,Roh, Jung Koo,Kim, Hyoung Chin,Kim, Jeong Hwan,Jeon, Yeong Joong,Kim, Dal Hyun,Kim,Je Hak,Park, Kwan Ha 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.1
The antigenic potential of CFA-001, cefazolin, a cephalosporin derivative produced by an enzymatic semisynthesis, was determined in Hartley guinea pigs. A battery of tests employed consisted of active systemic anaphylaxis (ASA), passive cutaneous anaphylaxis (PCA), and indirect hemagglutination test (IHA). The results were as follows: 1) In ASA, no signs attributable to anaphylaxis was observed in guinea pigs sensitized with CFA-001, whereas OVA-sensitized animals induced severe anaphylactic symptoms; 2) guinea pigs did not produce antibodies against CFA-001 when sensitized with or without Freund's complete adjuvant (FCA) in homologous PCA tests. Meanwhile, antibodies against ovalbumin (OVA) were clearly detected; 3) No CFA-001-specific hemagglutination was observed in the IHA using sera obtained from CFA-001-sensitized guinea pigs. These results suggest that CFA-001 has no antigenicity potential in guinea pigs.
Park, Hye-Kyung,Hong, Jun-Hee,Oh, Young Taek,Kim, Sung Soo,Yin, Jinlong,Lee, An-Jung,Chae, Young Chan,Kim, Jong Heon,Park, Sung-Hye,Park, Chul-Kee,Park, Myung-Jin,Park, Jong Bae,Kang, Byoung Heon American Association for Cancer Research 2019 Cancer Research Vol.79 No.7
<P>Discovery and functional analysis of a TRAP1-SIRT3 complex in glioma stem cells identify potential target proteins for glioblastoma treatment.</P><P><B></B></P><P>Glioblastoma (GBM) cancer stem cells (CSC) are primarily responsible for metastatic dissemination, resistance to therapy, and relapse of GBM, the most common and aggressive brain tumor. Development and maintenance of CSCs require orchestrated metabolic rewiring and metabolic adaptation to a changing microenvironment. Here, we show that cooperative interplay between the mitochondrial chaperone TRAP1 and the major mitochondria deacetylase sirtuin-3 (SIRT3) in glioma stem cells (GSC) increases mitochondrial respiratory capacity and reduces production of reactive oxygen species. This metabolic regulation endowed GSCs with metabolic plasticity, facilitated adaptation to stress (particularly reduced nutrient supply), and maintained “stemness.” Inactivation of TRAP1 or SIRT3 compromised their interdependent regulatory mechanisms, leading to metabolic alterations, loss of stemness, and suppression of tumor formation by GSC <I>in vivo</I>. Thus, targeting the metabolic mechanisms regulating interplay between TRAP1 and SIRT3 may provide a novel therapeutic option for intractable patients with GBM.</P><P><B>Significance:</B></P><P>Discovery and functional analysis of a TRAP1–SIRT3 complex in glioma stem cells identify potential target proteins for glioblastoma treatment.</P>
Current Status of Industrial Waste Generation and Symbiosis Network in Gyeongsangbuk-do, South Korea
( Jong-hun Park ),( In-gyung Jung ),( Jae-gun Seo ),( Sang-hyoun Kim ) 한국폐기물자원순환학회(구 한국폐기물학회) 2015 한국폐기물자원순환학회 춘계학술발표논문집 Vol.2015 No.-
This work aimed to analyze current status of by-products generation and industrial symbiosis network in Gyeongsangbuk-do, South Korea. Manufacturing sector of the province mainly consists of electronics, machinery, steel, metal-working industries. Gumi and Pohang have the 1st and 2nd largest worker population in the manufacturing sector. 21,950.7 ton/d of waste is generated from the industries in 2011, of which 82.2% is recycled. The industrial waste, which is not recycled, is mainly composed of sludge cake from domestic wastewater treatment plants, waste plastic, incinerator ash, and slag. Pohang is the largest generating city of both total and the non-recycled industrial waste in the province, and most of the waste is from Pohang steel industrial park. Symbiosis map in Pohang steel industrial park shows that most of the current material symbiosis in the industrial park is for waste refractories and slag.
Postural Instability and Cognitive Dysfunction in Early Parkinson's Disease
Lee, Jong Moon,Koh, Seong-Beom,Chae, Sung Won,Seo, Woo-Keun,Kwon, Do Young,Kim, Ji Hyun,Oh, Kyungmi,Baik, Jong Sam,Park, Kun Woo Cambridge University Press 2012 The Canadian journal of neurological sciences Vol.39 No.4
<B>Background:</B><P>Postural instability is one of the most disabling features of Parkinson's disease, usually occurring in late and advanced stages. The aim of this study was to investigate the postural performance of early-stage de novo Parkinson's disease patients with no clinical postural instability using computerized dynamic posturography. We sought to understand the relationship between postural sway and disease severity and the relationship between postural instability quantitatively measured by computerized dynamic posturography and cognitive impairment in early-stage Parkinson's disease patients.</P><B>Method:</B><P>Thirty-one subjects with Parkinson's disease and 20 healthy controls were assessed by the computerized dynamic posturography protocol using the sensory organization test and the motor control test. A neuropsychological assessment was also administered.</P><B>Results:</B><P>The mean equilibrium score for sensory organization test and the vestibular input ratio were significantly correlated with Hoehn-Yahr stage. No associations between motor latency for any motor control test condition and Hoehn-Yahr stage were found. The equilibrium score for sensory organization test correlated with the mini-mental status examination scores. There was a significant correlation between motor latency for large backward translation and mini-mental status examination scores. There were significant correlations between visual perception/construction/ memory of the neuropsychological battery test and the equilibrium score for sensory organization test and between verbal word learning test, controlled word association test and motor latency for large backward translation.</P><B>Conclusion:</B><P>These findings showed the postural instability present in early-stage (Hoehn-Yahr stage 2-2.5) Parkinson's disease. We also found a close relationship between postural instability and cognitive function in Parkinson's disease patients.</P>
Catalytic oxidation of benzene with ozone over Mn/KIT-6.
Park, Jong Hwa,Kim, Ji Man,Jurng, Jongsoo,Bae, Gwi-Nam,Park, Sung Hoon,Kim, Sang Chai,Jeon, Jong-Ki,Park, Young-Kwon American Scientific Publishers 2013 Journal of Nanoscience and Nanotechnology Vol.13 No.1
<P>Benzene is one of the target compounds to be removed from air owing to its carcinogenicity. In this study, benzene oxidation with ozone over a MnOx/KIT-6 catalyst was carried out for the first time. MnOx/KIT-6 was synthesized using two different Mn precursors: Mn acetate and Mn nitrate. The characteristics of the synthesized catalysts were examined by X-ray diffraction, X-ray photoelectron spectroscopy, temperature-programmed reduction, Brunauer-Emmett-Teller (BET) surface area, and N2 adsorption-desorption. The catalytic activity was found to be dependent on the amount of ozone consumed and the dispersion and reducibility of MnOx on the catalyst surface.</P>
Catalytic Oxidation of Benzene with Ozone Over Nanoporous Mn/MCM-48 Catalyst
Park, Jong-Hwa,Jurng, Jongsoo,Bae, Gwi-Nam,Park, Sung Hoon,Jeon, Jong-Ki,Kim, Sang Chai,Kim, Ji Man,Park, Young-Kwon American Scientific Publishers 2012 Journal of Nanoscience and Nanotechnology Vol.12 No.7
<P>The catalytic oxidation of a representative volatile organic compound, benzene, with ozone at a low temperature was investigated. A nanoporous MCM-48 material with a high specific surface area was used as the support for the catalytic oxidation for the first time. Mn, which has high activity at a low temperature, was used as the metal catalyst. To examine the effect of the Mn precursor, MCM-48 was impregnated with two different Mn precursors: Mn acetate and Mn nitrate. The characteristics of the synthesized catalysts were analyzed by Brunauer Emmett Teller surface area, X-ray diffraction, X-ray photoelectron spectroscopy, and temperature-programmed reduction. MCM-48 impregnated with Mn acetate showed higher catalytic activity than MCM-48 impregnated with Mn nitrate. This result was attributed to the better dispersion within nanoporous MCM-48 and higher oxygen mobility of Mn oxides produced by Mn acetate. The catalytic activity was also shown to depend closely on the ozone concentration.</P>
Park Jong Sung,Lee Jang Hoon,Hong Chae Moon,Park Bo Eun,Park Yoon Jung,Kim Hong Nyun,Kim Namkyun,Jang Se Yong,Bae Myung Hwan,Yang Dong Heon,Park Hun Sik,Cho Yongkeun 대한의학회 2023 Journal of Korean medical science Vol.38 No.46
Background: Positron emission tomography (PET) viability scan is used to determine whether patients with a myocardial scar on single-photon emission computed tomography (SPECT) may need revascularization. However, the clinical utility of revascularization decision-making guided by PET viability imaging has not been proven yet. The purpose of this study was to investigate the impact of PET to determine revascularization on clinical outcomes. Methods: Between September 2012 and May 2021, 53 patients (37 males; mean age = 64 ± 11 years) with a myocardial scar on MIBI SPECT who underwent PET viability test were analyzed in this study. The primary outcome was a temporal change in echocardiographic findings. The secondary outcome was all-cause mortality. Results: Viable myocardium was presented by PET imaging in 29 (54.7%) patients. Revascularization was performed in 26 (49.1%) patients, including 18 (34.0%) with percutaneous coronary intervention (PCI) and 8 (15.1%) with coronary artery bypass grafting. There were significant improvements in echocardiographic findings in the revascularization group and the viable myocardium group. All-cause mortality was significantly lower in the revascularization group than in the medical therapy-alone group (19.2% vs. 44.4%, log-rank P = 0.002) irrespective of viable (21.4% vs. 46.7%, log-rank P = 0.025) or non-viable myocardium (16.7% vs. 41.7%, log-rank P = 0.046). All-cause mortality was significantly lower in the PCI group than in the medical therapy-alone group (11.1% vs. 44.4%, log-rank P < 0.001). Conclusion: Revascularization improved left ventricular systolic function and survival of patients with a myocardial scar on SPECT scans, irrespective of myocardial viability on PET scans.