Key Features in the Operation of KSTAR

Jong-Gu Kwak,Oh, Y. K.,Kim, K. P.,Kim, S. W.,Hong, S. H.,Chu, Y.,Lee, H. J.,Kim, Y. O.,Kim, J.,Park, S. L.,Hahn, S. H.,Park, M. K.,Kim, H. K.,Bak, J. G.,Bae, Y. S.,Ko, W. H.,Lee, S. G.,Lee, J. H.,Jung IEEE 2012 IEEE transactions on plasma science Vol.40 No.3

<P>The Korea Superconducting Tokamak Advanced Research (KSTAR) device is aimed at advanced tokamak (AT) research. Three years have passed since it achieved its first plasma in 2008. Because it is a superconducting machine and is working toward AT research, it has unique features in terms of the machine engineering and operation. The toroidal field (TF) magnet coils are made of Nb<SUB>3</SUB>Sn, which provide high TFs up to 3.5 T, and have been fully tested. The poloidal field (PF) magnet coils, consisting of both Nb<SUB>3</SUB>Sn and NbTi, which have a maximum current of 25 kA in their design, were tested up to 15 kA. A thermal hydraulic analysis is being conducted for PF magnet coil operation. All plasma-facing components (PFCs) are equipped with water cooled graphite tiles and have the capability of being baked up to 350°C. A startup scenario, which considered both the effect of the ferromagnetic material in the cable in conduit conductor jacket of the magnet coils as well as a nonferromagnetic up-down asymmetry in the cryostat structure, was developed and demonstrated its effectiveness by the last two year's reliable operations. Passive stabilizers and in-vessel control coils (IVCCs) are key components to realize AT operation in KSTAR. The segmented IVCC coils were connected to form circular coils for internal vertical control in 2010, and diverted plasmas with high elongation (κ~1.8, δ>;0.6) were achieved. A neutral beam injection (NBI) system was developed aiming at 2 MW, 300 s per ion source which meets the long-pulse requirement of KSTAR. An NBI ion source with a power of 1.7 MW at 100 kV has been commissioned for 10 s. Finally, ELMy H-modes were successfully produced with 1.3-MW NBI power at a plasma current of 0.6 MA in the 2010 campaign. The first H-mode discharge (#4200) in KSTAR was achieved one year earlier than officially planned and was done at B<SUB>T</SUB> = 2 T with I<SUB>p</SUB> = 0.6 MA in a well-balanced double null configuration after boronization on the PFC. Successful operations in the early days of KSTAR including H-mode experiments revealed the capability of advanced and steady-state operation which is essential for the international thermonuclear experimental reactor (ITER) and future fusion reactors.</P>

HYBRID VOLTERRA SYSTEM WITH TWO TYPES OF IMPULSES

Park, Jong-Seo,S.A. Belbas,Kim, Seon-Yu 晋州敎育大學校 科學敎育硏究院 2006 科學敎育硏究 Vol.29 No.-

본 연구의 목적은 충격을 받는 조건이 두 가지 유형과 다중 적분을 갖는 볼테라 적분 방정식의 어떤 특성을 포함하는 방정식의 색다른 부류를 조직적으로 확립하고 분석해 보고자 한다. 여기서 우리는 반복하는 방법에 의하여 주어진 조건의 적분방정식에 대한 해의 존재성과 유일성을 구조적으로 밝히는데 그 목적이 있다. 본 논문을 통한 발전적인 연구가 수행되면 여러 가지 자연현상을 모델화하여 적용함으로 인해 이론적인 부분뿐만 아니라 응용적인 면에서 아주 많이 적용될 것으로 생각되며 전자공학, 자동제어, 생물학, 의학 등의 다양한 실생활의 문제에 활용이 가능한 충분한 가치가 있으리라 생각한다. In this paper, we formulate and analyze a novel class of equations that contain some of the characteristics of Volterra intergral equations with multiple integrals and two types of impulsive terms. We will give a constructive proof of existence and uniqueness of solutions by an iteration method.

Clinical Significance of Chronic Kidney Disease and Atrial Fibrillation on Morbidity and Mortality in Patients with Acute Myocardial Infarction

Hwang, Hyeon Seok,Park, Mahn-Won,Yoon, Hye Eun,Chang, Yoon Kyung,Yang, Chul Woo,Kim, Suk Young,Cho, Jung Sun,Kim, Chan Joon,Park, Gyung-Min,Park, Chul-Soo,Choi, Yun-Seok,Koh, Yoon-Seok,Lee, Jong Min,S S. Karger AG 2014 American journal of nephrology Vol.40 No.4

<P>Abstract</P><P><B><I>Background/Aims:</I></B> Atrial fibrillation (AF) often coexists with acute myocardial infarction (AMI), and chronic kidney disease (CKD) is a major risk for AMI. However, the combined impact of CKD and AF on the mortality and morbidity in AMI population has not been determined. <B><I>Methods:</I></B> Between January 2004 and December 2009, a total of 4,738 AMI patients were enrolled prospectively. Patients were divided into four groups according to the combined status of CKD and AF. The primary endpoint was a combination of 5-year major adverse cardiac and cerebrovascular events (MACCE). <B><I>Results:</I></B> The prevalence of AF was significantly higher in CKD patients than in non-CKD patients (6.76 vs. 3.31%, p < 0.001). The highest cumulative event rate of MACCE and death was observed in patients with both CKD and AF (68.5 and 64.0%), respectively. In multivariable analyses, compared with patients with neither AF nor CKD, hazard ratios (HR) for composite of MACCE were 1.66 (95% CI, 1.14-2.41), 1.24 (95% CI, 1.06-1.46), and 2.10 (95% CI, 1.42-3.13) for patients with AF only, those with CKD only, and those with both CKD and AF, respectively (p for interaction = 0.935). Patients with both CKD and AF had a greatest risk for all-cause mortality (HR 2.54; 95% CI, 1.60-4.53), and the significant synergistic interaction was observed between CKD and AF (p for interaction = 0.015). <B><I>Conclusion:</I></B> The combined effect of AF and CKD on the risk of MACCE after an AMI is stronger than any separate condition, and it confers a synergistic effect on the all-cause mortality risk.</P><P>© 2014 S. Karger AG, Basel</P>

원발성 간암에 있어서 혈청 Alphafetoprotein 의 진단적 의의에 관하여

박종춘(Jong Chun Park),김세종(S.J. Kim) 대한소화기학회 1984 대한소화기학회지 Vol.16 No.1

N/A An elevated serum alphafetoprotein (AFP) concentration in a nonpregnant adult is the most discriminating laboratory test indicative of malignant disease now available. AFP is found on low concentration in the serum of normal adults, but it appears in high concentration in fetal serum at 12 weeks gestation. Elevations in adults are associated with pregnancy, a variety of nonneoplastic liver diseases, primary hepatocellular carcinoma and teratocarcinoma containing yolk sac elements. Extensive evaluation of the serum AFP concentration as a diagnostic marker for primary hepatocellular carcinoma has been carried out over the last 10 years. The measurement of serum AFP concentration is very useful in the diagnosis of hepatocellular carcinoma. Hepatitis B virus has been linked to hepatocarcinogenesis and recent evidence suggests incorporation of the hepatitis B virus genome into the cancer cell chromosome. Serum AFP was measured quantitatively by radioimmunoassay technique in 296 patients, who visited the out-clinic or were hospitalized at Chonnam University Hospital during the period from June 1981 to July 1983. Those who were tested included 33 cases of normal population as control group, 133, hepatic diseases(46, primary hepatocelluar carcinoma; 11, hepatic metastatic tumor; 76, cirrhosis of liver; 13, acute viral hepatitis; 24, chronic hepatitis), 70 cases of nonhepatic malignant diseases, and 23 cases of the other nonhepatic diseases as the disease group. HBsAg was measured by enzyme immunoassay technique in 35 out of 46 cases of primary hepatocellular carcinoma. The results obtained were as follows; 1) The serum AFP concentration in 33 cases of normal control subjects was 4+-3 ng/ml (Mean+-S.D., Range: 0-12 ng/ml). Upper limit of serum AFP concentration in the normal adult was considered 10 ng/ml, which was derived from mean+-1.96 S.D. 2) In hepatic diseases, the serum AFP concentration was 30+-67 ng/ml(2-248 ng/ml) in acute viral hepatitis, 34+-57 ng/ml(1-260 ng/ml) in chronic active hepatitis, 10+-17 ng/ml (1-35 ng/ml) in chronic persistent hepatitis, 46+-74 ng/ml(0-350 ng/ml) in cirrhosis, 1,590+-2,245 ng/ml(0-8,000 ng/ml) in primary hepatocellular carcinoma and 86+-132 ng/ml(0-360ng/ml) in metastatic tumor of the liver. 3) Serum AFP concentration was exceeded the 400ng/ml only in hepatocellular carcinoma, which was revealed in 26 cases out of 46 cases of primary hepatocellular carcinoma. 4) HBsAg was positive in 21 cases out of 35 cases of primary hepatocellular carcinoma. In 16 out of 21 HBsAg positive cases, AFP was exceeded 400 ng/ml. 5) There were no significant changes of serum AFP concentration in the process of disease. Follow-up examination had been done at 2 to 6 weeks later the initial examination.

Wine Production Using Osmotic Solution from Dried Mango Process

Annalene S. Garcia,Jae Ho Park,Hyung Jin Jeong,Youn Moon Park,Koo Min Chung,Jong Hwa Lee 한국산업식품공학회 2009 산업 식품공학 Vol.13 No.2

This study evaluated the potential of utilizing the osmotic solution from dried mango processing as alternative raw material for mango wine making. Fermentation was carried out using two kinds of yeast strains Saccharomyces bayanus, Lalvin EC-1118 and Saccharomyces cerevisiae, Lalvin D-47 at 20℃ for 28 days. Physicochemical analysis during fermentation was performed for each treatment and the resulting wine samples were analyzed for color, volatiles and sensory properties. Results of physicochemical analysis between the two fermenting samples as well as the wine samples show almost similar results regardless of the yeast strains. Wine color of sample wines after storage were not significantly different at p<0.05 and when compared with a commercial mango wine. From the volatile analysis, esters and alcohols constituted majority of the compounds. Production of several esters, alcohols, acids and terpenes were affected by yeast strain used in fermentation. Results of sensory analysis showed that wines fermented by S. bayanus EC-1118 strain was more acceptable although sensory scores between the treatments and the reference wine showed significant differences in all the attributes evaluated, except for bitterness. The utilization of osmotic solution from dried mango process could produce similar properties with existing commercial mango wines although there is still need for further work on the improvement of some sensory attributes of the mango wines.

창의적 문제해결력 신장을 위한 초등학교 사회과 수업에서 학습효과에 영향을 미치는 학생변인 분석

이종연 ( Jong Yeon Lee ),구양미 ( Yang Mi Koo ),남민우 ( M. Nam ),박상훈 ( S. Park ),김병수 ( B. Kim ),박도인 ( D. Park ),서정희 ( J. Seo ),고범석 ( B. Go ),진석언 ( Suk Un Jin ) 한국교육정보미디어학회(구 한국교육정보방송학회) 2007 교육정보미디어연구 Vol.13 No.1

본 연구의 목적은 초등학생들의 사전 창의적 문제해결력, 사회과 영역지식, 메타인지, 학습동기, ICT활용능력 수준이 사회과 창의적 문제해결력 신장을 위한 교육 프로그램을 경험한 후 최종적인 창의적 문제해결력 및 사회과 학업성취도에 어떠한 영향을 미치는지 분석하여, 프로그램의 개선 및 효과적인 운영의 시사점을 도출하는 것이다. 연구대상은 서울 마포구 소재 S초등학교 5학년 5개 학급이었다. 5학년 3개 반에는 창의적 문제해결력 증진을 위한 프로그램 온·오프 연계 버전이 적용되었고, 2개 반에는 오프라인 버전이 적용되었다. 학기 시작 전, 본 연구에 참여한 학생들 모두 사전 창의적 문제해결력 검사와 사회과 영역지식 검사를 받았다. 온·오프 연계 그룹 학생들은 메타인지, 학습동기, ICT활용능력 수준을 조사하는 설문지에 응답했고, 오프라인 그룹 학생들은 메타인지, 학습동기 수준을 조사하는 설문지에 응답했다. 조사가 끝난 후, 창의적 문제해결력 증진을 위한 프로그램을 포함한 5학년 2학기 사회과 수업을 진행하였고 모든 수업을 완료한 후, 사후 창의적 문제해결력 검사와 학업성취도 검사를 받았다. 처치그룹별로 단계적 회귀분석을 실시한 결과, 온·오프 연계 버전을 운영하였을 경우, 학습자들의 사전 창의적 문제해결력과 영역지식이 사후 창의적 문제해결력과 학업성취도에 공통적으로 영향력이 있는 것으로 나타났다. 즉 사전 창의적 문제해결력 수준이 높을수록 사회과 기초지식이 많을수록 사후 창의적 문제해결력이 높았고 학업성취도도 높았다. 오프라인 버전을 운영하였을 경우, 학습자들의 영역지식 수준은 사후 창의적 문제해결력과 학업성취도에 공통적으로 영향력을 미치는 것으로 나타났고, 메타인지 수준은 사후 창의적 문제해결력 수준에 영향력이 있는 것으로 나타났다. 본 연구의 결과는 우선 사회과 창의적 문제해결력 증진을 위한 프로그램의 수업효과를 증진시키기 위해서는 버전에 관계없이 학습자의 영역지식 수준을 증진시키는 방안에 주력해야 함을 시사하고 있다. 또한 온·오프 연계 버전 적용 시 학습자의 사전 창의적 문제해결력과 영역지식 수준을 고려하는 운영방안 또는 교과과정 차별화 방안과, 오프라인 버전 적용 시 학습자의 영역지식과 메타인지 수준을 고려하는 운영방안 또는 교과과정 차별화 방안을 마련하는 것이 필요하다는 것을 알 수 있도록 한다. The purpose of this study was to analyze the effects of learners variables such as entry-level creative problem solving skills, domain-knowledge, meta-cognition, motivation, and the level of ICT use on learners` final creative problem solving skills and learning achievement in social studies after running Creative Thinker Program. Creative Thinker Program was composed of 9 units reorganized by Creative Problem Solving Model. A unique online support system was developed to assist teacher`s and students` six step activities in each unit. Five 5th grade classes from an elementary schools located in Seoul were participated in this study and they were divided into two treatment groups, on- & off-line blended treatment group and off-line treatment group. On- & off-line blended treatment meant that the online support system was fully utilized. Off-line treatment meant that most options of the system were substituted by printed materials. Stepwise multiple regression analysis showed that both students` entry-level creative problem solving skills and domain knowledge were significant predictors of final creative problem solving skills and achievement in social studies when running on- & off-line blended version of Creative Thinker Program. In case of off-line version, students` domain knowledge was a significant predictor of their final creative problem solving skills and achievement in social studies. Also students` level of meta-cognition was found to be a significant predictor of their final creative problem solving skills.

Wine Production Using Osmotic Solution from Dried Mango Process

Annalene S. Garcia,Jae-Ho Park,Hyung-Jin Jeong,Youn-Moon Park,Koo-Min Chung,Jong-Hwa Lee 한국산업식품공학회 2009 산업 식품공학 Vol.13 No.2

This study evaluated the potential of utilizing the osmotic solution from dried mango processing as alternative raw material for mango wine making. Fermentation was carried out using two kinds of yeast strains Saccharomyces bayanus, Lalvin EC-1118 and Saccharomyces cerevisiae, Lalvin D-47 at 20oC for 28 days. Physicochemical analysis during fermentation was performed for each treatment and the resulting wine samples were analyzed for color, volatiles and sensory properties. Results of physicochemical analysis between the two fermenting samples as well as the wine samples show almost similar results regardless of the yeast strains. Wine color of sample wines after storage were not significantly different at p<0.05 and when compared with a commercial mango wine. From the volatile analysis, esters and alcohols constituted majority of the compounds. Production of several esters, alcohols, acids and terpenes were affected by yeast strain used in fermentation. Results of sensory analysis showed that wines fermented by S. bayanus EC-1118 strain was more acceptable although sensory scores between the treatments and the reference wine showed significant differences in all the attributes evaluated, except for bitterness. The utilization of osmotic solution from dried mango process could produce similar properties with existing commercial mango wines although there is still need for further work on the improvement of some sensory attributes of the mango wines.

The effects of topical mesenchymal stem cell transplantation in canine experimental cutaneous wounds

Kim, Ju-Won,Lee, Jong-Hwan,Lyoo, Young S,Jung, Dong-In,Park, Hee-Myung Blackwell Publishing Ltd 2013 Veterinary dermatology Vol.24 No.2

<P><B>Background</B></P><P>Adult stem cells have been widely investigated in bioengineering approaches for tissue repair therapy. We evaluated the clinical value and safety of the application of cultured bone marrow-derived allogenic mesenchymal stem cells (MSCs) for treating skin wounds in a canine model.</P><P><B>Hypothesis</B></P><P>Topical allogenic MSC transplantation can accelerate the closure of experimental full-thickness cutaneous wounds and attenuate local inflammation.</P><P><B>Animals</B></P><P>Adult healthy beagle dogs (<I>n</I> = 10; 3–6 years old; 7.2–13.1 kg) were studied.</P><P><B>Methods</B></P><P>Full-thickness skin wounds were created on the dorsum of healthy beagles, and allogenic MSCs were injected intradermally. The rate of wound closure and the degree of collagen production were analysed histologically using haematoxylin and eosin staining and trichrome staining. The degree of cellular proliferation and angiogenesis was evaluated by immunocytochemistry using proliferating cell nuclear antigen-, vimentin- and α-smooth muscle actin-specific antibodies. Local mRNA expression levels of interleukin-2, interferon-γ, basic fibroblast growth factor and matrix metalloproteinase-2 were evaluated by RT-PCR.</P><P><B>Results</B></P><P>Compared with the vehicle-treated wounds, MSC-treated wounds showed more rapid wound closure and increased collagen synthesis, cellular proliferation and angiogenesis. Moreover, MSC-treated wounds showed decreased expression of pro-inflammatory cytokines (interleukin-2 and interferon-γ) and wound healing-related factors (basic fibroblast growth factor and matrix metalloproteinase-2).</P><P><B>Conclusion and clinical importance</B></P><P>Topical transplantation of MSCs results in paracrine effects on cellular proliferation and angiogenesis, as well as modulation of local mRNA expression of several factors related to cutaneous wound healing.</P><P><B>Résumé</B></P><P><B>Contexte</B></P><P>Les cellules souches adultes ont été largement étudiées dans les approches de bio-ingénierie pour la thérapie de réparation tissulaire. Nous évaluons l'efficacité clinique et la sécurité de l'application de cellules souches mésenchymateuses allogéniques en culture dérivées de moelle osseuse (MSCs) pour le traitement de plaies cutanées dans un modèle canin.</P><P><B>Hypothèse</B></P><P>La transplantation de MSC allogénique topique peut accélérer la fermeture en toute épaisseur de plaies cutanées expérimentales et atténuer l'inflammation locale.</P><P><B>Sujets</B></P><P>Des chiens beagles adultes sains (<I>n</I> = 10; 3–6 ans; 7.2–13.1 kg) ont été étudiés.</P><P><B>Méthodes</B></P><P>Des plaies cutanées en pleine épaisseur ont été crées sur la face dorsale des beagles sains et des MSCs allogènes ont été injectées par voie intradermique. Le taux de cicatrisation et le degré de production de collagène ont été analysés sur le plan histologique par colorations à l'hématoxyline et éosine et par trichrome. Le degré de prolifération cellulaire et d'angiogénèse ont été évalués par immunohistochimie à l'aide d'anticorps spécifiques d'antigène nucléaire de prolifération cellulaire, de vimentine et d'actine de muscle lisse α. Les taux d'expression local d'ARNm d'interleukine-2, d'interféron-γ, du facteur de croissance basique de fibroblaste et de métalloprotéinase-2 de matrice, ont été évalués par RT-PCR.</P><P><B>Résultats</B></P><P>Comparé avec les plaies traité

Design of a compact rectangular mono-cone antenna for UWB applications

Choi, Il H.,Choi, Sang S.,Park, Jong K.,Song, Hyo W.,An, Hee S. JOHN WILEY & SONS LTD 2007 MICROWAVE AND OPTICAL TECHNOLOGY LETTERS Vol.49 No.6

<P>In this articel, we have designed, fabricated, and measured a compact rectangular mono-cone antenna for UWB applications. The measured bandwidth is 8.2 GHz from 2.8 GHz to 11 GHz for S<SUB>11</SUB> < −10 dB. The path loss S<SUB>11</SUB> and phase were measured and discussed. The radiation patterns and antenna gain across the frequency bands are also presented. From the measured results, the proposed antenna shows a good characteristic (almost linear phase, omni-directional pattern, and very low gain variation). © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 1320–1323, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22430</P>

Nanostructured glycan architecture is important in the inhibition of influenza A virus infection

Kwon, Seok-Joon,Na, Dong Hee,Kwak, Jong Hwan,Douaisi, Marc,Zhang, Fuming,Park, Eun Ji,Park, Jong-Hwan,Youn, Hana,Song, Chang-Seon,Kane, Ravi S.,Dordick, Jonathan S.,Lee, Kyung Bok,Linhardt, Robert J. Nature Publishing Group, a division of Macmillan P 2017 Nature nanotechnology Vol.12 No.1

<P>Rapid change(1) and zoonotic transmission to humans(2) have enhanced the virulence of the influenza A virus (IAV)(3). Neutralizing antibodies fail to provide lasting protection from seasonal epidemics(1),(4). Furthermore, the effectiveness of anti influenza neuraminidase inhibitors has declined because of drug resistances. Drugs that can block viral attachment and cell entry independent of antigenic evolution or drug resistance might address these problems. We show that multivalent 6'-sialyllactose-polyamidoamine (6SL-PAMAM) conjugates, when designed to have well-defined ligand valencies and spacings, can effectively inhibit IAV infection. Generation 4 (G4) 6SL-PAMAM conjugates with a spacing of around 3 nm between 6SL ligands (S3-G4) showed the strongest binding to a hemagglutinin trimer (dissociation constant of 1.6 x 10(-7) M) and afforded the best inhibition of H1N1 infection. S3-G4 conjugates were resistant to hydrolysis by H1N1 neuraminidase. These conjugates protected 75% of mice from a lethal challenge with H1N1 and prevented weight loss in infected animals. The structure-based design of multivalent nanomaterials, involving modulation of nanoscale backbone structures and number and spacing between ligands, resulted in optimal inhibition of IAV infection. This approach may be broadly applicable for designing effective and enduring therapeutic protection against human or avian influenza viruses.</P>