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상아질 표면 구조와 광중합형 글라스 아이오노머의 전단강도에 대한 레이저 조사의 효과
박미령,김종수,김용기 大韓小兒齒科學會 1998 大韓小兒齒科學會誌 Vol.25 No.1
The purpose of this study was to evaluate the possible efficacy of Nd-YAG laser as a dentin conditioner by observing the laser irradiation dentin surface under scanning elestron micrograph and measuring shear bond strength of restored light-cured glass ionomer mold. Fifty intact premolars were prepared for shear bond strength tests. The teeth were randomly divided into five groups as follows; Group Ⅰ. no treatment Group Ⅱ. 10% polyacrylic acid, 20 sec Group Ⅲ. laser treatment 2 w, 20 ㎐, 2 sec Group Ⅳ. laser treatment 2 w, 20 ㎐, 5 sec Group Ⅴ. laser treatment 2 w, 20 ㎐, 10 sec Samples of each froup were restored with light-cured glass ionomer cement after dentin conditioning and then measuring the shear bond strenght of each specimen were measured using universal testing machine. Additional ten premoarls were prepared for SEM analysis The result from the this study can be summarized as follows. 1. Shear bond strength of polyacrylic acid-treated group (Ⅱ) was significantly higher than other froupa (p<0.05). 2. No statistically significant difference could be found between three laser-treated groups (Ⅲ,Ⅳ,Ⅴ) in shear bond strength(p>0.05). 3. According to the result of observation under SEM, Polyacrylic acid was shown tohave removed the smear layer effectively and opened the dentinal tubules, whereas the laser has produced the irregular mainly composed of melted and fused structure. The microcracks found in laser-treated groups increased in number with irradiation time and formed the regular mesh-type in 10 sec-irradiation group. 4. The ultrastructural change of dentin surface created by laser irradiation was found to the improper for bonding of the glass ionomer restorative materials. And the lower shear bond strength of laser irradiater group might have been due to the failure to form the suitable dentin surface for the glass ionomer to penetrated into and form the proper micromechanical retention.
Microabrasion Techinique을 이용한 치아변색의 치료증례
박미령,김용기,김종수 大韓小兒齒科學會 1997 大韓小兒齒科學會誌 Vol.24 No.3
Tooth discoloration detracts from one's appearance and influences self-image and it is particularly true in children. Therfore, pediatric dentists are required to treat tooth discoloration manifested in children for the normal development of their psycosocial health. Three treatment modalities are currently availabler for the removal of a variety of intrinsic stains from vital teeth. These are enamel microabrasion technique using hydrochloric acid, offece bleaching and home bleaching and home bleaching technique with carbamide. Microabrasion technique has several advantages over bleaching in that it is easy to accomplish and does not require multiple office visits or the expensive instruments and the color change seems to be permanent after treatment. The process relies on decalcification, a softening with HCI and then removal of the enamel containing the stain with rubbing. Due to the mechanism of stain removal,this method is indicated for the removal of superficial enamel stains or discoloration only. We report four successfully treated cases by enamel microabrasion using 15% HCI and pumice. Entire clinical steps are described in detail with some discussions on the outcome.
Bong-Soo Park,Jong-Jin Kil,Hae-Mi Kang,Su-Bin Yu,Dan-Bi Park,Jin-A Park,In-Ryoung Kim 대한구강생물학회 2018 International Journal of Oral Biology Vol.43 No.2
Oral squamous cell carcinoma (OSCC) is the most common type of oral malignancy. Numerous therapies have been proposed for its cure. Research is continually being conducted to develop new forms of treatment as current therapies are associated with numerous side-effects. Luteolin, a common dietary flavonoid, has been demonstrated to possess strong anti-cancer activity against various human cancer cell lines. Nevertheless, research into luteolin-based anticancer activity against oral cancer remains scarce. Thus, the objective of this study was to assess the effect of luteolin as an anti-cancer agent. After treatment with luteolin, Ca9-22 and CAL-27 oral cancer cells showed condensed nuclei and enhanced apoptotic rate with evidence of mitochondria-mediated apoptosis. Epithelial-mesenchymal transition (EMT) is closely related to tumor migration and invasion. Luteolin suppressed cancer cell invasion and migration in the current study. Elevated expression of E-cadherin, an adherens junction protein, was evident in both cell lines after luteolin treatment. Luteolin also significantly inhibited transcription factors (i.e., N-cadherin, Slug, Snail, Twist, and ZEB-1) that regulated expression of tumor suppressors such as E-cadherin based on Western blot analysis and quantitative PCR. Thus, luteolin could induce mitochondrial apoptosis and inhibit cancer cell invasion and migration by suppressing EMT-induced transcription factors.
Seminal CD38 is a pivotal regulator for fetomaternal tolerance
Kim, Byung-Ju,Choi, Yun-Min,Rah, So-Young,Park, Dae-Ryoung,Park, Seon-Ah,Chung, Yun-Jo,Park, Seung-Moon,Park, Jong Kwan,Jang, Kyu Yun,Kim, Uh-Hyun National Academy of Sciences 2015 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.112 No.5
<P><B>Significance</B></P><P>In natural matings, semen delivers spermatozoa and immunoregulatory fluids to the female reproductive tract. Here, a soluble form of CD38 (sCD38) is shown to play an important role in facilitating maternal immune tolerance against the fetus by inducing the development of uterine tolerogenic DCs and forkhead box P3<SUP>+</SUP> (Foxp3<SUP>+</SUP>) regulatory T cells. Deficiency of sCD38 in seminal fluid increased the rates of loss of allogeneic fetuses, and this loss was rescued by a direct injection of recombinant sCD38 into the uterus. Thus, seminal sCD38 acts as a pivotal immune suppressor for establishing maternal immune tolerance against the fetus. sCD38 could potentially be used to prevent failed pregnancies.</P><P>A successful pregnancy depends on a complex process that establishes fetomaternal tolerance. Seminal plasma is known to induce maternal immune tolerance to paternal alloantigens, but the seminal factors that regulate maternal immunity have yet to be characterized. Here, we show that a soluble form of CD38 (sCD38) released from seminal vesicles to the seminal plasma plays a crucial role in inducing tolerogenic dendritic cells and CD4<SUP>+</SUP> forkhead box P3<SUP>+</SUP> (Foxp3<SUP>+</SUP>) regulatory T cells (Tregs), thereby enhancing maternal immune tolerance and protecting the semiallogeneic fetus from resorption. The abortion rate in BALB/c females mated with C57BL/6 <I>Cd38</I><SUP><I>−/−</I></SUP> males was high compared with that in females mated with <I>Cd38</I><SUP><I>+/+</I></SUP> males, and this was associated with a reduced proportion of Tregs within the CD4<SUP>+</SUP> T-cell pool. Direct intravaginal injection of sCD38 to CBA/J pregnant mice at preimplantation increased Tregs and pregnancy rates in mice under abortive sonic stress from 48 h after mating until euthanasia. Thus, sCD38 released from seminal vesicles to the seminal plasma acts as an immunoregulatory factor to protect semiallogeneic fetuses from maternal immune responses.</P>
Jong-Ryoul Kim,Sung-Hee Kim,In-Ryoung Kim,Bong-Soo Park,Yong-Deok Kim 대한구강악안면외과학회 2016 대한구강악안면외과학회지 Vol.42 No.1
Objectives: The purpose of this study was to investigate the effects of low-level laser therapy (LLLT) with a diode gallium-aluminum-arsenide (GaAl-As) low-level laser device on the healing and attachment of titanium implants in bone. Materials and Methods: Thirteen New Zealand white male rabbits weighing 3.0±0.5 kg were used for this study. Dental titanium implants (3.75 mm in diameter and 8.5 mm in length, US II RBM plus fixture; Osstem, Seoul, Korea) were implanted into both femurs of each rabbit. The rabbits were randomly divided into a LLLT group and a control group. The LLLT was initiated immediately after surgery and then repeated daily for 7 consecutive days in the LLLT group. Six weeks and 12 weeks after implantation, we evaluated and compared the osseointegration of the LLLT group and control group, using histomorphometric analysis, removal torque testing, and resonance frequency analysis (RFA). The results were statistically significant when the level of probability was 0.05 or less based on a non-parametric Mann-Whitney U-test. Results: The implant survival rate was about 96%. Histologically and histomorphometrically, we observed that the titanium implants were more strongly attached in LLLT group than in control group. However, there was no significant difference between the LLLT group and control group in removal torque or RFA. Conclusion: Histologically, LLLT might promote cell-level osseointegration of titanium implants, but there was no statistically significant effects.
Immobilization stress increased cytochrome P450 1A2 (CYP1A2) expression in the ovary of rat
Jong-Chan Hwang,Hwan-Deuk Kim,Byung-Joon Park,Ryoung-Hoon Jeon,Su-Min Baek,Seoung-Woo Lee,Min Jang,Seul-Gi Bae,Sung-Ho Yun,Jin-Kyu Park,Young-Sam Kwon,Seung-Joon Kim,Won-Jae Lee 한국동물생명공학회(구 한국동물번식학회) 2021 Journal of Animal Reproduction and Biotechnology Vol.36 No.1
Under the stressed condition, a complex feedback mechanism for stress is activated to maintain homeostasis of the body and secretes several stress hormones. But these stress hormones impair synthesis and secretion of the reproductive hormones, followed by suppression of ovarian function. Cytochrome P450 1A2 (CYP1A2) plays a major role in metabolizing exogenous substances and endogenous hormones, and its expression is recently identified at not only the liver but also several organs with respect to the pancreas, lung and ovary. Although the expression of CYP1A2 can be also affected by several factors, understanding for the changed pattern of the ovarian CYP1A2 expression upon stress induction is still limited. Therefore, CYP1A2 expression in the ovaries from immobilization stress-induced rats were assessed in the present study. The stress-induced rats in the present study exhibited the physiological changes in terms of increased stress hormone level and decreased body weight gains. Under immunohistological observation, the ovarian CYP1A2 expression in both control and the stressed ovary was localized in the antral to pre-ovulatory follicles. However, its expression level was significantly (p < 0.01) higher in the stress-induced group than control group. In addition, stress-induced group presented more abundant CYP1A2-positive follicles (%) than control group. Since expression of the ovarian CYP1A2 was highly related with follicle atresia, increased expression of CYP1A2 in the stressed ovary might be associated with changes of the ovarian follicular dynamics due to stress induction. We hope that these findings have important implications in the fields of the reproductive biology.