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초내열합금 B1900의 미세조직과 인장특성에 미치는 고온노출의 영향
김인수,최백규,서성문,조창용 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.7
Influence of thermal exposure on microstructural evolution and tensile properties of Ni-base superalloy B1900 has been investigated. Phase transformations during thermal exposure and their effects on tensile behavior of the alloy have been analyzed by microstructural observations. Considerable amount of acicular type M_(6)C carbide precipitated in the interdendritic regions (including γ/γ' eutectic) and in the vicinity of MC carbide as a result of thermal exposure above 871°C. Thermal exposure also assisted precipitation of small discrete M_(23)C_(6) carbide which is hard to be found in the alloy. Thermal exposure deteriorated tensile properties of the alloy. The effect of M_(6)C precipitation on the tensile properties of the alloy is not clear. However, degradation of tensile properties of the alloy is primarily attributed to the coarsening of y' phase during thermal exposure. While the localized deformation bands were observed in the as-cast tensile specimen due to shearing of γ' particle, dislocation network formed at γ/γ'interface in the thermally exposed tensile specimen.
hcp-Mg 입자분산형 Mg-Zn-Ce계 비정질합금의 제조와 기계적 성질
Kim, Seong-Gyu,Park, Heung-Il,Kim, U-Yeol,Jo, Seong-Myeong,Kim, Yeong-Hwan,Inoue, A.,Masumoto, T. 한국재료학회 1994 한국재료학회지 Vol.4 No.8
Mg-Zn-Ce계 합금에서 비정질 단상 및 hcp-Mg입자분산형 비정질합금이 20-40%, Zn, 0-10%Ce과 5-20%Zn, 0-5%Ce 의 조성범위에서 각각 생성되었다. 초미세 hcp-Mg입자분산형 $Mg_{85}Zn_{12}Ce_{3}$비정질합금은 급속응고 또는 급속응고리본의 열처리에 의해 Mg입자의 입경을 4-20nm의 범위로 조절할 수 있었으며, 이 범위에서는 밀착굽힘이 가능할 만큼 충분한 인성을 가지고 있었다. 이 합금의 최대인장강도($\sigma_{B}$)와 파단 연신율($\varepsilon_{f}$)은 hcp-Mg입자의 체적분율에 따라서 670-930MPa, 5.2-2.0%의 범위였으며, 최대 비강도($\sigma_{B}$밀도 =$\sigma_{s}$)는 $3.6 \times 10^5N \cdot m/kg$에 달하였다. 이와 같이 Mg입자분산형 비정질 합금의($\sigma_{B}$), ($\sigma_{s}$)그리고 $\varepsilon_{f}$의 최대치가 Mg-Zn-Ce계 비정질합금(690MPa, $2.5 \times 10^5N \cdot m/kg$, 2.5%)보다 월등하게 높다는 것은 주목할 만 하다. 복합상 조직이 형성됨으로서 기계적 강도가 증가하는 것은 동일 조성의 비정질상보다 강한 hcp과포화 고용체의 분산강화에 기인하는 것이라고 고찰되었다. An amorphous single phase and coexistent amorphous and hcp-Mg phases in Mg-Zn-Ce system were found to form in the composition ranges of 20 to 40% Zn, 0 to 10% Ce and 5 to 20% Zn, 0 to 5% Ce, respectively. A $Mg_{85}Zn_{12}Ce_{3}$ amorphous alloy containing nanoscale hcp-Mg particles was found to form either by melt spinning or by heat treatment of melt -spun ribbon. The particle size of the hcp-Mg phase can be controlled in the range of 4 to 20 nm. The mixed phase alloy prepared thus has a good bending ductility and exhibits high ultimate tensile strength($\sigma_{B}$) ranging from 670 to 930 MPa and fracture elongation($\varepsilon_{f}$) of 5.2 to 2.0%. The highest specific strength($\sigma_{B}$/density =$\sigma_{s}$)$3.6 \times 10^5N \cdot m/kg$. It should be noted that the highest values of flB, US and ?1 are considerably higher than those (690MPa,$2.5 \times 10^5N \cdot m/kg$and 2.5%) for amorphous Mg-Zn-Ce alloys. The increase of the mechanical strengths by the formation of the mixed phase structure is presumably due to a dispersion hardening of the hcp supersaturated solution which has the hardness higher than that of the amorphous phase with the same composition.
조지형 ( Jo Ji Hyeong ),장민화 ( Jang Min Hwa ),조영준 ( Jo Yeong Jun ),박선희 ( Park Seon Hui ),조동규 ( Jo Dong Gyu ),김성호 ( Kim Seong Ho ),황중하 ( Hwang Jung Ha ),조규향 ( Jo Gyu Hyang ),도준영 ( Do Jun Yeong ),윤경우 ( Yun 대한내과학회 2003 대한내과학회지 Vol.65 No.4
목적: 학교, 군, 직장 등에서 집단 신체검사가 의무적으로 행해지면서 우리 나라에서 무증상 요 이상은 임상에서 흔히 접할 수 있는 질환임에도 아직 이에 대한 임상 및 조직 병리학적 소견에 관한 연구는 부족한 상태이다. 저자들은 무증상 요 이상을 주소로 내원한 환자들의 임상양상 및 신 생검을 통한 병리학적 소견을 조사하여 이전의 보고들과 비교 분석하고자 하였다. 방법: 1998년 1월부터 2002년 7월까지 대구지역 3개 종합병원에 무증상 요 이상을 주소 Background: Asymptomatic urinary abnormalities are one of the most frequent abnormalities in clinical nephrology. However, there are few large-scaled studies about the clinical manifestations and the pathologic findings of the disease. The aim of present
밤나무 꽃과 화학성분 및 항균활성 검색 -제2보. 항균활성 검색-
조규성 ( Jo Gyu Seong ),김해영 ( Kim Hae Yeong ) 한국응용생명화학회 2003 Applied Biological Chemistry (Appl Biol Chem) Vol.46 No.3
Chestnut (Castanea crenata S. et Z.) leaves and flowers were extracted with 80% methanol and then fractionated with ethylacetate, methanol and water. Their antimicrobial activities in each fraction were investigated. Methanol fraction of the chestnut leaves and flower showed strong antimicrbial activities against both of Gram positive and Gram negative bacteria. The ethylacetate and water fraction, however, showed only weak antimicrobial activities when the antimicrobial activities were occurred. Minimal inhibitory concentration (MIC) of the methanol extracts of the chestnut leaves and flowers against 5 strains of Gram positive and Gram negative bacteria were at 60 ㎍/disc. The extracts of the chestnut leaves and flowers inhibited the growth of Bacillus subtilis at 0.5% (w/w) concentration. In order to investigate the effect of extraction methods on the B. subtilis, scanning electron microscope was used. The B. subtilis was damaged when the methanol extracts of the chestnut leves and flowers were at 500 ppm.
Intense Pulsed Light의 유래, 작용 원리와 임상 진료에서의 올바른 사용
조성문 ( Seong Moon Jo ),김방순 ( Bang Soon Kim ),김혜성 ( Hei Sung Kim ),고주연 ( Joo Yeon Ko ),노미령 ( Mi Ryung Roh ),양성규 ( Seong Gyu Yang ),유화정 ( Hwa Jung Ryu ),최재우 ( Jae Woo Choi ),황지환 ( Ji Hwan Hwang ),박현선 ( H 대한피부과학회 2013 大韓皮膚科學會誌 Vol.51 No.11
Intense pulsed light (IPL) is a high-intensity polychromatic incoherent light of a determined wavelength spectrum, fluence, and pulse duration. Clinicians can combine these variable factors of IPL for the purpose of selective destruction of target chromophores. Due to these properties, IPL has been widely used for numerous indications including hair removal and treatment of vascular or pigmented lesions. For skilled and experienced clinicians, IPL is a great treatment modality; however it can be a source of serious adverse effects when performed by untrained clinicians. Thus, to promote the proper and safe use of IPL, we summarized the origin, history, basic principles, and clinical application of IPL and discussed qualification factors needed for clinicians who use IPL. (Korean J Dermatol 2013;51(11):845∼850)
밤나무 꽃과 잎의 화학성분 및 항균활성 검색 -제1보. 화학성분 조성-
조규성 ( Jo Gyu Seong ),조재선 ( Jo Jae Seon ) 한국응용생명화학회 2003 Applied Biological Chemistry (Appl Biol Chem) Vol.46 No.3
Chemical components relevant to the characteristic antimicrobial activities of the Korean chestnut(Castanea crenata S. et Z.) leaves and flowers were analyzed. The composition of free sugar were sucrose, maltose in the chestnut flower and 1.98% in the chestnut leaves. In fatty acids case, the linoleic contents were significantly high in the chestnut leaves and flowers. The organic acids showed high composition to succnic and citric acid in the chestnut leaves. The amino acid compositions showed high contents to aspatic acid, proline, glutamic acid, glycine and methionine in the chestnut leaves than flowers. The total amino acid showed significantly higher in the chestnut leaves than flowers. The major minerals contained in the chestnut leaves and flowers were K, Ca, Ng. Fe, Mn and Al. Ascorbic acids were detected highly in the chestnut leaves and flowers.
조성 ( Jo Seong ),김용림 ( Kim Yong Lim ),김성록 ( Kim Seong Log ),조동규 ( Jo Dong Gyu ),김용진 ( Kim Yong Jin ),강성규 ( Kang Seong Gyu ) 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.6
카드뮴은 도금, 플라스틱, 유리, 합금, 전기소재 등의 제조에 널리 사용되고 있으며 이로 인한중독은 요세관 장애, 폐기종, 폐암, 골연화증, 요로결석 등을 일으킨다. 제련업, 배터리 제조업 등카드뮴 관련 산업이 많은 국내에서 카드뮴 중독증에 대한 체계적인 연구는 아직 없는 실정이다. 이에 저자들은 한국산업안전공단 산업보건연구원과 공동으로 카드뮴 중독이 진단된 5예에 대한요검사, 혈액검사, 신장조직 검사, 골밀도검사, 폐기능 검사 등을 실시하여 결과를 보고한다. 요중 카드뮴 농도가 5예 모두 1회 이상 5 μg/g creatinine 이상으로 측정[1차 38.51±42.68(7.27-101.07) μg/g creatinine, 2차 10.70±7.16(3.88-21.05) μg/g creatinine]되어 카드뮴 중독으로 진단하였다. 요중 N-acetyl-β-D-glucosaminidase(NAG)는 9.19±2.21(7.25-12.79)U/g creatinine[기준치 4.5U/g creatinine]로 증가되어 있었다. 요중 β2-microglobulin, Metallothionein(MT), 24시간요 단백량, 24시간요 칼슘량 모두 정상이었다. 요중 카드뮴 농도와 요중 NAG 배설량과는 양의 상관관계(r=0.912, p=0.031)를 보였다. 사구체 여과율은 109.8±8.9(96.5-118) mL/min로 정상이었다. 혈액 검사, 간기능검사, 신기능검사, 전해질 검사는 모두 정상이었다. 요검사에서 1예의 단백뇨 및 혈뇨(조직검사에서 IgA 신증으로 진단)를 제외하곤 모두정상 이었다. 병리조직검사에서는 전예 모두 간질의 경한 섬유화를 보였으나 염증세포의 침윤은 없었다. IgA 신증이 1예에서 동반되었다. 1예에서 골다공증 및 폐쇄성 폐질환이 동반되었다. Cadmium-containing compounds are widely used in the manufacturing of pigments, plastics, glass, metal alloys, and electrical equipment. Chronic low exposure of cadmium causes renal tubular dysfunction, emphysema, bronchial cancer, osteomalasia, multiple fracture or urethral stone. Occupations exposed to cadmium are increasing in industsralized country such as Korea, but there is a few systemic study on cadmium intoxication until nowadays. We studied the effects of cadmium on renal function, pulmonary function and bone mineral density in 5 workers exposed to cadmium. Cadmium in urine were increased [38.51±42.68 (7.27-101.07) μg/g creatinine(1 st exam), 0.70±7.16 (3.88-21.05) μg/g creatinine(2 nd exam)], respectively. Urine N-acetyl-β-D-glucosaminidase(NAG) excretion rates[9.19±2.21(7.25-12.79) U/g creatinine] were increased, but urinary β2-microglobulin(β2- MG), urinary methalothionein(MT) excretion, 24 hour urinary protein, calcium excretions were not increased. Cadmium in urine was correlated with urine NAG(r=0.912, p=0.031) but no relationship with others. Glomerular filtration rate were all within normal limits. Complete blood counts, liver function, renal function, electrolytes were all within normal limits. In urinalysis and sediment examination, 4 cases showed no abnormalities, but 1 case showed proteinuria(30 mg/dL) and hematuria with dysmorphic RBC dominance(This case was diagnosed accompanying IgA nephropathy). In pathologic examination, all biopsy specimens showed mild interstitial fibrosis without inflammatory cell infiltration. Osteoporosis and obstructive lung defect were diagnosed in one case. We found urinary NAG excretion were increased and mild interstitial fibrosis at biopsy specimen were seen in all cases. It is necessary to follow- up for detection of proteinuria and decrement of GFR in each patients.
카테킨 섭취와 지구성 운동이 Obese Zucker Rat의 골격근 형태별 GLUT-4 단백질과 혈청 지질 성분에 미치는 영향
이규성(Lee Gyu Seong),김문희(Kim Mun Hui),홍순모(Hong Sun Mo),허성민(Heo Seong Min),원상호(Won Sang Ho),김윤만(Kim Yun Man),윤지성(Yun Ji Seong),조준용(Jo Jun Yong) 한국사회체육학회 2003 한국사회체육학회지 Vol.20 No.2
Obesity and diabetes have been increased at an alaming rate in recent years and is now a worldwide health problem. We investigate the effects of 8wk feeding tea catechin which is natural polyphenolic compounds and 8wk treadmill exercise on the skeletal muscle GLUT-4 protein, serum glucose, insulin and lipids(TC, TG, HDL-C, LDL-C) in the insulin resistant obese Zucker rats(fa/fa). Male obese Zucker rats either remained sedentary(fa/fa, n=4), recieved catechins(5㎖=2.5g/250㎖(1%) day-1, fa/fa, n=4), performed treadmill exercise(fa/fa, n=4) or underwent both catechin supplementation and treadmill exercise(fa/fa, n=4) for 8wk. During oral glucose tolerance test(OGTT), treadmill exercise alone or in combination with catechins resulted in a significant lowering of the glucose, insulin and TC, TG, LDL-C responses compared with sedentary controls. Treadmill exercise or in combination with catechin group individually increased insulin-regulated glucose transporter(GLUT-4) in isolated soleus, plantaris and gastrocnemius muscle. The greatest expressions in GLUT-4 protein in these muscles were observed in the treadmill exercise group. Thus, enhancement in glucose transport in soleus, plantaris and gastrocnemius muscle due to treadmill exercise and in combination with catechin was related to enhanced GLUT-4 protein and decrease glucose, insulin and TC, TG, LDL-C. These results suggest that treadmill exercise and in combination with catechin individually may reduce the risk of associated diseases including diabetes and coronary heart disease.