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Lim Yu Jeong,Bang Jisun,Ko Youngsun,Seo Hyun-Min,Jung Woon Yong,Yi Joo Hark,Han Sang-Woong,유미연 대한의학회 2020 Journal of Korean medical science Vol.35 No.35
Nephrogenic systemic fibrosis (NSF) is a progressive systemic fibrosing disease that may occur after gadolinium contrast exposure. It can lead to severe complications and even death. NSF is highly prevalent among patients with advanced chronic kidney disease (CKD). In this report, however, we describe the case of a patient with NSF that occurred during early CKD. A 65-year-old man with stage 3a CKD was transferred to our hospital because of lower extremity edema. The medical history revealed that he was exposed to gadolinium 185 days earlier, and the result of his tibial skin biopsy was consistent with NSF. The patient underwent a combined therapy with ultraviolet-A1 phototherapy and methotrexate and steroid therapy for 6 months. The combined therapy stopped the systemic progression of NSF.
소아 천식의 진단에서 호기산화질소와 메타콜린 및 adenosine-5`-monophosphate 기관지유발시험의 비교
윤지선 ( Jisun Yoon ),박준성 ( Jun Sung Park ),조현주 ( Hyun Ju Cho ),이은 ( Eun Lee ),양송이 ( Song I Yang ),홍수종 ( Soo Jong Hong ),유진호 ( Jinho Yu ) 대한천식알레르기학회 2016 Allergy Asthma & Respiratory Disease Vol.4 No.2
Purpose: Asthma is a chronic airway inflammatory disease characterized by bronchial hyperresponsiveness and reversible airway obstruction. Bronchial challenge with methacholine or adenosine-5`-monophosphate (AMP) has been used to diagnose asthma. Recently, measurement of exhaled nitric oxide (eNO) can also be used for the diagnosis of asthma. The aim of this study was to compare the diagnostic value for asthma between challenge with methacholine or AMP and eNO in children with chronic nonspecific respiratory symptoms. Methods: One hundred thirty-three children who have chronic nonspecific respiratory symptoms were enrolled. Bronchial challenge with methacholin and AMP were performed, and eNO was measured in all subjects. Subjects were defined as asthma based on the clinical symptoms and bronchodilator response during follow-up of at least 3 months after test. Results: Thirty-three subjects (34%) were finally diagnosed as asthma among 97 patients after 3-month follow-up. The area under the receiver operating characteristic curves for the diagnosis of asthma were 0.903 (95% confidence interval [CI], 0.838-0.969; P<0.001) for methacholline challenge, 0.867 (95% CI, 0.783-0.950; P<0.001) for AMP challenge, and 0.588 (95% CI, 0.467-0.709, P=0.156) for eNO measurement. The cutoff values of these tests were methacholine PC20 (provocative concentration of methacholine causing a 20% fall in forced expiratory volume in one second) 12.0 mg/mL (sensitivity, 87.9%; specificity, 82.8%), AMP PC20 566.2 mg/mL (sensitivity, 84.8%; specificity, 85.9%), and eNO 18.5 ppb (sensitivity, 45.5%; specificity, 71.9%). Conclusion: Measurement of eNO may be inferior to challenge with methacholine and AMP for the diagnosis of asthma in children. (Allergy Asthma Respir Dis 2016;4:100-106)
아동기 외상 경험과 문제행동에 대한 청소년 자신과 부모 평가 간의 관계
유재학(Jaehak Yu),서민재(Min-Jae Seo),박지선(Jisun Park) 대한소아청소년정신의학회 2013 소아청소년정신의학 Vol.24 No.1
Objectives:The aim of this study was to investigate correlation of childhood trauma experience and parent-adolescents’ assessment reports on problem behavior through comparison of delinquent and general adolescents. Methods:First, delinquent adolescents and general adolescents were asked to complete the Childhood Trauma Questionnaire (CTQ). Then, 71 pairs of delinq uent adolescents and their parents and 133 pairs of general adolescents and their parents were asked to complete the Korean Youth Self-Report (K-YSR) and the Korean Child Behavior Checklist (K-CBCL). Finally, responses from 410 people were used for the analysis. Results:First, childhood trauma experience score was significantly higher for delinquent adolescents, compared to general adolescents. Second, t-test showed a greater difference between K-YRS and K-CBCL for general adolescents than for delinquent adolescents. Third, in the case of delinquent adolescents, the correlation analysis of K-YSR filled out by adolescents and K-CBCL filled out by parents showed significant correlation in certain areas, including social immaturity, delinquent behaviors, internalization issues, and externalization issues. On the other hand, the correlation analysis of K-YSR and K-CBCL of general adolescents showed significant correlation in all sub-categories. Fourth, the correlation analysis of delinquent adolescents’ CTQ and K-YSR showed minimal yet significant correlation in social adaptation, withdrawing, depression/anxiety, and delinquent/aggressive behaviors, however, no correlation was observed between CTQ and K-CBCL. The correlation analysis of general adolescents’ CTQ and K-YSR, and CTQ and K-CBCL showed significant correlation in all sub-categories, although the degree of correlation varied. Conclusion:Delinquent adolescents had more childhood traumatic experiences. However, general adolescents’ childhood traumatic experiences showed minimal yet significant correlation with various adaptation indicators and their parents responded in a similar way, indicating that general adolescents with childhood traumatic experiences need close care and attention even if they have not shown prominent delinquent behaviors.
( Sungsu Jung ),( Jisun Yoon ),( Jinho Yu ) 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-
Background: Bronchiolitis obliterans syndrome (BOS) is a life-threatening respiratory complication of allogeneic hematopoietic cell transplant. Even though lung function test is crucial in the diagnosis and monitoring of BOS, the trajectory of lung function in patients with bronchiolitis obliterans syndrome (BOS) is poorly understood. Methods: Twenty three children aged 11.8±4.9 years with BOS after allogeneic hematopoietic cell transplantation were enrolled, and their clinical data were reviewed retrospectively. All subjects were performed pulmonary function test regularly after occurrence of BOS. Results: The number of subjects expired due to respiratory failure was 8 (34.8%), and 4 (17.4%) subjects underwent lung transplantation among 23 subjects with BOS. The mean value of FEV1% predicted at the diagnosis of BOS was 37.0±13.0%, and it rose after 12months (47.0±24.9%). Baseline FEV1 and FVC % predicted were tended to be lower in the expired group (85.5±11.7%) than those in the survival group (93.7±12.0%). The changes in FEV1 % predicted after 3 months of BOS diagnosis were significantly lower in the expired group (-0.29±0.28%) than in survival group (0.02±0.18%). However, there were no significant differences of the change of FEV1 Predicted % at 6 and 12 months after baseline between two groups. Conclusion: The change of FEV1 was significantly different between the expired group and the survival group during the first 3months after BOS. These results suggest active intervention strategy is needed during the first 3monts after BOS to improve prognosis.