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Jinyao Chen,Yang Song,Lishi Zhang 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.5
Lycopene is a potentially useful compound for preventing and treating cardiovascular diseases and cancers. Studies on the effects of lycopene on oxidative stress offer insights into its mechanism of action and provide evidence-based rationale for its supplementation. In this analysis, randomized controlled trials of the effects of oral lycopene supplementation on any valid outcomes of oxidative stress were identified and pooled through a search of international journal databases and reference lists of relevant publications. Two reviewers extracted data from each of the identified studies. Only studies of sufficient quality were included. Twelve parallel trials and one crossover trial were included in the systematic review, and six trials provided data for quantitative meta-analysis. Our results indicate that lycopene supplementation significantly decreases the DNA tail length, as determined using comet assays, with a mean difference (MD) of - 6.27 [95% confidence interval (CI)- 10.74, - 1.90] (P = .006) between the lycopene intervention groups and the control groups. Lycopene supplementation does not significantly prolong the lag time of low-density lipoprotein (MD 3.76 [95% CI - 2.48, 10.01]; P = .24). Lycopene possibly alleviates oxidative stress; however, biomarker research for oxidative stress needs be more consistent with the outcomes in lycopene intervention trials for disease prevention.
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( Hongwei Guo ),( Jinyao Han ),( Jingjing Wu ),( Hongwen Chen ) 한국미생물생명공학회(구 한국산업미생물학회) 2019 Journal of microbiology and biotechnology Vol.29 No.4
The engineered Aspergillus oryzae has a high NADPH demand for xylose utilization and overproduction of target metabolites. Glucose-6-phosphate dehydrogenase (G6PDH, E.C. 1.1.1.49) is one of two key enzymes in the oxidative part of the pentose phosphate pathway, and is also the main enzyme involved in NADPH regeneration. The open reading frame and cDNA of the putative A. oryzae G6PDH (AoG6PDH) were obtained, followed by heterogeneous expression in Escherichia coli and purification as a his6-tagged protein. The purified protein was characterized to be in possession of G6PDH activity with a molecular mass of 118.0 kDa. The enzyme displayed maximal activity at pH 7.5 and the optimal temperature was 50°C. This enzyme also had a half-life of 33.3 min at 40°C. Kinetics assay showed that AoG6PDH was strictly dependent on NADP+ (K<sub>m</sub> = 6.3 μM, k<sub>cat</sub> = 1000.0 s<sup>-1</sup>, k<sub>cat</sub>/K<sub>m</sub> =158.7 s<sup>-1</sup>·μM<sup>-1</sup>) as cofactor. The K<sub>m</sub> and k<sub>cat</sub>/K<sub>m</sub> values of glucose-6-phosphate were 109.7 s<sup>-1</sup>·μM<sup>-1</sup> and 9.1 s<sup>-1</sup>·μM<sup>-1</sup> respectively. Initial velocity and product inhibition analyses indicated the catalytic reaction followed a two-substrate, steady-state, ordered BiBi mechanism, where NADP<sup>+</sup> was the first substrate bound to the enzyme and NADPH was the second product released from the catalytic complex. The established kinetic model could be applied in further regulation of the pentose phosphate pathway and NADPH regeneration of A. oryzae to improve its xylose utilization and yields of valued metabolites.
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He, Dehua,Huang, Weiguo,Liu, Jinyao,Zhou, Mingxing,Zhu, Qiming 한국화학공학회 1998 Korean Journal of Chemical Engineering Vol.15 No.5
Catalytic performance of various acids in the coupling reaction of formaldehyde and methyl formate to produce methyl glycolate and methyl methoxy acetate has been studied. The influence of reaction conditions, such as catalyst amount, reaction temperature, reaction time, and molar ratio of formaldehyde to methyl formate, has also been investigated. The results showed that the acid strength had great influence on the reaction, namely, stronger acds had higher activities. It was also found that the reaction temperature and time had significant effect on the reaction, and the preferable conditions were quite different as different acids were used.
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Haitao Zheng,Meng Wang,Lixin Jiang,Haidi Chu,Jinchen Hu,Jinyao Ning,Baoyuan Li,Dong Wang,Jie Xu 대한암학회 2016 Cancer Research and Treatment Vol.48 No.2
Purpose The importance of long noncoding RNAs (lncRNAs) in tumorigenesis has recently been demonstrated. However, the role of lncRNAs in development of thyroid cancer remains largely unknown. Materials and Methods Using quantitative reverse transcription polymerase chain reaction, expression of three lncRNAs, including BRAF-activated long noncoding RNA (BANCR), papillary thyroid cancer susceptibility candidate 3 (PTCSC3), and noncoding RNA associated with mitogen-activated protein kinase pathway and growth arrest (NAMA), was investigated in the current study. Results Of the three lncRNAs (BANCR, PTCSC3, and NAMA), expression of BANCR was significantly up-regulated while PTCSC3 and NAMA were significantly down-regulated in papillary thyroid carcinoma (PTC) compared to that in normal tissue. BANCR-knockdown in a PTC-derived cell line (IHH-4) resulted in significant suppression of thyroid stimulating hormone receptor (TSHR). BANCR-knockdown also led to inhibition of cell growth and cell cycle arrest at G0/G1 phase through down-regulation of cyclin D1. In addition, BANCR was enriched by polycomb enhancer of zeste homolog 2 (EZH2), and silencing BANCR led to decreased chromatin recruitment of EZH2, which resulted significantly reduced expression of TSHR. Conclusion These findings indicate that BANCR may contribute to the tumorigenesis of PTC through regulation of cyclin D1 and TSHR.
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