Comparison of Multiple Chronic Obstructive Pulmonary Disease (COPD) Indices in Chinese COPD Patients

( Jinsong Zhang ),( Anastasia Miller ),( Yongxia Li ),( Qinqin Lan ),( Ning Zhang ),( Yanling Chai ),( Bing Hai ) 대한결핵 및 호흡기학회 2018 Tuberculosis and Respiratory Diseases Vol.81 No.2

Background: Chronic obstructive pulmonary disease (COPD) is a serious chronic condition with a global impact. Symptoms of COPD include progressive dyspnea, breathlessness, cough, and sputum production, which have a considerable impact on the lives of patients. In addition to the human cost of living with COPD and the resulting death, COPD entails a huge economic burden on the Chinese population, with patients spending up to one-third of the average family income on COPD management in some regions is clinically beneficial to adopt preventable measures via prudent COPD care utilization, monetary costs, and hospitalizations. Methods: Toward this end, this study compared the relative effectiveness of six indices in predicting patient healthcare utilization, cost of care, and patient health outcome. The six assessment systems evaluated included the three multidimensional Body mass index, Obstruction, Dyspnea, Exercise capacity index, Dyspnea, Obstruction, Smoking, Exacerbation (DOSE) index, and COPD Assessment Test index, or the unidimensional measures that best predict the future of patient healthcare utilization, cost of care, and patient health outcome among Chinese COPD patients. Results: Multiple linear regression models were created for each healthcare utilization, cost, and outcome including a single COPD index and the same group of demographic variables for each of the outcomes. Conclusion: We conclude that the DOSE index facilitates the prediction of patient healthcare utilization, disease expenditure, and negative clinical outcomes. Our study indicates that the DOSE index has a potential role beyond clinical predictions.

Research on Data Transmission Security Technology of Wireless Sensor Networks

Jinsong Zhang,Hua Zhang 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.12

In this paper, regarding to the online data compression issue of wireless sensor networks, a disconnected segmented linear compression algorithm GDPLA is proposed. The algorithm uses the least number of disconnected segments to approximate describing the original time series under the condition of the error limit ε be guaranteed. The algorithm GDPLA is an optimal algorithm from the number of segments generated. In addition, the GDPLA algorithm requires linear run-time only, and the linear coefficient is 6, which makes it suitable for resource-constrained wireless sensor networks. Finally, the experiments on two real data sets show that the compression rate of our algorithm is obviously superior to other algorithms.

Comparison of Multiple Chronic Obstructive Pulmonary Disease (COPD) Indices in Chinese COPD Patients

Zhang, Jinsong,Miller, Anastasia,Li, Yongxia,Lan, Qinqin,Zhang, Ning,Chai, Yanling,Hai, Bing The Korean Academy of Tuberculosis and Respiratory 2018 Tuberculosis and Respiratory Diseases Vol.81 No.2

Background: Chronic obstructive pulmonary disease (COPD) is a serious chronic condition with a global impact. Symptoms of COPD include progressive dyspnea, breathlessness, cough, and sputum production, which have a considerable impact on the lives of patients. In addition to the human cost of living with COPD and the resulting death, COPD entails a huge economic burden on the Chinese population, with patients spending up to one-third of the average family income on COPD management in some regions is clinically beneficial to adopt preventable measures via prudent COPD care utilization, monetary costs, and hospitalizations. Methods: Toward this end, this study compared the relative effectiveness of six indices in predicting patient healthcare utilization, cost of care, and patient health outcome. The six assessment systems evaluated included the three multidimensional Body mass index, Obstruction, Dyspnea, Exercise capacity index, Dyspnea, Obstruction, Smoking, Exacerbation (DOSE) index, and COPD Assessment Test index, or the unidimensional measures that best predict the future of patient healthcare utilization, cost of care, and patient health outcome among Chinese COPD patients. Results: Multiple linear regression models were created for each healthcare utilization, cost, and outcome including a single COPD index and the same group of demographic variables for each of the outcomes. Conclusion: We conclude that the DOSE index facilitates the prediction of patient healthcare utilization, disease expenditure, and negative clinical outcomes. Our study indicates that the DOSE index has a potential role beyond clinical predictions.

Planning performance based contracts of repairable system using discrete event simulation

Xinghui Zhang,Jianshe Kang,Jinsong Zhao,Hongzhi Teng 대한기계학회 2014 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.28 No.10

This paper investigates a discrete event simulation approach for managing performance based contracts of repairable systems. We focuson an integrated service delivery environment where the manufacturer develops capital-intensive systems and also provides aftersalessupport. We propose a simulation model to calculate system availability comprehending four performance drivers: life time distribution,repair time distribution, spare parts inventory, and repair facility. This simulation model allows the service supplier to minimizethe total cost by optimizing the four performance drivers. In this simulation model, the failure time and repair time can follow arbitrarydistribution. This will allow the customer to monitor the supplier’s service through comparing the actual availability and its theoreticalvalue. The costs of three maintenance policies also can be studied under the performance based contracts framework. Two cases are consideredin this paper. One is a system containing single unit, one warehouse, and one repair center. Another is a system containing twofleets with different installed units, two spare part warehouses with one for each fleet, and a central repair depot.

Soil Classification Using Near Infrared Spectroscopy and Ga-Plsda Procedure

Hongtu Xie,Jinsong Zhao,Qiubing Wang,Yueyu Sui,Jingkuan Wang,Xueming Yang,Xudong Zhang 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6

Research on Development Strategies of Distributed Generation Based on Micro Grid Technology

Qishun Zhu,Jinsong Liu,Minghao Zhang,Xin Sun 보안공학연구지원센터 2015 International Journal of Grid and Distributed Comp Vol.8 No.3

With the continuous development of economy and social progress, the social requirement of power network is more and more high. This paper, as a basis research of distributed generation, proceed mainly from the impact of distributed generation on power grid, detailed fine analysis of the influence of all kinds of distributed generation on power network adverse, including power system stability, power quality, power supply reliability effect. In order to avoid these adverse effects, we combining the distributed grid technology and smart micro grid, put distributed generation as a branch of the micro grid that can be ideal to connect grid and can avoid most of the problems mentioned above. Distributed intelligent micro grid system uses variety of new energy supply, it is a comprehensive model of power electronic technology, distributed generation, renewable energy power technology and energy storage technology .The paper provides a reference for the use of future distributed power generation.

Design and Simulation Research on Energy Consumption of Electric Vehicle Charging Stations

Qiang Gao,Jinsong Liu,Guangming Zhang,Qi Liu 보안공학연구지원센터 2016 International Journal of Smart Home Vol.10 No.9

Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination.

Zan, Hong,Zhang, Jinsong,Ardeshna, Sona,Xu, Zhenming,Park, Seok-Rae,Casali, Paolo Harwood 2009 Autoimmunity Vol.42 No.2

<P>Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of an array of pathogenic autoantibodies, including high-affinity anti-dsDNA IgG antibodies. These autoantibodies are mutated and class-switched, mainly to IgG, indicating that immunoglobulin (Ig) gene somatic hypermutation (SHM) and class switch DNA recombination (CSR) are important in their generation. Lupus-prone MRL/fas(lpr/lpr) mice develop a systemic autoimmune syndrome that shares many features with human SLE. We found that Ig genes were heavily mutated in MRL/fas(lpr/lpr) mice and contained long stretches of DNA deletions and insertions. The spectrum of mutations in MRL/fas(lpr/lpr) B cells was significantly altered, including increased dG/dC transitions, increased targeting of the RGYW/WRCY mutational hotspot and the WGCW AID-targeting hotspot. We also showed that MRL/fas(lpr/lpr) greatly upregulated CSR, particularly to IgG2a and IgA in B cells of the spleen, lymph nodes and Peyer's patches. In MRL/fas(lpr/lpr) mice, the significant upregulation of SHM and CSR was associated with increased expression of activation-induced cytidine deaminase (AID), which mediates DNA lesion, the first step in SHM and CSR, and translesion DNA synthesis (TLS) polymerase (pol) theta, pol eta and pol zeta, which are involved in DNA synthesis/repair process associated with SHM and, possibly, CSR. Thus, in lupus-prone MRL/fas(lpr/lpr) mice, SHM and CSR are upregulated, as a result of enhanced AID expression and, therefore, DNA lesions, and dysregulated DNA repair factors, including TLS polymerases, which are involved in the repair process of AID-mediated DNA lesions.</P>

Identification and Functional Characterization of R3 MYB Transcription Factor Genes in Soybean

Shucai Wang,Jinsong Pang,Hongwei Xun,Zhibing Zhang,Yunxiao Zhou,Xueyan Qian,Yingshan Dong,Xianzhong Feng,Bao Liu 한국식물학회 2018 Journal of Plant Biology Vol.61 No.2

In Arabidopsis, trichome formation is regulatedby a MYB-bHLH-WD40 (MBW) transcriptional activatorcomplex, which can activate the expression of GLABRA2(GL2) and R3 MYB genes. GL2 is required for trichomeformation, whereas R3 MYBs inhibit trichome formation byblocking the formation of the MBW complex, thus inhibitingthe expression of GL2. By using the amino acid sequence of theArabidopsis R3 MYB transcription factor TRICHOMELESS1(TCL1) to BLAST the soybean (Glycine max) protein database,we found that there are a total of six R3 MYB genes insoybean, namely Glycine max TRICHOMELESS1 through 6(GmTCL1-GmTCL6). By generating transgenic plants, wefound that trichome formation in soybean plants overexpressingeach of the GmTCLs remained largely unchanged, and theexpression of putative GL1 and GL2 genes in the transgenicplants was unaffected. However, all the GmTCLs interactedwith GLABRA3 (GL3) in transfected Arabidopsis protoplasts,expression each of the GmTCLs in Arabidopsis inhibitedtrichome formation, and the expression levels of GL1 andGL2 were greatly reduced in the Arabidopsis transgenicplants. Moreover, phenotypic complementary analysis showedthat GmTCL1 is functionally equivalent to TCL1. Takentogether, these results suggest that GmTCLs are functionalR3 MYBs, however, they do not regulate trichome formationin soybean.

Rheological Behaviors and Microstructure of Oviductus Ranae Hydrogels

Qing Liang,Shouqin Zhang,Jinsong Zhang 한국식품과학회 2012 Food Science and Biotechnology Vol.21 No.2

The rheological properties of Oviductus Ranae (OR) hydrogels were systematically investigated with shear viscosity, dynamic oscillation, and creep-recovery measurements. The viscosity curves displayed phenomena of shear thinning with increase of shear rate. The flow behaviors of the hydrogels were described using 2representative rheological models. The lesser water was absorbed by OR, the higher viscosity and greater extent of thixotropy it presents. Dynamic viscoelasticity measurements indicated that the samples exhibit viscoelastic properties as physical gels. Creep curves also revealed that the hydrogels behave as viscoelastic solids. Damped oscillations were observed in the initial stage of creep tests (0-1 s). The viscoelastic moduli obtained from dynamic oscillations and those from damped oscillations agreed with each other. The strong dependence of rheological behaviour on network of OR hydrogels had been confirmed by electron microscopy.