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Heo, Jinsol,Kim, Se Hyeuk,Lee, Pyung Cheon American Society for Microbiology 2013 Applied and environmental microbiology Vol.79 No.11
<P>Carotenoid cleavage dioxygenases (CCDs) are enzymes that catalyze the oxidative cleavage of carotenoids at a specific double bond to generate apocarotenoids. In this study, we investigated the activity and substrate preferences of NSC3, a CCD of <I>Nostoc</I> sp. strain PCC 7120, <I>in vivo</I> and <I>in vitro</I> using natural and nonnatural carotenoid structures. NSC3 cleaved β-apo-8′-carotenal at 3 positions, C-13[Formula]C-14, C-15[Formula]C-15′, and C-13′[Formula]C-14′, revealing a unique cleavage pattern. NSC3 cleaves the natural structure of carotenoids 4,4′-diaponeurosporene, 4,4′-diaponeurosporen-4′-al, 4,4′-diaponeurosporen-4′-oic acid, 4,4′-diapotorulene, and 4,4′-diapotorulen-4′-al to generate novel cleavage products (apo-14′-diaponeurosporenal, apo-13′-diaponeurosporenal, apo-10′-diaponeurosporenal, apo-14′-diapotorulenal, and apo-10′-diapotorulenal, respectively). The study of carotenoids with natural or nonnatural structures produced by using synthetic modules could provide information valuable for understanding the cleavage reactions or substrate preferences of other CCDs <I>in vivo</I> and <I>in vitro</I>.</P>
Sunhwa Jung,Jinsol Cheon,Seulgi Lee,Yoo Kyoung Park 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Personalized nutrition may be an effective strategy in the near future. We evaluated the effect of a 12-week genetic-based personalized randomized nutrition intervention on weight loss and health outcome in 62 obese adults. Physical measurements, body mass tests, blood profiles and MEQ etc before and after the study. nine obesity-related genes were assessed. Individualized nutrition counseling was performed once a week to the EG according to genetic risk factors for 12 weeks while CG received weekly SNS message. Body weight and body fat mass decreased significantly between weeks 0 and 12 in both the CG and the EG but the difference showed a greater weight loss effect in the EG than the CG (ΔCG-1.26±2.13 kg vs ΔEG-2.89±2.74 kg, p<0.05). As a result of genetic risk factors, among those with risk genes for gluttony, showed significant reduction in the total score of MEQ score (10±2.88 vs 6.14±2.19, P<0.05). CHO intake ratio was significantly decreased in the EG (53.8±1.98% to 44.3±2.16% p<0.05). In conclusion, we confirmed that genetic-based nutritional intervention can be served as an efficient tool.