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Identification and characterization of triamcinolone acetonide, a microglial-activation inhibitor
Hong, Jinpyo,Kim, Bo-Kyong,Lim, Hyoungsub,Lee, Soojin,Lee, Sung Joong Informa Healthcare 2012 Immunopharmacology and immunotoxicology Vol.34 No.6
<P>Recent studies show that necrotic neuronal cells (NNC) activate microglia, thereby leading to neuronal cell death. This suggests that chemicals that inhibit microglia activation may be used as neuroprotective drugs. In this context, we screened a chemical library for inhibitors of microglia activation. Using a screening system based on a nitrite assay, we isolated two chemicals that inhibit nitric oxide (NO) release from activated microglia: triamcinolone acetonide (TA) and amcinonide. The half-maximal inhibitory concentrations (IC50) of TA and amcinonide for NO release inhibition were 1.78 nM and 3.38 nM, respectively. These chemicals also inhibited NNC-induced expression of the proinflammatory genes iNOS, TNF-α, and IL-1β in glial cells. A study based on a luciferase assay revealed that TA attenuated NNC-induced microglia activation by blocking the NF-κB signaling pathway. In addition, TA protected cortical neurons in coculture with microglia from LPS/IFN-γ-induced neuronal cell death. In conclusion, TA may inhibit microglia activation and may protect neuronal cells from death induced by microglial activation.</P>
Epidemiology of Suicide in Korea
JinPyo Hong,MyengJi Bae,Tongwoo Suh 대한신경정신의학회 2006 PSYCHIATRY INVESTIGATION Vol.3 No.2
In 2002, an estimated 877,000 lives were lost worldwide through suicide. In Korea, suicidal deaths have increased very rapidly since the economic crisis in 1997, and suicide is regarded as one of the most serious public health and social issues in Korea. This study examines the current situation and trends of the recently increasing rates of suicidal deaths, ideas, and attempts in Korea. This study reanalyzed the 20-year statistics of suicidal deaths recently published by the National Statistical Office and the data of the National Health Interview Survey conducted in 1995 and 1998. The suicidal mortality rate in Korea is quite high compared to those in other OECD countries and the rate of increase is the highest. The rate of suicidal idea is high among males, those in their late teens and those in their seventies. The suicidal attempt rate is higher among females and those in their late teens. Suicide, one of the important causes of death in the younger age group, has a greater socioeconomic impact than other common causes of death in the older age group. Therefore, we are in urgent need of a public mental health network to prevent suicide and to detect and treat early mental health problems leading to suicide.
An empirical framework for user mobility models: Refining and modeling user registration patterns
Hong, Jinpyo,Kim, Hwangnam Elsevier 2011 Journal of Computer and System Sciences Vol.77 No.5
<P><B>Abstract</B></P><P>In this paper, we examine user registration patterns in empirical WLAN traces, identify elusive patterns that are abused as user movements in constructing empirical mobility models, and analyze them to build up a realistic user mobility model. The examination shows that about 38–90% of transitions are irrelevant to actual user movements. In order to refine the elusive movements, we investigate the geographical relationships among APs and propose a filtering framework for removing them from the trace data. We then analyze the impact of the <I>false-positive</I> movements on an empirical mobility model. The numerical results indicate that the proposed framework improves the fidelity of the empirical mobility model. Finally, we devise an analytical model for characterizing realistic user movements, based on the analysis on the elusive user registration patterns, which emulates elusive user registration patterns and generates true user mobile patterns.</P>
Jinpyo Hong,티루세 테카파우 멍에샤,홍석원,Hyung-Kook Kim,황윤회 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.76 No.3
We have synthesized binary reduced-graphene-oxide (RGO)/metal-oxide (Ni(OH)2, NiO, MnO2, and Fe3O4) nanocomposites by using a facile hydrothermal process. The morphology and the structure of the composite are confirmed by using x-ray diffraction (XRD), high-resolution transmission electron microscope (HRTEM), field-emission scanning electron microscopy (FESEM) and Raman spectroscopy. The electric capacitances that have been achieved for the nanocomposites at a current density of 1 A/g are 55, 140, 150 and 183 F/g for RGO/Fe3O4, RGO/Ni(OH)2, RGO/NiO and RGO/MnO2, respectively. Among them, RGO/MnO2 having the best electric capacity was used for preparing a current collector electrode by using various methods to attach the RGO/MnO2 nanocomposite to nickel foams. The supercapacitor performances of differently prepared current collector electrodes were tested, and the electric capacities found with the nanocomposites having a current density of 1 A/g are 28, 53, 112 and 212 F/g when the two-step drop method, the hydrothermal method, the doctor-blade method and the nanocomposite-drop method were used, respectively. Compared to a single metal-oxide, RGO/MnO2 nanocomposites show a superior electric conductivity, an electric capacity and a charge/discharge efficiency for supercapacitor performance, indicating that the RGO/metal-oxide nanocomposite is a promising material for supercapacitor applications.