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Chao Li,Tao Li,Zhongqi Shi,Jinhui Li,Guoye Jing 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.11
Shaft boring machine (SBM) plays a significant role in mechanized construction of deep and large shafts. However, surrounding soil instability of SBM pose great threats to the shaft construction. Therefore, it is necessary to analyse the soil stability underlying SBM’s gripper. On the basis of the first SBM (MSJ5.8/1.6D) that independently developed in China, the interaction between the SBM’s gripper and surrounding soil is investigated. According to the failure mode of the shaft obtained by numerical simulation, the geometry of the failure surfaces is first derived, and the stresses distribution on the failure surfaces are clearly presented. Then, the ultimate bearing capacity formula of the surrounding soil underlying SBM’s gripper is derived based on plastic limit equilibrium theory with Mohr-Coulomb criterion. The change rules of bearing capacity factors and the influence rules of basic parameters in this formula are obtained. Finally, the theoretical values in typical soils are compared with those from the numerical simulation to illustrate the rationality of the formula. The results of this investigation not only provide an advanced method for evaluating the surrounding soil stability of SBM in shaft construction, but also provide guidelines for the design and construction risk control of SBM.
( Jinhui Yu ),( Yun Geng ),( Han Xia ),( Deyuan Ma ),( Chao Liu ),( Rina Wu ),( Junrui Wu ),( Shengbo You ),( Yuping Bi ) 한국미생물생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.4
In this study we investigated the effect of lactic acid bacteria (LAB) fermentation on the ingredients and anti-oxidant activity of Withania somnifera extract. Four strains of LAB could proliferate normally in medium containing W. somnifera extract after the pH reached 3.1~3.5. LAB fermentation increased the content of alcohols and ketones, endowing the extract with the characteristic aroma of fermentation. Compared to the control, the DPPH and ABTS free radical scavenging rates in the fermented samples were significantly improved, ranging from 48.5% to 59.6% and 1.2% to 6.4%. The content of total phenols was significantly increased by 36.1% during the fermentation of mixed bacteria. Moreover, the original composition spectrum of the extract was significantly changed while the differentially accumulated metabolites (DAMs) were closely related to bile secretion, tryptophan metabolism and purine metabolism. Therefore, LAB fermentation can be used as a promising way to improve the flavor and bioactivity of the extracts of W. somnifera, making the ferments more attractive for use as functional food.
CCL12 induces trabecular bone loss by stimulating RANKL production in BMSCs during acute lung injury
Ma Chao,Gao Juan,Liang Jun,Wang Feizhen,Xu Long,Bu Jinhui,He Bo,Liu Guangpu,Niu Ru,Liu Guangwang 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
In the last three years, the capacity of health care systems and the public health policies of governments worldwide were challenged by the spread of SARS-CoV-2. Mortality due to SARS-CoV-2 mainly resulted from the development of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Moreover, millions of people who survived ALI/ARDS in SARS-CoV-2 infection suffer from multiple lung inflammation-induced complications that lead to disability and even death. The lung-bone axis refers to the relationship between lung inflammatory diseases (COPD, asthma, and cystic fibrosis) and bone diseases, including osteopenia/osteoporosis. Compared to chronic lung diseases, the influence of ALI on the skeleton has not been investigated until now. Therefore, we investigated the effect of ALI on bone phenotypes in mice to elucidate the underlying mechanisms. In vivo bone resorption enhancement and trabecular bone loss were observed in LPS-induced ALI mice. Moreover, chemokine (C-C motif) ligand 12 (CCL12) accumulated in the serum and bone marrow. In vivo global ablation of CCL12 or conditional ablation of CCR2 in bone marrow stromal cells (BMSCs) inhibited bone resorption and abrogated trabecular bone loss in ALI mice. Furthermore, we provided evidence that CCL12 promoted bone resorption by stimulating RANKL production in BMSCs, and the CCR2/Jak2/STAT4 axis played an essential role in this process. Our study provides information regarding the pathogenesis of ALI and lays the groundwork for future research to identify new targets to treat lung inflammation-induced bone loss.