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Endoscopic Endonasal Treatment of a Pott's Puffy Tumor
Jung, Jinho,Lee, Hak Chun,Park, Il-Ho,Lee, Heung-Man Korean Society of Otorhinolaryngology-Head and Nec 2012 Clinical and Experimental Otorhinolaryngology Vol.5 No.2
<P>Pott's puffy tumor is an infrequent entity characterized by a subperiosteal abscess associated with frontal bone osteomyelitis. It has become rare due to the development of antibiotics and is usually seen as a complication of frontal sinusitis. Although Pott's puffy tumor is more commonly described in children, it should also be included in the differential diagnosis of swelling on the forehead in adults. Once the diagnosis is suspected, appropriate imaging should be performed to evaluate the possible complications. The treatment of Pott's puffy tumor combines medical and surgical approaches in order to prevent further complications. The goal of surgery is to drain the sinus and to excise the infected bone if necessary. The endoscopic endonasal approach is a safe and effective alternative to the external approach. This report describes the case of a 25-year-old man with Pott's puffy tumor resulting from frontal sinusitis.</P>
( Jung Nam An ),( Jinho Hwang ),( Hack Lyoung Kim ),( Sang Hyun Kim ),( Dong Ki Kim ),( Yun Kyu Oh ),( Yon Su Kim ),( Chun Soo Lim ),( Jung Pyo Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Contrast-induced nephropathy (CIN) is the important cause of hospital acquired acute kidney injury. Accurate understanding of the pathogenesis and the prevention and early intervention of CIN are crucial. Thus, the aim of this study was to evaluate the clinical role of circulating tumor necrosis factor receptors (cTNFRs) as predictors for CIN. Methods: During the period of May 2013 to February 2014, a total of 262 patients who underwent coronary angiography and/or percutaneous coronary intervention in Seoul National University Boramae Medical Center, were enrolled. CIN was defi ned as either an increase in serum creatinine (sCr) = 0.25 mg/dL or = 25% within 48 hours after procedure. Results: Male gender was 64.1%, mean age was 64.6 ± 10.9 years, and the patients with diabetes and chronic kidney disease were 27.5% and 17.6%, respectively. Overall patients had fi uid therapy and 36.3% underwent percutaneous coronary intervention. CIN developed in 4.2% of patients and the risk factors were younger age, underlying diseases as stroke and chronic kidney disease, the use of N-acetylcysteine, and higher levels of ln(cTNFRs). Increased value of ln(cTNFR1) (OR 18.77; 95% CI 2.57-137.00; P = 0.004) and ln(cTNFR2) (OR 4.79; 95% CI 1.32-17.43; P = 0.018) were signifi cantly associated with the development of CIN after adjusting other risk factors including baseline renal function. Moreover, increased serum cTNFRs were an independent risk factor for renal function deterioration. Conclusions: Markedly elevated concentrations of circulating TNFRs were correlated with the occurrence of CIN. The higher serum levels of cTNFRs adversely affected prolonged renal dysfunction without regard to CIN.
Potential involvement of Drosophila flightless-1 in carbohydrate metabolism
( Jung-eun Park ),( Jinho Jang ),( Eun Ji Lee ),( Su Jung Kim ),( Hyun Ju Yoo ),( Semin Lee ),( Min-ji Kang ) 생화학분자생물학회(구 한국생화학분자생물학회) 2018 BMB Reports Vol.51 No.9
A previous study of ours indicated that Drosophila flightless-1 controls lipid metabolism, and that there is an accumulation of triglycerides in flightless-1 (fliI)-mutant flies, where this mutation triggers metabolic stress and an obesity phenotype. Here, with the aim of characterizing the function of FliI in metabolism, we analyzed the levels of gene expression and metabolites in fliI-mutant flies. The levels of enzymes related to glycolysis, lipogenesis, and the pentose phosphate pathway increased in fliI mutants; this result is consistent with the levels of metabolites corresponding to a metabolic pathway. Moreover, high-throughput RNA sequencing revealed that Drosophila FliI regulates the expression of genes related to biological processes such as chromosome organization, carbohydrate metabolism, and immune reactions. These results showed that Drosophila FliI regulates the expression of metabolic genes, and that dysregulation of the transcription controlled by FliI gives rise to metabolic stress and problems in the development and physiology of Drosophila. [BMB Reports 2018; 51(9): 462-467]
Jung Jinho,Park Hyun Joon,Jung Minyoung 대한의학회 2021 Journal of Korean medical science Vol.36 No.30
Background: Environmental tobacco smoke exposure due to parents is a modifiable risk factor for childhood asthma, but many studies have evaluated parental smoking using selfreported data. Therefore, we aimed to analyze the relationship between parental cotinineverified smoking status and asthma in their children. Methods: This population-based cross-sectional study used data from the Korean National Health and Nutrition Examination Survey from 2014 to 2017. Participants aged 0 to 18 years with complete self-reported physician-diagnosed childhood asthma and measurement of their parental urinary cotinine levels were included. Parental urinary cotinine-verified smoking status was defined using both urinary cotinine levels and self-report, as active, passive, and non-smoker. Sample weights were applied to all statistical analyses because of a complex, multistage and clustered survey design. Logistic regression model was used to analyze the relationship between childhood asthma and parental smoking. Results: A total of 5,264 subjects aged < 19 years were included. The prevalence of asthma was 3.4%. The proportions of paternal and maternal urinary cotinine-verified active smokers during the study period were 50.4% and 16.9%, respectively. When parental urinary cotinine level increased, the proportion of parental low household income was increased (P < 0.001). There was no significant association between the parental urinary cotinine-verified smoking group and childhood asthma group. However, the adjusted odds ratios of childhood asthma in the middle and highest tertile of paternal urinary cotinine levels compared with those in lowest tertile were 1.95 (95% confidence interval [CI], 0.98–3.89) and 2.34 (95% CI, 1.21–4.54), respectively. Conclusion: There seems to be a dose-related association between paternal urinary cotinine levels and the risk of childhood asthma. Because of the high rate of paternal smoking, further studies are needed to develop a targeted strategy to reduce parental smoking for childhood asthma.