Geographical distribution patterns of Metaeuchromius in Asia and description of a new species from China (Lepidoptera, Crambidae)

Jingbo Yang,Wei Liu,Weichun Li 한국응용곤충학회 2020 Journal of Asia-Pacific Entomology Vol.23 No.3

The geographical distribution patterns of Asian Metaeuchromius are analysed with MaxEnt and ArcGIS based on known localities and nineteen environmental variables. The results suggest that the most highly suitable area of the genus located in southeastern China. Precipitation of the warmest quarter (Bio18) and temperature seasonality (Bio4) are the most significant variables affecting geographical distribution Metaeuchromius. Furthermore, a new species from Jiangxi Province, southeast China is added to the genus, Metaeuchromius grandispinata Li, sp. nov. Its habitus, tympanic organs and genitalia are illustrated, and two maps showing geographical distribution patterns of Metaeuchromius in Asia are provided.

CDH17 nanobodies facilitate rapid imaging of gastric cancer and efficient delivery of immunotoxin

Jingbo Ma,Xiaolong Xu,Chunjin Fu,Peng Xia,Ming Tian,Liuhai Zheng,Kun Chen,Xiaolian Liu,Yilei Li,Le Yu,Qinchang Zhu,Yangyang Yu,Rongrong Fan,Haibo Jiang,Zhifen Li,Chuanbin Yang,Chengchao Xu,Ying Long,J 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4

Background: It is highly desirable to develop new therapeutic strategies for gastric cancer given the low survival rate despite improvement in the past decades. Cadherin 17 (CDH17) is a membrane protein highly expressed in cancers of digestive system. Nanobody represents a novel antibody format for cancer targeted imaging and drug delivery. Nanobody targeting CHD17 as an imaging probe and a delivery vehicle of toxin remains to be explored for its theragnostic potential in gastric cancer. Methods: Naïve nanobody phage library was screened against CDH17 Domain 1-3 and identified nanobodies were extensively characterized with various assays. Nanobodies labeled with imaging probe were tested in vitro and in vivo for gastric cancer detection. A CDH17 Nanobody fused with toxin PE38 was evaluated for gastric cancer inhibition in vitro and in vivo. Results: Two nanobodies (A1 and E8) against human CDH17 with high affinity and high specificity were successfully obtained. These nanobodies could specifically bind to CDH17 protein and CDH17-positive gastric cancer cells. E8 nanobody as a lead was extensively determined for tumor imaging and drug delivery. It could efficiently co-localize with CDH17-positive gastric cancer cells in zebrafish embryos and rapidly visualize the tumor mass in mice within 3 h when conjugated with imaging dyes. E8 nanobody fused with toxin PE38 showed excellent anti-tumor effect and remarkably improved the mice survival in cell-derived (CDX) and patient-derived xenograft (PDX) models. The immunotoxin also enhanced the anti-tumor effect of clinical drug 5-Fluorouracil. Conclusions: The study presents a novel imaging and drug delivery strategy by targeting CDH17. CDH17 nanobodybased immunotoxin is potentially a promising therapeutic modality for clinical translation against gastric cancer.

Study on the Buckling Behaviour of Cold-Formed Angles in Transmission Towers

Fengli Yang,Junke Han,Jingbo Yang,Zhenbao Li 한국강구조학회 2011 International Journal of Steel Structures Vol.11 No.4

Considering the structural characteristics of transmission towers, four sections of cold-formed angles with different slenderness ratios and constrained types were selected for the experimental and numerical study. Experiments and finite element analysis for the ultimate loads of the compression cold-formed angles were carried out. The finite element model well predicts the buckling behaviour of the cold-formed members. For the axial compression members, the load-strain curves as well as the ultimate loads were analyzed, and the experimental ultimate loads were compared with those of calculated by the applicable standards. It shows that the applicable standards aren’t adaptive to the strength design of the compression cold-formed members in transmission towers. Through the analysis of the experimental and FEA results, the fitting curve of the stability coefficients for the cold-formed members in transmission towers was determined. The ultimate loads calculated by the fitting curve are well agreed with the experimental values, especially for the members with relatively low slenderness ratios. Some modification suggestions were proposed for the calculation of the ultimate load for the axial compression cold-formed angle. Experimental analysis on the cold-formed members of the other five constrained types was completed, and the modification formulas of the slenderness ratios for members of different constrained types were obtained.

The Design of Anti-aliasing Analog Filter for Data Acquisition in the Surface Measurement

Xu Jingbo,Xu Xiaohong,Yang Pengyu,Lin Haijun,Guo Xin 보안공학연구지원센터 2014 International Journal of Signal Processing, Image Vol.7 No.5

In the surface measurement system, the data acquisition is key part and the anti-aliasing analog filter is necessary. This paper deals with the design of the anti-aliasing analog filter. Based on the principle of anti-aliasing filtering, the parameters of filter are computed, the filter circuit is designed, and the frequency characteristic is drawn. Combined with digital filter, the filtering can maintain the low frequency components very well and suppress effectively the high frequency signals in the original surface profile, which reduces the distortion caused by noise and makes the filtering effect better. This method has been applied in the surface measurement system and the actually measured data verified the performance of the filter.

Up-regulation of Insulin-like Growth Factor Binding Protein-3 Is Associated with Brain Metastasis in Lung Adenocarcinoma

Yang, Lishi,Li, Junyang,Fu, Shaozhi,Ren, Peirong,Tang, Juan,Wang, Na,Shi, Xiangxiang,Wu, Jingbo,Lin, Sheng Korean Society for Molecular and Cellular Biology 2019 Molecules and cells Vol.42 No.4

The brain is the most common metastatic site of lung adenocarcinoma; however, the mechanism of this selective metastasis remains unclear. We aimed to verify the hypothesis that exposure of tumor cells to the brain microenvironment leads to changes in their gene expression, which promotes their oriented transfer to the brain. A549 and H1299 lung adenocarcinoma cells were exposed to human astrocyte-conditioned medium to simulate the brain microenvironment. Microarray analysis was used to identify differentially expressed genes, which were confirmed by quantitative real-time PCR and western blotting. Knockdown experiments using microRNAs and the overexpression of genes by cell transfection were performed in addition to migration and invasion assays. In vitro findings were confirmed in clinical specimens using immunohistochemistry. We found and confirmed a significant increase in insulin-like growth factor binding protein-3 (IGFBP3) levels. Our results also showed that the up-regulation of IGFBP3 promoted A549 cell epithelial-mesenchymal transition, migration, and invasion, while the knockdown of IGFBP3 resulted in decreased cell motility. We also found that Transforming growth factor-${\beta}$ (TGF-${\beta}$)/Mothers against decapentaplegic homolog 4 (Smad4)-induced epithelial-mesenchymal transition was likely IGFBP3-dependent in A549 cells. Finally, expression of IGFBP3 was significantly elevated in pulmonary cancer tissues and intracranial metastatic tissues. Our data indicate that up-regulation of IGFBP3 might mediate brain metastasis in lung adenocarcinoma, which makes it a potential therapeutic target.

Compositional Dependence of the Recrystallization and Grain Growth in Strongly-distorted Pd-containing Multi-Component Equiatomic Alloys

Jingbo Qiao,Hongmin Zhang,Haoyan Meng,Fanchao Meng,Yang Tong,Daiyi Chao,Peter K. Liaw,Shuying Chen 대한금속·재료학회 2024 METALS AND MATERIALS International Vol.30 No.2

The equiatomic high entropy alloy (HEA) NiCoCrFePd crystalizes as a single face-centered cubic (FCC) phase with stronglocal lattice distortion due to large atomic size mismatch between Pd element and other constitute elements. To betterunderstand this quinary alloy, a family of single FCC phase equiatomic alloys made from the constituent elements of theNiCoCrFePd HEA, including the binary NiPd alloy, medium entropy alloys (MEAs) of NiCoPd, NiCrPd, and NiFePd, andthe quinary NiCoCrFePd HEA with fully-recrystallized microstructure was experimentally investigated to understand thechemical effects on grain growth kinetics and solid solution hardening. With the principal elements increasing from two tofive, the grain growth was increasingly inhibited in the annealing temperature range of 800–900 °C, while at 1000 °C andabove, the NiCrPd MEA showed the slowest grain growth, which may attribute to the higher melting temperature of Crand negative mixing enthalpy between Cr and other constituent elements, increasing the activation energy of grain growth. Moreover, the hardness depending on the grain size complied with the Hall-Petch relationship, in which NiCoPd exhibitedthe lowest hardness, while NiPd had a comparable hardness with NiCrPd and NiFePd. The above results suggested thatthe number of alloying elements was not the sole factor determining the sluggish diffusion and hardness. Instead, thetype of constituent elements in the Pd-containing multicomponent alloys played more critical role. Furthermore, it wasconcluded that the strength of MEAs and HEA should depend on the combination of atomic size and modulus mismatchand electronegativity difference.

Transceiver Optimization for the Multi-Antenna Downlink in MIMO Cognitive System

( Wentao Zhu ),( Jingbo Yang ),( Tingting Jia ),( Xu Liu ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.12

Transceiver optimization in multiple input multiple output (MIMO) cognitive systems is studied in this paper. The joint transceiver beamformer design is introduced to minimize the transmit power at secondary base station (SBS) while simultaneously controlling the interference to primary users (PUs) and satisfying the secondary users (SUs) signal-to-interference-plus-noise ratio (SINR) based on the convex optimization method. Due to the limited cooperation between SBS and PUs, the channel state information (CSI) usually cannot be obtained perfectly at the SBS in cognitive system. In this study, both perfect and imperfect CSI scenarios are considered in the beamformer design, and the proposed method is robust to CSI error. Numerical results validate the effectiveness of the proposed algorithm.

Open‑circuit fault diagnosis of three‑phase PWM rectifier circuits based on transient characteristics and random forest classification

RenZhong Shan,JingBo Yang,ShengLi Huang 전력전자학회 2024 JOURNAL OF POWER ELECTRONICS Vol.24 No.1

Fault diagnosis is becoming increasingly important in improving the reliability of power electronic devices. The research in this paper focuses on the issue of the faulty operation that can occur after partial IGBT open-circuit faults in three-phase PWM rectifier circuits. To promptly and effectively diagnose faults and to determine their locations, a fault diagnosis method based on transient characteristics and random forest classification is proposed. First, the characteristics of single and double IGBT open-circuit faults in three-phase PWM rectifier circuits are analyzed. It is discovered that these faults do not immediately manifest. Instead, they exhibit fault characteristics in the corresponding time sequence. Then the random forest classifier is trained using transient fault samples from the three-phase PWM rectifier circuit. Finally, generalized testing is performed on data that was not involved in the training process, with an accuracy rate of over 98%. The use of frequency distribution graphs for visual analysis of the diagnostic results solves the problem of diagnosing multiple IGBT open-circuit faults.

Potential distribution analysis of an invasive alien species Parapediasia teterrella (Lepidoptera, Crambidae) in East Asia

Lulan Jie,Jingbo Yang,Weichun Li 한국응용곤충학회 2020 Journal of Asia-Pacific Entomology Vol.23 No.1

The bluegrass webworm moth Parapediasia teterrella (Zincken, 1821) is a notorious pest that is native to North America. However, it has invaded East Asia and has caused serious economic losses in China and Japan. The objective of this paper is to analyse the potential geographic distribution of P. teterrella in East Asia with MaxEnt, using predictor variables related to temperature and precipitation. It is suggested that this species has potential to establish in Southeast China, most areas of Jeollanam-do, eastern coastal region of South Korea, and most areas of Japan. Furthermore, we applied the Jackknife test to evaluate the significance of climatic variables in modelling the potential distribution of P. teterrella. The result indicates that annual mean temperature (Bio1), mean temperature of the coldest quarter (Bio11) and precipitation of the coldest quarter (Bio19) mainly affect its geographical distribution. A map showing the potential distribution of P. teterrella in East Asia is provided, and morphological diagnosis of the species is also given.

Response evaluation and vibration control of a transmission tower-line system in mountain areas subjected to cable rupture

Chen, Bo,Wu, Jingbo,Ouyang, Yiqin,Yang, Deng Techno-Press 2018 Structural monitoring and maintenance Vol.5 No.1

Transmission tower-line systems are commonly slender and generally possess a small stiffness and low structural damping. They are prone to impulsive excitations induced by cable rupture and may experience strong vibration. Excessive deformation and vibration of a transmission tower-line system subjected to cable rupture may induce a local destruction and even failure event. A little work has yet been carried out to evaluate the performance of transmission tower-line systems in mountain areas subjected to cable rupture. In addition, the control for cable rupture induced vibration of a transmission tower-line system has not been systematically conducted. In this regard, the dynamic response analysis of a transmission tower-line system in mountain areas subjected to cable rupture is conducted. Furthermore, the feasibility of using viscous fluid dampers to suppress the cable rupture-induced vibration is also investigated. The three dimensional (3D) finite element (FE) model of a transmission tower-line system is first established and the mathematical model of a mountain is developed to describe the equivalent scale and configuration of a mountain. The model of a tower-line-mountain system is developed by taking a real transmission tower-line system constructed in China as an example. The mechanical model for the dynamic interaction between the ground and transmission lines is proposed and the mechanical model of a viscous fluid damper is also presented. The equations of motion of the transmission tower-line system subjected to cable rupture without/with viscous fluid dampers are established. The field measurement is carried out to verify the analytical FE model and determine the damping ratios of the example transmission tower-line system. The dynamic analysis of the tower-line system is carried out to investigate structural performance under cable rupture and the validity of the proposed control approach based on viscous fluid dampers is examined. The made observations demonstrate that cable rupture may induce strong structural vibration and the implementation of viscous fluid dampers with optimal parameters can effectively suppress structural responses.