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Park, Jinbong,Jeon, Yong-Deok,Kim, Hye-Lin,Lim, Hara,Jung, Yunu,Youn, Dong-Hyun,Jeong, Mi-Young,Kim, Hyun-Ju,Kim, Sung-Hoon,Kim, Su-Jin,Hong, Seung-Heon,Um, Jae-Young Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-
<P>Obesity has become a major health threat in developed countries. However, current medications for obesity are limited because of their adverse effects. Interest in natural products for the treatment of obesity is thus rapidly growing. Korean Medicine (KM) is characterized by the wide use of herbal formulas. However, the combination rule of herbal formulas in KM lacks experimental evidence. According to <I>Shennong's Classic of Materia Medica</I>, the earliest book of herbal medicine, <I>Veratrum nigrum</I> (VN) has antagonistic features against <I>Panax ginseng</I> (PG), and the PG-VN pair is strictly forbidden. In this study, we have shown the effects of PG, VN, and their combination on obesity in high-fat (HF) diet-induced obese mice and in 3T3-L1 cells. PG, VN, and PG-VN combination significantly reduced weight gain and the fat pad weight in HF diet-induced obese mice. They also significantly decreased lipid accumulation and the expressions of two major adipogenesis factors, PPAR<I><I>γ</I></I> and C/EBP<I><I>α</I></I>, in 3T3-L1 cells. In addition, the PG-VN combination had synergistic effects compared with the mixture of extracts of PG and VN on inhibition of PPAR<I><I>γ</I></I> and C/EBP<I><I>α</I></I> expressions at lower doses. These results indicate a new potential anti-obese pharmacotherapy and also provide scientific evidence supporting the usage of herbal combinations instead of mixtures in KM.</P>
Jinbong Hwang,Hae Won Jang,Bae Namgung,Mira Oh,Soyoung Kim,Dongwon Seo,Se-Na Kim,Youngmin Choi,Jin-Sik Nam,Mi-Ok Yang 한국산업식품공학회 2015 산업 식품공학 Vol.19 No.2
The analytical method for the determination of phosphorus in foods was validated by inductively coupled plasma optical emission spectrometry (ICP-OES) in terms of precision, accuracy, recovery efficiency and linearity. Regression analysis revealed good correlation coefficient, higher than 0.999. Recovery efficiencies of the minerals ranged from 90.36% to 110.63%, and the limit of detection (LOD) and the limit of quantification (LOQ) were 0.0745 mg/ kg and 0.2482 mg/kg, respectively. The value of inter-day and intra-day ranged from 1.43 to 3.23% and from 0.40 to 1.77%. The recovery efficiencies ranged from 97.8 to 110.6%. The method was also compared with Molybdenum blue colorimetric method using certified and statistically significant difference was also not observed in the between two different analytical methods. The ICP-OES method was applied to phosphorus determination in commonly consumed foods. The obtained results suggest that the method verified in the present study may be used as an official analytical method for clear understanding of phosphorus database for national health promotion.
( Jinbong Hwang ),( Hae Won Jang ),( Bae Namgung ),( Mira Oh ),( Soyoung Kim ),( Dongwon Seo ),( Se Na Kim ),( Youngmin Choi ),( Jin Sik Nam ),( Mi Ok Yang ) 한국산업식품공학회 2015 산업 식품공학 Vol.19 No.2
The analytical method for the determination of phosphorus in foods was validated by inductively coupled plasma optical emission spectrometry (ICP-OES) in terms of precision, accuracy, recovery efficiency and linearity. Regression analysis revealed good correlation coefficient, higher than 0.999. Recovery efficiencies of the minerals ranged from 90.36% to 110.63%, and the limit of detection (LOD) and the limit of quantification (LOQ) were 0.0745 mg/ kg and 0.2482 mg/kg, respectively. The value of inter-day and intra-day ranged from 1.43 to 3.23% and from 0.40 to 1.77%. The recovery efficiencies ranged from 97.8 to 110.6%. The method was also compared with Molybdenum blue colorimetric method using certified and statistically significant difference was also not observed in the between two different analytical methods. The ICP-OES method was applied to phosphorus determination in commonly consumed foods. The obtained results suggest that the method verified in the present study may be used as an official analytical method for clear understanding of phosphorus database for national health promotion.
KIM, SU-JIN,SHIN, HYUN-JI,LEE, GEUN-HYUK,KIM, DAE-SEUNG,KIM, HYE-LIN,PARK, JINBONG,JUNG, YUNU,YOUN, DONG-HYUN,KANG, JONGWOOK,HONG, SEUNG-HEON,UM, JAE-YOUNG SPANDIDOS PUBLICATIONS 2015 MOLECULAR MEDICINE REPORTS Vol.12 No.3
<P>Ulcerative colitis (UC) is a type of inflammatory bowel disease and is considered a chronic gastrointestinal disorder. Igongsan (IGS) is a Korean herbal medicine, which has been used to treat digestive disorders. However, the ameliorative effect and molecular mechanisms of IGS in intestinal inflammation have not yet been studied in detail. The present study aimed to investigate the protective effects of IGS and its constituent, ergosterol, in a mouse model of dextran sulfate sodium (DSS)?induced colitis. Colitis was induced in mice by supplementing their drinking water with 5% (w/v) DSS for 7 days. The effects of IGS were then determined on DSS?induced clinical signs of colitis, including weight loss, colon shortening, diarrhea and obscure/gross bleeding. In addition, the effects of IGS were determined on the expression levels of inflammation?associated genes in the colon tissue of DSS?treated mice. The results of the present study demonstrated that mice treated with DSS exhibited marked clinical symptoms, including weight loss and reduced colon length. Treatment with IGS attenuated these symptoms and also suppressed the expression levels of tumor necrosis factor?α and interleukin?6, as well as the expression of cyclooxygenase?2 in the colon tissue of DSS?treated mice. IGS also reduced the activation of the transcription factor nuclear factor?κB p65 in the colon tissue of DSS?treated mice. In addition, ergosterol was shown to attenuate the DSS?induced clinical symptoms of colitis in mice. In conclusion, the present study provided experimental evidence that IGS may be a useful therapeutic drug for patients with UC.</P>
Kim, Dae-Seung,Kim, Sung-Hee,Kee, Ji-Ye,Han, Yo-Han,Park, JinBong,Mun, Jeong-Geon,Joo, Moon-Jung,Jeon, Yong-Deok,Kim, Su-Jin,Park, Sang-Hyun,Park, Sung-Joo,Um, Jae-Young,Hong, Seung-Heon Institute for Advanced Research in Asian Science a 2017 The American journal of Chinese medicine Vol. No.
<P><I>Eclipta prostrata</I> (EP) and its compounds are known to have several pharmacological effects including anti-inflammatory effects. In the present study, we demonstrated that EP improves the dextran sulfate sodium (DSS)-induced colitis symptoms such as body weight loss, colon length shortening and disease activity index. In DSS-induced colitis tissue, EP controls the protein expressions of cyclooxygenase-2 (COX-2) and hypoxia inducible factor-1<TEX>$ \alpha $</TEX> (HIF-1<TEX>$ \alpha $</TEX>). In addition, the release of prostaglandin E<SUB>2</SUB> and vascular endothelial growth factor-A were significantly reduced by EP administration. EP also inhibited COX-2 and HIF-1<TEX>$ \alpha $</TEX> expressions in the tumor necrosis factor-<TEX>$ \alpha $</TEX> stimulated HT-29 cells. These inhibitory effects of EP occurred by reducing the phosphorylation of I<TEX>$ \kappa $</TEX>B and the translocation of the nuclear factor-<TEX>$ \kappa $</TEX>B (NF-<TEX>$ \kappa $</TEX>B). Additionally, we found through HPLC analysis that wedelolactone, which is an inhibitor of NF-<TEX>$ \kappa $</TEX>B transcription, was contained in water extract of EP. These results indicate that EP can improve colitis symptoms through the modulation of immune function in intestinal epithelial cells and suggests that EP has the potential therapeutic effect to intestinal inflammation.</P>
Kim, Un Jeong,Kim, Jun Suk,Park, Noejung,Lee, Sanghyub,Lee, Ukjae,Park, Yeonsang,Seok, Jinbong,Hwang, Sungwoo,Son, Hyungbin,Lee, Young Hee American Chemical Society 2018 ACS NANO Vol.12 No.12
<P>The metal/graphene interface has been one of the most important research topics with regard to charge screening, charge transfer, contact resistance, and solar cells. Chemical bond formation of metal and graphene can be deduced from the defect induced D-band and its second-order mode, 2D band, measured by Raman spectroscopy, as a simple and nondestructive method. However, a phonon mode located at ∼1350 cm<SUP>-1</SUP>, which is normally known as the defect-induced D-band, is intriguing for graphene deposited with noble metals (Ag, Au, and Cu). We observe anomalous K-point phonons in nonreactive noble metal/graphene heterostructures. The intensity ratio of the midfrequency mode at ∼1350 cm<SUP>-1</SUP> over G-band (∼1590 cm<SUP>-1</SUP>) exhibits nonlinear but resonant behavior with the excitation laser wavelength, and more importantly, the phonon frequency-laser energy dispersion is ∼10-17 cm<SUP>-1</SUP> eV<SUP>-1</SUP>, which is much less than the conventional range. These phonon modes of graphene at nonzero phonon wave vector (<B>q</B> ≠ 0) around K points are activated by localized surface plasmon resonance and not by the defects due to chemical bond formation of metal/graphene. This hypothesis is supported by density functional theory (DFT) calculations for noble metals and Cr along with the measured contact resistances.</P> [FIG OMISSION]</BR>