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연골 조직 재생을 위한 나노섬유/알지네이트 복합 재료 스캐폴드의 제작
장진아(Jinah Jang),이종완(Jongwan Lee),설영준(Yeong-Joon Seol),정영훈(Young Hun Jeong),조동우(Dong-Woo Cho) 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.10
Three-dimensionally polycaprolactone(PCL) nanofiber reinforced alginate hydrogel scaffold were fabricated for the regeneration of functional cartilage construct with G-glucono-δ-lactone(GDL) cross linker that was applied to alginate hydrogel crosslinking with calcium carbonate (CaCO<SUB>3</SUB>) to maintain its structural integrity. In order to analyze new types of PCL nanofiber/alginate gel composite scaffold, four kinds of PCL nanofiber/alginate hydrogel composite scaffold were fabricated depends on the amount of nanofiber using dual-nozzle electrospinning process. Young’s moduli of each composite scaffolds were increased better than alginate only structure, also its value nearly approached normal articular cartilage. In conclusion, these results indicate feasibility of the new type of functional scaffold for cartilage regeneration from PCL nanofiber/alginate hydrogel composite scaffold.
체계적 간병 서비스 지원을 위한 인간공학적 간병 시스템 개발
장진아(Jinah Jang),장준호(Joonho Chang),정기효(Kihyo Jung) 대한인간공학회 2019 大韓人間工學會誌 Vol.38 No.1
Objective: This study is intended to develop an Ergonomic caregiver-supporting system that can provide and manage care services in a systematic way. Background: The demands on patient care at nursing homes and hospitals are increasing as aged population and life expectancy increase. However, the quality of current care services merely depends on caregiver"s experiences and thus inconsistent care services are often provided to patients. Therefore, a systematic caregiver-supporting is warranted to provide professional care services to patients. Method: A user needs survey was performed to identify care services by a omprehensive literature review. In addition, a usage scenario analysis was conducted to define system functions required to fulfill the care services surveyed. Next, to develop the caregiver-supporting system, this study prepared a comprehensive set of user interface design principles by combining Nielsen"s heuristics, Gerhardt-Powals" cognitive engineering principles, and Weinschenk and Barker"s classification. Results: The user needs survey listed up care services, and the usage scenario analysis defined three main modules of the system: (1) user management module, (2) care service module, and (3) care manual module. This study implemented the caregiver-supporting system that can be operated on a tablet computer with a touchscreen based on the user interface design principles defined in this study. The caregiver-supporting system developed in this study can help provide professional care services in a systematic way, which can improve user experience and satisfaction. Conclusion: The caregiver-supporting system is expected to improve the extent of care service quality by systematically providing and managing care services. Application: The caregiver-supporting system can be used at nursing homes and hospitals in order to provide professional and systematic care services.
장진아(Jinah Jang),조동우(Dong-Woo Cho) 한국기계가공학회 2015 한국기계가공학회지 Vol.14 No.6
3D printing technology is a promising technique for fabricating complex 3D architectures based on the CAD/CAM system, and it has been extensively investigated to manufacture structures in the fields of mechanical engineering, space technology, automobiles, and biomedical and electrical applications. Recent advances in the 3D printing of soft structures have received attention for the application of the construction of flexible sensors of soft robotics or the recreation of tissue/organ-specific microenvironments. In this review paper, we would like to focus on delivering state-of-the-art fabrication of soft structures with 3D printing technology and its various applications.
3차원 세포 프린팅과 탈세포화 된 췌장 유래 세포외기질 바이오잉크를 이용한 3차원 췌장 전조직 구조체의 제작
김석원(Seok-Won Kim),장진아(Jinah Jang),한원일(Won-il Han),김송철(Song-Cheol Kim),조동우(Dong-Woo Cho) 대한기계학회 2015 대한기계학회 춘추학술대회 Vol.2015 No.11
Islet transplantation into the portal vein has been widely used for the treatment of type 1 diabetes. However, intra-hepatic transplantation has many disadvantages including lack of vasculature, low efficacy and gradual graft attrition. Bio-engineered pancreas potentially provide an alternative transplantation site such as subcutaneous or directly into pancreas for islets with improving blood supply and cell viability compared to conventional intra portal transplantation. In this study, we developed printable pancreas derived decelluarized extracellular matrix (pdECM) bioink which enhances islet functionality and long-term survival by mimicking pancreas microenvironment. pdECM bioink have been tested for INS1β-cell viability and proliferation. To fabricate the optimal pancreas tissue construct by 3D cell printing, we checked the proper cell concentration by encapsulating INS1β-cell into pdECM bioink in different concentration. Our result shows the biological utility of pdECM bioink as a suitable biomaterial to fabricate the 3D pancreas tissue construct and to enhance cell functionality.
3 차원 프린팅 기술로 제작된 조직공학용 3 차원 구조체
박정훈(Jeong Hun Park),장진아(Jinah Jang),조동우(Dong-Woo Cho) 대한기계학회 2014 大韓機械學會論文集B Vol.38 No.10
조직공학 분야에서의 3 차원 구조체는 세포의 성장과 분화를 유도하기 위한 미세 환경을 제공하고, 재생하고자 하는 조직의 형태를 유지할 수 있도록 지탱해 주는 역할을 수행한다. 현재까지 다양한 생체재료 및 이의 가공 기법들이 이러한 3 차원 구조체를 제작하는데 적용되고 있다. 특히, 3 차원 프린팅 기술은 다양한 재료를 이용하여 원하는 외부 형상과 내부 구조를 제작할 수 있기 때문에 오늘날 조직공학 분야에 많이 이용되고 있고, 이 기술을 통해 새로운 조직공학적 접근 방법도 시도되고 있다. 본 논문에서는, 현재 조직공학 분야에 적용되고 있는 3 차원 프린팅 기술과, 이를 통해 제작된 기능성 인공지지체 및 세포 프린팅 구조체, 그리고 이의 다양한 조직공학적 적용에 대해서 서술하고자 한다. One of the main issues in tissue engineering has been the development of a three-dimensional (3D) structure, which is a temporary template that provides the structural support and microenvironment necessary for cell growth and differentiation into the target tissue. In tissue engineering, various biomaterials and their processing techniques have been applied for the fabrication of 3D structures. In particular, 3D printing technology enables the fabrication of a complex inner/outer architecture using a computer-aided design and manufacturing (CAD/CAM) system, and it has been widely applied to the fabrication of 3D structures for tissue engineering. Novel cell/organ printing techniques based on 3D printing have also been developed for the fabrication of a biomimetic structure with various cells and biomaterials. This paper presents a comprehensive review of the functional scaffold and cell-printed structures based on 3D printing technology and the application of this technology to various kinds of tissues regeneration.
이식거부반응을 줄이기 위한 cyclosporine A 탑재형 약물전달체의 개발
송태하(Tae-Ha Song),장진아(Jinah Jang),심진형(Jin-Hyung Shim),조동우(Dong-Woo Cho) 대한기계학회 2013 대한기계학회 춘추학술대회 Vol.2013 No.12
Systemic administration of Cyclosporine A (CsA) is frequently associated with a number of side effects which restrict the use of effective dose of immunosuppressant drug. For the purpose of local and controlled delivery of CsA, scaffoldbased CsA delivery system was developed. CsA-Poly(lactic-co-glycolic) acid(PLGA) microspheres-loaded drug carriers were prepared using Multi-head Tissue/Organ Building System which is based on the 3D printing technique. Proinflammatory cytokine expressions, which are secreted by Concanavalin A activated spleen cells such as Interleukin-2, Interleukin-17 and Interferon-gamma were significantly decreased by acting of CsA-loaded drug carrier in-vitro. Human lung fibroblasts-seeded CsA-loaded drug carriers were subcutaneously implanted into the BALB/c mouse model. Infiltration of mononuclear cells and CD4+, CD8+ T-cell populations at the site of implantation were investigated by H&E staining and immunohistochemistry. Mononuclear cells infiltration and population of T-cells were significantly suppressed by CsA-loaded drug carrier in-vivo. These results show that the CsA-loaded drug carrier can be a promising solution for local and controlled delivery of CsA.
코 성형을 위한 코 보형물 형태의 인공지지체 설계 및 제작과 코 연골조직의 재생
정진우(Jin Woo Jung),장진아(Jinah Jang),심진형(Jin-Hyung Shim),김성원(Sung Won Kim),조동우(Dong-Woo Cho) 대한기계학회 2012 大韓機械學會論文集B Vol.36 No.11
이상적인 코 보형물은 환자가 원하는 모양을 그대로 재현하면서, 그 상태를 안정적으로 유지할 수 있는 재료적 특성을 지녀야 한다. 현재 보편적으로 사용되고 있는 실리콘 코 보형물은 면역 반응이나 피부를 뚫고 돌출하는 문제점 등이 보고되고 있다. 이러한 부작용을 최소화 하기 위해 본 연구에서는 조직공학 기술을 이용하여 새로운 코 성형술을 제안하고자 한다. 조직공학 기반의 코 성형술의 가능성을 확인하기 위해 코 보형물 형상의 인공지지체를 상용 CAD 소프트웨어와 자유형상제작 기술 중에 하나인 다축 적층 시스템을 이용하여 설계 및 제작하였다. 그리고 코 성형술 인공지지체로서의 사용이 적합한지 확인하기 위해 비중격 유래 연골 세포를 이용하여 세포 증식, 기능 실험을 수행하였다. Implants for rhinoplasty should ideally be biocompatible and possess long-term stability after implantation. Silicone implants are most widely used for rhinoplasty. However, these implants suffer from problems related to high extrusion and infection rates. To minimize these complications, we propose a novel augmentation rhinoplasty technique using tissue engineering. To demonstrate its feasibility, a nasal-implant-shaped scaffold was designed using commercialized CAD software and fabricated using a Multi-head Deposition System, which is a solid freeform fabrication system that dispenses material. In vitro cell proliferation and chondrogenic differentiation tests were carried out using nasal septal chondrocytes.