http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Jin’e Wan,Jian Yang,Cuixia Qiao,Xiaomei Sun,Aiting Di,Lize Zhang,Dandan Wang,Gang Zhao 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.5
Purpose: Colorectal cancer (CRC) is the third most common cancer in China and poses high morbidity and mortality. In recentyears, increasing evidence has indicated that microRNAs played important functions in the occurrence and development of tumors. The purpose of this study was to identify the biological mechanisms of miR-362 in CRC. Materials and Methods: Quantitative real-time PCR was carried out to assess the expression of miR-362 and SIX1. The Kaplan-Meier method was employed to evaluate the 5-year overall survival of CRC patients. The proliferative and invasive abilities of CRCcells were assessed by MTT and transwell assays. Results: miR-362 was significantly decreased in CRC tissues and cell lines, compared to the normal tissues and normal cells. Asignificant connection was confirmed between the overall survival of 53 CRC patients and low expression of miR-362. Downregulationof miR-362 inhibited the proliferation and invasion through binding to the 3'-UTR of SIX1 mRNA in CRC. Additionally, wediscovered that SIX1 was a direct target gene of miR-362 and that the expression of miR-362 had a negative connection with SIX1expression in CRC. SIX1 could reverse partial functions in the proliferation and invasion in CRC cells. Conclusion: miR-362 may be a prognostic marker in CRC and suppress CRC cell proliferation and invasion in part through targetingthe 3'-UTR of SIX1 mRNA. The newly identified miR-362/SIX1 axis provides insight into the progression of CRC.
張金成,楊坤 啓明大學校 産業經營硏究所 2002 經營經濟 Vol.35 No.2
서비스의 가장 중요한 특징의 하나가 바로 고객 참여이다. 서비스 질 또한 중요하게 고객의 인식된 질로 표현되는 것이지 서비스 시스템의 운영된 질이 아니다. 그러나 서비스의 저장 불가능성과 이질성은 서비스로 하여금 기본적으로 서비스 시스템의 제한된 서비스 능력으로써 고객의 다양화한 서비스 수요, 참여행위와 인식된 결과에 대응하게 한다. 그래서 서비스관리의 boundary는 조직boundary에만 멈출 것이 아니라 앞으로 곧, 혹은 지금 한창, 혹은 이미 조직과 서비스 관계를 수립한 고객에게도 적극적이고 과학적인 관리를 실행해야 한다. 이것이 혹시 서비스 관리가 생산관리와 구별되는 하나의 선명한 특징일지도 모른다. 본문에서는 서비스 기업의 고객관리 문제에 대해 비교적 깊은 탐구적 토론을 진행하고자 한다. An important trait of service is the participation of customers in the service process, and the quality of service is mainly represented by the customer's perception quality, rather than by the service system operation quality. However, the simultaneous production and consumption as well as the heterogeneity of service make the service companies have to face the diversified customer's demands, participation behaviors, and perception results with the limited capacity of the service system. Therefore, the service management should not stop at the boundary of the nature service organization. The active and scientific management should be applied to the customers who are going to have, or are having, of have had service relationships with the service organizations. This may be one of signigicant different characteristics between service management and production management. This article intends to make a deep discussion about the problem of customer management.
A new species of Stibadocerella Brunetti, 1918 from China (Diptera, Cylindrotomidae)
Zhang Bing,Gao Shang,Yang Qi-Cheng,Ren Jin-Long,Yang Ding 한국응용곤충학회 2022 Journal of Asia-Pacific Entomology Vol.25 No.3
Four species of the genus Stibadocerella Brunetti, 1918 were previously known from the world. Here one new species, Stibadocerella shennongensis Zhang & Yang, sp. nov. is reported from Hubei, China. New record Stiba docerella pristina Brunetti, 1918 from Hainan, China is re-described and illustrated. A key to the known species of Stibadocerella is presented. www.zoobank.org/urn:lsid:zoobank.org:pub:45002F67-2C20-4F3C-A543-81F802EA3900.
A new species of Stibadocerella Brunetti, 1918 from China (Diptera, Cylindrotomidae)
Zhang Bing,Gao Shang,Yang Qi-Cheng,Ren Jin-Long,Yang Ding 한국응용곤충학회 2022 Journal of Asia-Pacific Entomology Vol.25 No.2
Four species of the genus Stibadocerella Brunetti, 1918 were previously known from the world. Here one new species, Stibadocerella shennongensis Zhang & Yang, sp. nov. is reported from Hubei, China. New record Stiba docerella pristina Brunetti, 1918 from Hainan, China is re-described and illustrated. A key to the known species of Stibadocerella is presented. www.zoobank.org/urn:lsid:zoobank.org:pub:45002F67-2C20-4F3C-A543-81F802EA3900.
Jin, Xin,Zhang, Ke-Jin,Guo, Xu,Myers, Ronald,Ye, Zhong,Zhang, Zhi-Pei,Li, Xiao-Fei,Yang, Hu-Shan,Xing, Jin-Liang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17
Over-expression of de novo lipogenesis (DNL) genes is associated with the prognosis of various types of cancers. However, the effects of single nucleotide polymorphisms (SNPs) in these genes on recurrence and survival of non-small cell lung cancer (NSCLC) patients after surgery are still unknown. In this study, a total of 500 NSCLC patients who underwent surgery treatment were included. Eight SNPs in 3 genes (ACACA, FASN and ACLY) of the DNL pathway were examined using the Sequenom iPLEX genotyping system. Multivariate Cox proportional hazards regression and Kaplan-Meier curves were used to analyze the association of SNPs with patient survival and tumour recurrence. We found that two SNPs in the FASN gene were significantly associated with the recurrence of NSCLC. SNP rs4246444 had a significant association with lung cancer recurrence under additive model (hazard ratio [HR], 0.82; 95% confidence interval [95%CI], 0.67-1.00; p=0.05). Under the dominant model, rs4485435 exhibited a significant association with recurrence (HR, 0.75; 95%CI, 0.56-1.01; p=0.05). Additionally, SNP rs9912300 in ACLY gene was significantly associated with overall survival in lung cancer patients (HR, 1.41; 95%CI, 1.02-1.94, p=0.04) under the dominant model. Further cumulative effect analysis showed moderate dose-dependent effects of unfavorable SNPs on both survival and recurrence. Our data suggest that the SNPs in DNL genes may serve as independent prognostic markers for NSCLC patients after surgery.
Yang Hui-Hui,Jiang Hui-Ling,Tao Jia-Hao,Zhang Chen-Yu,Xiong Jian-Bing,Yang Jin-Tong,Liu Yu-Biao,Zhong Wen-Jing,Guan Xin-Xin,Duan Jia-Xi,Zhang Yan-Feng,Liu Shao-Kun,Jiang Jian-Xin,Zhou Yong,Guan Cha-Xi 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Necroptosis is the major cause of death in alveolar epithelial cells (AECs) during acute lung injury (ALI). Here, we report a previously unrecognized mechanism for necroptosis. We found an accumulation of mitochondrial citrate (citratemt) in lipopolysaccharide (LPS)-treated AECs because of the downregulation of Idh3α and citrate carrier (CIC, also known as Slc25a1). shRNA- or inhibitor–mediated inhibition of Idh3α and Slc25a1 induced citratemt accumulation and necroptosis in vitro. Mice with AEC-specific Idh3α and Slc25a1 deficiency exhibited exacerbated lung injury and AEC necroptosis. Interestingly, the overexpression of Idh3α and Slc25a1 decreased citratemt levels and rescued AECs from necroptosis. Mechanistically, citratemt accumulation induced mitochondrial fission and excessive mitophagy in AECs. Furthermore, citratemt directly interacted with FUN14 domain-containing protein 1 (FUNDC1) and promoted the interaction of FUNDC1 with dynamin-related protein 1 (DRP1), leading to excessive mitophagy-mediated necroptosis and thereby initiating and promoting ALI. Importantly, necroptosis induced by citratemt accumulation was inhibited in FUNDC1-knockout AECs. We show that citratemt accumulation is a novel target for protection against ALI involving necroptosis.