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Flow-conditioning of a subsonic wind tunnel to model boundary layer flows
Tarek Ghazal,Jiaxiang Chen,Moustafa Aboutabikh,Haitham Aboshosha,Sameh Elgamal 한국풍공학회 2020 Wind and Structures, An International Journal (WAS Vol.30 No.4
This study aims at modeling boundary layers (BLs) encountered in sparse and built environments (i.e. open, suburban and urban) at the subsonic Wind Tunnel (WT) at Ryerson University (RU). This WT has an insignificant turbulence intensity and requires a flow-conditioning system consisting of turbulence generating elements (i.e., spires, roughness blocks, barriers) to achieve proper turbulent characteristics. This system was developed and validated in the current study in three phases. In phase I, several Computational Fluid Dynamic (CFD) simulations of the tunnel with generating elements were conducted to understand the effect of each element on the flow. This led to a preliminary design of the system, in which horizontal barriers (slats) are added to the spires to introduce turbulence at higher levels of the tunnel. This design was revisited in phase II, to specify slat dimensions leading to target BLs encountered by tall buildings. It was found that rougher BLs require deeper slats and, therefore, two-layer slats (one fixed and one movable) were implemented to provide the required range of slat depth to model most BLs. This system only involves slat movement to change the BL, which is very useful for automatic wind tunnel testing of tall buildings. The system was validated in phase III by conducting experimental wind tunnel testingof the system and comparing the resulting flow field with the target BL fields considering two length scales typically used for wind tunnel testing. A very good match was obtained for all wind field characteristics which confirms accuracy of the system.
Dong Jiale,Wang Wenzhi,Zhou Wei,Zhang Siming,Li Meng,Li Ning,Pan Guoqing,Zhang Xianzuo,Bai Jiaxiang,Zhu Chen 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Implant-associated infection (IAI) is increasingly emerging as a serious threat with the massive application of biomaterials. Bacteria attached to the surface of implants are often difficult to remove and exhibit high resistance to bactericides. In the quest for novel antimicrobial strategies, conventional antimicrobial materials often fail to exert their function because they tend to focus on direct bactericidal activity while neglecting the modulation of immune systems. The inflammatory response induced by host immune cells was thought to be a detrimental force impeding wound healing. However, the immune system has recently received increasing attention as a vital player in the host’s defense against infection. Anti-infective strategies based on the modulation of host immune defenses are emerging as a field of interest. This review explains the importance of the immune system in combating infections and describes current advanced immune-enhanced anti-infection strategies. First, the characteristics of traditional/conventional implant biomaterials and the reasons for the difficulty of bacterial clearance in IAI were reviewed. Second, the importance of immune cells in the battle against bacteria is elucidated. Then, we discuss how to design biomaterials that activate the defense function of immune cells to enhance the antimicrobial potential. Based on the key premise of restoring proper host-protective immunity, varying advanced immune-enhanced antimicrobial strategies were discussed. Finally, current issues and perspectives in this field were offered. This review will provide scientific guidance to enhance the development of advanced anti-infective biomaterials.