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Siqi Xu,Xiaoyan Wu,Zhihua Tao,Hongsheng Li1,Chenliang Fan,Songjin Chen,Jianwei Guo,Yao Ning,Xuqi Hu 한국유전학회 2020 Genes & Genomics Vol.42 No.3
Background Androgen-independent prostate cancer (AIPC) is an extremely malignant tumor developed from the androgen dependent (ADPC). However, the mechanism of transition process from ADPC to AIPC remains unknown. Objective Here we aimed to identify the androgen receptor (AR) target gene and its roles in AIPC. Methods Target genes of AR were identified by ChIP-seq in AIPC cells. AR target gene PCDH7 was detected by real time PCR and western blot. Methylation of PCDH7 was measured by bisulfite sequencing and bisulfite amplicon sequencing. Cell growth, invasion and apoptosis were measured by CCK-8, transwell and flow cytometry, respectively. Results AR was significantly enriched in the upstream of PCDH7 gene. The expression of PCDH7 was significantly decreased, while the methylation of PCDH7 was increased in the AIPC cells compared to the ADPC cells. DNA methyltransferase inhibitor significantly suppressed the methylation and increased the mRNA and protein level of PCDH7. Moreover, overexpression of DNMT1 remarkably reduced the mRNA and protein level of PCDH7. DNA methyltransferase inhibitor decreased the cell growth and invasion while promote the cell apoptosis in the AIPC cells. AR significantly target PCDH7, whose hypermethylation may repress cell growth and invasion, and promote apoptosis in AIPC. Conclusions This study might provide a novel potential target for the treatment of AIPC.
Jianwei Li,Guanjie Mi,Jie Zhang,Biaohua Chen 한국화학공학회 2010 Korean Journal of Chemical Engineering Vol.27 No.6
Based on the information from GC-MS on-line measurement and thermodynamic analysis, the reaction network of gas-phase hydroxylation of benzene with nitrous oxide over Fe-ZSM-5 zeolite was systematically investigated. The main reactions and side reactions were identified, and a kinetic reaction network was proposed as follows:benzene+N2O→phenol→CO/CO2. According to the mechanism, the experimental results were interpreted reasonably. The hydroxylation kinetic experiments were carried out in an isothermal integral microreactor under the conditions of n(benzene)/n(N2O)=8-12, T=663-763 K and atmospheric pressure. Based on the reaction network proposed, the parameters in the rate model of power-law were estimated by means of Gauss-Newton optimal method with the Levenberg-Marquardt modifications, and the results were in good agreement with the experimental data.
Few-Layered MoS2 Nanostructures for Highly Efficient Visible Light Photocatalysis
Dan Li,Jianwei Li,Caiqin Han,Xinsheng Zhao,Haipeng Chu,Wenyan Lei,Xinjuan Liu 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2016 NANO Vol.11 No.10
Few-layered MoS2 nanostructures were successfully synthesized by a simple hydrothermal method without the addition of any catalysts or surfactants. Their morphology, structure and photocatalytic activity were characterized by X-ray diffraction, scanning electron microscopy, energy dispersive X-ray spectroscopy, transmission electron microscopy, electrochemical impedance spectra and UV-Vis absorption spectroscopy, respectively. These results show that the MoS2 nanostructures synthesized at 180℃ exhibit an optimal visible light photocatalytic activity (99%) in the degradation of Rhodamine B owing to the relatively easier adsorption of pollutants, higher visible light absorption and lower electron–hole pair recombination.
Li Chen,Daiyue Yuan,Gui-lan Wang,You Wang,Yuan-Yuan Wu,Jianwei Zhu 대한의학회 2010 Journal of Korean medical science Vol.25 No.10
The aim of this study was to investigate the expression of Tspan-1, Jab1 and p27 in human hepatocellular carcinoma (HCC) and their clinicopathological significance. The expression of Tspan-1, Jab1 and p27 was detected in HCC tissues, the tissues around cancer (76 cases),and the normal tissues around the liver hemangiomas (10 cases). The overexpression of Tspan-1 and Jab1 was found in HCC tissues, positively correlated with clinical stage and negatively correlated with survival rate. The expression of p27 was found inversely linked to which of Tspan-1 and Jab1. In conclusion, the expression of Tspan-1, Jab1 and p27 is significantly associated with development of HCC. Overexpression of Tspan-1 and Jab1suggests poor prognosis but overexpression of p27 may expect good prognosis for patients with HCC.
A Facile and Efficient Synthesis of Dronedarone Hydrochloride
Li, Feng,Jin, Chunhua,Zou, Jianwei,Wu, Jun Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.7
A facile and efficient synthesis of dronedarone hydrochloride starting from commercially available 4-nitrophenol is described. This approach features a tandem-type synthesis of 3-carbonylated benzofuran involving cyclization of 2-ethynylphenol followed by $CO_2$ fixation at the 3-position of the benzofuran ring mediated by potassium carbonate without the addition of any transition metal catalyst.
Settlement behaviours and control measures of twin-tube curved buildings-crossing shield tunnel
Jianwei Jia,Ruiqi Gao,Defeng Wang,Jianjun Li,Ziwen Song,Jinghui Tan 국제구조공학회 2022 Structural Engineering and Mechanics, An Int'l Jou Vol.84 No.5
Settlement control techniques are critical for the safety of shield tunnel constructions, especially for facing complex situations. In this study, the shield tunnel structure from Huaita east road station to Heping Road station in Xuzhou metro No.3 line (China) is taken as engineering background, which has various complex problems of the upper-soft and lower-hard composite stratum conditions, twin curve shield tunnels, and underpass the foundation of the piled raft. The deformation characteristics of shield tunnelling passing through buildings are explored. Subsequently, comprehensive research methods of numerical simulation and field measurement are adopted to analyzing the effectiveness of settlement control by using the top grouting technique. The results show that the settlement of the buildings has obvious spatial characteristics, and the hysteresis effect can be obviously observed in soil deformation caused by shield construction. Meanwhile, the two shield constructions can cause repeated disturbances, reducing the soil deformation's hysteresis effect. Moreover, the shield tunnel's differential settlement is too large when a single line passes through, and the shield construction of the outer curve can cause more significant disturbance in the tunnel than the inside curve. Notably, the proposed process control parameters and secondary topgrouting method can effectively control the deformation of the shield tunnel, especially for the long-term deformation.
Next Location Prediction with a Graph Convolutional Network Based on a Seq2seq Framework
( Jianwei Chen ),( Jianbo Li ),( Manzoor Ahmed ),( Junjie Pang ),( Minchao Lu ),( Xiufang Sun ) 한국인터넷정보학회 2020 KSII Transactions on Internet and Information Syst Vol.14 No.5
Predicting human mobility has always been an important task in Location-based Social Network. Previous efforts fail to capture spatial dependence effectively, mainly reflected in weakening the location topology information. In this paper, we propose a neural network-based method which can capture spatial-temporal dependence to predict the next location of a person. Specifically, we involve a graph convolutional network (GCN) based on a seq2seq framework to capture the location topology information and temporal dependence, respectively. The encoder of the seq2seq framework first generates the hidden state and cell state of the historical trajectories. The GCN is then used to generate graph embeddings of the location topology graph. Finally, we predict future trajectories by aggregated temporal dependence and graph embeddings in the decoder. For evaluation, we leverage two real-world datasets, Foursquare and Gowalla. The experimental results demonstrate that our model has a better performance than the compared models.
Minghe Li,Saifei Hu,Jianwei Xia,Jing Wang,Xiao-Na Song,Hao Shen 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.9
In this work, the problem of predictive control of dissolved oxygen for the activated sludge process model with high nonlinearity and strong coupling is addressed. Firstly, the determination of the structure of fuzzy rules is displayed established upon Activated sludge model 1 (ASM1). Besides, the fuzzy space is divided through the clustering algorithm of fuzzy C-means. The corresponding parameters are estimated by means of the wellknown least squares method. Subsequently, a fuzzy predictive model of dissolved oxygen is established by using the historical data. The aim is to design a predictive controller that is capable of performing the online track of dissolved oxygen attributed to better dynamic response and steadier output in different weather. Ultimately, the availability and validity of the developed technique are verified by a comparison example.