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      • A novel adaptive unscented Kalman Filter with forgetting factor for the identification of the time-variant structural parameters

        Jianqing Bu,Yanzhe Zhang,Yong Ding,Lina Guo 국제구조공학회 2023 Smart Structures and Systems, An International Jou Vol.32 No.1

        The parameters of civil engineering structures have time-variant characteristics during their service. When extremely large external excitations, such as earthquake excitation to buildings or overweight vehicles to bridges, apply to structures, sudden or gradual damage may be caused. It is crucially necessary to detect the occurrence time and severity of the damage. The unscented Kalman filter (UKF), as one efficient estimator, is usually used to conduct the recursive identification of parameters. However, the conventional UKF algorithm has a weak tracking ability for time-variant structural parameters. To improve the identification ability of time-variant parameters, an adaptive UKF with forgetting factor (AUKF-FF) algorithm, in which the state covariance, innovation covariance and cross covariance are updated simultaneously with the help of the forgetting factor, is proposed. To verify the effectiveness of the method, this paper conducted two case studies as follows: the identification of time-variant parameters of a simply supported bridge when the vehicle passing, and the model updating of a sixstory concrete frame structure with field test during the Yangbi earthquake excitation in Yunnan Province, China. The comparison results of the numerical studies show that the proposed method is superior to the conventional UKF algorithm for the time-variant parameter identification in convergence speed, accuracy and adaptability to the sampling frequency. The field test studies demonstrate that the proposed method can provide suggestions for solving practical problems.

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        Study of upfront surgery versus neoadjuvant chemotherapy followed by interval debulking surgery for patients with stage IIIC and IV ovarian cancer, SGOG SUNNY (SOC-2) trial concept

        Rong Jiang,Jianqing Zhu,김재원,Jihong Liu,Kazuyoshi Kato,김희승,Yuqin Zhang,Ping Zhang,Tao Zhu,Daisuke Aoki,Aijun Yu,Xiaojun Chen,Xipeng Wang,Ding Zhu,Wei Zhang,Huixun Jia,Ting-Yan Shi,Wen Gao,Sheng Yin,Yan 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.5

        Background: Two randomized phase III trials (EORTC55971 and CHORUS) showed similarprogression-free and overall survival in primary or interval debulking surgery in ovariancancer, however both studies had limitations with lower rate of complete resection and lack ofsurgical qualifications for participating centers. There is no consensus on whether neoadjuvantchemotherapy followed by interval debulking surgery (NACT-IDS) could be a preferred approachin the management of advanced epithelial ovarian cancer (EOC) in the clinical practice. Methods: The Asian SUNNY study is an open-label, multicenter, randomized controlled,phase III trial to compare the effect of primary debulking surgery (PDS) to NACT-IDS instages IIIC and IV EOC, fallopian tube cancer (FTC) or primary peritoneal carcinoma (PPC). The hypothesis is that PDS enhances the survivorship when compared with NACT-IDS inadvanced ovarian cancer. The primary objective is to clarify the role of PDS and NACT-IDS inthe treatment of advanced ovarian cancer. Surgical quality assures include at least 50% of nogross residual (NGR) in PDS group in all centers and participating centers should be nationalcancer centers or designed ovarian cancer section or those with the experience participatingsurgical trials of ovarian cancer. Any participating center should be monitored evaluatingthe proportions of NGR by a training set. The aim of the surgery in both arms is maximalcytoreduction. Tumor burden of the disease is evaluated by diagnostic laparoscopy orpositron emission tomography/computed tomography scan. Patients assigned to PDS groupwill undergo upfront maximal cytoreductive surgery within 3 weeks after biopsy, followed by6 cycles of standard adjuvant chemotherapy. Patients assigned to NACT group will undergo 3cycles of NACT-IDS, and subsequently 3 cycles of adjuvant chemotherapy. The maximal timeinterval between IDS and the initiation of adjuvant chemotherapy is 8 weeks. Major inclusioncriteria are pathologic confirmed stage IIIC and IV EOC, FTC or PPC; ECOG performancestatus of 0 to 2; ASA score of 1 to 2. Major exclusion criteria are non-epithelial tumors as wellas borderline tumors; low-grade carcinoma; mucinous ovarian cancer. The sample size is 456subjects. Primary endpoint is overall survival. Trial Registration: ClinicalTrials.gov Identifier: NCT02859038

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        Transmission of symbiotic fungus with a nonsocial leaf-rolling weevil

        Xiaoqiong Li,Wenfeng Guo,Yuanguang Wen,Manoj Kumar Solanki,Jianqing Ding 한국응용곤충학회 2016 Journal of Asia-Pacific Entomology Vol.19 No.3

        Transmission modes of symbionts with fungus-growing insects are closely related to the stability of symbioses. As compare to social fungus-farming insects, transmission modes of nonsocial fungus-farming insects need to be further investigated. Euops chinensis, a nonsocial leaf-rolling weevil, harbors a symbiotic fungus Penicillium herquei in the specialized mycangium. Previous works have indicated that P. herquei is cultivated to host plants by females during oviposition process, however, it is still unclear when (before or after oviposition) and how P. herquei is transmitted. In this study, we observed fungal cultivating behaviors and adult bodies by scanning electron microscopy (SEM), and compared isolation rates of P. herquei on ovary eggs, newly oviposited eggs, cradle leaves (leaf pieces cut before rolling cradles), cradles, and female mycangia. Fungal isolateswere identified by internal transcribed spacers (ITS) and cytochrome oxidase I (COI) genes.Wefound the female's serrated tarsi and comb-like setae on the abdomen were specialized structures for fungal transmission. Newly oviposited eggs showed 81.11% frequency of fungal symbionts, but ovary eggs did not showany growth of fungal symbionts. Isolation rates of P. herquei on cradle leaves, mycangia and cradles were 76.67%, 77.71% and 87.72%, respectively. Analyses of ITS and COI genes showed that isolated fungal strains belong to the same species. We concluded that P. herquei was transmitted before oviposition, and the female's tarsi are newly found specialized structures for fungal transmission. This study elucidates the cultivar transmission modewith fungus-farming attelabidweevils, and might be useful to study of other fungiculture mutualisms.

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