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RISS 인기검색어
- 검색키워드
- 저자 : Jiangang Hou (검색결과 4 건)
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Noninvasive monitoring of mouse renal allograft rejection using micro-CT
Jiangang Hou,Masayuki Fujino,Songjie Cai,Qiang Ding,Xiao-Kang Li 대한외과학회 2015 Annals of Surgical Treatment and Research(ASRT) Vol.88 No.5
Purpose: Acute renal graft rejection can only be definitively diagnosed by renal biopsy. However, biopsies carry a risk of renal transplant injury and loss. Micro-CT is widely used in preclinical studies of small animals. Here, we propose micro-CT could noninvasively monitor and evaluate renal location and function in a mouse kidney transplant model. Methods: Orthotopic kidney transplantation was performed in a BALB/c -to- C57BL/6j or C57BL/6j-to- C57BL/6j mouse model. After optimizing imaging techniques, five mice were imaged with micro-CT and the findings were verified histologically. Results: Micro-CT can monitor and evaluate renal location and function after orthotopic kidney transplantation. There were no mice deaths while renal transplants were failure. Conclusion: We propose that graft micro-CT imaging is a new option that is noninvasive and specific, and can aid in early detection and follow-up of acute renal rejection. This method is potentially useful to improve posttransplant rejection monitoring.
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Yuelun Wang,Bo Hou,Jiangang Chen,Litao Jia,Debao Li,Yuhan Sun 한국화학공학회 2009 Korean Journal of Chemical Engineering Vol.26 No.3
Co/SiO2 catalysts were prepared by sol-gel method with varied en (ethylenediamine)/Co molar ratios under the same pH. Their physical-chemical properties were compared with those prepared with similar en/Co molar ratios at natural pH or without adding ethylenediamine. Regardless of pH, the catalysts prepared using ethylenediamine possessed high microporosity, which led to a better selectivity to C5-18 hydrocarbons, versus the catalyst possessing higher mesoporosity which showed slightly higher C18+ selectivity. As enough positions in the coordination sphere were blocked by ethanediamine ligands, the formation of cobalt silicate disfavored for (en/Co=2) catalysts, which resulted in the higher activity in FT reaction. Whereas the catalysts prepared with lower or higher en/Co molar ratio both showed lower activity due to the formation of [(SiO)Co(en)(EtOH)3] species or the electronic adsorption of cobalt complexes in the negatively charged silica surface, respectively. However, for the catalyst without using ethylenediamine, the lowest activity and the highest CH4 selectivity obtained due to its much lower reducibility.
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Inhibiting N-Cadherin-Mediated Adhesion Affects Gap Junction Communication in Isolated Rat Hearts
Zhu, Hongjun,Wang, Hegui,Zhang, Xiwen,Hou, Xiaofeng,Cao, Kejiang,Zou, Jiangang Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.30 No.3
Cadherin-mediated adherens junctions is impaired concomitant with a decrease in connexin 43 (Cx43) in diseases or pathological processes. We have investigated the acute effects of adherens junction impairment in isolated rat hearts by introducing Ala-His-Ala-Val-Asp-$NH_2$ (AHAVD, a synthetic peptide) as a specific inhibitor of N-cadherin. Effect of AHAVD on N-cadherin mediated adhension was analyzed by Cardiomy-ocyte aggregation assay. Laser confocal microscopy showed disrupted cell-cell contacts in cultured neonatal cardiomyocytes co-incubated with 0.2 mM AHAVD. In isolated adult rat hearts, Cx43 was redistributed along the bilateral of cardiomyocytes from the intercalated discs and significant dephosphorylation of Cx43 on serine368 occurred concomitantly with decreased gap junction (GJ) function in dose dependent manner after 1 h perfusion with AHAVD. These results indicate that impairing cad-herin-mediated adhesion by AHAVD rapidly results in Cx43 redistribution and dephosphorylation of serine368, thereby impairing GJ communication function.
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Inhibiting N-Cadherin-Mediated Adhesion Affects Gap Junction Communication in Isolated Rat Hearts
Hongjun Zhu,Hegui Wang,Xiwen Zhang,Xiaofeng Hou,Kejiang Cao,Jiangang Zou 한국분자세포생물학회 2010 Molecules and cells Vol.30 No.3
Cadherin-mediated adherens junctions is impaired conco-mitant with a decrease in connexin 43 (Cx43) in diseases or pathological processes. We have investigated the acute effects of adherens junction impairment in isolated rat hearts by introducing Ala-His-Ala-Val-Asp-NH2 (AHAVD, a synthetic peptide) as a specific inhibitor of N-cadherin. Effect of AHAVD on N-cadherin mediated adhension was analyzed by Cardiomy-ocyte aggregation assay. Laser confocal microscopy showed disrupted cell-cell contacts in cultured neonatal cardiomyocytes co-incubated with 0.2 mM AHAVD. In isolated adult rat hearts, Cx43 was redis-tributed along the bilateral of cardiomyocytes from the intercalated discs and significant dephosphorylation of Cx43 on serine368 occurred concomitantly with decreased gap junction (GJ) function in dose dependent manner after 1 h perfusion with AHAVD. These results indicate that im-pairing cad-herin-mediated adhesion by AHAVD rapidly results in Cx43 redistribution and dephosphorylation of serine368, thereby impairing GJ communication function.
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