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- 저자 : Jiang Xuewu (검색결과 3 건)
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Di Wang,Lili Tong,Luguo Liu,XUEWU CAO,Zhiqiang Zou,Lingjun Wu,Xiaowei Jiang 한국원자력학회 2019 Nuclear Engineering and Technology Vol.51 No.6
Hydrogen-steam gas mixture may be injected into containment with flow regime varying both spatiallyand transiently due to wall effect and pressure difference between primary loop and containment insevere accidents induced by loss of coolant accident. Preliminary CFD analysis is conducted to gain informationabout the helium flow regime transition process from jet to buoyancy plume for forthcomingexperimental study. Physical models of impinging jet and wall condensation are validated using separatedeffect experimental data, firstly. Then helium transportation is analyzed with the effect of jetmomentum, buoyancy and wall cooling discussed. Result shows that helium distribution is totallydominated by impinging jet in the beginning, high concentration appears near gas source and wallwhere jet momentum is strong. With the jet weakening, stable light gas layer without recirculating eddyis established by buoyancy. Transient reversed helium distribution appears due to natural convectionresulted from wall cooling, which delays the stratification. It is necessary to concern about hydrogenaccumulation in lower space under the containment external cooling strategy. From the perspective ofexperiment design, measurement point should be set at the height of connecting pipe and near the wallfor stratification stability criterion and impinging jet modelling validation.
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Ping Hongyan,Wang Degang,Fu Maxian,Chen Kaihong,Zhang Jiuhong,Li Ke,Jiang Xuewu,Duan Shouxing,Zhang Xuan 대한독성 유전단백체 학회 2022 Molecular & cellular toxicology Vol.18 No.4
Background Diethylstilbestrol (DES) has been shown to disrupt the morphology and proliferation of gubernaculum testis cells. Objective This study aimed to elucidate the mechanism underlying DES induced damage to gubernaculum testis based on proteome analysis. Results Neonatal mice were exposed to DES or control vehicle and the gonads were collected for isobaric tags for relative and absolute quantitation based proteomics analysis. We found that at the early and late stages of gubernaculum development, treatment with different concentrations of DES upregulated the expression of proteins which were generally involved in several function categories including single-organism process, cellular process, binding, catalytic activity, cell part and organelle. KEGG pathway analysis showed that cardiac muscle contraction, oxidative phosphorylation, calcium signaling and cGMP-PKG signaling pathway were the most dysregulated pathways associated with DES in the late stage of gubernaculum development, while steroid biosynthesis was the only enriched pathway in the early stage of gubernaculum development. Conclusion Proteomics profi ling and functional analysis reveal new clues on how DES interferes with cellular processes and disrupts the development of gubernaculum. These findings have potential applications in the treatment of genitourinary diseases such as cryptorchidism.
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The Two Echelon Open Vehicle Routing Problem: Optimization of Crowdshipping Based Parcel Delivery
Xue Wu,Dawei Hu,Bingshan Ma,Ruisen Jiang 대한토목학회 2022 KSCE Journal of Civil Engineering Vol.26 No.9
Crowdshipping is a revolutionary concept of the sharing economy. In this study, two carriers are used to perform the following expedition: the truck starts from the depot to complete part of the deliveries, shares part of the load with the crowdshipper at the relay point, and the private driver selected as the crowdshipper continues from that point onward. This study proposes the two-echelon open vehicle routing problem with crowdshipping (2EOVRP-CS) and formulates a mathematical model to determine the crowdshipper, parcel relay location, truck route, and crowdsource route. A tangible nested genetic algorithm (NGA) is proposed, and its efficiency is demonstrated by comparison with CPLEX and genetic algorithm (GA). A real case study is investigated in Xi'an city to test the applicability of the proposed model. The results show that using crowdshipping instead of truck delivery alone can save approximately 14% of the total cost and 26% of truck vehicle miles traveled (VMT). Moreover, several sensitivity analyses are performed. The results show that crowdshipping is sensitive to the detour limit and the time value of carriers. For the detour limit, after the acceptable detour distance increases by 8%, the total cost can be reduced by up to 5.94%.
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