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Yi, Jisook,Lee, Young Han,Song, Ho-Taek,Suh, Jin-Suck Williams & Wilkins Co 2018 Medicine Vol.97 No.48
<P><B>Abstract</B></P><P>The objectives of this study were to compare the ultrashort T2∗ relaxation time with the T2∗ relaxation time using the 3 dimensional (3D) cones sequence in 3 groups of patients with normal, degenerated, and torn knee menisci, and to demonstrate the additional effect of the ultrashort echo time (UTE) signal intensity.</P><P>Following institutional review board approval, 42 knee magnetic resonance imaging (MRI) scans of 42 patients who presented with knee pain and underwent knee MRIs, with the 3D Cones of UTE sequence (minimum TEs: 32 μs) and a 3T MRI scanner (Discovery 750, GE Healthcare, Waukesha, WI), were analyzed. The enrolled patients were classified into 3 subgroups:</P><P>normal meniscus on conventional MRI, with no positive meniscus-related physical examination in medical records;</P><P>meniscal degeneration with signal changes on conventional MRI; and</P><P>meniscal tear.</P><P>For the quantitative assessment, the mean values inside user-drawn regions of interest (ROIs) of the medial menisci were drawn on UTE T2∗ map and T2∗ map. For statistical analyses, 1-way analysis of variance (ANOVA) with post-hoc analysis using the Tukey HSD test was conducted to compare groups, and effect size was used to compare the discrimination power.</P><P>The ultrashort T2∗ relaxation times were higher in patients with meniscal tear than in those with normal and degeneration groups (<I>P</I> <.05, respectively) whereas T2∗ relaxation times were not statistically significantly different. The ultrashort T2∗ relaxation times showed higher effect sizes than the T2∗ times between tear and normal/degeneration.</P><P>The ultrashort T2∗ relaxation times showed better delineation of meniscal degeneration or tears than T2∗ relaxation times. The ultrashort T2∗ relaxation times could be more sensitive at differentiating between normal and pathologic meniscal conditions in patients.</P>
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Yi, Jisook,Lee, Young Han,Song, Ho-Taek,Suh, Jin-Suck unknown 2018 KOREAN JOURNAL OF RADIOLOGY Vol.19 No.2
<P><B>Objective</B></P><P>To evaluate the feasibility of synthetic magnetic resonance imaging (MRI) compared to conventional MRI for the diagnosis of internal derangements of the knee at 3T.</P><P><B>Materials and Methods</B></P><P>Following Institutional Review Board approval, image sets of conventional and synthetic MRI in 39 patients were included. Two musculoskeletal radiologists compared the image sets and qualitatively analyzed the images. Subjective image quality was assessed using a four-grade scale. Interobserver agreement and intersequence agreement between conventional and synthetic images for cartilage lesions, tears of the cruciate ligament, and tears of the meniscus were independently assessed using Kappa statistics. In patients who underwent arthroscopy (n = 8), the sensitivity, specificity, and accuracy for evaluated internal structures were calculated using arthroscopic findings as the gold standard.</P><P><B>Results</B></P><P>There was no statistically significant difference in image quality (<I>p</I> = 0.90). Interobserver agreement (κ = 0.649– 0.981) and intersequence agreement (κ = 0.794–0.938) were nearly perfect for all evaluated structures. The sensitivity, specificity, and accuracy for detecting cartilage lesions (sensitivity, 63.6% vs. 54.6–63.6%; specificity, 91.9% vs. 91.9%; accuracy, 83.3–85.4% vs. 83.3–85.4%) and tears of the cruciate ligament (sensitivity, specificity, accuracy, 100% vs. 100%) and meniscus (sensitivity, 50.0–62.5% vs. 62.5%; specificity, 100% vs. 87.5–100%; accuracy, 83.3–85.4% vs. 83.3–85.4%) were similar between the two MRI methods.</P><P><B>Conclusion</B></P><P>Conventional and synthetic MRI showed substantial to almost perfect degree of agreement for the assessment of internal derangement of knee joints. Synthetic MRI may be feasible in the diagnosis of internal derangements of the knee.</P>
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Yi, Jisook,Lee, Young Han,Hahn, Seok,Albakheet, Salman S.,Song, Ho-Taek,Suh, Jin-Suck Elsevier 2019 European journal of radiology Vol.112 No.-
<P><B>Abstract</B></P> <P><B>Objectives</B></P> <P>To investigate the feasibility of three-dimensional fast spin echo (3D-FSE) imaging with compressed sensing (CS) and parallel imaging (PI) compared to 3D-FSE imaging with only PI in evaluating ankle joint pathologies.</P> <P><B>Materials and methods</B></P> <P>Twenty consecutive patients underwent ankle magnetic resonance imaging (MRI), including acquisition of image sets of 2D-FSE sequences, and 3D-FSE sequences without and with CS, between June 2016 and November 2017. Three MR image sets were independently rated by two radiologists for the presence/absence of ankle pathology. Quantitative image similarity and subjective image quality were evaluated using 3D-FSE images without CS and those with CS-PI. Inter-sequence agreement between 3D-FSE sequences without CS and with CS-PI in both readers was evaluated.</P> <P><B>Results</B></P> <P>Interobserver agreements were nearly perfect for sprain of the anterior talofibular ligament (ATFL, <I>κ=</I>0.77), osteochondral lesion of the talus (OLT, <I>κ=</I>0.76-0.88), osteochondral lesion of the distal tibia (OLTi, <I>κ=</I>0.74) and os subfibulare (OSF, <I>κ=</I>0.62-0.64). The structural similarity index (mean, 0.996; range, 0.990-0.997) between the 3D-FSE sequences without CS and with CS-PI was acceptable. There was no significant difference in subjective image quality between the two imaging sequences (ATFL, <I>p</I> = 0.317; bone marrow, <I>p</I> = 0.083; cartilage, <I>p</I> = 1.000, tendon, <I>p</I> = 1.000). Intersequence agreement between the 3D-FSE sequences with and without CS was nearly perfect (ATFL and OLTi, <I>κ=</I>1.00; OLT, <I>κ=</I>0.87-0.96; OSF, <I>κ=</I>0.62-0.64) in both readers.</P> <P><B>Conclusions</B></P> <P>Isotropic 3D-FSE ankle MRI with CS provides acceptable diagnostic performance with reduced scan time. Compressed sensing-related artifacts could be minimized with CS reconstruction enhancement, allowing for better image quality for evaluating ankle joint pathologies.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Utilization of MRI for the ankle can be maximized by using the multiplanar imaging. </LI> <LI> Isovoxel 3D-fast spin echo sequence of ankle MRI has the capabilities of acquiring thin-sliced sections without any loss of spatial resolution. </LI> <LI> The CS technique is a method to accelerate MR acquisition by acquiring undersampling κ-space data. </LI> <LI> Compressed sensing accelerated isotropic 3D-FSE ankle MRI provides acceptable diagnostic performance with reduced scan time. </LI> </UL> </P>
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Kim Jisook,Bae Inhwan,Song Jiyoung,Kim Younghoon,Ahn Younggil,Park Hyun‐Ju,Kim Ha Hyung,Kim Dae Kyong 대한화학회 2021 Bulletin of the Korean Chemical Society Vol.42 No.6
Apoptosis inhibitor (IAP) proteins are overexpressed in many cancers and implicated in tumor growth, so the development of antagonist that disrupts with the binding of IAP to their partner protein is a promising therapeutic strategy. In an effort to increase cellular activity and improve favorable drug-like properties, we newly designed and synthesized monovalent analogues based on imidazopyrazinone structure of 9. Optimization of cellular potency led to the identification of 17, which showed increase of submicromolar activity (GI50 = 234 nM) and caspase-3 activation (6.3-fold) in MDA-MB-231 breast cancer cells. These findings clearly show the potential for 17 as a promising monovalent antagonist for the development of an effective anticancer treatment.
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박지숙(Jisook Park),송병호(Byoungho Song),이석호(Sukho Lee) 한국정보과학회 1993 정보과학회논문지 Vol.20 No.7
최근의 데이타베이스 분야에서는 기존의 정형화된 데이타뿐만 아니라 텍스트, 이미지, 그래픽, 음성, 비디오 등과 같은 비정형 멀티미디어 데이타에 관한 처리가 요구되고 있다. 이에 따라 멀티미디어 데이타베이스 관리 시스템에서는 각각의 미디어 데이타의 특성과 그들간의 복잡한 관계성을 관리해줄 수 있는 데이타 모델이 필요해졌다. 특히, 다양한 미디어 데이타들을 표현시킬 때 그들간의 시간적 관계성을 표현하고 관리해주는 방법이 필요하다. 본 연구에서는 멀티미디어 데이타간의 존재할 수 있는 시간적인 관계성을 객체 지향 기법에 의해 표현하고 그 정보를 동적으로 이용할 수 있는 방안을 제시하였다. Nowadays, many applications of database systems require the capability to manage unformattad data, i.e. text, image, graphics, voice, and video, as well as formatted data. Accordingly, a data model is needed that can manage the properties of multimedia data and complex relationships among them in a multimedia database management system. Especially. the mechanism for representing and managing the temporal realtioships in a multimedia data presentation is required. This paper proposes the mechanism to represent temporal relationships among multimedia data as well as to utilize the represented information dynamically using object-oriented paradigm.
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Dong-Woog Choi,Hwa-Jee Chung,Suk Min Ko,Dong Soo In,JiSook Song,Sung-Sick Woo,유장렬 한국식물생명공학회 2009 식물생명공학회지 Vol.36 No.3
Activation tagging that uses T-DNA vectors containingmultimerized transcriptional enhancers from the cauliflowermosaic virus (CaMV) 35S gene is a powerful tool todetermine gene function in plants. This approach has beensuccessfully applied in screening various types of mutationsand cloning the corresponding genes. We generated an activationtagged hairy root pool of ginseng (Panax ginseng C.A. Meyer) in an attempt to isolate genes involved in the biosyntheticpathway of ginsenoside (triterpene saponin), whichis known as the major active ingredient of the root. Quantitativeand qualitative variation of ginsenoside in activationtagged hairy root lines were profiled using LC/MS. Metabolicprofiling data enabled selection of a specific hairy root linewhich accumulated ginsenoside at a higher level than otherlines. The relative expression level of several genes of triterpenebiosynthetic pathway in the selected hairy root linewas determined by real time RT-PCR. Overall results suggestthat the activation tagged ginseng hairy root system describedin this study would be useful in isolating genes involved in acomplex metabolic pathway from genetically intractableplant species by metabolic profiling.
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Kim, Chul,Park, Ji-Min,Kong, TaeHo,Lee, Seungmin,Seo, Ki-Weon,Choi, Yuri,Song, Young Sook,Moon, Jisook Springer US 2018 Molecular neurobiology Vol.55 No.6
<P>Traumatic brain injury (TBI), a complicated form of brain damage, is a major cause of mortality in adults. Following mechanical and structural primary insults, a battery of secondary insults, including neurotransmitter-mediated cytotoxicity, dysregulation of calcium and macromolecule homeostasis, and increased oxidative stress, exacerbate brain injury and functional deficits. Although stem cell therapy is considered to be an alternative treatment for brain injuries, such as TBI and stroke, many obstacles remain. In particular, the time window for TBI treatment with either drugs or stem cells and their efficacy is still vague. Human placenta-derived mesenchymal stem cells (hpMSCs) have received extensive attention in stem cell therapy because they can be acquired in large numbers without ethical issues and because of their immune-modulating capacity and effectiveness in several diseases, such as Alzheimer’s disease and stroke. Here, we tested the feasibility of hpMSCs for TBI treatment with an animal model and attempted to identify appropriate time points for cell treatments. Double injections at 4 and 24 h post-injury significantly reduced the infarct size and suppressed astrocyte and microglial activation around the injury. With reduced damage, double-injected mice showed enhanced anti-inflammatory- and TNF-α receptor 2 (TNFR2)-associated survival signals and suppressed pro-inflammatory and oxidative responses. In addition, double-treated TBI mice displayed restored sensory motor functions and reduced neurotoxic Aβ<SUB>42</SUB> plaque formation around the damaged areas. In this study, we showed the extended therapeutic potentials of hpMSCs and concluded that treatment within an appropriate time window is critical for TBI recovery.</P>
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