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Huang, Rong-Hui,Lu, Ri-Yu,Chen, Wen,Chen, Ji-Rong Korean Meteorological Society 2003 大氣 Vol.13 No.2
Recent advances in the studies on the interaction between Asian monsoon and ENSO cycle are reviewed in this paper. Through the recent studies, the East Asian summer monsoon circulation system and the East Asian climate system have proposed. Moreover, different responses of the (winter and summer) monsoon circulation and summer rainfall anomalies in East Asia to ENSO cycle during its different stages have been understood further. Recently, the studies on the dynamical effect of East Asian monsoon on the thermal variability of the tropical western Pacific and ENSO cycle have been greatly advanced. These studies demonstrated further that ENSO cycle originates from the tropical western Pacific, and pointed out that the dynamical effect of East Asian winter and summer monsoons on ENSO cycle may be through the atmospheric circulation and zonal wind anomalies over the tropical western Pacific, which can excite the oceanic Kelvin wave and Rossby waves in the equatorial Pacific. Besides, the scientific problems in the interaction between Asian monsoon and ENSO cycle, which should be studied further in the near future, are also pointed out in this paper.
PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1
Chen, Gang,Kim, Yong Ho,Li, Hui,Luo, Hao,Liu, Da-Lu,Zhang, Zhi-Jun,Lay, Mark,Chang, Wonseok,Zhang, Yu-Qiu,Ji, Ru-Rong NATURE AMERICA 2017 NATURE NEUROSCIENCE Vol.20 No.7
<P>Programmed cell death ligand-1 (PD-L1) is typically produced by cancer cells and suppresses immunity through the receptor PD-1 expressed on T cells. However, the role of PD-L1 and PD-1 in regulating pain and neuronal function is unclear. Here we report that both melanoma and normal neural tissues including dorsal root ganglion (DRG) produce PD-L1 that can potently inhibit acute and chronic pain. Intraplantar injection of PD-L1 evoked analgesia in naive mice via PD-1, whereas PD-L1 neutralization or PD-1 blockade induced mechanical allodynia. Mice lacking Pd1 (Pdcd1) exhibited thermal and mechanical hypersensitivity. PD-1 activation in DRG nociceptive neurons by PD-L1 induced phosphorylation of the tyrosine phosphatase SHP-1, inhibited sodium channels and caused hyperpolarization through activation of TREK2 K+ channels. PD-L1 also potently suppressed nociceptive neuron excitability in human DRGs. Notably, blocking PD-L1 or PD-1 elicited spontaneous pain and allodynia in melanoma-bearing mice. Our findings identify a previously unrecognized role of PD-L1 as an endogenous pain inhibitor and a neuromodulator.</P>
Ping-Rong Yuan,Shi-Dong Ji,안상낙,김현정,Qiong-Hua Chen,Hong-Guang Ju 한국작물학회 2010 Journal of crop science and biotechnology Vol.13 No.4
Quantitative trait loci (QTL) associated with four milling recovery properties, two chemical properties, six paste properties of grain, and six textural parameters of cooked rice were identified using an introgression line (IL) population of rice developed from an interspecific cross over two years. The IL population consisted of 121 lines from a cross between wild rice (O. rufipogon Griff.) and a japonica cultivar. A total of 28 QTLs were identified for the 14 traits using inter mapping. Of these, 10 were significant over two years indicating that these QTLs are stable across years and environments. For eight (21%) of the QTLs identified, the O. rufipogonderived alleles contributed a desirable effect on amylose content, protein content, minimum viscosity, final viscosity, and consistency. Among these, pc3 for protein content and ac7 for amylose content were significant in both years and showed an R² value of 25.5and 30.9%, respectively. The markers closely associated with these useful alleles can be used to trace the inheritance of specific chromosome segments in the IL population and also offer a starting point for map-based cloning of genes underlying these traits.
Ping-Rong Yuan,Hyun-Jung Kim,Qiong-Hua Chen,Hong-Guang Ju,Seung-Joon Lee,Shi-Dong Ji,안상낙 한국작물학회 2009 Journal of crop science and biotechnology Vol.12 No.4
The nearly isogenic nature of the introgression lines (ILs) provides a relative advantage over other segregating populations in therapid implementation of pyramiding approach through crosses and marker analysis. A set of 126 ILs carrying various introgressedsegments from a presumed wild progenitor, Oryza rufipogon Griff. Acc. W1944 in the background of an elite Korea japonica cultivar(O. sativa L.), Hwayeongbyeo, was constructed using the marker assisted selection (MAS) technique combined with repeatedbackcrosses. The 126 ILs have different W1944 segments on each chromosome, with 100% coverage of wild segments on chromosome1, while for chromosome 10, the coverage was only 33.3%. The mean number of homozygous and heterozygous donor segmentswere 3 (ranging from 0 to 7) and 4.7 (ranging from 1 to 14.5), respectively, and 31.6% of introgressed segments had sizes ofless than 10.5 cM. A total of 41 quantitative trait loci (QTLs) and two loci associated with pericarp coloration were identified. Thenumber of QTLs per trait ranged from 2 to 6. Phenotypic variance associated with each QTL varied from 9.1 to 52.2%, with an averageof 17.1%. For 11 (26.8%) of the QTLs detected in this study, the O. rufipogon-derived alleles contributed the desired agronomiceffect despite the overall inferior characteristics of the wild phenotype. Favorable alleles from the O. rufipogon accession were identifiedfor panicle number, panicle length, days to heading, secondary branches, spikelets per panicle, and 1,000-grain weight.
Wei Ji,Wei Zhao,Rong‑Chen Liu,Xiao‑Bo Jiao,Kai Han,Zhong‑Yi Yang,Mei‑Ying Gao,Rui Ren,Xiu‑Juan Fan,Ming‑Xia Yang 한국식물생명공학회 2019 Plant biotechnology reports Vol.13 No.6
Flower color variegation has been observed in many plant species. However, pink flowers on the white-blooming hawthorn trees found by our group earlier have never been reported. To better understand the differentially expressed genes (DEGs) in variegated hawthorn flowers, white and pink flowers at different developmental stages (S1 and S2) underwent transcriptome sequencing separately. Approximately 34.28 Gb of high-quality data were obtained and assembled into 100,013 unigenes with an average length of 706.93 bp. These unigenes were further subjected to functional annotation and biochemical pathway analysis, and DEGs of two types of hawthorn flowers at different developmental stages were studied. Based on the enrichment analysis of DEGs, eight anthocyanin-modified enzyme genes or other enzyme genes that indirectly affect anthocyanin synthesis (5AT, 3GGT , and AI, β-Glu, two Aux/IAAs, two PODs), eight structural genes (UFGT, DFR, CHI, two F3Hs, and three PALs), and three transcription factors (one MYB and two bHLHs) were also identified. We randomly selected 15 genes, and the trends in the expression levels of these genes in the organs of white and pink flowers at different developmental stages were verified by quantitative real-time PCR. Mass sequence data obtained by RNA-seq of variegated hawthorn flowers provided basic sequence information and a unique opportunity to uncover the genetic mechanisms under-lying flower color variegation.
Yuan, Ping-Rong,Kim, Hyun-Jung,Chen, Qiong-Hua,Ju, Hong-Guang,Ji, Shi-Dong,Ahn, Sang-Nag 한국작물학회 2010 Journal of crop science and biotechnology Vol.13 No.4
Quantitative trait loci (QTL) associated with four milling recovery properties, two chemical properties, six paste properties of grain, and six textural parameters of cooked rice were identified using an introgression line (IL) population of rice developed from an interspecific cross over two years. The IL population consisted of 121 lines from a cross between wild rice (O. rufipogon Griff.) and a japonica cultivar. A total of 28 QTLs were identified for the 14 traits using inter mapping. Of these, 10 were significant over two years indicating that these QTLs are stable across years and environments. For eight (21 %) of the QTLs identified, the O. rufipogon-derived alleles contributed a desirable effect on amylose content, protein content, minimum viscosity, final viscosity, and consistency. Among these, pc3 for protein content and ac7 for amylose content were significant in both years and showed an $R^2$ value of 25.5 and 30.9%, respectively. The markers closely associated with these useful alleles can be used to trace the inheritance of specific chromosome segments in the IL population and also offer a starting point for map-based cloning of genes underlying these traits.
Yuan, Ping-Rong,Kim, Hyun-Jung,Chen, Qiong-Hua,Ju, Hong-Guang,Lee, Seung-Joon,Ji, Shi-Dong,Ahn, Sang-Nag 한국작물학회 2009 Journal of crop science and biotechnology Vol.12 No.4
The nearly isogenic nature of the introgression lines (ILs) provides a relative advantage over other segregating populations in the rapid implementation of pyramiding approach through crosses and marker analysis. A set of 126 ILs carrying various introgressed segments from a presumed wild progenitor, Oryza rufipogon Griff. Acc. W1944 in the background of an elite Korea japonica cultivar (O. sativa L.), Hwayeongbyeo, was constructed using the marker assisted selection (MAS) technique combined with repeated backcrosses. The 126 ILs have different W1944 segments on each chromosome, with 100% coverage of wild segments on chromosome 1, while for chromosome 10, the coverage was only 33.3%. The mean number of homozygous and heterozygous donor segments were 3 (ranging from 0 to 7) and 4.7 (ranging from 1 to 14.5), respectively, and 31.6% of introgressed segments had sizes of less than 10.5 cM. A total of 41 quantitative trait loci (QTLs) and two loci associated with pericarp coloration were identified. The number of QTLs per trait ranged from 2 to 6. Phenotypic variance associated with each QTL varied from 9.1 to 52.2%, with an average of 17.1%. For 11 (26.8%) of the QTLs detected in this study, the O. rufipogon-derived alleles contributed the desired agronomic effect despite the overall inferior characteristics of the wild phenotype. Favorable alleles from the O. rufipogon accession were identified for panicle number, panicle length, days to heading, secondary branches, spikelets per panicle, and 1,000-grain weight.
Hong-Liang Feng,Ji-Hua Huang,Jian Yang,Shao-Kun Zhou,Rong Zhang,Yue Wang,Shu-Hai Chen 대한금속·재료학회 2017 ELECTRONIC MATERIALS LETTERS Vol.13 No.6
Ni/Ni-Sn/Ni sandwiched simulated package structures weresuccessfully bonded under low temperature and low pressure byNi-Sn transient liquid-phase sintering bonding. The results showthat, after isothermally holding for 240 min at 300 °C and 180 minat 340 °C, Sn was completely transformed into Ni3Sn4 intermetalliccompounds. When the Ni3Sn4 phases around Ni particles werepressed together, the porosity of the bonding layer increased, whichobviously differed from the normal sintering densification process. With further analysis of this phenomenon, it was found that largevolume shrinkage (14.94% at 340 °C) occurred when Ni reactedwith Sn to form Ni3Sn4, which caused void formation. Amechanistic model of the microstructural evolution in the bondinglayer was proposed. Meanwhile, the resistivity of the bonding layerwas measured and analyzed by using the four-probe method; themicrostructural evolution was well reflected by the resistivity ofthe bonding layer. The relationship between the resistivity andmicrostructure was also discussed in detail.