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Salmon-Calcitonin 의 진통효과 및 Morphine 과의 상호작용
임정길 대한마취과학회 1995 Korean Journal of Anesthesiology Vol.28 No.3
Calcitonin is a peptide hormone involved primarily in the regulation of calcium homeostasis. However,clinical observations have shown that calcitonin does in fact possess an analgesic effect in a variety of painful disorders. So I studied the analgesic effect of intracerebroventricularly(i.c.v.) administered salmon calcitonin(s-CT) using the hot plate test and writhing test. The influence on the analgesia induced by morphine and naloxone reversibility was also studied. When s-CT was administered i.c.v., analgesia was observed in both tests,although it was greater in the writhing test than in the hot plate test. The analgesic effect of s-CT was partially but significantly reversed by naloxone. Thus, these results provide information about the antinociceptive effect of s-CT via interaction with both opiate and non-opiate mechanisms.
백서에서 Capsaicin이 일차감각신경원에 미치는 영향
신광일,임정길 대한마취과학회 1998 Korean Journal of Anesthesiology Vol.35 No.4
Background : Capsaicin acts specifically on a subset of primary sensory neurons involved in nociception. In addition to its excitatory actions, capsaicin can have subsequent antinociception and anti-inflammatory effects due to pharmacological, functional desensitization and axonal degeneration. Because capsaicin has selective actions on unmyelinated C and thinly myelinated Aδ primary sensory neurons, it can be speculated that intrathecally adminstered capsaicin results prolonged analgesia without adverse effects related to the destruction of the nonnociceptive nerve fibers. Methods : We performed experiments to investigate the effects of capsaicin on electrophysiological responses of acutely dissociated rat dorsal root ganglion neurons and pain-like behaviors, such as tail flick responses to hot water (53oC), formalin-induced hyperalgesic responses and allodynic responses induced by peripheral nerve injury. Results : Capsaicin affects preferentially small- to medium-diameter rat dorsal root ganglion neuron. In capsaicin responsive cells, superfusion with capsaicin evoked membrane potential depolarization and large inward currents. Cellular excitablity was continuously suppressed even after 3 min wash-out. Intrathecally administered capsaicin had no effect on tail withdrawal latencies, but flinching responses induced by subcutaneous formalin and allodynic responses induced by peripheral nerve injury were suppressed by capsaicin. Conclusions : The results suggest that capsaicin which acts on primary sensory neurons carrying nociceptive information is effective in managing pain induced in a pathological condition, such as inflammatory and neuropathic pain. The data may also be applicable for seeking novel pharmacological strategies for managing intractable pain, i.e. chemical neurolysis. (Korean J Anesthesiol 1998; 35: 642∼653)