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Jen-Fin Lin,Te-Hua Fang,Cheng-Da Wu,Ko-Han Houng 한국물리학회 2010 Current Applied Physics Vol.10 No.1
The frictional and indented behavior of a diamond asperity on a diamond plate was carried out using a molecular dynamics (MD) and experiments. The contact load, contact area, dynamic frictional force,and dynamic frictional coefficient increased as the contact interference increased at a constant loading velocity. The microcontact and frictional behavior can be evaluated between a rigid smooth hemisphere to a deformable rough flat plane by combined the deformed behavior of the asperity obtained from MD results with the fractal and statistic parameters. The comparison and the discrepancy of simulated results and nanoindentation and scratching experimental results will be discussed.
Increasing the Lifetime of Ad Hoc Networks Using Hierarchical Cluster-based Power Management
( Tin-yu Wu ),( Kai-hua Kuo ),( Hua-pu Cheng ),( Jen-wen Ding ),( Wei-tsong Lee ) 한국인터넷정보학회 2011 KSII Transactions on Internet and Information Syst Vol.5 No.1
One inevitable problem in Ad Hoc networks is the limited battery capacity, which explains why portable devices might shut down suddenly when the power of hardware is depleted. Hence, how to decrease the power consumption is an important issue in ad hoc networks. With the development of wireless technology, mobile devices can transmit voices, surf the Internet, download entertaining stuffs, and even support some P2P applications, like sharing real-time streaming. In order to keep the quality stable, the transmission must be continuous and it is thus necessary to select some managers to coordinate all nodes in a P2P community. In addition to assigning jobs to the staffs (children) when needed, these managers (ancestors) are able to reappoint jobs in advance when employees retire. This paper proposed a mechanism called Cluster-based Power Management (CPM) to stabilize the transmissions and increase Time to Live (TTL) of mobile hosts. In our new proposed method, we establish the clusters according to every node`s joining order and capability, and adjust their sleep time dynamically through three different mathematical models. Our simulation results reveal that this proposed scheme not only reduces the power consumption efficiently, but also increases the total TTLs evidently.
Wang Hui-Ching,Moi Sin-Hua,Chan Leong-Perng,Wu Chun-Chieh,Du Jeng-Shiun,Liu Pei-Lin,Chou Meng-Chun,Wu Che-Wei,Huang Chih-Jen,Hsiao Hui-Hua,Pan Mei-Ren,Chen Li-Tzong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Personalized genetic profiling has focused on improving treatment efficacy and predicting risk stratification by identifying mutated genes and selecting targeted agents according to genetic testing. Therefore, we evaluated the role of genetic profiling and tumor mutation burden (TMB) using next-generation sequencing in patients with head and neck squamous cell carcinoma (HNSC). The relapse mutation signature (RMS) and chromatin remodeling mutation signature (CRMS) were explored to predict the risk of relapse in patients with HNSC treated with concurrent chemoradiotherapy (CCRT) with platinum-based chemotherapy. Patients in the high RMS and CRMS groups showed significantly shorter relapse-free survival than those in the low RMS and CRMS groups, respectively (p < 0.001 and p = 0.006). Multivariate Cox regression analysis showed that extranodal extension, CCRT response, and three somatic mutation profiles (TMB, RMS, and CRMS) were independent risk predictors for HNSC relapse. The predictive nomogram showed satisfactory performance in predicting relapse-free survival in patients with HNSC treated with CCRT.
Diem Ngoc Hong Tran,I-Hsuan Hwang,Fun-Jou Chen,Yuan-Pu Tseng,Ching-Mao Chang,Shih-Jen Tsai,Jen-Lin Yang,Ta-Peng Wu,Chung-Hua Hsu,Fang-Pey Chen,Yen-Ying Kung 한국한의학연구원 2021 Integrative Medicine Research Vol.10 No.3
Background: Depressive disorders (DD) affect not only mood and behavior but also various physical functions. Traditional Chinese medicine (TCM) has been shown to have some benefits in treating DD. However, one formula or one single herb might be not show high efficacy when used to treat depression. Thus, this study aimed to examine the core prescription pattern of Chinese herbal medicine (CHM) among patients with DD in Taiwan as a reference for related research and clinical applications. Methods: All patients, who had been diagnosed with major depressive disorder or minor depression or dysthymia without any other baseline diseases and had at least one CHM outpatient clinical visit from 2002 to 2011, were extracted from three randomly sampled cohorts, namely the 2000, 2005 and 2010 cohorts of the National Health Insurance Research Database (NHIRD) of Taiwan. The collected data was analyzed to explore the patterns of herbal products. Results: There were 197,146 patients with a diagnosis of DD and of these 1806 subjects had only a diagnosis of DD and utilized CHM. The most common formula was Gan-Mai-Da-Zao-Tang (12.19%), while Suan-Zao-Ren (3.99%) was the most commonly prescribed single herb. The core pattern of prescriptions consisted of a combination of Gan-Mai-Da-Zao-Tang, Jia-Wei-Xiao-Yao-San, Chai-Hu-Jia-Long-Gu-Mu-Li-Tang, He-Huan-Pi, Yuan-Zhi and Shi-Chang-Pu. Conclusions: This study describes the CHM core prescription pattern used to treat patients in Taiwan with DD and it is a potential candidate for study in future pharmacological or clinical trials targeting DD.