SDN controller detection Openflow software

Jea-Rin Kim,Muhammad Afaq,Gwan-Woo Kang,Wang-Cheol Song 중소기업융합학회 2015 중소기업융합학회 국제학술대회논문집 Vol.2 No.1

Sufficient Calorie Intake Ameliorates Cognitive Impairment in Alcoholic Liver Disease

( Ye Rin Choi ),( Min Jea Shin ),( Gi Soo Youn ),( Sang Jun Yoon ),( Haripriya Gupta ),( Na Young Lee ),( Hyeong Seop Kim ),( Dong Joon Kim ),( Ki Tae Suk ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: Alcoholic liver disease (ALD) is the most common cause of chronic liver disease. And cognitive dysfunction is one of the complications and associated with calorie intake in ALD. However, relation between nutrition and cognitive function has not been fully evaluated. The aim of this study is to explore the effect of diet on cognitive function in ALD. Methods: A total of 43 patients were enrolled and neuropsychological tests assessed according to the nutritional state (BMI<21.7 and BMI≥21.7). In animal study, mice were sub-divided into 4 groups (n=9/group; control (5% EtOH liquid diet), low fat (5% EtOH+low fat diet), high fat (5% EtOH+high fat diet), and high protein (5% EtOH+high protein diet)) for 8 weeks. For the cognitive function, we performed T-maze study weekly before and after alcohol binge. Results: In the comparison of cognitive function (BMI<21.7 and BMI≥21.7), language score of Korea mini-mental state (7.37 ± 1.4 and 7.85 ± 0.4 P=0.04), rey-complex figure (72.0±25.9 and 58.4±33.6, P=0.05), boston naming (11.7±2.7 and 13.0±1.8, P=0.02), forward digit span (6.7±1 .8 and 7.5±1.6, P=0.04), Korean-color word stroop (24.2±26.5 and 43.6±32.4, P=0.006), interference score (33.9±31.9 and 52.3±33.9, P=0.02) showed high scores in BMI≥21.7 group. In the animal study on day 40, all groups shortened the time to find feed (low fat: P=0.004, high fat: P=0.02) compared to the control group. Interestingly, binge drinking mice reduced the time than before trained mice. Conclusions: ALD patients with BMI<21.7 enhance their cognitive dysfunction. Although it needs more studies which correlation of calorie intake and cognitive function, this study indicates that sufficient intake of calories provides major benefits for preventing cognitive dysfunction.

수열에너지 이용 후 재방류 시 낙동강 수온에 미치는 영향

신재우(Jea Woo Shin),윤린(Rin Yun) 대한설비공학회 2022 대한설비공학회 학술발표대회논문집 Vol.2022 No.6

본 연구는 하절기의 하천수는 외기 온도보다 낮은 온도를 가지고 있다는 특징을 이용하여 공기 열원 히트펌프가 아닌 취수와 방류를 진행하여 수열원 히트펌프의 열원으로써 하천수를 사용할 수가 있다. 이러한 수열원 히트펌프를 이용하여 낙동강 하구 하천수를 이용하여 수열원 히트펌프의 열원으로써 취수를 진행한 하천수는 재방류를 진행하게 되는데 이때 취수 및 재방류시 하천수로 돌아가는 열원으로 인하여 하천에 수온 변화로 인하여 생태계가 파괴될 수 있다. 낙동강을 열원으로 하절기 500RT의 수열원 히트펌프를 적용할 때 방류수로 인한 낙동강의 회복거리를 2차원 횡방향 평균 수리 및 수질모형인 CE-QUAL-W2 프로그램을 이용하여 산출하였다. 낙동강하구언 녹산2교를 시작으로 서낙동강교 까지 연구를 진행하였고, 그 결과 segment 3번에서 취수를 진행하고 segment 4번에서 재방류를 진행하였을 때 segment 5 즉 재방류지점에서 약 300 m 떨어진 구간에서 수온이 회복되는 것을 확인할 수가 있었다.

수열에너지 이용 후 재방류 시 낙동강 수온에 미치는 영향

신재우(Jea Woo Shin),윤린(Rin Yun) 대한설비공학회 2022 대한설비공학회 학술발표대회논문집 Vol.2022 No.6

본 연구는 하절기의 하천수는 외기 온도보다 낮은 온도를 가지고 있다는 특징을 이용하여 공기 열원 히트펌프가 아닌 취수와 방류를 진행하여 수열원 히트펌프의 열원으로써 하천수를 사용할 수가 있다. 이러한 수열원 히트펌프를 이용하여 낙동강 하구 하천수를 이용하여 수열원 히트펌프의 열원으로써 취수를 진행한 하천수는 재방류를 진행하게 되는데 이때 취수 및 재방류시 하천수로 돌아가는 열원으로 인하여 하천에 수온 변화로 인하여 생태계가 파괴될 수 있다. 낙동강을 열원으로 하절기 500RT의 수열원 히트펌프를 적용할 때 방류수로 인한 낙동강의 회복거리를 2차원 횡방향 평균 수리 및 수질모형인 CE-QUAL-W2 프로그램을 이용하여 산출하였다. 낙동강하구언 녹산2교를 시작으로 서낙동강교 까지 연구를 진행하였고, 그 결과 segment 3번에서 취수를 진행하고 segment 4번에서 재방류를 진행하였을 때 segment 5 즉 재방류지점에서 약 300 m 떨어진 구간에서 수온이 회복되는 것을 확인할 수가 있었다.

수열에너지 이용 후 재방류 시 낙동강 수온에 미치는 영향

신재우(Jea Woo Shin),윤린(Rin Yun) 대한설비공학회 2022 대한설비공학회 학술발표대회논문집 Vol.2022 No.6

본 연구는 하절기의 하천수는 외기 온도보다 낮은 온도를 가지고 있다는 특징을 이용하여 공기 열원 히트펌프가 아닌 취수와 방류를 진행하여 수열원 히트펌프의 열원으로써 하천수를 사용할 수가 있다. 이러한 수열원 히트펌프를 이용하여 낙동강 하구 하천수를 이용하여 수열원 히트펌프의 열원으로써 취수를 진행한 하천수는 재방류를 진행하게 되는데 이때 취수 및 재방류시 하천수로 돌아가는 열원으로 인하여 하천에 수온 변화로 인하여 생태계가 파괴될 수 있다. 낙동강을 열원으로 하절기 500RT의 수열원 히트펌프를 적용할 때 방류수로 인한 낙동강의 회복거리를 2차원 횡방향 평균 수리 및 수질모형인 CE-QUAL-W2 프로그램을 이용하여 산출하였다. 낙동강하구언 녹산2교를 시작으로 서낙동강교 까지 연구를 진행하였고, 그 결과 segment 3번에서 취수를 진행하고 segment 4번에서 재방류를 진행하였을 때 segment 5 즉 재방류지점에서 약 300 m 떨어진 구간에서 수온이 회복되는 것을 확인할 수가 있었다.

다구찌 실험계획법을 이용한 소구경화기 총열 내부용 Cr-Mo-V강의 질화공정 최적화

권혁린(Hyuk-Rin Kwon),김동은(Dong-Eun Kim),손형동(Hyung-Dong Son),신재원(Jea-Won Shin),박재하(Jae-Ha Park),강명창(Myung-Chang Kang) 한국기계가공학회 2018 한국기계가공학회지 Vol.17 No.3

When shooting small arms, the inner surface temperature is heated up to about 700~1,000℃ by the friction of the bullet and the inner wall of the barrel and the combustion of propellant. High-temperature propellant gas and high-speed movement of the bullet cause corrosion of the inner wall, which is noticeable immediately in front of the chamber. In this study, the mechanical properties of Cr-Mo-V steel, which is the base material, were tested using Taguchi experimental design to find the best nitriding treatment conditions. For the nitriding process, the working time, salt bath temperature, and salt concentration were combined as three conditions and placed in the L9(3⁴), orthogonal array table. The thicknesses of the white layer and the nitrogen diffusion layer were measured after nitriding under each condition in a salt bath furnace. Durability was evaluated by measuring the degree of dispersion through actual shooting because it was difficult to evaluate the mechanical properties of the cylinder inner structure. As a result, it was confirmed that the durability was optimal at 565℃, 1 hour, 0.5%. These optimal conditions were selected by the statistical analysis of the Minitab program(ver.17).

원예치료 프로그램을 위한 중년여성의 반려식물 선호도 조사

김혜린(Hye-Rin Kim), 박화진(Hwa-Jin Park), 이은령(Eun-Ryoung Lee), 제의숙(Eu-Suk Jea) 인간식물환경학회 2023 인간식물환경학회 학술대회 Vol.2023 No.1

Anti-Fibrotic Effects of Gut-Microbiome on Liver

( Na Young Lee ),( Min Jea Shin ),( Gi Soo Youn ),( Sang Jun Yoon ),( Ye Rin Choi ),( Hyeong Seop Kim ),( Dong Joon Kim ),( Sang Hak Han ),( Ki Tae Suk ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: Treatment for liver cirrhosis is intended to slow the progression and deterioration of liver function. Although many studies have shown that microbiome is an important factor in improving liver disease progression through the gut-liver axis, the exact mechanism is still unknown. The microbiome in the gut regulates nutrient metabolism and immune response and interacts closely with the host if the gut microbiome can suppress the progression of liver cirrhosis and analyze clinical data. Therefore, our study aim is to suppress the progression of liver fibrosis due to the modulation of gut-microbiome. Methods: Liver cirrhosis in mice was induced by DDC (3,5-diethoxycarboncyl-1,4-dihydrocollidine) diet. 6-week-old male C57BL/6J mice were divided into 5 groups (n=10/group; normal, liver fibrosis-induced control, strain X, L. lactis, and UDCA). Strain X group was given the strain X twice a week [109 CFU/g, 4-week]. Gene expression was compared and analyzed through mRNA sequencing analysis of mouse hepatic stellate cells in the DDC model. Results: The Strain X showed improvement in the Staging level and Sirius red areas compared to the fibrosis group induced by the DDC diet (P<0.05). The levels of the liver fibrosis markers TIMP1 (P=0.02), Col1a (P<0.001), and TGF-ß (P<0.001) were decreased in the Strain X group compared with fibrosis models. When HSCs were isolated, expression of TIMP1 (P=0.38) and Col1a (P=0.055) decreased in strain X. Strain X compared to DDC in the mRNA sequencing, the up-regulated gene is Ecm1, Fos, Serpina1e and the down-regulated gene is Cd5l, Cd63, Marco (P<0.03). Conclusions: Strain X improved fibrosis by modulating the gut microbial composition in a mouse model induced cirrhosis.

Anti-Fibrotic Effect of Urushiol (Rhus Verniciflua Stokes) on Thioacetamide-Induced Liver Fibrosis of Mice Model

( Hyeong Seop Kim ),( Ye Rin Choi ),( Mi Gun Hong ),( Min Jea Shin ),( Sang Jun Yoon ),( Na Young Lee ),( Hyun Ji Ye ),( Sang Hak Han ),( Dong Joon Kim ),( Gi Soo Youn ),( Ki Tae Suk ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: Liver fibrosis constitutes a serious problem worldwide due to its rapidly leads to cirrhosis, and even cancer. However, there is no clear medical treatment other than treating the cause. Urushiol has been known to have anti-inflammatory and anti-oxidative effects on various disease. We investigated the effect of urushiol on liver fibrosis induced by thioacetamide (TAA). Methods: Thirty C57BL/6 mice were randomly divided into 3 groups and urushiol was dissolved in vehicle (DMSO) for in vivo experiments: (1) control group; (2) TAA (normal saline as solvent, 300 mg/kg/day, 3 times/week, i.p.) + vehicle (gavage). (3) TAA (300 mg/kg/day, 3 times/week, i.p.) + urushiol (0.128 mg/ mL/day, 28 times, gavage). These groups were analyzed by immunohistochemical staining, reverse transcription polymerase chain reaction, and microarray. Results: The TAA + Urushiol group improved the deposition of fibrillar collagen (Sirius Red (%) 1.55 ± 0.25 vs. TAA, P<0.0001), Fibrosis stage reduced (1.64 ± 0.20 vs. TAA, P<0.0001) and Inflammation activity decreased concurrently (1.17 ± 0.16 vs. TAA, P<0.0001). The analysis of mRNA expression showed that Col1a1 (2.30-fold change vs. TAA, P<0.0001) and TIMP-1 (1.48-fold change vs. TAA, P<0.05), IL-6 (3.03- fold change vs. TAA, P<0.0001), JAK2 (0.89-fold change vs. TAA, P<0.05), STAT3 (3.26-fold change vs. TAA, P<0.0001) downregulated significantly. As shown microarray analysis, downregulation of Col1a1 (1.12-fold change vs. TAA, P<0.05), Chka, lipid metabolic process gene (2.21-fold change vs. TAA, P<0.001), Pnpla3, patatin-like phospholipase domain containing 3 (1.57-fold change, P<0.001) Contrast, Orm2, regulation of immune system process gene (2.28-fold change vs. TAA, P<0.001) Saa1, serum amyloid A (2.25-fold changes vs. TAA, P<0.05), Saa2 (3.09-fold change, P<0.001) Conclusions: Our results indicated that urushiol has therapeutic effect on liver fibrosis. Although it is needed more clinical research, urushiol can be a potential agent for the treatment of liver fibrosis.

Lactobacillus attenuates progression of nonalcoholic fatty liver disease by lowering cholesterol and steatosis

( Na Young Lee ),( Min Jea Shin ),( Gi Soo Youn ),( Sang Jun Yoon ),( Ye Rin Choi ),( Hyeong Seop Kim ),( Haripriya Gupta ),( Sang Hak Han ),( Byoung Kook Kim ),( Do Yup Lee ),( Tae Sik Park ),( Hotai 대한간학회 2021 Clinical and Molecular Hepatology(대한간학회지) Vol.27 No.1

Background/Aims: Nonalcoholic fatty liver disease (NAFLD) is closely related to gut-microbiome. There is a paucity of research on which strains of gut microbiota affect the progression of NAFLD. This study explored the NAFLD-associated microbiome in humans and the role of Lactobacillus in the progression of NAFLD in mice. Methods: The gut microbiome was analyzed via next-generation sequencing in healthy people (n=37) and NAFLD patients with elevated liver enzymes (n=57). Six-week-old male C57BL/6J mice were separated into six groups (n=10 per group; normal, Western, and four Western diet + strains [10⁹ colony-forming units/g for 8 weeks; L. acidophilus, L. fermentum, L. paracasei, and L. plantarum]). Liver/body weight ratio, liver pathology, serum analysis, and metagenomics in the mice were examined. Results: Compared to healthy subjects (1.6±4.3), NAFLD patients showed an elevated Firmicutes/Bacteroidetes ratio (25.0±29.0) and a reduced composition of Akkermansia and L. murinus (P<0.05). In the animal experiment, L. acidophilus group was associated with a significant reduction in liver/body weight ratio (5.5±0.4) compared to the Western group (6.2±0.6) (P<0.05). L. acidophilus (41.0±8.6), L. fermentum (44.3±12.6), and L. plantarum (39.0±7.6) groups showed decreased cholesterol levels compared to the Western group (85.7±8.6) (P<0.05). In comparison of steatosis, L. acidophilus (1.9±0.6), L. plantarum (2.4±0.7), and L. paracasei (2.0±0.9) groups showed significant improvement of steatosis compared to the Western group (2.6±0.5) (P<0.05). Conclusions: Ingestion of Lactobacillus, such as L. acidophilus, L. fermentum, and L. plantarum, ameliorates the progression of nonalcoholic steatosis by lowering cholesterol. The use of Lactobacillus can be considered as a useful strategy for the treatment of NAFLD. (Clin Mol Hepatol 2021;27:110-124)