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Jang, Joo Hee,Lee, Hoyeon,Sharma, Amit,Lee, Sang Min,Lee, Tae Hoon,Kang, Chulhun,Kim, Jong Seung The Royal Society of Chemistry 2016 Chemical communications Vol.52 No.64
<P>An indomethacin-guided drug delivery conjugate (IGDDC) has been designed by utilizing cancer associated elevated HDAC and CTSL activities as consecutive demasking ventures for drug activation. IGDDC exhibited preferential uptake by COX-2 positive cells both in vitro and ex vivo highlighting indomethacin's role in designing new cancer-specific drug delivery frameworks.</P>
Subjectivity on Patient Safety Recognized by Inpatients
Lee, HoYeon,Jang, SunYoung,Wang, MeeSuk The Institute of Internet 2020 International Journal of Internet, Broadcasting an Vol.12 No.3
The purpose of this study is to identify the subjectivity of patient and describe the characteristics of each type to understand the categorization of types on patient safety. Q methodology was applied to the study. A total of 40 patients admitted to the S hospital in Seoul were asked to categorize 33 statements on patient safety. The collected data was analyzed using QUANL PC Program. After analysis, patient safety as perceived by the admitted patient was categorized into 6 types. The types were as follows: Type 1 'Those who note adequate patient safety', Type 2 'Those who consider preventive safety to be lacking' Type 3 'Those who see the evaluation criteria to be met', Type 4 'Those who see the facility safety to be lacking', Type 5 'Those who find the patient and facility safety to be adequate', Type 6 'Those who see patient support to be lacking'. The study provides a basic set of data for developing mediation measures needed to identify the direction in which patient safety should be promoted.
공학 Reading & Writing 교재 개발 및 학습성과 분석
정호연(Hoyeon Chung),전오성(Oh Sung Jun),유규선(Kyusun Yoo),장미영(Mi Young Jang) 한국공학교육학회 2011 공학교육연구 Vol.14 No.6
The authors have developed a reading & writing textbook for engineering students to improve their communication capability, and also analyzed the outcomes that the students accomplished through the Engineering Reading and Writing class. The reading & writing textbook has been organized to be used as a guidebook with which the engineering students can practically solve the problems that they would face continuously after they finish their regular curriculum and when they are employed. The questionnaire survey analysis has been performed in order to evaluate the textbook contents, lecturing, and learning outcomes for the lecturers and students finished the engineering reading and writing classes. Desirable evaluation has been resulted in the broad areas: subject extraction from the readings, logical understanding, summarizing, practical writing, writing principle, etc.
Production of high-quality chemical materials through the catalytic pyrolysis of e-waste
( Hyunji Yim ),( Hoyeon Jang ),( Bo Sung Kang ),( Sugyeong Jeon ),( Haneul Shim ),( Youngeun Kang ),( Young-min Kim ),( Sumin Pyo ),( Young-kwon Park ) 한국폐기물자원순환학회 2022 ISSE 초록집 Vol.2022 No.-
With the recent development of electronic device manufacturing technology, the demand of electrical and electronic equipment has increased rapidly, and the amount of electronic waste (e-waste) is also increasing accordingly. Although the recycling of e-waste has increased, it is still limited as metal recovery and most of organic parts, polymers and additives, were still treated simply via incineration or landfill. Pyrolysis can be considered as an eco-friendly process not only for the effective recovery of metal but also for the chemical recycling of organic parts of e-wastes. In this research, the thermal and catalytic pyrolysis of e-wastes have investigated focused on the production of high-quality oil and chemical feedstock. The non-catalytic pyrolysis of organic part in e-waste was prepared after the elimination of inorganic part and applied the pyrolysis under inert gas atmosphere using thermogravimetric (TG) analyzer and pyrolyzer-gas chromatography/mass spectrometry (Py-GC/MS). Kinetic analysis, analyzed by a model free kinetic analysis method to the TG analysis results of organic e-waste, indicated the change of thermal degradation pattern by applying the catalytic pyrolysis. Py-GC/MS result also indicated the quality of the pyrolysis oil can be upgraded efficiently with the decrease of undesirable product, such as halogen containing chemicals and oxygen containing pyrolyzates.
생물학적 탈황공정 부산물을 이용한 중금속 처리 적용성 검토
박혜옥(Hye Ok Park),장재용(Jang Jae Yong),이경호(Kyeong Ho Lee ),이호연(Hoyeon Lee ),박정현(Jung Hyun Park) 유기성자원학회 2019 유기성자원학회 학술발표대회논문집 Vol.2019 No.춘계
매립가스(LandFill Gas) 활용을 통해 전기를 생산하는 발전공정에서 매립가스 내황화수소(H2S)는 배관과 설비의 부식을 유발하고 SOX 발생 및 불완전연소 시 황화수소의 대기 방출 등에 따른 문제점을 야기시킨다. 따라서 매립가스 내 활용을 위해서는 황화수소 제거가 반드시 필요하며 국내에서는 이를 위한 다양한 기술들이적용되고 있다. 일반적인 탈황 기술로는 습식탈황(약액법) 또는 건식탈황(흡착법)의물리적, 화학적인 탈황, 생물학적 탈황이 있다. 이중에서도 미생물을 이용하여 황화수소를 생물학적 처리 시 발생되는 황은 원소황(S°)으로 바이오황(Bio-Sulfur)이라한다. 일반적으로 바이오황은 화학공정을 통해 생산된 원소황에 비해 입자의 크기가 작고, 물에 대한 친수성이 뛰어난 장점을 가지고 있어 다양한 응용제품의 개발이 용이하다고 알려져 있다. 그러나 국내에서는 적절한 수요처의 확보와 활용성 증대 측면에서 한계가 있으며, 현재 총 생산량의 일부만 비료나 기타 화학물질의 원료로 소비되고 있는 실정이다. 본 연구에서는 수도권 매립지에서 발생하는 매립 가스 중 황화수소를 생물학적으로 전환하여 생산된 바이오황을 이용하여 중금속 처리가능성 평가를 위한 기초연구로서 바이오황의 흡착 시간에 따른 중금속 제거 효율을 분석하고자 하였다.
Seo, Hye-Sook,Ku, Jin Mo,Choi, Han-Seok,Woo, Jong-Kyu,Jang, Bo-Hyoung,Go, Hoyeon,Shin, Yong Cheol,Ko, Seong-Gyu SPANDIDOS PUBLICATIONS 2015 MOLECULAR MEDICINE REPORTS Vol.12 No.2
<P>Phytoestrogens have been demonstrated to inhibit tumor induction; however, their molecular mechanisms of action have remained elusive. The present study aimed to investigate the effects of a phytoestrogen, apigenin, on proliferation and apoptosis of the human epidermal growth factor receptor 2 (HER2)-expressing breast cancer cell line SKBR3. Proliferation assay, MTT assay, fluorescence-activated cell sorting analysis, western blot analysis, immunocytochemistry, reverse transcription-polymerase chain reaction and ELISA assay were used in the present study. The results of the present study indicated that apigenin inhibited the proliferation of SKBR3 cells in a dose-and time-dependent manner. This inhibition of growth was accompanied by an increase in the sub-G0/G1 apoptotic population. Furthermore, apigenin enhanced the expression levels of cleaved caspase-8 and -3, and induced the cleavage of poly(adenosine diphosphate ribose) polymerase in SKBR3 cells, confirming that apigenin promotes apoptosis via a caspase-dependent pathway. Apigenin additionally reduced the expression of phosphorylated (p)-janus kinase 2 and p-signal transducer and activator of transcription 3 (STAT3), inhibited CoCl2-induced vascular endothelial growth factor (VEGF) secretion and decreased the nuclear localization of STAT3. The STAT3 inhibitor S31-201 decreased the cellular proliferation rate and reduced the expression of p-STAT3 and VEGF. Therefore, these results suggested that apigenin induced apoptosis via the inhibition of STAT3 signaling in SKBR3 cells. In conclusion, the results of the present study indicated that apigenin may be a potentially useful compound for the prevention or treatment of HER2-overexpressing breast cancer.</P>
Nham Eliel,Kim Young-Eun,Jung Jaehun,Kim Dong Wook,Jang Hoyeon,Hyun Hakjun,Seong Hye,Yoon Jin Gu,Noh Ji Yun,Song Joon Young,Kim Woo Joo,Cheong Hee Jin 대한의학회 2022 Journal of Korean medical science Vol.37 No.45
As most individuals acquire immunity to severe acute respiratory syndrome coronavirus 2, South Korea declared a return to normalcy a few months ago. However, epidemic waves continue because of endlessly emerging variants and waning immunity. Health authorities are focusing on those at high risk of severe coronavirus disease 2019 to minimize damage to public health and the economy. In this regard, we investigated the vaccination rates in patients with various chronic medical conditions by examining the national health insurance claims data and the national immunization registry. We found that patients with chronic medical conditions, especially those of higher severity, such as malignancy, had vaccination rates approximately 10–20% lower than those of the general population. Public health authorities and healthcare providers should try to vaccinate these patients to avoid preventable morbidity and mortality.
Park, Sunju,Nahmkoong, Won,Cheon, ChunHoo,Park, Jeong-Su,Jang, Bo-Hyoung,Shin, Yongcheol,Kim, Kyung-Soo,Go, Hoyeon,Song, Yun-Kyung,Ko, Seong-Gyu Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-
<P><I>Objective</I>. The purpose of this study was to assess the efficacy and safety of Taeeumjowi-tang (TJ001) as well as to estimate obesity-related factors. <I>Methods</I>. This was a 12-week trial with 5 visits. A total of 102 participants of both genders were randomized to either TJ001 (<I>n</I> = 57) group or the placebo group (<I>n</I> = 55). Subjects were administered 7 g of either TJ001 or placebo 3 times a day. The primary outcome was a rate of subjects who lost 5% or more of initial weight. Secondary outcomes included anthropometric parameters, lipid profiles, and body fat composition. <I>Results</I>. The subject response rate of ≥5% weight loss compared to baseline was similar in both groups, and no statistically significant difference was observed (<I>P</I> = 0.87). Changes in anthropometric parameters were greater during the first 4 weeks in the treatment group (<I>P</I> < 0.0001). There were no significant changes in both within groups and between groups for lipid profile and body fat composition. No adverse event was reported in either group. <I>Conclusion</I>. Although the difference between the groups regarding a rate of subjects who lost 5% or more of initial weight did not show statistical significance, TJ001 appears to be beneficial in safely controlling weight.</P>