Effect of sintering duration on structural and electrical properties of Ba0.9Sr0.1Ti0.96Zr0.04O3 solid solution

Aditya Jain,Rakesh Saroha,Mukul Pastor,A.K. Jha,A.K. Panwar 한국물리학회 2016 Current Applied Physics Vol.16 No.8

Strontium and zirconium substituted barium titanate, Ba0.9Sr0.1Ti0.96Zr0.04O3 (BSZT) was prepared through the solid state reaction route. The compound was sintered for 6, 9 and 12 h and the effect of sintering duration has been studied. Structural investigation has been carried out using X-ray diffraction pattern of the samples following the Rietveld refinement, which confirms the formation of tetragonal phase with P4mm space group. The effect of Sr and Zr substitution in the BT lattice and effect of sintering duration in BSZT has been evaluated by Raman spectroscopy. The microstructural and dielectric studies show the increase in grain size as well as dielectric constant with increasing sintering duration. No appreciable change in Curie temperature (Tc) is observed for all three samples viz. BSZT6, BSZT9 and BSZT12. A decrease in activation energy and increase in diffusivity constant with increasing sintering duration is observed. I-V measurement was carried out to study the resistive properties of the synthesized compositions.

Retraction: Midazolam use in pediatric dentistry: a review

Jain, Shreyans Aditya,Rathi, Nilesh,Thosar, Nilima,Baliga, Sudhindra The Korean Dental Society of Anesthsiology 2020 Journal of Dental Anesthesia and Pain Medicine Vol.20 No.2

Midazolam use in pediatric dentistry: a review

Jain, Shreyans Aditya,Rathi, Nilesh,Thosar, Nilima,Baliga, Sudhindra The Korean Dental Society of Anesthsiology 2020 Journal of Dental Anesthesia and Pain Medicine Vol.20 No.1

Behaviour management and dental procedures performed in very young, pre-cooperative, highly anxious, or medically disabled children are challenging tasks. Various drugs and methods have, however, been introduced to facilitate treatment for this patient population. Midazolam is a benzodiazepine used as an adjunct to behavior management techniques in the dental treatment of pediatric patients. Midazolam can be used as a safe and effective drug for conscious sedation, general anesthetic premedication, and treatment of seizures during dental procedures. Nevertheless, further research involving pediatric patients would be beneficial.

Genetic alterations in Wnt family of genes and their putative association with head and neck squamous cell carcinoma

Aditya, Jain,Smiline Girija, A.S.,Paramasivam, A.,Priyadharsini, J. Vijayashree Korea Genome Organization 2021 Genomics & informatics Vol.19 No.1

Head and neck squamous cell carcinoma (HNSCC) is the most frequent type of head and neck cancer that usually arises from the mucosal surfaces of several organs including nasal cavity, paranasal sinuses, oral cavity, tongue, pharynx, and larynx. The Wnt signaling pathway is a crucial mechanism for cellular maintenance and development. It regulates cell cycle progression, apoptosis, proliferation, migration, and differentiation. Dysregulation of this pathway correlates with oncogenesis in various tissues including breast, colon, pancreatic as well as head and neck cancers. The present study aims to assess the gene alterations in the Wnt family of genes so as to derive an association with HNSCC. Computational approaches have been utilized for the identification of gene alterations in the Wnt family of genes. Several databases such as cBioportal, STRING, and UALCAN were used for the purpose. The frequency of alteration was high in case of Wnt family member 11 (5%). Gene amplification, deep deletions, missense and truncating mutations were observed in HNSCC patients. There was a marked difference in the gene expression profile of WNT11 between grades as well as normal samples. The survival probability measured using the Kaplan-Meier curve also presented with a significant difference among male and female subjects experiencing a low/medium level expression. The female patients showed less survival probability when compared to the male subjects. This provides the prognostic significance of the WNT11 gene in HNSCC. Taken together, the present study provides clues on the possible association of WNT11 gene alterations with HNSCC, which has to be further validated using experimental approaches.

Comparable outcomes with low-dose and standard-dose horse anti-thymocyte globulin in the treatment of severe aplastic anemia

Arihant Jain,Aditya Jandial,Thenmozhi Mani,Kamal Kishore,Charanpreet Singh,Deepesh Lad,Gaurav Prakash,Alka Khadwal,Reena Das,Neelam Varma,Subhash Varma,Pankaj Malhotra 대한혈액학회 2024 Blood Research Vol.59 No.1

Background The standard dose (SD) of horse anti-thymocyte globulin (hATG) ATGAM (Pfizer, USA) or its biosimilar thymogam (Bharat Serum, India) for the treatment of Aplastic Anemia (AA) is 40 mg/kg/day for 4 days in combination with cyclosporine. Data on the impact of hATG dose on long-term outcomes are limited. Here, we describe our comparative experience using 25 mg/kg/day (low-dose [LD]) hATG for 4 days with SD for the treatment of AA. Methods We retrospectively studied patients with AA (age > 12 years) who received two doses of hATG combined with cyclosporine. Among 93 AA patients who received hATG, 62 (66.7%) and 31 (33.3%) patients received LD and SD hATG with cyclosporine, respectively. Among these,seventeen(18.2%) patients also received eltrombopag with hATG and cyclosporine. Overall response rates [complete response (CR) and partial response (PR)] of LD and SD hATG groups at 3 months (50% vs. 48.4%; p = 0.88), 6 months (63.8% vs. 71.4%; p = 0.67), and 12 months (69.6% vs. 79.2%; p = 0.167) were comparable. The mean (Standard Deviation) 5-year Kaplan–Meier estimate of overall survival and event-free survival was 82.1 (4.6)% and 70.9 (5.5)% for the study population. The mean (standard deviation) 5-year Kaplan–Meier estimate of overall survival and event-free survival of those who received LD hATG versus SD hATG dose was 82.9 (5·3)% versus 74.8 (10·3)% (P = 0·439), and 75.2 (6.2)% versus 61.4(11.2)% (P = 0·441). Conclusion Our study revealed that the response rates of patients with AA and LD were similar to those of patients with SD to hATG combined with cyclosporine in a real-world setting.

High-Flexion Posterior-Stabilized Total Knee Prosthesis: Is It Worth the Hype?

( Sanjeev Jain ),( Aditya Chandrashekhar Pathak ),( Kalaivanan Kanniyan ),( Sourabh Kulkarni ),( Sandeep Tawar ),( Prashant Mane ) 대한슬관절학회 2013 대한슬관절학회지 Vol.25 No.3

High-flexion knee prosthesis was introduced with the aim of obtaining higher degree of flexion and good survivorship in patients with high functional demands or those requiring squatting, kneeling, etc., which is more common in Asians. Based on all the research and experience with this prosthesis, it was concluded that high flexion designs meet the need of deeper degrees of flexion in selected sets of patients only. Results were equal and comparable to the traditional standard posterior-stabilized total knee arthroplasty design and superior to it in terms of gaining more flexion and fulfilling activities, such as squatting, kneeling, and sitting cross-legged.

Quantitative evaluation of grain boundary sliding and its dependence on orientation and temperature in pure Zn

Gokhale, Aditya,R, Sarvesha,Huang, E-Wen,Lee, Soo Yeol,Prasad, Rajesh,Singh, Sudhanshu S.,Jain, Jayant Elsevier 2019 Materials letters Vol.246 No.-

<P><B>Abstract</B></P> <P>In the present work, grain boundary sliding (GBS) has been studied for the grains exhibiting different orientations (for indentation parallel and perpendicular to < c > axis) at different temperatures (RT to 200 °C) using nanoindentation in pure Zn. Electron back scattered diffraction was utilized to determine the orientation of the indented grains and identify the deformation mechanism, whereas atomic force microscopy was utilized to systematically quantify the GBS. Results indicated that indentation perpendicular to < c > axis exhibits slip induced GBS, whereas the indentation parallel to < c > axis results in pure GBS. The amount of GBS was also found to be strongly dependent upon the orientation of the neighboring grain. Further, the contribution from GBS towards total stain was found to increase with an increase in temperature.</P> <P><B>Highlights</B></P> <P> <UL> <LI> First study that characterises orientation and temperature effect on GBS in Zn. </LI> <LI> Indentation perpendicular to <c> axis exhibits slip induced GBS. </LI> <LI> Indentation parallel to <c> axis results in pure GBS. </LI> <LI> The contribution of GBS increases with an increase in temperature. </LI> </UL> </P>

Does Increasing Experience Improve Outcomes of Surgical ‘Step-Up Approach’ in Acute Necrotizing Pancreatitis? Lessons Learnt from a Tertiary Referral Center

( Rajesh Gupta ),( Aditya Atul Kulkarni ),( Rahul Gupta ),( Sunil Shenvi ),( Tanvi Jain ),( Raghavendra Babu ),( Mandeep Kang ),( Surinder Rana ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: Step-up approach is becoming a standard of care for management of acute necrotizing pancreatitis. We aimed to investigate the learning curve effect and increasing experience on management and outcomes of surgical step-up approach at our high-volume tertiary referral center. Methods: In a retrospective analysis of database of patients with acute necrotizing pancreatitis referred to our unit, we divided patients into three distinct time periods: Group-1 (2008-2012), Group-2 (2013-2016) and Group-3 (2017-2019). Outcomes between different time periods were compared. Results: Total of 335 patients were included, with 92 patients in Group-1, 117 in Group-2 and 126 in Group-3. Patients treated on surgical side in later time period had higher incidence of multiorgan failure (26.1% vs. 49.6% vs. 45.2%, P<0.001), APACHE II scores at presentation (8 vs. 10 vs. 9, P=0.006) and at first intervention (9 vs. 11 vs. 10, P=0.037), as well higher mCTSI score (8 vs. 10 vs. 10, P<0.001). Over time, median percutaneous drain size (10Fr vs. 12Fr vs. 14 Fr, P<0.001) as well as sepsis reversal after drainage (40.2% vs. 59% vs. 49.2%, P=0.026) increased, whereas median number of drains (P=0.001) and interventions (4 vs. 3 vs. 3, P=0.005) decreased significantly. Necrosectomy requirement, length of stay and mortality remained similar over time despite more severe cases referred to surgical side. Conclusions: With increasing experience of step-up approach, sicker patients with higher severity of pancreatitis could be managed successfully with fewer drains and procedures leading to significantly higher sepsis reversal with drainage, with no increase in surgery requirement or mortality.

Bendamustine in combination with ifosfamide, etoposide, and vinorelbine (VIBE) is an effective salvage regimen for heavily pre-treated patients with relapsed or refractory Hodgkin lymphoma: a single-center experience

Gaurav Prakash,Arihant Jain,Kamalkant Sahu,Amanjit Bal,Charanpreet Singh,Rajender Basher,Harmandeep Singh,Kundan Mishra,Aditya Jandial,Deepesh Lad,Alka Khadwal,Radhika Srinivasan,Ashim Das,Neelam Varm 대한혈액학회 2021 Blood Research Vol.56 No.3

Background This study evaluated the outcomes of patients with refractory/relapsed Hodgkin lymphoma (RRHL) treated with a bendamustine-based regimen in combination with ifosfamide, etoposide, and vinorelbine (VIBE). Methods Consecutive RRHL patients who were treated with the VIBE regimen were identified and studied for clinicopathologic characteristics, response to VIBE regimen, event-free survival (EFS), and feasibility of an autologous stem-cell transplant (autoSCT). Results In total, 24 patients received the VIBE regimen, and a median of 3 cycles were administered. In this cohort, 80% of the patients had received ≥2 prior lines of therapy. The overall and complete response rates with VIBE were 79% and 42%, respectively. After a median follow-up (following VIBE regimen) of 14 months (range, 3‒76), the 3-year EFS and OS were 46% and 74%, respectively. Of the eligible patients, 92% underwent successful AutoSCT. The mean CD34+ cell count in the autograft was 5.5×106 /kg (SD 2.07). Neutropenia was the commonest hematologic toxicity and it was observed in 42% of the patients. However, only 9% of the patients developed grade III/IV febrile neutropenia. Chemotherapy-induced nausea and vomiting were the second most common grade III/IV toxicities in our cohort of patients. Conclusion In this retrospective analysis, the combination regimen, VIBE, has shown good efficacy in heavily pre-treated patients with RRHL without compromising stem cell collection. These encouraging results provide a rationale for further development of this regimen.

Relationship Between Occupational Safety and Health Policy Principles, Organizational Action on Work-related Stress and the Psychosocial Work Environment in Italy

Leka Stavroula,Torres Luis,Jain Aditya,Di Tecco Cristina,Russo Simone,Iavicoli Sergio 한국산업안전보건공단 산업안전보건연구원 2023 Safety and health at work Vol.14 No.4

Background: It is acknowledged that legislation acts as a motivator for organizational action on psychosocial risks. Our study aims to provide evidence on the relationship between key occupational safety and health (OSH) policy principles and organizational action on work-related stress, and, in turn, with reported employee job demands and resources and their experience of work-related stress. We focus on Italy where specific legislation and practices on work-related stress were introduced in 2008 which are underpinned by these key OSH policy principles. Methods: Secondary analysis of the Italian samples from the employer ESENER-2 and employee 6th EWCS surveys was conducted, using path analysis in structural equation modeling (SEM) linking the two datasets. Results: We found a strong statistically significant relationship between OSH policy principles and organizational action on work-related stress (C.I. = .62-.78 p < .001). The existence of an organizational action plan on work-related stress was found to be significantly associated with more reported job resources (C.I. = .02-.24, p < .05) but these were not found to be significantly associated with less work-related stress. No significant association was found between having an organizational action plan for work-related stress and reported job demands. However, job demands were significantly related to reported work-related stress (C.I. = .27-.47, p < .001). Conclusions: Findings add support to the call for specific legislation on work-related psychosocial risks and highlight how an organizational OSH culture underpinned by key OSH principles, and awareness/competence development on psychosocial risk management can have a positive effect on organizational action. However, further support needs to be provided to organizations around developing primary prevention interventions at the organizational level with the aim of reducing job demands.