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Hur, Jin,Shin, Jaewon,Yoo, Jeseung,Seo, Young-Soo Hindawi Publishing Corporation 2015 The Scientific World Journal Vol.2015 No.-
<P>Competitive adsorption isotherms of Cu(II), Pb(II), and Cd(II) were examined on a magnetic graphene oxide (GO), multiwalled carbon nanotubes (MWCNTs), and powered activated carbon (PAC). A series of analyses confirmed the successful synthesis of the magnetic GO based on a simple ultrasonification method. Irrespective of the adsorbents, the adsorption was highly dependent on pH, and the adsorption was well described by the Langmuir isotherm model. The maximum adsorption capacities of the adsorbents were generally higher in the order of Pb(II) > Cu(II) > Cd(II), which is the same as the degree of the electronegativity and the hydrated radius of the metals, suggesting that the metal adsorption may be governed by an ion exchange between positively charged metals and negatively charged surfaces, as well as diffusion of metals into the surface layer. The adsorption of each metal was mostly lower for multi- versus single-metal systems. The antagonistic effects were influenced by solution pH as well as the type of metals, and they were higher in the order of the magnetic GO > MWCNT > PAC. Dissolved HS played a greater role than HS adsorbed onto the adsorbents, competing with the adsorption sites for metal complexation.</P>
Oh, Jaewon,Lee, Chan Joo,Kim, Doo Il,Rhee, Moo-Yong,Lee, Byoung-Kwon,Ahn, Youngkeun,Cho, Byung Ryul,Woo, Jeong-Taek,Hur, Seung-Ho,Jeong, Jin-Ok,Jang, Yangsoo,Lee, Sang-Hak Wiley (John WileySons) 2017 Clinical cardiology Vol.40 No.12
<P>Conclusions: The target achievement of LDL-C < 100 mg/dL was low, and 50% LDL-C reduction was moderately achieved in Korean patients with FH receiving maximal statin-based LLT. Pretreatment LDL-C levels and diabetes mellitus were associated with target achievement. Our results provide rare and informative data on FH treatment in Asian patients.</P>
Han, Songhee,Hanh Nguyen, Thi Thanh,Hur, Jaewon,Kim, Nahyun M.,Kim, Seong-Bo,Hwang, Kyeong-Hwan,Moon, Young-Hwan,Kang, Choongil,Chung, Byoungsang,Kim, Young-Min,Kim, Tae Sung,Park, Jun-Seong,Kim, Doma Elsevier 2017 Enzyme and microbial technology Vol.103 No.-
<P>Astragalin (kaempferol-3-O-beta-D-glucopyranoside, Ast) is a kind of flavonoid known to have anti-oxidant, anti-HIV, anti-allergic, and anti-inflammatory effects. It has low solubility in water. In this study, novel astragalin galactosides (Ast-Gals) were synthesized using beta-galactosidase from Bacillus circulans and reaction conditions were optimized to increase the conversion yield of astragallin. Purified Ast-Gal1 (11.6% of Ast used, w/w) and Ast-Gal2 (6.7% of Ast used, w/w) were obtained by medium pressure chromatography (MPLC) with silica C-18 column and open column packed with Sephadex LH-20. The structures of Ast-Gal1 and Ast-Gal2 were identified by nuclear magnetic resonance (NMR) to be kaempferol-3-O-beta-D-glucopyranosyl-(1 -> 6)-beta-D-galactopyranoside and kaempferol-3-O-beta-D-glucopyranosyl-(1 -> 6)-beta-D-galactopyranosyl-(1 -> 4)-beta-D-galactopyranoside, respectively. The water solubility of Ast, Ast-Gal1, and Ast-Gal2 were 28.2 +/- 1.2 mg/L, 38,300 +/- 3.5 mg/L, and 38,800 +/- 2.8 mg/L, respectively. The SC50 value (the concentration required to scavenge 50% of the ABTS.+) of Ast, Ast-Gal1, and Ast-Gal2 were 5.1 +/- 1.6 mu M, 6.5 +/- 0.4 mu M, and 4.9 +/- 1.1 mu M, respectively. The IC50 values (the half maximal inhibitory concentration) of Ast, Ast-Gal1, and Ast-Gal2 against angiotensin converting enzyme (ACE) were 171.0 +/- 1.2 mu M, 186.0 mu M, and 139.0 +/- 0.2 mu M, respectively.</P>
Kang, Jeehoon,Yun, Ji-Yeon,Hur, Jin,Kang, Jin-A,Choi, Jae-Il,Ko, Seung Bum,Lee, Jaewon,Kim, Ju-Young,Hwang, In-Chang,Park, Young-Bae,Kim, Hyo-Soo Oxford University Press 2014 Cardiovascular research Vol.104 No.1
<P><B>Aims</B></P><P>From our previous clinical trials, intracoronary infusion of granulocyte-colony stimulating factor (G-CSF)-mobilized peripheral blood mononuclear cells (<SUP>mob</SUP>PBMCs) proved to be effective in improving myocardial contractility and reducing infarct volume in acute myocardial infarction. We tested the effect of priming <SUP>mob</SUP>PBMCs with erythropoietin (EPO) to augment its therapeutic efficacy.</P><P><B>Methods and results</B></P><P><SUP>mob</SUP>PBMCs were obtained from healthy volunteers after a 3-day subcutaneous injection of G-CSF (10 μg/kg). About 40% of <SUP>mob</SUP>PBMCs were EPO receptor (EPOR) (+) and responded to 6 h EPO-priming (10 IU/mL) by increasing the expression of vasculogenic factors (i.e. IL8, IL10, bFGF, PDGF, MMP9) and adhesion molecules (i.e. integrin αV, β1, β2, β8) through the JAK2 and Akt pathway. These responses were also observed in PBMCs from elderly patients with coronary disease. The conditioned media from EPO-primed <SUP>mob</SUP>PBMCs contained various cytokines such as IL8, IL10, TNFα, and PDGF, which enhanced the migration and tube formation capability of endothelial cells. EPO-primed <SUP>mob</SUP>PBMCs also showed increased adhesion on endothelial cells or fibronectin. Augmented vasculogenic potential of EPO-primed <SUP>mob</SUP>PBMCs was confirmed in a Matrigel plug assay, ischaemic hindlimb, and myocardial infarction models of athymic nude mice. There were two action mechanisms: (i) cellular effects confirmed by direct incorporation of human <SUP>mob</SUP>PBSCs into mouse vasculature and (ii) indirect humoral effects confirmed by the therapeutic effect of the supernatant of EPO-primed <SUP>mob</SUP>PBMCs.</P><P><B>Conclusion</B></P><P>Brief <I>ex vivo</I> EPO-priming is a novel method to augment the vasculogenic potential of human <SUP>mob</SUP>PBMCs, which would help to achieve better results after intracoronary infusion in myocardial infarction patients.</P>