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Small molecule–based reversible reprogramming of cellular lifespan
Won, Jaejoon,Kim, Mina,Kim, Nuri,Ahn, Jin Hee,Lee, Woo Gil,Kim, Sung Soo,Chang, Ki-Young,Yi, Yong-Weon,Kim, Tae Kook Nature Publishing Group 2006 Nature chemical biology Vol.2 No.7
Most somatic cells encounter an inevitable destiny, senescence. Little progress has been made in identifying small molecules that extend the finite lifespan of normal human cells. Here we show that the intrinsic 'senescence clock' can be reset in a reversible manner by selective modulation of the ataxia telangiectasia–mutated (ATM) protein and ATM- and Rad3-related (ATR) protein with a small molecule, CGK733. This compound was identified by a high-throughput phenotypic screen with automated imaging. Employing a magnetic nanoprobe technology, magnetism-based interaction capture (MAGIC), we identified ATM as the molecular target of CGK733 from a genome-wide screen. CGK733 inhibits ATM and ATR kinase activities and blocks their checkpoint signaling pathways with great selectivity. Consistently, siRNA-mediated knockdown of ATM and ATR induced the proliferation of senescent cells, although with lesser efficiency than CGK733. These results might reflect the specific targeting of the kinase activities of ATM and ATR by CGK733 without affecting any other domains required for cell proliferation.
The Korean Society for Neuro-Oncology (KSNO) Guideline for Glioblastomas: Version 2018.01
( Young Zoon Kim ),( Chae-Yong Kim ),( Jaejoon Lim ),( Kyoung Su Sung ),( Jihae Lee ),( Hyuk-Jin Oh ),( Seok-Gu Kang ),( Shin-Hyuk Kang ),( Doo-Sik Kong ),( Sung Hwan Kim ),( Se-Hyuk Kim ),( Se Hoon K 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2019 Brain Tumor Research and Treatment Vol.7 No.1
Background There has been no practical guidelines for the management of patients with central nervous system (CNS) tumors in Korea for many years. Thus, the Korean Society for Neuro-Oncology (KSNO), a multidisciplinary academic society, started to prepare guidelines for CNS tumors from February 2018. Methods The Working Group was composed of 35 multidisciplinary medical experts in Korea. References were identified through searches of PubMed, MEDLINE, EMBASE, and Cochrane CENTRAL using specific and sensitive keywords as well as combinations of keywords. Results First, the maximal safe resection if feasible is recommended. After the diagnosis of a glioblastoma with neurosurgical intervention, patients aged ≤70 years with good performance should be treated by concurrent chemoradiotherapy with temozolomide followed by adjuvant temozolomide chemotherapy (Stupp’s protocol) or standard brain radiotherapy alone. However, those with poor performance should be treated by hypofractionated brain radiotherapy (preferred)±concurrent or adjuvant temozolomide, temozolomide alone (Level III), or supportive treatment. Alternatively, patients aged >70 years with good performance should be treated by hypofractionated brain radiotherapy+concurrent and adjuvant temozolomide or Stupp’s protocol or hypofractionated brain radiotherapy alone, while those with poor performance should be treated by hypofractionated brain radiotherapy alone or temozolomide chemotherapy if the patient has methylated MGMT gene promoter (Level III), or supportive treatment. Conclusion The KSNO’s guideline recommends that glioblastomas should be treated by maximal safe resection, if feasible, followed by radiotherapy and/or chemotherapy according to the individual comprehensive condition of the patient.
Hae Young Kim,Hye Jin Lee,Tae-lim Kim,EunYoung Kim,Daehoon Ham,Jaejoon Lee,Tayeun Kim,Ji Won Shin,Minkyoung Son,Jun Hun Sung,Zee-A Han 대한재활의학회 2020 Annals of Rehabilitation Medicine Vol.44 No.6
Objective To identify the prevalence and characteristics of neuropathic pain (NP) in patients with spinal cord injury (SCI) and to investigate associations between NP and demographic or disease-related variables. Methods We retrospectively reviewed medical records of patients with SCI whose pain was classified according to the International Spinal Cord Injury Pain classifications at a single hospital. Multiple statistical analyses were employed. Patients aged <19 years, and patients with other neurological disorders and congenital conditions were excluded. Results Of 366 patients, 253 patients (69.1%) with SCI had NP. Patients who were married or had traumatic injury or depressive mood had a higher prevalence rate. When other variables were controlled, marital status and depressive mood were found to be predictors of NP. There was no association between the prevalence of NP and other demographic or clinical variables. The mean Numeric Rating Scale (NRS) of NP was 4.52, and patients mainly described pain as tingling, squeezing, and painful cold. Females and those with below-level NP reported more intense pain. An NRS cut-off value of 4.5 was determined as the most appropriate value to discriminate between patients taking pain medication and those who did not. Conclusion In total, 69.1% of patients with SCI complained of NP, indicating that NP was a major complication. Treatment planning for patients with SCI and NP should consider that marital status, mood, sex, and pain subtype may affect NP, which should be actively managed in patients with an NRS ≥4.5.
( Young Zoon Kim ),( Chae-Yong Kim ),( Jaejoon Lim ),( Kyoung Su Sung ),( Jihae Lee ),( Hyuk-Jin Oh ),( Seok-Gu Kang ),( Shin-Hyuk Kang ),( Doo-Sik Kong ),( Sung Hwan Kim ),( Se-Hyuk Kim ),( Se Hoon K 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2019 Brain Tumor Research and Treatment Vol.7 No.2
Background There was no practical guideline for the management of patients with central nervous system tumor in Korea in the past. Thus, the Korean Society for Neuro-Oncology (KSNO), a multidisci-plinary academic society, developed the guideline for glioblastoma successfully and published it in Brain Tumor Research and Treatment, the official journal of KSNO, in April 2019. Recently, the KSNO guideline for World Health Organization (WHO) grade III cerebral glioma in adults has been established. Methods The Working Group was composed of 35 multidisciplinary medical experts in Korea. References were identified by searches in PubMed, MEDLINE, EMBASE, and Cochrane CENTRAL databases using specific and sensitive keywords as well as combinations of keywords. Scope of the disease was confined to cerebral anaplastic astrocytoma and oligodendroglioma in adults. Results Whenever radiological feature suggests high grade glioma, maximal safe resection if feasible is globally recommended. After molecular and histological examinations, patients with anaplastic astrocytoma, isocitrate dehydrogenase (IDH)-mutant should be primary treated by standard brain radiotherapy and adjuvant temozolomide chemotherapy whereas those with anaplastic astrocytoma, NOS, and anaplastic astrocytoma, IDH-wildtype should be treated following the protocol for glioblastomas. In terms of anaplastic oligodendroglioma, IDH-mutant and 1p19q-codeletion, and anaplastic oligodendroglioma, NOS should be primary treated by standard brain radiotherapy and neoadjuvant or adjuvant PCV (procarbazine, lomustine, and vincristine) combination chemotherapy. Conclusion The KSNO’s guideline recommends that WHO grade III cerebral glioma of adults should be treated by maximal safe resection if feasible, followed by radiotherapy and/or chemotherapy according to molecular and histological features of tumors.
Virtual reality application on MFL gas pipeline inspection system
Jaejoon Kim(김재준) 한국산업정보학회 2010 한국산업정보학회논문지 Vol.15 No.4
This paper describes a visualization technique that animates geometrical defect data that are extracted using a magnetic flux leakage (MFL) operating system on nondestructive evaluation (NDE). Since data are collected from different locations and often not regular, the data must be converted to the standard format that is used within the pipeline in visualization procedures. In order to navigate inside of the pipeline, 3D virtual objects are generated and are able to explore the pipeline continuously. The major objectives of this paper are to characterize, generate general shape of defects, and enable computer interaction in virtual environment. Pipeline navigation system (PNS) has introduced the framework for interactive visual applications based upon the principles of modeling 3D objects. PNS presents some preliminary efforts to enable the user to interact human and computer with each other.
Locating Mechanical Damages Using Magnetic Flux Leakage Inspection in Gas Pipeline System
Jaejoon Kim 한국비파괴검사학회 2010 한국비파괴검사학회지 Vol.30 No.6
Gas transmission pipelines are often inspected and monitored using the magnetic flux leakage method. An inspection vehicle known as a “pig” is launched into the pipeline and conveyed along the pipe by the pressure of natural gas. The pig contains a magnetizer, an array of sensors and a microprocessor-based data acquisition system for logging data. This paper describes magnetic flux leakage (MFL) signal processing used for detecting mechanical damages during an in-line inspection. The overall approach employs noise removal and clustering technique. The proposed method is computationally efficient and can easily be implemented. Results are presented and verified by field tests from an application of the signal processing.
Implementation of efficient parking enforcement system using smartphone
Kim, Doyeon,Kim, Jaejoon The Korea Contents Association 2013 International Journal of Contents Vol.9 No.1
To date, parking enforcement systems have only been used by parking enforcement authorities, who detect and penalize violators. This paper introduces a modified version of the parking enforcement system utilizing smartphones that allows ordinary citizens to report parking violators to parking enforcement officers. The procedures of the system are taking a picture of a vehicle in violation, receiving the violation report virtually and finally reporting if violation car still remained at same location after five minutes have passed. The proposed system contains properties for transmission and receiving data about whether the complaint report of the violator's vehicle has been received in real time. It also works in conjunction with the existing parking enforcement system. This paper describes implementation of the proposed system.