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      • SCIESCOPUSKCI등재

        Oxytocin produces thermal analgesia via vasopressin-1a receptor by modulating TRPV1 and potassium conductance in the dorsal root ganglion neurons

        Han, Rafael Taeho,Kim, Han-Byul,Kim, Young-Beom,Choi, Kyungmin,Park, Gi Yeon,Lee, Pa Reum,Lee, JaeHee,Kim, Hye young,Park, Chul-Kyu,Kang, Youngnam,Oh, Seog Bae,Na, Heung Sik The Korean Society of Pharmacology 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.2

        Recent studies have provided several lines of evidence that peripheral administration of oxytocin induces analgesia in human and rodents. However, the exact underlying mechanism of analgesia still remains elusive. In the present study, we aimed to identify which receptor could mediate the analgesic effect of intraperitoneal injection of oxytocin and its cellular mechanisms in thermal pain behavior. We found that oxytocin-induced analgesia could be reversed by $d(CH_2)_5[Tyr(Me)^2,Dab^5]$ AVP, a vasopressin-1a (V1a) receptor antagonist, but not by $desGly-NH_2-d(CH_2)_5[D-Tyr^2,Thr^4]OVT$, an oxytocin receptor antagonist. Single cell RT-PCR analysis revealed that V1a receptor, compared to oxytocin, vasopressin-1b and vasopressin-2 receptors, was more profoundly expressed in dorsal root ganglion (DRG) neurons and the expression of V1a receptor was predominant in transient receptor potential vanilloid 1 (TRPV1)-expressing DRG neurons. Fura-2 based calcium imaging experiments showed that capsaicin-induced calcium transient was significantly inhibited by oxytocin and that such inhibition was reversed by V1a receptor antagonist. Additionally, whole cell patch clamp recording demonstrated that oxytocin significantly increased potassium conductance via V1a receptor in DRG neurons. Taken together, our findings suggest that analgesic effects produced by peripheral administration of oxytocin were attributable to the activation of V1a receptor, resulting in reduction of TRPV1 activity and enhancement of potassium conductance in DRG neurons.

      • THE INFLUENCE OF DESIGN INNOVATION ATTRIBUTES ON PERCEPTIONS, ATTITUDES, AND PURCHASE INTENTIONS AMONG DESIGNERS AND CONSUMERS

        Jaehee Chung,EunjuKo,Jinghe Han 글로벌지식마케팅경영학회 2016 Global Marketing Conference Vol.2016 No.7

        Design innovation is acquiring greater importance as consumers’ emotional needs grow ever greater and the cycle of technological innovation grows ever faster. Apple in particular led and strengthened this trend, achieving incomparable business success in the technology-driven electronics industry. However, although the importance of design innovation has increased, very little research has been done to explain the influence of design innovation on business success. This study aims to investigate the influence of design innovation attributes on perceptions, attitudes, and purchase intentions among designers and consumers. 408 designers and 464 consumers participated in an online survey that presented as stimuli four different smart watches. Design innovation attributes were evaluated based on the criteria of features, aesthetics, and ergonomics; consumer-perceived values were categorized as emotional, social, and functional. Regarding consumers attitudes, attitude toward product and attitude toward brand were measured separately. Overall results indicate that purchase intention among designers and consumers alike is influenced by their attitude toward product as well as brand. However, in the case of designers, these attitudes are most influenced by emotional value, while consumers are influenced by emotional as well as social values. Moreover, all three innovation attributes - namely, features, aesthetics, and ergonomics - affect designers’ perception of emotional value, but only aesthetics and ergonomics affect consumers’ emotional and social value. The study demonstrates three significant differences in the responses of designers and consumers. First, there is correlation of aesthetics and ergonomics to functional (price) value among designers, but not consumers. Second, there is correlation of functional (quality) value to attitudes toward product and brand for consumers, but much less or none at all for designers. Third, the influence of features on perception of emotional value is more pronounced among designers as compared to consumers. In conclusion, aesthetics and ergonomics are important design innovation attributes for consumers as well as designers, but the latter also attach significance to features. While perception of emotional as well as social value is important to consumers, designers consider only emotional value. It is anticipated that the relative importance of design innovation attributes will vary according to product categories and price ranges; therefore, further comparative studies will be meaningful in investigation of design innovation.

      • KCI등재

        실존주의상담의 철학적 가치관이 상담자의 자기인식 및 상담과정에 미치는 영향

        한재희 ( Jaehee Han ),남지연 ( Jiyeon Nam ) 서강대학교 학생생활상담연구소 2017 人間理解 Vol.38 No.1

        본 연구는 실존주의 상담의 철학적 가치관이 상담자의 자기인식 및 상담과정에게 미치는 영향이 무엇인지를 밝히고자 하였다. 본 연구를 위한 자료수집은 실존주의상담의 철학적 개념과 가치관에 대한 14주간의 세미나와 워크샵에 참여한 17명의 상담학전공 박사과정에 있는 상담사들을 중심으로 이루어졌다. 연구의 분석방법은 합의적 질적연구방법(Consensual Qualitative Research)을 활용하였으며 그 결과, 자각, 경험, 변화의 3가지 대범주와 각각의 영역에서 4개의 소범주가 도출되었다. 그리고 자각의 영역에서 14개의 구성적 개념이, 경험의 영역에서 13개, 마지막으로 변화의 영역에서 18개의 구성적 개념이 최종 도출되었다. 연구의 분석결과 실존주의상담의 철학적 가치관에 대한 인식 및 이해 경험은 참여자들의 개인적 삶의 변화와 함께 상담자 역할에서의 변화에 영향을 준 것으로 드러났다. 삶 가운데서 경험하였던 실존적 자기대면은 상담관계 안에서 내담자와의 관계맺기에 대한 인식의 확장으로 이어졌을 뿐 아니라 보다 깊이 있는 차원으로의 내담자에 대한 공감과 함께 상담자와 내담자간의 상호주관적 관계맺기를 가능하게 하였다. This study examined the effects of philosophical values of existential counseling on the counseling process and on counselors` self-awareness. This study included 17 individuals deeply interested in professional existential counseling. Participants were doctoral candidate students taking a 14-week seminar and workshop training series with backgrounds of various skills levels and a wide range of experiences. Based on a qualitative framework, Consensual Qualitative Research (CQR), the following three domains emerged based on the results: awareness, experience, and changes. In the awareness area, there were 4 categories and 14 subcategories. In the experience area, there were 4 categories and 13 subcategories. And finally, in the area of changes, 4 categories and 18 subcategories emerged. Results revealed that the participants who were aware of philosophical values of existential counseling experienced changes in their personal life as well to their role as a counselor. The counselors were able to expand their awareness of values in existential counseling and build in-depth relationships with their clients in the counseling setting through facing their existential real self. These factors were able to help develop the counselors` in-depth empathy towards their clients and also enhance their intersubjective relationships.

      • 함께 읽기의 즐거움 Thesuarus Literaturae Buddhicae의 현재와 발전방향

        한재희 ( Han Jaehee ) 동국대학교 전자불전문화콘텐츠연구소 2020 전자불전 Vol.22 No.-

        Thesaurus Literaturae Buddhicae (TLB) is a digital archive project of Buddhist literature initiated by Jens Braarvig in 2000 in order to document historically and culturally significant Buddhist texts which have been translated into various languages over the past two millennia. In this paper, as a follow-up study of “Thesaurus Literaturae Buddhicae (TLB): Its Scope, and a Description of Its Routines” (Braarvig: 2001), we examine the present state of TLB, including its achievements and challenges over the past 20 years. We also discuss plans for its further development as a tool for research and education in the field of Buddhist studies. It is hoped that this paper will make a small contribution to promoting the use of this online multilingual digital library, drawing the attention of students, scholars, and the general public in Korea.

      • 차량 하체 이상 소음에 대한 연구

        한재희(Jaehee Han),김상진(Sangjin Kim),한성제(Sungje Han) 한국자동차공학회 2017 한국자동차공학회 학술대회 및 전시회 Vol.2017 No.11

        The purpose of this thesis is to identify the main cause of abnormal noise in order to eliminate noise from on the vehicle"s under body, and to analyze and propose solution. Today consumers’ expectations for the domestic automotive industry have risen sharply and the quality of the automobile has a major factor affecting customers. The abnormal noise from the under body is affecting the customer’s complaint index. This study attempted to establish the cause of abnormal noise happened from the inside of the shock absorber. The red-x tool that has statistical technique was used. The Red-X tool has a more specific and objective method, making it possible to present a clear root cause of the noise. Component analysis methods were used to identify the occurrence of noise, and further experiments were conducted, such as selecting control factors and sensitivity analysis to eliminate fundamental noise. Based on the sensitivity analysis results, the optimal process conditions were configured, and finally, the components that is produce used this process conditions was confirmed making it has good performance and was removed the noise.

      • 차량내 전자 조향시스템의 치타음에 대한 연구

        한재희(Jaehee Han),김광영(Kwangyoung Kim),황준영(Joonyoung Hwang) 한국자동차공학회 2018 한국자동차공학회 학술대회 및 전시회 Vol.2018 No.11

        The purpose of this thesis is to define the main root cause of rattle noise from on the steering system in vehicle and it was analyzed to propose solution. Accurate identification of parts that generate rattle noise is needed. So, the study used a Red-X tool. It has statistical technique. The Red-X tool has a more specific and objective method, making it possible to present a clear root cause of the noise. Component analysis method was used to identify the occurrence parts of noise, and further experiments were conducted such as Tooth Mesh test and Swap test in RMA bench. This study attempted to identify the cause of rattle noise happened from the inside of steering system and in this study, a subjective test was conducted to determine the impact of the friction level on the performance of the steering system. Based on the sensitivity analysis, tooth mesh test and subjective test, it was intended to make an optimal level of steering performance while eliminating rattle noise.

      • 동일 시스템 차량에서 Watt linkage 특성에 대한 연구

        한재희(Jaehee Han),김상진(Sangjin Kim),박기승(Geeseung Park) 한국자동차공학회 2019 한국자동차공학회 학술대회 및 전시회 Vol.2019 No.11

        The stable behavior of the vehicle is one of the important factors in order to reduce driver anxiety and increasing vehicle satisfaction. This purpose of this thesis is to study the watt linkage, which is included in the suspension system and it helps with the lateral behavior. The behavior and the basic characteristic values of the vehicle that have the watt linkage parts or don’t have watt linkage parts have been studied in the same suspension package. In this study, the design requirements of this part were studied through FEM analysis. Furthermore, the study on the effects of the behavior performance on the cases mounted to the vehicle through the Vehicle Dynamics CAE was conducted. Based on the results of the above study, several times test were conducted in accordance with ISO test methods to determine the level of performance in the actual vehicle by making the prototype. The unique characteristics of the vehicle were analyzed through the Vehicle Dynamics CAE. It was able to study the performance of a vehicle with Watt linkage in same suspension systems.

      • KCI등재

        허공장보살경 티베트역 대조교정과 전승계통(1) : 네사르(Nesar)와 랑(Lang) 칸쥬르를 중심으로

        한재희(Han Jaehee) 보조사상연구원 2020 보조사상 Vol.58 No.-

        1970년대 후반부터 Helmut Eimer를 비롯한 일군의 학자들에 의해 티베트 대장경에 대한 문헌비평 연구가 이루어졌고, 이를 통해 칸쥬르의 발전과 전승에 대한 우리의 이해가 급격히 발전할 수 있었다. 티베트 대장경 전승의 두 가지 주요한 계통, 즉 ??빠(Tshal pa)와 템빵마(Them spangs ma)가 정립되고, 판본들 간의 관계가 밝혀졌으며, 여러 가지 문헌전승 계통도가 만들어졌다. 하지만, 근래 들어 더 많은 판본들에 대한 접근이 가능해지면서 더욱 복잡하고 다양한 질문들에 마주하게 되었다. 특히, 2010년대 중반부터 Helmut Tauscher등에 의해 티베트 서부에서 발견된 판본들에 대한 1차적인 연구가 이루어지면서, 그동안 정립해 왔던 칸쥬르에 대한 우리의 이해를 점검하고, 동시에 더 많은 새로운 자료를 해석해야 하는 상황에 놓인 것이다. 이에 본고에서는 아직까지 연구가 거의 이루어지지 않은 판본들, 즉 네사르 칸쥬르와 랑 칸쥬르를 중심으로, Mahāsannipāta의 8번째 경전인 Gaganagañjaparipṛcchā에 대한 교감결과를 분석하고, 두 판본간의 관계를 살펴보았다. 네팔 서부 될뽀 지역의 네사르 사원에 함께 보관되어 온 네사르와 랑 칸쥬르는 다른 모든 판본들과 확연히 구분되는 이문(異文)을 상당 수 포함하고 있었으며, 그 중에는 8세기에 번역된 불공의 한역본(T.404)과 단독으로 상응하는 것도 있었다. 두 문헌간의 관계에 있어서는, 랑 칸쥬르가 네사르 칸쥬르를 저본으로 하여 제작되었음을 말해주는 근거들이 다수 발견되었다. 따라서 이들이 향후 이루어질 티베트 대장경 문헌비평 연구에서 반드시 참고해야 하는 중요한 판본임을 증명할 수 있었다. Since the late 1970s, the study of the Kanjur, initiated by Helmut Eimer and followed by Paul Harrison, Peter Skilling and other scholars, has drastically improved our understanding of Kanjur transmission, particularly of its historical background and stemmatic relationship. Building on the knowledge and insights gained from past research, I have examined some central parts of the Gaganagañjaparipṛcchā, the eighth chapter of the Mahāsaṃnipāta, as a sample of the whole, based on twenty-one textual witness, viz., Basgo, Cone, Derge, Gondhla, Hemis I, Hemis II, Lang, Lhasa, Lithang, London, Namgyal, Narthang, Nesar, Phug brag I, Phug brag II, Qianlong, Ragya, Shey, Stog Palace, Tabo II, and Urga. In the present article, I first offer an overview of my text-critical work on the Gaganagañjaparipṛcchā, and then analyze the results obtained by evaluating the textual witnesses mentioned above, focusing on two newly available Kanjurs, Nesar and Lang, both of which are from the same monastery in western Tibet. In doing so, I argue that the Nesar and Lang Kanjurs show a high affinity with one another, sharing a number of unique variants, and thus that these should be consulted as important witnesses in future Kanjur studies.

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