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A Systematic Review of Kinesiology Taping in Patients With Lymphedema
Jaehee Yang,Eun Jin Lim 한국전문물리치료학회 2023 한국전문물리치료학회지 Vol.30 No.4
Background: The compression therapy, which is the standard treatment for lymphedema patients, may be difficult to implement and contraindicated to some patients depending on their health condition. Objects: The purpose of this study is to investigate whether kinesiology taping (KT) can be used effectively and safely in the management of lymphedema as an alternative treatment through systematic review and meta-analysis. Methods: In February 2023, the literature was systematically collected through eight search engines with a combination of terms, ‘lymphedema’ and ‘kinesiology taping.’ We qualitatively analyzed the differences and safety of KT methods, and quantitatively meta-analyzed the effects of volume reduction in edema, range of motion (ROM), and pain improvement using Review Manager ver. 5. 4. To assess the risk of bias in the randomized controlled trial (RCT) studies, Risk of Bias was used. Results: A total of 616 articles searched and 20 studies were selected, including 12 RCTs and eight case studies. KT intervention could not replace multilayer compression bandage (MLB), but it demonstrated similar or better results compared to compression garment (CG), with reduced pain and improved intervention comfort. Studies reported skin adverse events ranging from 2.5% to 20.68%, with a total adverse event incidence of 7.7%. There was no significant difference in the application method of KT. As a result of the meta-analysis from the 8 RCTs, the KT intervention showed a mean difference (MD) of –7.18 with a 95% confidence interval (CI) [–12.64 to –1.72] in the volume change of lymphedema, while the pain difference was MD 0.82 with CI 95% [0.50 to 1.15], in comparison to the MLB and CG intervention. Conclusion: KT therapy led to a reduction in edema size, volume, pain, and improved ROM and quality of life. KT may be a viable option for lymphedema patients who have trouble applying traditional compression therapies.
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Are Spinal GABAergic Elements Related to the Manifestation of Neuropathic Pain in Rat?
Jaehee Lee,Seung Keun Back,Eun Jeong Lim,Gyu Chong Cho,Myung Ah Kim,Hee Jin Kim,Min Hee Lee,Heung Sik Na 대한생리학회-대한약리학회 2010 The Korean Journal of Physiology & Pharmacology Vol.14 No.2
Impairment in spinal inhibition caused by quantitative alteration of GABAergic elements following peripheral nerve injury has been postulated to mediate neuropathic pain. In the present study, we tested whether neuropathic pain could be induced or reversed by pharmacologically modulating spinal GABAergic activity, and whether quantitative alteration of spinal GABAergic elements after peripheral nerve injury was related to the impairment of GABAergic inhibition or neuropathic pain. To these aims, we first analyzed the pain behaviors following the spinal administration of GABA antagonists (1Ռg bicuculline/rat and 5Ռg phaclofen/rat), agonists (1Ռg muscimol/rat and 0.5Ռg baclofen/rat) or GABA transporter (GAT) inhibitors (20Ռg NNC-711/rat and 1Ռg SNAP-5114/rat) into naïve or neuropathic animals. Then, using Western blotting, PCR or immunohistochemistry, we compared the quantities of spinal GABA, its synthesizing enzymes (GAD65, 67) and its receptors (GABA<sub>A</sub> and GABA<sub>B</sub>) and transporters (GAT-1, and -3) between two groups of rats with different severity of neuropathic pain following partial injury of tail-innervating nerves; the allodynic and non-allodynic groups. Intrathecal administration of GABA antagonists markedly lowered tail-withdrawal threshold in naïve animals, and GABA agonists or GAT inhibitors significantly attenuated neuropathic pain in nerve-injured animals. However, any quantitative changes in spinal GABAergic elements were not observed in both the allodynic and non-allodynic groups. These results suggest that although the impairment in spinal GABAergic inhibition may play a role in mediation of neuropathic pain, it is not accomplished by the quantitative change in spinal elements for GABAergic inhibition and therefore these elements are not related to the generation of neuropathic pain following peripheral nerve injury.
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( Jaehee Mun ),( Seokyung Kim ),( Eun Ji Lee ),( Soo Jin Park ),( Joo-hyuk Son ),( Maria Lee ),( Tae-wook Kong ),( Hee Seung Kim ),( Jiheum Paek ),( Hyun Hoon Chung ),( Suk-joon Chang ),( Jae Weon Kim 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
Objective: Cremophor-free polymeric micelle formulation of paclitaxel (Genexol-PM) plus carboplatin (PM/C) has been reported to have a non-inferior effect with tolerable toxicities when compared to the standard paclitaxel plus carboplatin (P/C) in ovarian cancer. However, there is still a lack of evidence on the effect of an increased dose of paclitaxel in PM/C, especially, when compared to P/C and paclitaxel plus carboplatin with bevacizumab (P/C/B) in advanced high-grade serous ovarian cancer (HGSO). Thus, we performed a prospective cohort study on PM/C and compared the effect of PM/C with historical control of P/C and P/C/B in HGSO. Methods: We performed a prospective cohort study between October 2015 and June 2019. Patients aged 20 or more years with FIGO stage III-IV HGSO who received PM (260 mg/m<sup>2</sup>)/C (AUC 5) after primary debulking surgery (PDS) were enrolled. We collected clinico-pathologic data from a retrospective cohort when P (175 mg/m<sup>2</sup>)/C (AUC 5) or P (175 mg/m<sup>2</sup>)/C (AUC 5)/B (15 mg/kg) were used as adjuvant treatment after PDS during the same period. Results: A total of 104 patients were enrolled, and 17, 28, and 59 received P/C, P/C/B and, PM/C respectively (Table 1). Complete response was significantly highest in PM/C (29.4 vs. 39.3 vs. 61%, P=0.030; Table 1). Progression-free survival was longest in PM/C (Figure 1) and multivariate analysis showed that gross residual tumor after PDS and P/C were poor prognostic factors (adjusted hazard ratios, 2.415 and 2.751; 95% confidence intervals, 1.172-4.976 and 1.214-6.236; Table 2). Even after adjustment of the patient pool to those with no gross residual tumor after PDS, multivariate analysis still showed that P/C lowered the survival curve (adjusted hazard ratio, 3.342; 95% confidence interval, 1.143-9.777; Table 2). Conclusion: This interim analysis showed that PM/C had a comparable effect to P/C/B for stage III-IV HGSO patients who received optimal cytoreduction during PDS.
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Development of a Novel Prototype Nozzle for Pressurized Intraperitoneal Aerosol Chemotherapy
( Jaehee Mun ),( Whasun Lim ),( Ji Yeon Ahn ),( Gwonhwa Song ),( Byeong-cheol Kang ),( Suk Joon Chang ),( Jung Chan Lee ),( Jeong Mook Lim ),( Hee Seung Kim ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
Objective: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) has been suggested as an alternative option for treating peritoneal carcinomatosis (PC). However, even with its clinical advantages, the current PIPAC system still suffers from limitations regarding area of drug distribution and penetration depth. Thus, we evaluated another PIPAC system using a novel prototype, and compared its performance to results of previous studies related to the current MIP. However, the comparison was only done indirectly as this system is currently not available for purchase in the market. Methods: The developed prototype includes a syringe pump, nozzle, and controllers (Figure 1). Drug distribution was evaluated using a methylene blue solution while the penetration depth was assessed by conducting an ex-vivo experiment with porcine tissues in a 3.5l plastic box. Doxorubicin was sprayed using the novel prototype, and its penetration depth was investigated by confocal laser scanning microscopy. The experiment was repeated with varying nozzle levels beginning from the bottom. The novel prototype sprayed approximately 30 m drug droplets at a flow rate of 30 ml/min with 7 bars of pressure. Results: The average diameter of sprayed region with concentrated dye was 18.5±1.2 cm, which was comparable to that of the current MIP (about 10 cm; Figure 1). The depth of concentrated diffusion (DCD) did not differ among varying nozzle levels, whereas the depth of maximal diffusion (DMD) decreased with increasing distance between the prototype and the bottom (mean values, 515.3 um at 2 cm; 437.6 um at 4 cm; 363.2 um at 8 cm), which was comparable to those of the current MIP (about 350-500 um; Figure 2). Conclusion: We developed a novel prototype that can generate small droplets for drug aerosolization and can produce an equally widely sprayed area and deep penetration compared to the current MIP but at a lower pressure.
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Application of GASPAR Code for Regulatory Clearance
Jaehee Kwon,Ki-Baek Shin,Tack-Jin Kim 한국방사성폐기물학회 2022 한국방사성폐기물학회 학술논문요약집 Vol.20 No.1
According to the Atomic Energy Act of Korea, radioactive waste can be cleared when it meets the criteria, less than 10 uSv·y?1 for individual dose and 1 person · Sv·y?1 for collective dose. Consequently, it is necessary to evaluate radiation dose to get permission for regulatory clearance from the regulatory body of Korea. Several computational programs can be used for dose calculation depending on disposal methods such as landfill, incineration, and recycling. As for incineration, the effects of radionuclide emitted during combusting radwaste have to be considered to figure out exposure dose. In this study, GASPAR code is described to assess exposure dose from effluents released to the atmosphere during incinerating combustible radioactive wastes for regulatory clearance. GASPAR is the code programmed by Radiation Safety Information Computational Center at Oak Ridge National Laboratory for computing annual dose due to radioactive effluents released from a nuclear power plant to the atmosphere during routine operation. The calculating methods of the code are based on the mathematical model of U.S. NRC regulatory guide 1.109, about beta and gamma radiation from noble gas in semi-infinite plume, radioiodine, and particulates. GASPAR evaluates both individual dose and population dose. The considering pathways are composed of external exposure by plume and ground deposition of effluents, and internal exposure as a result of inhalation and food ingestion. Since the calculation model of GASPAR requires various variables about the radionuclide and disposal site, the accuracy of the results is decided by inputted values. The program contains the default values to parameters such as the humidity, fraction of deposition, and storage time of foods. However, to get permission, it is important to use the appropriate data representing the condition of the combustion scenario as substitutes for the default since the values are localized to the country where the code was developed. Therefore, dose assessment by GASPAR code can be applied for regulatory clearance by incineration, when reliable values depending on the disposal plan inputted.
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