하악골에 발생된 Low grade 골육종:증례보고

조현이,정종철,김호성,최재욱,성대경,서지훈,김성범,이계혁 大韓顎顔面成形再建外科學會 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.1

Osteosarcoma is a primary malignant tumor arising most often in the long bone, but rare in jaw bone. Especially osteogenic sarcoma of the mandible is a rare tumor, comprising less than 0.5% of all head and neck tumors. Osteosarcoma occurs cheifly in young persons, and presenting very survival rates. Histopathologically this tumor can be classified three types, osteoblastic, fibroblastic, chondroblastic and classified from low grade to high grade by anaplasia or mitosis of the tumor cells. Sometimes, the exact diagnosis of osteosarcoma is difficult especially in low grade osteosarcoma, even if clinical or radiographical findings suggest to osteosarcoma. So suspcious to malignant bone tumor in clinical or radiological findings, biopsy should be taked from deep portion and multiple area, and sharing the patient history and radiographs with pathologist will assist in the development of the diagnosis. We report a case of low grade osteosarcoma on the mandible initially difficulty in accurate diagnosis. The patient visited our hospital for routine dental treatment but radiographic findings displayed ill-defined radiolucency with osteoid formation on the mandible. Final diagnosis was difficulty in initial biopsy but subsequent biopsy taked from deep portion presented infiltrative growth and mitosis of the tumor cell in some area with small osteoid bone formation, so we could reach final diagnosis as low grade sarcoma. We treated this patient with bloc resection of the mandible and immediate reconstruction with iliac corticocancellous block.

RAPD법을 이용한 양파품종(Allium cepa L.)간의 유전변이와 유연관계분석

양보경,김도훈,이영병,남재성,정순재 동아대학교 농업생명과학연구소 2001 農業生命資援硏究 Vol.10 No.1

This study was carried out to investigate genetic variation and relationships among onion varieties, Allium cepa L., by RAPD-PCR analysis. In the test of 120 primers with 58 onion varieties collected from local and abroad, eight primers turned out to be useful for further analysis. These primers eventually provided a total of 71 bands, consisting of 68 polymorphic and three monomorphic ones. The polymorphic bands were subjected to phylogenetic analysis using NTSYS and PAUP computer programs. In the NTSYS analysis, similarity coefficient of the 58 onion varieties ranged from 0 to 0.9179 and that of 27 varieties with obvious origin ranged from 0.0306 to 0.9032, The dendrogram of 58 varieties obtained by NTSYS analysis resulted in 15 groups, but overall groupings were not consistent with bulb phenotypes (e.g., color, weight, and shape) or origin of the varieties either In the PAUP analysis, genetic divergence of the 58 onion varieties ranged from 0.042 to 0.532 and that of 27 varieties with obvious origin ranged from 0.042 to 0.394. Phylogenetic analysis using PAUP revealed 13 group with 58 varieties and nine group with 27 varieties, but these were not consistent with any bulb phenotypes or origin either, as seen in the NTSYS analysis.

소규모 제조업에서 재해발생과 사업장 특성간의 관련성 분석

이건세,김형수,,장성훈,정최경희,오원기,최재욱,이관형,오지영 大韓産業醫學會 2006 대한직업환경의학회지 Vol.18 No.2

목적: 소규모 제조업 사업장의 재해 발생 유무에 따른 사업장 조직 특성을 비교하여 재해 발생과 관련된 요인을 사업장 수준에서 파악하고자 하였다. 방법: 한국산업안전공단이 실시한 2004년도 산업안전 보건 동향조사 자료 중 5인 이상 50인 미만 제조업 1,886개 사업장(가중치를 부여하여 추정한 모집단 사업장은 65,921개)의 재해(산재 및 공상, 경상 포함) 발생 여부와 사업장의 조직 특성(일반적 특성, 고용특성 및 산업안전보건 특성)간 다변량 분석을, 사업장의 일반적 특성은 지역, 산업형태, 업종 등이며, 고용특성은 전체 근로자중에서 생산직 근로자의 분포, 여성근로자의 분포, 1주일 평균 근로시간, 교대근무 등이며, 산업안전보건 특성은 안전관리자/보건관리자의 선임형태, 산업안전보건위원회, 노동조합, 매월 정기안전보건교육시간, 안전보건관리 규정, 안전보건활동 점수, 안전문화 점수 등이다. 결과: 다변량 분석결과 재해가 발생한 사업장이 갖는 특성은 다음과 같았다. 첫째, 사업장의 일반적 특성에서 지역별로는 경인권에 비해 전라권, 산업형태 면에서 원청에 비해 사외협력업체, 업종별로는 전자부품/통신에 비해 코크스/석유정제업, 목재/나무제품업, 음식료품, 조립 금속제품에서 위험도가 높았다. 둘째, 사업장의 고용 특성에서는 전체 구성원 중에서 생산직 근로자가 증가할수록 재해발생 사업장이 유의하게 증가하였으며, 여성근로자의 증가할수록 재해발생 사업장이 유의하게 감소하였다. 주당 근무시간이 증가할수록 재해 발생 사업장이 유의하게 증가하였으며, 교대 근무와 사업장의 재해발생과는 유의한 관련성이 없었다. 셋째, 사업장의 산업안전보건 특성에서는 안전관리자가 전임으로 근무할수록, 산안전보건위원회가 활발히 활동할수록, 노동조합이 설립될수록, 안전보건규정이 갖추어지지 않을수록, 정기보건교육시간이 많을수록, 안전문화수준이 낮을수록 재해발생 사업장이 유의하게 증가하였다. 결론: 소규모제조업에서 사업장의 조직 특성에 따라 사업장 재해율이 다름을 확인할 수 있었으며, 이는 산업재해의 예방을 위해서는 근로자 요인이외에도 사업장 수준에서의 관련요인에 대한 접근이 필요함을 의미한다. Objective: This study evaluated the relationship between injury occurrence and workplace organization in small-sized, manufacturing factories in Korea. Methods: Using data from the 2004 Occupational Safety and Health Survey in Korea, this study compared workplace organizational factors (general characteristics, employee characteristics and health and safety characteristics) with injury occurrence of 1,866 small-sized, manufacturing factories (65,921 population factories after weighting). General characteristics of factories comprised location, type and classification of industry. Employee characteristics comprised proportion of manual workers and female workers, average working hours per week and shiftwork. Health and safety characteristics comprised type of safety and health manager, committee for occupational safety and health, labor union, health and safety regulation, monthly health and safety training time, score of health and safety activity and score of safety culture. Results: The following characteristics of injury-occurrence in small-sized, manufacturing factories were determined by multivariate analysis. In terms of general characteristics, the risk of injury-occurrence was higher in Jeolla area than Gyeongin area in outside associate than other enterprises and in coke, refined petroleum products and nuclear fuel, wood and products of wood, food products and beverages and fabricated metal products, except machinery and furniture industries than television and communication equipment and apparatus industries. In terms of employee characteristics, injury-occurrence significantly increased in factories with greater proportion of manual worker and with a higher rate of working hours per week. But significantly decreased in factories with a higher proportion of female workers. In terms of health and safety characteristics, injury-occurrence significantly increased in factories with a self-appointed safety manager, with unorganized union, with a more active committee for occupational safety and health, with unimplemented health and safety regulation, with longer monthly safety and health training time, and with a lower score of safety culture. Conclusions: This study demonstrated that several factors of workplace organization were significantly related with injury-occurrence in factories. These findings are supposed to raise the need for making effort in workplace organization to improve injury prevention.

보행속력과 동작의 부드러움과의 상관관계에 관한 연구

탁계래,한영민,최진승,이정한,임영태,전재훈,박상균,박승하,Stefanyshin Darren 한국운동역학회 2006 한국운동역학회지 Vol.16 No.1

Evaluation of Ergonomic Performance of Medical Smart Insoles

Jae-Hoon Yi,Jin-Wook Lee,서동권 물리치료재활과학회 2022 Physical therapy rehabilitation science Vol.11 No.2

Objective: This study was to resolve the limitations of the experimental environment and to solve the shortcomings of the method of measuring human gait characteristics using optical measuring instruments. Design: A cross-sectional study. Methods: Fifteen healthy adults without a history of orthopedic surgery on the lower extremities for the past 6 months were participated. They were analyzed gait variables using the smart guide and the 3D image analysis at the same time, and their results were compared. Visual-3D was used to calculate the analysis variables. Results: The reliability and validity of the data according to the two measuring instruments were found to be very high; gait speed(0.85), cycle time(0.99), stride time of both feet(0.98, 0.97) stride legnth of both feet(0.86, 0.88) stride per minute of both feet(0.99, 0.96), foot speed of both feet(0.90, 0.91), step time of both feet(0.77, 0.71), step per minute(0.72, 0.74), stance time of both feet(0.96, 0.97), swing time of both feet(0.93, 0.79), double step time(0.81), initial double step time(0.84) and terminal step time(0.76). Conclusions: In the case of the smart insole, which measures human gait variables using the pressure sensor and inertial sensor inserted in the insole, the reliability and validity of the measured data were found to be very high. It can be used as a device to replace 4D image analysis when measuring pathological gait.

Contraction Ratio Variation of the Lateral Abdominal Muscles in Elderly Gait

Jae-Hoon Yi 대한고유수용성신경근촉진법학회 2018 PNF and Movement Vol.16 No.2

Purpose: This study aimed to describe and identify the relationship between gait and contracted ratios of the transverse abdominal (TrA), internal oblique (IO), and external oblique (EO) muscles. Methods: This study was conducted on 50 elderly people. The contracted ratios of the lateral abdominal muscles (LAM) were measured using the abdominal drawing-in maneuver (ADIM) and ultrasonographic imaging. Gait was measured using the timed up and go test and the 10 m walk test. Results: The contracted ratios of the TrA and IO muscles significantly increased after ADIM. Those of the TrA muscles showed a significant correlation with gait in the limited community ambulatory group. The contracted ratios of the IO and EO muscles showed a significant correlation with gait in the community ambulatory group. Conclusion: Our findings suggest a specific training on the relationship between gait speed and the activation of the LAM in elderly people.

Prevalence of thyroid nodules and their associated clinical parameters: a large-scale, multicenter-based health checkup study

( Jae Hoon Moon ),( Min Kyung Hyun ),( Ja Youn Lee ),( Jung Im Shim ),( Tae Hyuk Kim ),( Hoon Sung Choi ),( Hwa Young Ahn ),( Kyung Won Kim ),( Do Joon Park ),( Young Joo Park ),( Ka Hee Yi ) 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.4

Background/Aims: We evaluated the prevalence and characteristics of thyroid nodules detected by thyroid ultrasound (US) at health checkups and the associated clinical parameters. Methods: A total of 72,319 subjects who underwent thyroid US at three health checkup centers in Korea from January 2004 to December 2010 were included in this study. The correlations between the presence of thyroid nodules and other clinical parameters were analyzed. Results: The prevalence of thyroid nodules and cysts was 34.2% (n = 24,757). Thyroid nodules were more prevalent in women and older age groups. Among the subjects with thyroid nodules with size information (n = 24,686), 18,833 (76.3%) had nodules measuring ≤ 1.0 cm. Women and older age groups showed higher proportion of larger nodules. Percentage of women, age, body mass index (BMI), waist circumference, body fat composition, blood pressure, and the level of fasting glucose, total cholesterol, and low density lipoprotein cholesterol were higher in the subjects with thyroid nodules compared to those without nodules. The prevalence of metabolic syndrome and overt/subclinical thyrotoxic state was higher in the subjects with thyroid nodules. In the multivariable logistic regression analysis, women, age, BMI, metabolic syndrome, and thyrotoxicosis were independently associated with the presence of thyroid nodules. Conclusions: The high prevalence of thyroid nodules in people who underwent thyroid US at a health checkup suggests that increased detection of thyroid nodules resulted in an increased prevalence in the general population. However, metabolic disturbances may also have contributed to the increase in thyroid nodule prevalence in Korea.

Contraction Ratio Variation of the Lateral Abdominal Muscles in Elderly Gait

Yi, Jae-Hoon Korea Proprioceptive Neuromuscular Facilitation As 2018 PNF and Movement Vol.16 No.2

Purpose: This study aimed to describe and identify the relationship between gait and contracted ratios of the transverse abdominal (TrA), internal oblique (IO), and external oblique (EO) muscles. Methods: This study was conducted on 50 elderly people. The contracted ratios of the lateral abdominal muscles (LAM) were measured using the abdominal drawing-in maneuver (ADIM) and ultrasonographic imaging. Gait was measured using the timed up and go test and the 10 m walk test. Results: The contracted ratios of the TrA and IO muscles significantly increased after ADIM. Those of the TrA muscles showed a significant correlation with gait in the limited community ambulatory group. The contracted ratios of the IO and EO muscles showed a significant correlation with gait in the community ambulatory group. Conclusion: Our findings suggest a specific training on the relationship between gait speed and the activation of the LAM in elderly people.

Thyroglobulin in Washout Fluid From Lymph Node Fine-needle Aspiration Biopsy in Papillary Thyroid Cancer: Large-scale Validation of the Cutoff Value to Determine Malignancy and Evaluation of Discrepant Results

Moon, Jae Hoon,Kim, Yong Il,Lim, Jung Ah,Choi, Hoon Sung,Cho, Sun Wook,Kim, Kyung Won,Park, Hyo Jin,Paeng, Jin Chul,Park, Young Joo,Yi, Ka Hee,Park, Do Joon,Kim, Sang Eun,Chung, June-Key The Endocrine Society 2013 The Journal of clinical endocrinology & metabolism Vol.98 No.3

<P><B>Context:</B></P><P>There are still some controversies regarding the cutoff value and the influential factors of thyroglobulin (Tg) concentration in washout fluid from fine-needle aspiration (FNA) biopsy (FNA-Tg) on cervical lymph nodes (LNs) in patients with papillary thyroid cancer (PTC).</P><P><B>Objective:</B></P><P>Our aims were to validate the cutoff value of FNA-Tg in diagnosing malignant LNs on a large scale and to investigate the influential factors that could result in the discrepancy between the final diagnosis and FNA-Tg.</P><P><B>Design, Setting, and Participants:</B></P><P>We conducted a retrospective cohort study based on hospital records with 528 cases of FNA-Tg measurement from 419 PTC patients.</P><P><B>Main Outcome Measure:</B></P><P>The cutoff value of FNA-Tg was obtained from receiver operating characteristic analysis with final diagnosis. Binary logistic regression analysis was performed to investigate the influential factors.</P><P><B>Results:</B></P><P>In the final diagnosis, 190 LNs were malignant, and 338 LNs were benign. The median FNA-Tg was 521.2 (3676.8) ng/mL in malignant LNs, and 0.1 (0.2) ng/mL in benign LNs. The optimal cutoff value of FNA-Tg in distinguishing malignant LNs from benign LNs was 1.0 ng/mL (sensitivity, 93.2%; specificity, 95.9%) in all cases. Combining FNA-Tg and FNA cytology showed superior diagnostic power (sensitivity, 98.4%; specificity, 94.4%) when compared with diagnostic strategy using either FNA cytology or FNA-Tg alone. FNA-Tg, serum TSH, and serum Tg were higher in nonthyroidectomized patients than in thyroidectomized patients (<I>P</I> < .001, respectively). FNA-Tg was correlated with serum TSH and Tg levels (<I>P</I> < .001, respectively), and binary logistic regression analysis showed that serum TSH suppression and serum Tg presence independently affected the diagnosis made by FNA-Tg.</P><P><B>Conclusions:</B></P><P>Our results validated 1.0 ng/mL of FNA-Tg as a cutoff value for diagnosing LN metastasis of PTC and suggested that serum TSH suppression and serum Tg presence should be considered in diagnosing LN malignancy with FNA-Tg in PTC patients.</P>

멈춤 유형에 따른 노인 보행의 생체역학적 변화

이재훈 ( Jae Hoon Yi ),류지선 ( Ji Seon Ryu ) 한국운동역학회 2011 한국운동역학회지 Vol.21 No.2

The purpose of this study was to verify the difference in biomechanical variation and pattern of the lower limb between planned and unexpected termination, which is related to the prevention of fatal fall in the elderly. Therefore, selected twenty subjects for each group which composed of females(age: 73.5 ± 4.63 year, height: 153.2 ± 6.46 cm, body mass: 58.98 ± 5.82 kg) and women(age: 23.4 ± 2.5 year, height: 164.65 ± 3.9 cm, body mass: 58.47 ± 5.53 kg) in their twenties. As a result, lower limb`s extension moment and power were increased significantly in statistics(p<.05). Also, knee joint power showed instant changes from concentric contraction to eccentric contraction and hip joint power from eccentric contraction to concentric contraction. During unexpected termination there were dramatical increase in eccentric contraction and power(p<.05). In both planned and unexpected termination, ankle joint moment were higher in young group, but the moment of the hip joint were higher in the elderly group(p<.05). In contrast to younger group, there were no changes in knee extension moment in elderly group(p<.05). but showed relatively higher hip joint extension moment and power(p<.05).