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DC-SIGN<sup>+</sup> Macrophages Control the Induction of Transplantation Tolerance
Conde, P.,Rodriguez, M.,van der Touw, W.,Jimenez, A.,Burns, M.,Miller, J.,Brahmachary, M.,Chen, H.m.,Boros, P.,Rausell-Palamos, F.,Yun, T.,Riquelme, P.,Rastrojo, A.,Aguado, B.,Stein-Streilein, J.,Tana Cell Press 2015 Immunity Vol.42 No.6
<P>Tissue effector cells of the monocyte lineage can differentiate into different cell types with specific cell function depending on their environment. The phenotype, developmental requirements, and functional mechanisms of immune protective macrophages that mediate the induction of transplantation tolerance remain elusive. Here, we demonstrate that costimulatory blockade favored accumulation of DC-SIGN-expressing macrophages that inhibited CD8(+) T cell immunity and promoted CD4(+)Foxp3(+) Treg cell expansion in numbers. Mechanistically, that simultaneous DC-SIGN engagement by fucosylated ligands and TLR4 signaling was required for production of immunoregulatory IL-10 associated with prolonged allograft survival. Deletion of DC-SIGN-expressing macrophages in vivo, interfering with their CSF1-dependent development, or preventing the DC-SIGN signaling pathway abrogated tolerance. Together, the results provide new insights into the tolerogenic effects of costimulatory blockade and identify DC-SIGN(+) suppressive macrophages as crucial mediators of immunological tolerance with the concomitant therapeutic implications in the clinic.</P>
M.F.P. Lopes,J.M. Paixao Conde,M. Gloria Gomes,J.G. Ferreira 한국풍공학회 2010 Wind and Structures, An International Journal (WAS Vol.13 No.6
When designing structures to the wind action, the variation of the mean wind velocity and turbulence parameters with the height above the ground must be taken into account. This paper presents the numerical simulation results of atmospheric boundary layer (ABL) airflows, in a numerical domain with no obstacles and with a cubic building. The results of the flow characterization, obtained with the FLUENT CFD code were performed using the k . ε turbulence model with the MMK modification. The mean velocity and turbulence intensity profiles in the inflow boundary were defined in accordance with the Eurocode 1.4, for different conditions of aerodynamic roughness. The maintenance of the velocity and turbulence characteristics along the domain were evaluated in an empty domain for uniform incident flow and the ABL Eurocode velocity profiles. The pressure coefficients on a cubic building were calculated using these inflow conditions.
RESULTS OF THERMAL CREEP TEST ON HIGHLY IRRADIATED ZIRLO
M. QUECEDO,M. LLORET,J. M. CONDE,C. ALEJANO,J.A. GAGO,F.J. FERNÁNDEZ 한국원자력학회 2009 Nuclear Engineering and Technology Vol.41 No.2
This paper presents a thermal creep test under internal pressure and post-test characterization performed on high burnup (68 MWd/kgU) ZIRLO. This research has been done by the CSN, ENRESA, and ENUSA in order to investigate the behavior of advanced cladding materials in contemporary PWRs at higher burnup under dry cask storage conditions. Also, to investigate the hydride reorientation, the cool-down of the samples after the test has been done in a coordinated manner with the internal pressure. The creep results obtained are consistent with the expected behavior from reference CWSR material, Zr-4. During the test, the material retained significant ductility: one specimen leaked during the test at an engineering strain of the tube section of 17%; remarkably, the crack closed due to de-pressurization. Although significant hydride reorientation occurred during the cool-down under pressure, no specimen failed during the cool-down.
Lopes, M.F.P.,Paixao Conde, J.M.,Gomes, M. Gloria,Ferreira, J.G. Techno-Press 2010 Wind and Structures, An International Journal (WAS Vol.13 No.6
When designing structures to the wind action, the variation of the mean wind velocity and turbulence parameters with the height above the ground must be taken into account. This paper presents the numerical simulation results of atmospheric boundary layer (ABL) airflows, in a numerical domain with no obstacles and with a cubic building. The results of the flow characterization, obtained with the FLUENT CFD code were performed using the ${\kappa}-{\varepsilon}$ turbulence model with the MMK modification. The mean velocity and turbulence intensity profiles in the inflow boundary were defined in accordance with the Eurocode 1.4, for different conditions of aerodynamic roughness. The maintenance of the velocity and turbulence characteristics along the domain were evaluated in an empty domain for uniform incident flow and the ABL Eurocode velocity profiles. The pressure coefficients on a cubic building were calculated using these inflow conditions.
RESULTS OF THERMAL CREEP TEST ON HIGHLY IRRADIATED ZIRLO
Quecedo, M.,Lloret, M.,Conde, J.M.,Alejano, C.,Gago, J.A.,Fernandez, F.J. Korean Nuclear Society 2009 Nuclear Engineering and Technology Vol.41 No.2
This paper presents a thermal creep test under internal pressure and post-test characterization performed on high burnup (68 MWd/kgU) ZIRLO. This research has been done by the CSN, ENRESA, and ENUSA in order to investigate the behavior of advanced cladding materials in contemporary PWRs at higher burnup under dry cask storage conditions. Also, to investigate the hydride reorientation, the cool-down of the samples after the test has been done in a coordinated manner with the internal pressure. The creep results obtained are consistent with the expected behavior from reference CWSR material, Zr-4. During the test, the material retained significant ductility: one specimen leaked during the test at an engineering strain of the tube section of 17%; remarkably, the crack closed due to de-pressurization. Although significant hydride reorientation occurred during the cool-down under pressure, no specimen failed during the cool-down.
Precision Control of the Electron Longitudinal Bunch Shape Using an Emittance-Exchange Beam Line
Ha, G.,Cho, M. H.,Namkung, W.,Power, J. G.,Doran, D. S.,Wisniewski, E. E.,Conde, M.,Gai, W.,Liu, W.,Whiteford, C.,Gao, Q.,Kim, K.-J.,Zholents, A.,Sun, Y.-E,Jing, C.,Piot, P. American Physical Society 2017 Physical Review Letters Vol.118 No.10
Phase growth control in low temperature PLD Co:TiO2 films by pressure
S. Rout,N. Popovici,S. Dalui,M.L. Paramês,R.C. da Silva,A.J. Silvestre,O. Conde 한국물리학회 2013 Current Applied Physics Vol.13 No.4
This paper reports on the structural and optical properties of Co-doped TiO2 thin films grown onto (0001)Al2O3 substrates by non-reactive pulsed laser deposition (PLD) using argon as buffer gas. It is shown that by keeping constant the substrate temperature at as low as 310 C and varying only the background gas pressure between 7 Pa and 70 Pa, it is possible to grow either epitaxial rutile or pure anatase thin films, as well as films with a mixture of both polymorphs. The optical band gaps of the films are red shifted in comparison with the values usually reported for undoped TiO2, which is consistent with n-type doping of the TiO2 matrix. Such band gap red shift brings the absorption edge of the Codoped TiO2 films into the visible region, which might favour their photocatalytic activity. Furthermore,the band gap red shift depends on the films’ phase composition, increasing with the increase of the Urbach energy for increasing rutile content.