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RISS 인기검색어
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- 저자 : J. Christa (검색결과 3 건)
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Change in Care Dependency of Stroke Patients: A Longitudinal and Multicenter Study
Nursiswati Nursiswati,Ruud J.G. Halfens,Christa Lohrmann 한국간호과학회 2017 Asian Nursing Research Vol.11 No.2
Purpose: The study was conducted to investigate the change of care dependency in stroke patients from inpatient wards and outpatient units in Indonesia. Methods: This study is longitudinal and multicentered. One hundred and nine patients were included from four hospitals on the island of Java. Care dependency was assessed using the Indonesian version of the 15-item Care Dependency Scale (CDS) at five points in time: at inpatient wards for admission and discharge and at outpatient units after discharge in the 1st week, the 5th week, and the 13th week. Results: Most of the patients were male (65.1%), and diagnosed with ischemic stroke (71.5%). The results showed that care dependency in stroke patients decreased significantly from admission to discharge, as well as from the 5th to the 13th week as measured by the CDS. At admission, 23.0% of the patients were completely dependent on care, and at the 13th week about 1.0% were. Patients' care dependency decreased significantly in all care dependency items of the CDS in the inpatient ward, but five care dependency items of the CDS did not significantly decrease in the outpatient unit. Conclusions: Based on the findings of this study,we recommend that hospital-based andcommunity-based services should include continual care dependence monitoring using this comprehensive instrument. Care dependency is subject to change over time, therefore nurses have to plan and tailor adequate nursing care measures to patient needs in the different stages, especially with respect to the aspect of mobility.
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T.S. Anirudhan,J. Christa,Binusreejayan 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.57 No.-
In the present study, a magnetic protein–polyelectrolyte complex of casein coated iron oxidenanoparticles and folic acid conjugated chitosan-graft-poly(2-dimethylaminoethyl methacrylate) wasprepared for the delivery of an anticancer drug, 5-fluorouracil (5-FU) and characterized using FTIR, XRD,VSM, FESEM, TEM, DLS and zeta potential studies. Sustained and controlled release of 5-FU was observedat acidic pH 5.0. Drug release kinetic studies indicated both swelling and diffusion controlled release. Invitro cytotoxicity studies revealed the low toxicity of the prepared nano drug carrier towards normal cellsand folate receptor targeting efficiency of 5-FU loaded carrier towards cancer cells.
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Malika Kengsakul,Gatske M. Nieuwenhuyzen-de Boer,Suwasin Udomkarnjananun,Stephen J. Kerr,Christa D. Niehot,Heleen J. van Beekhuizen 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.4
Objective: Advances in ovarian cancer cytoreductive surgery have enabled more extensive procedures to achieve maximal cytoreduction but with a consequent increase in postoperative morbidity and mortality. The aim of this study was to evaluate factors for postoperative morbidity after extensive cytoreductive surgery for primary epithelial ovarian cancer (EOC), particularly those which may be modifiable. Methods: Electronic databases were searched. Meta-analysis was conducted using random- effects models. Results: Fifteen relevant studies, involving 15,325 ovarian cancer patients, were included in this review. Severe 30-day postoperative complications occurred in 2,357 (15.4%) patients. The postoperative mortality rate was 1.92%. Meta-analysis demonstrated that patient with following risk factors; age (p<0.001), Eastern Cooperative Oncology Group score >0 (p=0.001), albumin level <3.5 g/dL (p<0.001), presence of ascites on CT scan (p=0.013), stage IV disease (p<0.001) and extensive surgical procedure (p<0.001) has a significantly increase risk of developing postoperative complications. Surgical procedures including peritonectomy (p=0.012), splenectomy (p<0.001) and colon surgery (p<0.001) were significant predictors for postoperative complications. Moreover, we found that patients who received neoadjuvant chemotherapy followed by interval debulking surgery (NACT-IDS) had a lower risk of developing severe complications compared to those who underwent primary debulking surgery (PDS) (p<0.001). Conclusion: Our study demonstrated that patient performance status and hypoalbuminemia were the only significant adjustable preoperative risk factors associated with postoperative complications. Patients who underwent NACT-IDS had a lower risk of developing severe complications compared to PDS.
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