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Priscila Vaz de Arruda,Júlio César dos Santos,Rita de Cássia Lacerda Brambilla Rodrigues,Débora Danielle Virgínio da Silva,Celina Kiyomi Yamakawa,George Jackson de Moraes Rocha,Jonas Nolasco Júnior,Jo 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.47 No.-
In this study, volumetric oxygen mass transfer coefficient (kLa) was selected as a criterion for facilitatingthe scale up of xylitol production by Candida guilliermondii at the bench and pilot-scale level. A kLa valueof 16 h 1 was applied in reactors with volumetric capacity of 2.4 L, 18 L and 125 L. Fermentation wassuccessfully scaled-up from the bench to pilot-scale level with all experiments demonstrating aminimum of 60% xylose to xylitol conversion efficiency. Under all evaluated conditions glycerol andethanol were also produced as by-products of xylose metabolism. Only minor differences were observedin the fermentation profile when reactor volumes ranging from 2.4 L to 125 L were used forexperimentation purposes, reaching, at pilot scale, yield and volumetric productivity of 0.55 g g 1and 0.31 g L 1 h 1, respectively, with maximum specific growth rate of 0.26 h 1. This demonstrates andreinforces the feasibility of using kLa as scale up criterion. The use of this parameter allowed precisereproduction of results obtained at bench bioreactor level to a larger scale; this is extremely crucial andimportant information considering that the aim of the proposed biotechnological process is to reach thelevel required for the industrial viability.
Terá,n Hilares, Ruly,dos Santos, Jú,lio Cé,sar,Ahmed, Muhammad Ajaz,Jeon, Seok Hwan,da Silva, Silvio Silvé,rio,Han, Jong-In Elsevier 2016 Bioresource technology Vol.214 No.-
<P><B>Abstract</B></P> <P>Hydrodynamic cavitation (HC) was employed in order to improve the efficiency of alkaline pretreatment of sugarcane bagasse (SCB). Response surface methodology (RSM) was used to optimize pretreatment parameters: NaOH concentration (0.1–0.5M), solid/liquid ratio (S/L, 3–10%) and HC time (15–45min), in terms of glucan content, lignin removal and enzymatic digestibility. Under an optimal HC condition (0.48M of NaOH, 4.27% of S/L ratio and 44.48min), 52.1% of glucan content, 60.4% of lignin removal and 97.2% of enzymatic digestibility were achieved. Moreover, enzymatic hydrolysis of the pretreated SCB resulted in a yield 82% and 30% higher than the untreated and alkaline-treated controls, respectively. HC was found to be a potent and promising approach to pretreat lignocellulosic biomass.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Hydrodynamic cavitation (HC) was combined with an alkaline pretreatment. </LI> <LI> HC-assisted pretreatment was statistically optimized and experimentally verified. </LI> <LI> High enzymatic digestibility of 97.2% was achieved. </LI> <LI> The HC increased enzymatic digestibility by 30%. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>