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Ito Ken,Okano Naoki,Takuma Kensuke,Iwasaki Susumu,Watanabe Koji,Kimura Yusuke,Yamada Yuto,Yoshimoto Kensuke,Hara Seiichi,Kishimoto Yui,Matsuda Takahisa,Igarashi Yoshinori 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.4
Background/Aims: Many Japanese institutions use electromagnetic extracorporeal shock wave lithotripsy (ESWL) systems for treating pancreatic duct stones. However, there are no reports on direct comparisons between recent electromagnetic lithotripters. This study aimed to verify whether the new electromagnetic lithotripter can improve the efficiency of pancreatic stone fragmentation, and to clarify the role of combined endoscopic treatment on the clearance of pancreatic duct stones. Methods: We retrospectively identified 208 patients with pancreatolithiasis who underwent endoscopic adjunctive treatment after pancreatic ESWL at a single Japanese center over a 17-year period. We evaluated the outcome data of this procedure performed with SLX-F2 (last 2 years; group A) and Lithostar/Lithoskop (first 15 years; group B), as well as additional endoscopic treatments for pancreatolithiasis. We also performed logistic regression analysis to detect various factors associated with the procedure. Results: For pancreatic head stones, ESWL disintegration was achieved in 93.7% of group A patients and 69.0% of group B patients (p=0.004), and adjunctive endoscopic treatment removed stones in 96.8% of group A patients and 73.0% of group B patients (p=0.003). Multivariate analysis revealed that lithotripter type (odds ratio, 6.99; 95% confidence interval, 1.56 to 31.33; p<0.01) and main pancreatic duct stricture (odds ratio, 2.87; 95% confidence interval, 1.27 to 6.45; p<0.01) were significant factors for ESWL fragmentation. Conclusions: The SLX F2 showed high performance in fragmenting the pancreatic duct stones. In addition, endoscopic adjunctive treatment improved the overall success rate of the procedure. The improved ESWL lithotripter has many advantages for patients undergoing pancreatic lithotripsy treatment.
Current Status of the Diagnosis and Management of Pancreatic Neuroendocrine Tumors in Japan
Tetsuhide Ito,Masami Miki,Keijiro Ueda,Lingaku Lee,Ken Kawabe,Hisato Igarashi,Nao Fujimori,Kazuhiko Nakamura,Kohei Yasunaga,Robert T. Jensen,Takao Ohtsuka,Yoshihiro Ogawa Korean Society of Gastrointestinal Cancer 2016 Journal of digestive cancer reports Vol.4 No.2
The epidemiology of pancreatic neuroendocrine neoplasms (PNENs) in Asia has been clarified through epidemiological studies, including one conducted in Japan, and subsequently another in South Korea. As endoscopic ultrasonography (EUS) has become more widely accessible, endoscopic ultrasound-fine needle aspiration (EUS-FNA) has been performed in pancreatic tumors for which the clinical course was only monitored previously. This has enabled accurate diagnosis of pancreatic tumors based on the 2010 WHO classification; as a result, the number of patients with an accurate diagnosis has increased. Although surgery has been the standard therapy for PNENs, new treatment options have become available in Japan for the treatment of advanced or inoperable PNENs; of particular note is the recent introduction of molecular target drugs (such as everolimus and sunitinib) and streptozocin. Treatment for progressive PNENs needs to be selected for each patient with consideration of the performance status, degree of tumor differentiation, tumor mass, and proliferation rate. Somatostatin receptor (SSTR)-2 is expressed in many patients with neuroendocrine tumor. Somatostatin receptor scintigraphy (SRS), which can visualize SSTR-2 expression, has been approved in Japan. The SRS will be a useful diagnostic tool for locating neuroendocrine neoplasms, detecting distant metastasis, and evaluating therapy outcomes. In this manuscript, we review the latest diagnostic methods and treatments for PNENs.
Hiroshi Shimatani,Ken Norizuki,Akihiro Ito,Masayoshi Kinoshita 한국영어평가학회 2009 영어평가 Vol.3 No.1
This is the fifth report on the research project which compared the older version of the TOEIC?? test with the new one. Through an examination of the ability measures based on the Rasch analysis, it is confirmed that there is a relatively high degree of parallelism between the two versions of the TOEIC?? in terms of examinees’ placement. A close examination of the exceptional measures revealed that 6.6% of the total 136 test takersmight have been misplaced due to personal factors such as lack of test time and lack of interest in answering questions. However, it is still too early to conclude that the observed differences are due to either test format or personal factors, or both.
Mogi, Toru,Kusunoki, Ken'ichirou,Kaieda, Hideshi,Ito, Hisatoshi,Jomori, Akira,Jomori, Nobuhide,Yuuki, Youichi Korean Society of Earth and Exploration Geophysici 2009 지구물리와 물리탐사 Vol.12 No.1
항공전자탐사기법은 대규모의 접근이 불가능한 지역에 대한 탐사가 가능하여 화산구조를 조사하는데 유용한 탐사기법이나, 낮은 정밀도와 제한된 가탐심도의 단점을 가지고 있다. 접지된 전기송신원을 이용한 시간영역 항공 전자탐사 (GREATEM) 시스템은 항공 시간영역 전자탐사에서 가용한 탐사심도를 높이기 위한 목적으로 개발되었으며, 일본 북동부의 반다이 산 조사에 시험 적용하였다 반다이 산은 해발 1819 m의 안산암 층운화산이다. 1888년 7월에 일어난 화산분출은 북쪽 분화구에 발굽모양의 붕피 암벽과 기반부에 붕락 쇄설암을 남겼다. 이전의 연구 결과들은 반다이 산에서 실시된 GREATEM과 다른 지구물리 기법을 통해 밝혀진 반다이 산의 구조와 붕괴 메커니즘에 대한 자료의 비교분석을 가능하게 하였다. 최근의 화구구에서는 비저항 구조가, 붕괴된 분화구 지역에서는 전도성 구조가 발견되었다. 붕괴벽 주위의 전도성 구조는 열수의 작용으로 인한 변진대와 일치하고 있으며. 이러한 견과는 1888년 발생한 분출과 관련된 붕괴의 주된 원인이 화산체 내부를 구조적으로 약화시킨 열수변질작용과 관련 있다는 주장을 뒷받침하고 있다
Yui Kishimoto,Naoki Okano,Ken Ito,Kensuke Takuma,Seiichi Hara,Susumu Iwasaki,Kensuke Yoshimoto,Yuto Yamada,Koji Watanabe,Yusuke Kimura,Hiroki Nakagawa,Yoshinori Igarashi 대한소화기내시경학회 2022 Clinical Endoscopy Vol.55 No.2
Background/Aims: Endoscopic evaluation of intraductal papillary mucinous neoplasms (IPMNs) is useful in determining whetherthe lesions are benign or malignant. This study aimed to examine the usefulness of peroral pancreatoscopy (POPS) in determiningthe prognosis of IPMNs. Methods: POPS with videoscopy was performed using the mother–baby scope technique. After surgery, computed tomography/magnetic resonance cholangiopancreatography or ultrasonography and blood tests were performed every 6 months during thefollow-up. Results: A total of 39 patients with main pancreatic duct (MPD)–type IPMNs underwent POPS using a videoscope, and theprotrusions in the MPD were observed in 36 patients. The sensitivity and specificity of cytology/biopsy performed at the time ofPOPS were 85% and 87.5%, respectively. Of 19 patients who underwent surgery, 18 (95%) patients had negative surgical margins and1 (5%) patient had a positive margin. Conclusions: In IPMNs with dilatation of the MPD, POPS is considered effective if the lesions can be directly observed. Thediagnosis of benign and malignant lesions is possible depending on the degree of lesion elevation. However, in some cases, slightlyelevated lesions may increase in size during the follow-up or multiple lesions may be simultaneously present; therefore, carefulfollow-up is necessary.