생체적합성과 생분해성을 갖는 Polypeptide Copolymers의 합성과 물성에 관한 연구(Ⅲ): Polypeptide Hydrogels의 약물조절방출

강인규,권대룡,성용길 동국대학교 자연과학연구소 1991 자연과학연구 논문집 Vol.11 No.-

Poly(γ-benzyl L-glutamate) (PBLG)의 측쇄에 polyethylene glycol(PEG) 또는 ethanolamie(EA)을 반응시켜 적심성이 서로 다른 몇가지 폴리펩티드 공중합체를 합성하였고, 이들 공중함체의 약물방출특성을 살펴보았다. 합성된 폴리펩티드공중합체의 수분흡수율은 공중합체 중의 PEG 또는 EA 함량이 높아짐에 따라 증가하였다. PEG-PBLG-EA 공중합체로부터의 5-fluorouracil의 방출속도는 PEG-PBLG 공중합체로부터의 방출속도보다 크게 나타났으며, 이러한 결과는 팽윤성의 폴리펩티드를 합성하고자 할 때 사용되는 치환제로서는 PEG보다도 EA가 더욱 효과적이라는 것이 나타났다. 한편, PEG를 가교시킨 PBLG 공중합체막상에서는 5-fluorouracil의 방출에 기인하여 작은 pores를 명료하게 나타나고 있음을 알 수 있었다. Several copolypeptides having different swellabilities are are synthesized by introducing polyethylene glycol(PEG) or ethanolamine(EA) to the side chains of poly(γ-benzyl L-glutamate) (PBLG) and their drug release characteristics are examined. The degree of swelling of copolypeptide is increased by increasing PEG or EA content in the polymer. The release rate of 5-fluorouracil from the PEG-PBLG-EA copolymers was higher than that of the PEG-PBLG copolymers. This results indicated that EA is more effective than PEG for the preparation of the swellable polypeptides. It was observed, from the morphological study by scanning electron microscope, the pores are generated on the PEG-crosslinked PBLG, but not on the PEG-grafted-PBLG.

제 5세대와 6세대 상아질 접착제의 전단접착강도 비교

이은경,김교한,강인규 대한치과기재학회 2001 대한치과재료학회지 Vol.28 No.1

The purpose of this study was to compare the shear bonding strength and the interfacial micromorpholoy of the 5th and 6th generation dentin bonding system. The evaluation of durability was performed by 1,000 thermocycling with 4℃ and 60℃ water. As the results, mean shear bond strengths of 5th generation dentin bonding systems ranged from 12.48 MPa to 16.71 MPa for One Step and OptiBond Solo, respectively. Mean shear bond strengths of 6th generation dentin bonding systems ranged from 19.03 for Prompt L-Pop to 20.12 MPa for One-Up Bond F. After the thermocycling, the shear bond strengths of 5th generation dentin bonding systems reduced more than that of the 6th generation dentin bonding system. In the thermocycle 0 and 1,000 groups, a significantly different bond strength was observed. The thickness of Hybrid layers were 2∼3㎛ and 1∼2㎛ for 5th and 6th generation dentin bonding systems, respectively. In the 5th generation dentin bonding systems, resin tags and resin penetration through lateral branches of tubules were prominent. In 6th generation, however, the same effect was not observed in the tubules.

심박수와 환기량을 이용한 최대산소섭취량 추정연구

김학렬,노성규,손태열,강인섭 龍仁大學校 體育科學硏究所 1991 體育科學硏究論叢 Vol.1 No.1

Direct measurement of oxygen uptake(V O₂??) is used to standard index of cardiorespiratory fitness, but is practical only in a laboratory setting. The purpose of this paper is presented assessing formular of V O₂?? with measured heart rate and ventilation as the independent variables and with directly measured V O₂?? as the dependent variables. Twenty males with college hand ball players volunteered to exercise on a bicycle ergometer by 2-min incremental load exercise. Incremented bicycle ergometer test was used to measure maximal values of metabolic variables. To calculated assessing formular of V O₂??, It was using linear regression and multiple linear regression. The conclusion were as follows : 1. Correlation Coefficient of heart rate and ventilation, oxygen uptake and ventilation, oxygen uptake and heart rate were presented r=0.918, r=0.936, r=0.930, respectively. also, multiple regression equation derived from data of the test group were; V O₂??(ml/kg/min)=HR(0.151)+VE-BTPS(0.012)-4.04…………(1) R²=0.9079 2. Linear regression of heart rate and oxygen uptake were: V O₂??(ml/kg/min)=HR(0.312)-14.03……………(2) R²=0.8654 3. Linear regression of ventilation and oxygen uptake were: V O₂??(ml/kg/min)=VE-BTPS(0.022)+6.997………(3) R²=0.8760 4. It was calculated more V O₂?? by using multiple linear regression considered two variables than assessing equation of V O₂?? with heart rate or ventilation.

전기화학법에 의해 형성된 Ti 양극산화피막의 특성

김태영,손원우,권태엽,강인규,김교한 大韓齒科器材學會 2002 대한치과재료학회지 Vol.29 No.3

The effects of electrolyte concentration and current density on the behaviour of volt-time curve of the anodizing, morphology, roughness, crystallinity and composition of the oxide layer were studied. Microstructural morphology, crystallinity, composition and surface roughness of oxide layer were analyzed by observed by scanning electron microscopy(SEM) and X-ray diffractometry(XRD), Energy-dispersive spectrometer(EDS), Electron Probe Micro Analyzer(EPMA)and roughness tester, respectively. The results of this study showed that the voltage incresed as the anodizing time increase. The growth of the oxide film developed a barrier layer to a pore-like layer with an increasing of current density, arising a spark discharge. On the morphology of anodic oxide layer the number and size of porosity was increased by increasing anodizing time at a constant concentration of electrolyte. The size of porosity and the roughness of the anodic oxide layer were increased by the increasing of concentration of electrolyte. The anodic oxide layer obtained in the conditions of this experiment was identified as anatase. The crystallinity of oxide layer was decreased by increasing the concentration of electrolyte at constant current density, and increased by the increasing current density at constant electrolyte concentration. In the EPMA analysis of anodic oxide layer, the concentration of phosphorous was increasing the electrolyte concentration and increasing the final voltage at constant electrolyte concentration, The ratio of O/Ti of the oxide layer obtained in this experiment was near 2 confirming this oxide layer was TiO₂

Barbituric acid 개시계 레진의 치질 접착성에 미치는 가교제의 영향

나환욱,이은경,김교한,강인규 대한치과기재학회 2001 대한치과재료학회지 Vol.28 No.2

Degree of polymerization, surface hardness and tensile bond strength of the bonding resin were carried out to examine the effect of crosslinking agent, triethylene glycol dimethacrylate(TEGDMA), on the adhesion of barbituric acid-initiated resin to dentin. As the results, degree of conversion and surface hardness increased with increasing the concentration of TEGDMA. Tensile bond strength of the resin increased with increasing the concentration of TEGDMA up to 6 wt% and, thereafter, decreased.

Design and Development of Nanofibrous Composite Scaffolds Using Hydroxyapatite for Bone Tissue Regeneration

Inn-Kyu Kang 대한치과재료학회 2014 대한치과재료학회지 Vol.41 No.S

Synthesis of Block Copolymers consisting of Polyoxypropylene and poly (ε-benzyloxycarbonyl L-lysine)

Kang, Inn Kyu,Kim, Woo Sik 慶北大學校 1989 論文集 Vol.47 No.-

양말단에 아미노기를 갖는 Polyoxypropylene(POP)을 개시제로 하여 ε-benzyloxycarbonyl L-lysine NCA의 개환중합을 행하므로써 ABA형 블록공중합체를 얻을수 있었다. 블록공중합체의 각 성분의 중합도는 개시체와 NCA의 비를 바꾸어주므로써 조절할 수 있었다. 이와 같은 사실로부터 POP 개시제에 의한 NCA의 중합은 친핵 부가반응이라고 결론 지을수 있다. 액적법에 의해 얻어진 블록공중합체 필름의 접촉각 측정을 행하고 표면자유에너지를 계산했다. 그 결과 POP의 함량이 감소함에 따라 표면장력의 분산력 항과 극성항의 기여도는 증가하고, 수소결합력항의 기여도는 감소함을 알았다. 또한 전체표면 자유에너지에 있어서는 블록공중합체보다 poly(Z-lysine) homopolymer가 더욱 큰값을 나타냈다.

Synthesis and surface characterization of heparin-immobilized polyetherurethanes

Kang, Inn-Kyu 경북대학교 생체재료연구소 1999 생체재료연구소보 Vol.2 No.-

Permeability and Metabolism of Ba-alginate Encapsulated Hepatocytes with Gelatin and Poly(vinyl alcohol)

Inn-Kyu Kang,Man-Woo Huh,Zhi-Cai Xing 한국고분자학회 2006 한국고분자학회 학술대회 연구논문 초록집 Vol.2006 No.10

Synthesis, Blood Compatibility, and Gas Permeability of Block Copolymers Consisting of Polyoxypropylene and Poly(γ-benzyl <small>L</small>-glutamate)

Kang, Inn-Kyu,Ito, Yoshihiro,Sisido, Masahiko,Imanishi, Yukio The Society of Polymer Science, Japan 1987 Polymer journal Vol.19 No.12

<P>A-B-A-type block copolymers were prepared by the polymerization of γ-benzyl <SMALL>L</SMALL>-glutamate NCA (A segment) using polyoxypropylene (POP, B segment) with amino groups at both ends of a chain as an initiator. Thrombus formation on the block copolymer films was minimum on a block copolymer containing a POP segment of 50 mol%. It was found that on the block copolymer, denaturation of plasma proteins such as albumin and fibrinogen upon adsorption was sufficiently low not to activate adhered platelets, leading to a low degree of thrombogenesis. The oxygen permeation coefficients (<I>P</I>) of block copolymer films in water were about twice as large as that of poly(γ-benzyl <SMALL>L</SMALL>-glutamate) (PBLG) film. The increased permeation was ascribed to an increased diffusion coefficient (<I>D</I>) of dissolved oxygen through the block copolymer films. Arrhenius plots of <I>P</I> and <I>D</I> showed a break point in the temperature range of 20–30°C. At lower temperatures than the break temperature, the activation energy for oxygen permeation of the block copolymer film was lower than that of PBLG film.</P>