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Incheol Seo,배성욱,김신,정운경,Seong Kyu Baek 대한미생물학회 2019 Journal of Bacteriology and Virology Vol.49 No.4
Purpose: Dysbiosis of gut microbiota has been reported to participate in the pathogenesis of colorectal cancer, but changes in microbiota due to radiotherapy have not been studied. In this study, we tried to elucidate the changes in the microbiome in rectal cancer after chemoradiotherapy using RNA sequencing analysis. Materials and methods: We included 11 pairs of human rectal cancer tissues before and after irradiation between August 2016 and December 2017 and performed RNA sequencing analysis. Mapped reads to human reference genomes were used for pair-wise transcriptome comparisons, and unmapped (non-human) reads were then mapped to bacterial marker genes using PathSeq. Results: At microbiome level, interindividual variability of mucosal microbiota was greater than the change in microbial composition during radiotherapy. This indicates that rapid homeostatic recovery of the mucosal microbial composition takes place short after radiotherapy. At single microbe level, Prevotella and Fusobacterium, which were identified as important causative microbes of the initiation and progression of rectal cancer were decreased by radiotherapy. Moreover, changes in Prevotella were associated with changes in the human transcriptome of rectal cancer. We also found that there was a gene cluster that increased and decreased in association with changes in microbial composition by chemoradiation. Conclusion: This study revealed changes in tumor-associated microbial community by irradiation in rectal cancer. These findings can be used to develop a new treatment strategy of neoadjuvant therapy for locally advanced rectal cancer by overcoming radio-resistance or facilitating radio-sensitivity.
Dual Sensing with Voltage Shifting Scheme for High Sensitivity Touch Screen Detection
Incheol Seo(서인철),HyungWon Kim(김형원) 대한전자공학회 2015 전자공학회논문지 Vol.52 No.4
본 논문에서는 상호 정전용량 터치스크린의 single line sensing 방법에서의 단점을 해결하기 위한 성능향상 구조를 제안한다. 제안 구조는 Dual sensing 기법과 voltage shifting 기법을 도입하여 센싱 신호의 노이즈를 효과적으로 제거하고 터치 유무의 센싱 신호 차이를 증가시킨다. Dual sensing 기법은 구동신호의 양방향 엣지를 사용하여 integration 속도를 2배로 증가시켜 감지시간을 감소시킨다. Voltage shifting은 ADC의 입력신호 동작범위를 최대화하여 신호 대 노이즈비 (SNR)를 개선한다. 23″ 대형 상용 터치스크린을 이용하여 simulation 및 측정한 결과로 제안된 센싱기법은 43dB의 SNR 성능을 가지며, 기존 방식 대비 2배의 스캔 속도를 제공하여 대형 터치스크린을 위한 적합한 기술임을 보인다. 제안된 센싱기법은 현재 매그나칩 CMOS 0.18um 공정으로 TSP 컨트롤러칩으로 구현되었다. This paper proposes a new touch screen sensing method that improves the drawback of conventional single-line sensing methods for mutual capacitance touch screen panels (TSPs). It introduces a dual sensing and voltage shifting method, which reduces the ambient noise effectively and enhances the touch signal strength. The dual sensing scheme reduces the detection time by doubling the integration speed using both edges of excitation pulse signals. The voltage shifting method enhances the signal-to-noise ratio (SNR) by increasing the voltage range of integrations, and maximizing the ADC’s input dynamic range. Simulation and experimental results using a commercial 23″ large touch screen show an SNR performance of 43dB and a scan rate 2 times faster than conventional schemes - key properties suited for a large touch screen panels. We implemented the proposed method into a TSP controller chip using Magnachip’s CMOS 0.18um process.
Cluster Analysis of the Incidence of National Notifiable Infectious Diseases by Region
Incheol Seo 계명대학교 자연과학연구소 2017 Quantitative Bio-Science Vol.36 No.2
Establishing regional infection control units is vital for effective national infection control. Therefore, an in-depth segmentation strategy is required. The annual incidence rates of Korea national notifiable infectious diseases in 16 different regions from 2001 to 2016 were analyzed using K-means clustering. Four clusters from non-normalized and normalized analyses were obtained for the annual incidence rates of these diseases by region. This study demonstrates the possibility of developing objective and reproducible approaches to regional segmentation for national infection control.
Genome-Wide Association Study of Medication Adherence in Chronic Diseases in the Korean Population
Seo, Incheol,Suh, Seong-Il,Suh, Min-Ho,Baek, Won-Ki Korea Genome Organization 2014 Genomics & informatics Vol.12 No.3
Medication adherence is generally defined as the extent of voluntary cooperation of a patient in taking medicine as prescribed. Adherence to long-term treatment with chronic disease is essential for reducing disease comorbidity and mortality. However, medication non-adherence in chronic disease averages 50%. This study was conducted a genome-wide association study to identify the genetic basis of medication adherence. A total of 235 medication non-adherents and 1,067 medication adherents with hypertension or diabetes were used from the Korean Association Resource project data according to the self-reported treatment status of each chronic disease, respectively. We identified four single nucleotide polymorphisms with suggestive genome-wide association. The most significant single nucleotide polymorphism was rs6978712 (chromosome 7, $p=4.87{\times}10^{-7}$), which is located proximal to the GCC1 gene, which was previously implicated in decision-making capability in drug abusers. Two suggestive single nucleotide polymorphisms were in strong linkage disequilibrium ($r^2$ > 0.8) with rs6978712. Thus, in the aspect of decision-making in adherence behavior, the association between medication adherence and three loci proximal to the GCC1 gene seems worthy of further research. However, to overcome a few limitations in this study, defining the standardized phenotype criteria for self-reported adherence should be performed before replicating association studies.
Seo, Jungmin,Park, Youngchul,Jeon, Incheol,Ryu, Taekyu,Park, Sangjune,Lee, Phil Ho American Chemical Society 2013 Organic letters Vol.15 No.13
<P>A rhodium-catalyzed cyclization using alkynes and arylphosphonic acid monoesters for the synthesis of phosphaisocoumarins is reported. A number of arylphosphonic acid monoesters were selectively cyclized in high yields with functional group tolerance. In addition, unsymmetrical alkynes are applied in high regioselectivity.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/orlef7/2013/orlef7.2013.15.issue-13/ol401407v/production/images/medium/ol-2013-01407v_0010.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ol401407v'>ACS Electronic Supporting Info</A></P>