흰쥐 경골의 신연 골형성술에서 염증성 싸이토카인의 발현

황일웅(Il Ung Hwang),조태준(Tae-Joon Cho),최인호(In Ho Choi),정진엽(Chin Youb Chung),유원준(Won Joon Yoo),김은희(Eun Hee Kim) 대한정형외과학회 2004 대한정형외과학회지 Vol.39 No.1

목적: 본 연구의 목적은 신연 골형성술에서의 염증성 싸이토카인의 발현 양상을 일반 골절 치유 과정과 비교하는 것이다. 대상 및 방법: 흰쥐 경골의 단순 골절 치유 모델과 신연 골형성술 모델을 대상으로 3주에 걸쳐서 단계적으로 골 조직을 채취하였다. 총 리보핵산을 추출하고 각종 염증성 싸이토카인 발현의 시간적 변화를 검사하였다. 수술 후 7일과 9일째에 조직에서 면역조직화학 검사를 통해서 IL-6의 공간적 발현 양상을 조사하였다. 결과: IL-1β, IL-6는 단순 골절 치유 과정에서 수술 후 1일째에 발현이 절정에 달하였다가 3일째부터 발현이 감소하여 수술 전 상태로 회복되었다. IL-1β는 신연 골형성술 중 신연 기간에도 발현의 변화가 없었으나 IL-6은 신연을 시작함에 따라 다시 발현이 증가하는 양상을 보였다. 면역조직화학 검사장 IL-6은 골수 세포 뿐 아니라 연골세포, 골모세포 그리고 신연 간격의 미성숙 간엽세포에서 발현이 확인되었다. 결론: 신연 변형력에 의한 IL-6의 발현이 유도되는 것을 확인하였으며, 이는 조절된 염증 반응이 신연 골형성술 과정에서 신생골 형성에 부분적으로 기여할 가능성을 시사하는 것으로 생각된다. Purpose: The purposes of this study were to investigate the expression pattern of pro-inflammatory cytokines during distraction osteogenesis and to compare these with expression during simple fracture healing. Materials and Methods: Regenerated bones from the rat tibia subjected distraction osteogenesis and simple fracture healing models were harvested over three-week periods. Temporal expressions of mRNA of pro-inflammatory cytokines were investigated by RNase protection assay. Immunohistochemical studies for IL-6 were performed in postoperative day 7 and 9 tissue section specimens. Results: IL-1β and IL-6 produced detectable signals, while IL-1α, TNF α and TNF β did not. The mRNA expressions of IL-1β and IL-6 were markedly upregulated on postoperative day 1 and then subsided to the preoperative level. IL-1β mRNA expression remained the same even when distraction began. However, IL-6 mRNA expression was reactivated during the distraction phase. Immunohistochemical study revealed the expressions of IL-6 not only at the transitional zone of the transchondroid ossification, in young osteoblasts lining newly formed trabeculae and in hematopoietic cells in the marrow but also in primitive mesenchymal cells at the distraction gap. Conclusion: Distraction strain re-induced IL-6 expression during distraction osteogenesis, which suggests that well-controlled inflammatory reaction might contribute to active new bone formation in distraction osteogenesis.

보리등겨로 제조한 간장의 향기성분

권오준,이은정,최웅규,손동화,이석일,정연건,지원대 한국위생과학회 2002 한국위생과학회지 Vol.8 No.2

새로운 장류제품으로서 보리등겨의 이용방안을 모색하기 위하여 간장을 만들어 연구하였다. 보리로 제조한 간장의 갈색화는 점차적으로 증가 하였으며 완만한 변화를 보였다. 향기성분으로는 4-vinyl-2-methoxy-phenol, benzeneacetaldehyde, palmitic acid, 2-furancatboxaldehyde, methyl-9, 12-octadecadienoate, di-(2-ethylhexyl)phthalate, diethyl phtalate, dibytyl-1,2-benzenedicatboxylate, 5-methyl-2-furancarboxaldehyde, 3,4-dimethyl-1h-pyrazole, phenylethyl alcohol, dioctyl-hexanedioate, dimethyl-1,2-benzenedicatboxylate, benzaldehyde, methional, 2-methoxy-phenol, n-furfurylidene-3-methylbutyl amine, 1-furfuryl-2-formyl pyrrole, tetradrcanoic acid, 5-methyl-pyrimidine, 4-methyl-5-hydroxymethyl-imidazole, maltol, 5-(5-methyl-2-furanyl)methyl-2-furancarboxaldehyde 순으로 높은 함량을 차지 하였다. For investigation of new utilization as jang-products, kanjang was prepared using barely bran. This study was conducted to investigate flavor components of kanjang during fermentation time. The optical density was gradually increased. Among the flavor components identified in kanjang made with barley bran, the contents of 4-viny1-2-methoxy-phenol was the most in quantity followed by benzeneacetaldehyde, palmitic acid, 2-furancarboxaldehyde, methyl-9,12-octadecadienoate, di-(2-ethylhexyl)phthalate, diethyl phtalate, dibutyl-1,2-benzendicarboxylate, 5-methyl-2-furancarboxaldehyde, 3,4-dimethyl-1h-pyrazole, phenylethyl alcohol, dioctyl-hexanedioate, dimethyl-1,2-benzenedicarboxylate, benzaldehyde, methional, 2-methoxy-phenol, n-furfurylidene-3-methylbutyl amine, 1-furfuryl-2-formyl pyrrole, tetradecanoic acid, 5-methyl-pyrimidine, 4-methyl-5-hydroxymethyl-imidazole, maltol and 5-(5-methyl-2-furanyl)methyl-2-furancarboxaldegyde.

Nonlinear Cardiac Dynamics and Morning Dip : 위험한 일중리듬 An Unsound Circadian Rhythm

염명걸,김남수,오재원,김창렬,이재웅,김순길,이철범,노정일,최정연,윤용수 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.3

The Modern Meaning of Comenius Educational Theology

Il-Ung Chung Presbyterian General Assembly Theological Seminary 2009 CHONGSHIN THEOLOGICAL JOURNAL Vol.14 No.1

Die gegenwa¨rtige Situation der Glaubensunterweisung fu¨r den Erwachsenen in der koreanischen Kirche

Chung, Il-ung Presbyterian General Assembly Theological Seminary 1998 CHONGSHIN THEOLOGICAL JOURNAL Vol.3 No.1

A Study on Comenius' Pampaedia

Chung, Il-Ung Presbyterian General Assembly Theological Seminary 2006 CHONGSHIN THEOLOGICAL JOURNAL Vol.12 No.1

This article is a study on Comenius' greatest work, Pampaedia. Comenius, a theologian dedicated to education, had introduced the basic understandings of the educational fundamental principle in the fourth book of his seven volume, 'De rerum humanarum emendatione consultatio catholica,' which he calles 'Pampaedia.' Located as the fourth book of his seven volume series, it is evident that Pampaedia is the central and most important part of the series. Through Pampaeida, Comenius was able to express his educational method in-depth, informing how deeply Comenius had dealt with the subject of mankind's education in relation to theology. In this study, an investigation of Comenius' intentions and accomplishments of Pampaedia, along with his methodology of education was examined. "All humans born of this world must learn and know of all things in this world through thorough exhaustion." A statement from Pampaedia, Comenius expresses his basic idea of his work. Three latin words are evident in this statement that explains his main concepts for Pampaedia: Omnes (All humans), Omnia (All things) and Omnino (Through thorough exhaustion). Biblically supported, these three concepts are presented with practical constructs for education which are 'Theories regarding the Pampaedia school,' 'Theories regarding Pampaedia education,' Teachers of Pampaedia,' and 'Theories on correct teaching.' Comenius' educational purpose is to restore mankind's basic human existence present in creation. Pampaeida is, therefore, applicable for all types of people and every generation of society. Through seven steps, which he divides in Pampaedia, Comenius attempts to cover all of mankind in his educational method. To properly understand the concept behind these steps, or actually of the whole Pampaedia, a notion of Pan sophia must be grasped. Pansophia refers not only to our rationality, but rather the interconnection between faith, rationality and emotions. Thus, a comparison of Descartes and Comenius was done in this study in order to bring light to Comenius' notion that rationality is incomplete without God. For man to restore rationality, according to Comenius, he must be in the light of Jesus Christ. Therefore, sacrifice of Jesus and the grace of salvation is focused as a crucial subject in Pampaedia. Not only is Comenius' work Pampaedia defined, this article examines the necessity of and the possibility of Pampaedia. If Comenius were to express the necessity of Pampaedia in one phrase, it is the work of care for the perfection of man. Through God's hidden purpose and of the self-importance to man, Comenius brings mankind to acquire the knowledge and wisdom of all things of the created world. As stated above, the necessity and all other aspects of Pampaedia is only possible through Christ. Thus, Comenius believed that the starting point of Pampaedia is Christian baptism. With Scriptural evidence of Matthew 28:19, baptism is not only an act or sign of Christian education, it is the starting point and the means of Pampaedia. Briefly explained above, this article points out and examines the foundational principle of education suggested by Pampaedia. The three concepts of 'omnes,' 'omnia' and 'omnino,' coming from the statement "All humans born of this world must learn and know of all things in this world through thorough exhaustion," are the fundamental and foundational principle that bring together the methodology of Pampaedia. An investigation of the intention and methodology of Comenius' pampaedia was examined in this article. Through restoration of God's image and being thoroughly obedient to the will of God, Pampaedia of Comenius rehabilitates humanity and brings sound Christian education to the whole of mankind. Through this study, an appropriate understanding of Pampaedia is attempted for the effective use in modern ministry and missions. In shaping God's people, the proper form of education is needed in both overseas and home missions. This hope and dream is an expectation of the method of Comenius' Pampaedia.

A New Understanding of Comenius' Pansophia and Pampaedia

Chung, Il-ung Presbyterian General Assembly Theological Seminary 2003 CHONGSHIN THEOLOGICAL JOURNAL Vol.8 No.1

A Study of the Modern Use in the Korean Church of the Historical Catechisms

Chung, Il-ung Presbyterian General Assembly Theological Seminary 2001 CHONGSHIN THEOLOGICAL JOURNAL Vol.6 No.2

Johann Amos Comenius als Denker, Erzieher und Theologe : Die Beziehung von Pa¨dagogik und Theologie bei Johann Amos Comenius

Chung, Il-ung Presbyterian General Assembly Theological Seminary 1996 CHONGSHIN THEOLOGICAL JOURNAL Vol.1 No.2

A Biblical Anthropology by J.A.Comenius, particulary in his Pansophia and Pampaedia

Chung, Il-Ung Presbyterian General Assembly Theological Seminary 2005 CHONGSHIN THEOLOGICAL JOURNAL Vol.10 No.1-2