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RISS 인기검색어
- 검색키워드
- 저자 : Hyunju Chang (검색결과 190 건)
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Treatment with spironolactone in Becker`s nevus associated with ipsilateral breast hypoplasia
( Jin Hwa Son ),( Hyunju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Margaret Song ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ),( Gun Wook Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Becker nevus syndrome is the association of becker``s nevus with breast hypoplasia and other ipsilateral bone or muscle changes. It is considered to be a hormone-dependent disorder caused by a disturbance in the activity of the androgen receptor. The receptor appears to be increased in Becker``s nevus, which may influence to the development of associated lesions. Herein, we report a case of Becker nevus syndrome improved after the treatment with spironolactone. A 13-year-old girl presented with well-defined brownish patch over left breast for 8 years. In addition, she noticed hypoplasia of her ipsilateral breast (12 x 10 cm) since 10 years age. Histopathologic examinations revealed acanthosis, elongation of rete ridges in epidermis and hyperpigmentation of the basal epidermal layer. The diagnosis has been confirmed to Becker``s nevus associated with ipsilateral breast hypoplasia. The Laboratory test (CBC, electrolytes, and LH/FSH) done and showed normal range. Her hypoplastic breast was treated with spironolactone with 50mg single dosage twice daily. She experienced mild menstrual irregularity and it was improved within 1 month. The left breast had enlarged abruptly to 13 x 10.5 cm after the treatment of 19 weeks.
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Three zone of purple, red and white patch, A characteristic dermoscopic sign for glomus tumor
( Woo-haing Shim ),( Geun-hwi Park ),( Sung-min Park ),( Hyun-joo Lee ),( Tae-wook Kim ),( Hyunju Jin ),( Hyang-suk You ),( Gun-wook Kim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-b 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Despite characteristic clinical features of glomus tumor, dermatologists can meet diagnostic difficulty in some cases with glomus tumor. Objectives: To investigate clinical features and dermoscopic findings of glomus tumors. Methods: For 22 cases of glomus tumors, sex, age of initial visit, disease duration, site of lesion, size, associated symptoms and nail deformities and dermoscopic findings were investigated. Results: Mean age of initial visit and disease duration was 43.4±13.4 years old and 5.6±5.1 years, respectively(19 female, 3 male). Both 1st Fingers(9, 40.9%) were most common involved site. Nail lunula(12,54.5%) was more frequently involved than proximal nail fold(6,27.3%) or nail bed(4,18.2%). 15 cases were identifiable for size, and mean size was 6.0±1.9mm. There was associated symptoms such as pain(16,72.7%), tenderness(7,31.8%) and cold intolerance(2,9.1%). Onychoschizia(13,59.1%), longitudinal ridging(12,54.5%) and distal nail notching(8,36.4%) were commonly associated nail changes. On dermoscopic examination, whitish patch(16, 72.7%), purplish patch(15, 68.2%), erythematous patch(13, 59.1%) and irregular linear vessel(1, 4.5%) were observed. In 9 cases(40.9%), characteristic three zone consisting of central purplish patch, middle erythematous patch and peripheral whitish patch were observed. Conclusion: Characteristic dermoscopic findings of this study can help making more accurate diagnosis and performing appropriated treatment in glomus tumors
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( Jung Min Park ),( Ju Hyun Jo ),( Hyunju Jin ),( Hyun Chang Ko ),( Moon Bum Kim ),( Jung Min Kim ),( Do Won Kim ),( Ho Sun Jang ),( Byung Soo Kim ) 대한피부과학회 2016 Annals of Dermatology Vol.28 No.4
Background: A small subset of adolescents atopic dermatitis (AD) tends to persist. This also leads to get more antibiotics exposure with advancing years. Antibiotic resistance has been regarded as a serious problem during Staphylococcus aureus treatment, especially methicillin-resistant S. aureus (MRSA). Objective: It was investigated the S. aureus colonization frequency in the skin lesions and anterior nares of adolescent AD patients and evaluated the changes in S. aureus antimicrobial susceptibility for years. Methods: Patients who visited our clinic from September 2003 to August 2005 were classified into group A, and patients who visited from August 2010 to March 2012 were classified into group B. To investigate the differences with regard to patients’ age and disease duration, the patients were subdivided into groups according to age. Lesional and nasal specimens were examined. Results: Among the 295 AD patients, the total S. aureus colonization rate in skin lesions was 66.9% (95/142) for group A and 78.4% (120/153) for group B. No significant changes in the systemic antimicrobial susceptibilities of S. aureus strains isolated from adolescent AD patients were ob-served during about 10-year period. The increased trend of MRSA isolation in recent adolescent AD outpatients suggest that the community including school could be the source of S. aureus antibiotic resistance and higher fusidic acid resistance rates provides evidence of imprudent topical use. Conclusion: Relatively high MRSA isolation and fusidic acid resistance rates in recent AD patients suggest that the community harbors antibiotic-resistant S. aureus. (Ann Dermatol 28(4) 470∼478, 2016)
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Chang, Namsoo,Jung, Ji A,Kim, Hyesook,Jo, Ara,Kang, Sujeong,Lee, Si-Won,Yi, Hyunju,Kim, Jihee,Yim, Jong-Gap,Jung, Byung-Moon The Korean Nutrition Society 2015 Nutrition Research and Practice Vol.9 No.4
BACKGROUND/OBJECTIVES: Breast milk is the best available food for optimum growth and development of infants and the breastfeeding rate is increasing in Korea. The purpose of this study is to measure the concentrations of macronutrients and to evaluate their changes according to lactation period in breast milk from lactating Korean women. SUBJECTS/METHODS: Milk samples were obtained from 2,632 healthy lactating women (mean age; $32.0{\pm}3.3years$), where the lactating period was up to a period of 8 months, who also volunteered to participate in the Human Milk Macronutrient Analysis Research. Lactose, protein, fat and water content in the breast milk samples were analyzed with infrared spectrometry using MilkoScan FT-2. RESULTS: The mean macronutrient composition per 100 mL of mature breast milk was 7.1 g for lactose, 1.4 g for protein and 3.0 g for fat, and energy content was 61.1 kcal. The protein concentration was significantly lower in milk samples at 1-2 weeks (2.0 g/dL) to 2-3 months (1.4 g/dL) than those at 0-1 week (2.2 g/dL), but it was similar among samples from 3-4 months to 7-8 months (1.3 g/dL). Mean lipid levels varied among different lactational period groups (2.7-3.2 g/dL), but presented no significant difference. Lactose concentration in the milk samples did not differ with lactation period. Maternal body mass index was positively related to protein and lipid breast milk contents, but was negatively related to lactose content. General linear models examining the associations between maternal variables and milk macronutrient content revealed that lactation period had a major impact on protein and lipid, but not on lactose content in breast milk. CONCLUSIONS: These results warrant future studies to explore factors that may be associated with changes in macronutrient content in human milk.
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Kim, Hyunju,Shin, Min-Ho,Yoon, Suk-Ja,Kweon, Sun-Seog,Lee, Young-Hoon,Choi, Chang-Kyun,Kim, OkJoon,Kim, Young-Joon,Chung, HyunJu,Kim, Ok-Su Korean Academy of Periodontology 2020 Journal of Periodontal & Implant Science Vol.50 No.6
Purpose: Vitamin D deficiency may cause bone loss and increased inflammation, which are well-known symptoms of periodontal disease. This study investigated whether serum 25-hydroxyvitamin D (25(OH)D) levels are associated with periodontal disease status and tooth loss. Methods: Cross-sectional data from 5,405 individuals aged ≥50 years (2,253 males and 3,152 females) were obtained from the 2008-2010 Dong-gu study, a prospective cohort study of risk factors for chronic diseases. Periodontal examinations were conducted to evaluate the number of remaining teeth, the periodontal probing depth (PPD), the clinical attachment level (CAL), and bleeding on probing. The percentages of sites with PPD ≥4 mm and CAL ≥4 mm were recorded for each participant. The severity of periodontitis was classified using the Centers for Disease Control and Prevention and the American Academy of Periodontology case definitions. Serum 25(OH)D levels were classified as reflecting severe deficiency, deficiency, insufficiency, or sufficiency. Multivariate linear regression analysis was performed to assess the associations of serum 25(OH)D levels with periodontal parameters and the number of remaining teeth after adjusting for confounders including age, smoking status, alcohol consumption status, month of blood collection, and physical activity. Multivariate logistic regression was used to evaluate the association between serum vitamin D levels and severe periodontitis. An overall statistical analysis and a stratified analysis by sex were performed. Results: Overall, the rates of severe deficiency, deficiency, insufficiency, and sufficiency were 6.5%, 67.9%, 22.4%, and 3.2%, respectively. After adjustment for confounders, vitamin D levels were directly associated with the number of remaining teeth, an association that was significant in males, but not in females. Sufficient serum 25(OH)D was associated with a low frequency of severe periodontitis. Conclusions: This population-based cross-sectional study indicates that low serum 25(OH) D is significantly associated with tooth loss and severe periodontitis in Koreans aged 50 years and older.
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Namsoo Chang,Ji A Jung,Hyesook Kim,Ara Jo,Sujeong Kang,Si-Won Lee,Hyunju Yi,Jihee Kim,Jong-Gap Yim,Byung-Moon Jung 한국영양학회 2015 Nutrition Research and Practice Vol.9 No.4
BACKGROUND/OBJECTIVES: Breast milk is the best available food for optimum growth and development of infants and the breastfeeding rate is increasing in Korea. The purpose of this study is to measure the concentrations of macronutrients and to evaluate their changes according to lactation period in breast milk from lactating Korean women. SUBJECTS/METHODS: Milk samples were obtained from 2,632 healthy lactating women (mean age; 32.0 ± 3.3 years), where the lactating period was up to a period of 8 months, who also volunteered to participate in the Human Milk Macronutrient Analysis Research. Lactose, protein, fat and water content in the breast milk samples were analyzed with infrared spectrometry using MilkoScan FT-2. RESULTS: The mean macronutrient composition per 100 mL of mature breast milk was 7.1 g for lactose, 1.4 g for protein and 3.0 g for fat, and energy content was 61.1 kcal. The protein concentration was significantly lower in milk samples at 1-2 weeks (2.0 g/dL) to 2-3 months (1.4 g/dL) than those at 0-1 week (2.2 g/dL), but it was similar among samples from 3-4 months to 7-8 months (1.3 g/dL). Mean lipid levels varied among different lactational period groups (2.7-3.2 g/dL), but presented no significant difference. Lactose concentration in the milk samples did not differ with lactation period. Maternal body mass index was positively related to protein and lipid breast milk contents, but was negatively related to lactose content. General linear models examining the associations between maternal variables and milk macronutrient content revealed that lactation period had a major impact on protein and lipid, but not on lactose content in breast milk. CONCLUSIONS: These results warrant future studies to explore factors that may be associated with changes in macronutrient content in human milk.
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Namsoo Chang,Ji A Jung,Hyesook Kim,Ara Jo,Sujeong Kang,Si-Won Lee,Hyunju Yi,Jihee Kim,Jong-Gap Yim,Byung-Moon Jung 대한지역사회영양학회 2015 Nutrition Research and Practice Vol.5 No.6
BACKGROUND/OBJECTIVES: Breast milk is the best available food for optimum growth and development of infants and the breastfeeding rate is increasing in Korea. The purpose of this study is to measure the concentrations of macronutrients and to evaluate their changes according to lactation period in breast milk from lactating Korean women. SUBJECTS/METHODS: Milk samples were obtained from 2,632 healthy lactating women (mean age; 32.0 ± 3.3 years), where the lactating period was up to a period of 8 months, who also volunteered to participate in the Human Milk Macronutrient Analysis Research. Lactose, protein, fat and water content in the breast milk samples were analyzed with infrared spectrometry using MilkoScan FT-2. RESULTS: The mean macronutrient composition per 100 mL of mature breast milk was 7.1 g for lactose, 1.4 g for protein and 3.0 g for fat, and energy content was 61.1 kcal. The protein concentration was significantly lower in milk samples at 1-2 weeks (2.0 g/dL) to 2-3 months (1.4 g/dL) than those at 0-1 week (2.2 g/dL), but it was similar among samples from 3-4 months to 7-8 months (1.3 g/dL). Mean lipid levels varied among different lactational period groups (2.7-3.2 g/dL), but presented no significant difference. Lactose concentration in the milk samples did not differ with lactation period. Maternal body mass index was positively related to protein and lipid breast milk contents, but was negatively related to lactose content. General linear models examining the associations between maternal variables and milk macronutrient content revealed that lactation period had a major impact on protein and lipid, but not on lactose content in breast milk. CONCLUSIONS: These results warrant future studies to explore factors that may be associated with changes in macronutrient content in human milk.
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A case of guttate morphea devoid of plaque morphea
( Dongyoung Roh ),( Hyunju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Gun Wook Kim ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Morphea is a rare inflammatory disorder of the skin characterized by sclerotic change in deep dermis. It is clinically divided into several subtypes according to morphology, number, or extent of lesions. Among them, guttate morphea is an extremely rare subtype of morphea and tends to be less infiltrated on palpation and to appear at an earlier age. It presents small, ‘drop like’ and atrophic skin lesions resembling those of lichen sclerosus et atrophicus. A 27-year-old woman presented with multiple whitish atrophic macules on both arms and thighs for 4 months. Compared to the normal skin, the histopathologic examination showed increased thick collagen bundles in lower dermis, minimal perivascular inflammatory infiltrations, and a reduced number of appendages. Changes in the amount of pigmentation and the number of melanocytes were not prominent. We diagnosed this patient as guttate morphea based on clinical manifestations and histopathology. Guttate morphea tends to be localized and usually occurs in combination with larger plaque-type lesions. To our knowledge, guttate morphea have been rarely reported in the literature and most of these have been associated with plaque morphea. We encountered a case of guttate morphea which presented without association with plaque morphea.
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