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Pyrantel Pamoate(Combantrin)에 依한 蛔蟲症의 減量療法
徐丙卨,李純炯,趙昇烈,姜信榮,梁龍石,黃邱一,朴定圭,李水月 中央醫學社 1973 中央醫學 Vol.25 No.4
The mass treatment trial with low dosage of pyrantel pamoate against Ascaris lumbricoides infection was conducted to school children in rural areas of Korea. A comparative trial in the use of piperazine salt, santonin-kainic acid complex in the treatment of ascariasis was also attempted to evaluate the efficacy of' pyrantel pamoate. A total of 804 Ascaris infected school children selected out of 822-positives, who were screened from the total 1, 699 collected specimens, were classified into 7 groups. One of the three kinds of anthelmintics, i.e., pyrantel pamoate, piperazine adipate and santonin-kainic acid complex was administered to each group according to the planned regimen. For the evaluation, the egg negative conversion rate(cure rate) and egg reduction rate were calculated 4 weeks after treatment on 623 follow-up cases with the obtained results from the stool examinations (Cellophane Thick Smear Method and Stoll's Egg Counting Technique). The results obtained were; 1. The egg negative conversion rate was the highest in pyrantel treated groups (Group 1, 2, 3), santonin-kainic acid complex treated group (Group 7) coming next, and the lowest in piperazine treated groups (Group 4, 5, 6). 2. The reduction rates were also obtained just as the same order of the above results. 3. Among the pyrantel pamoate treated groups, the low dosage groups (Group 2 8: 3) showed 90.6% and 85.7% of negative conversion rate, and 99. 2% and 98. 2% of reduction rate respectively, while 94.1% of negative conversion rate and 97.9% of reduction rate were obtained in the conventional dosage group (Group 1). 4. On the analysis of efficacy in the groups treated with piperazine adipate, the best results were. shown in 2 or 3 consecutively treated groups (Group 4 &.- 6) under the supervision of qualified doctors, and the worst was in the group treated with 2 consecutive administration by teachers without supervision (Group 5). 5. The side reactions were so negligible in all the trial groups that none of the treated cases complained about the known side effect of those anthelmintics. From the present study, it can be suggested that the pyrantel pamoate is the most effective among three drugs, and also be recommended to apply the low dosage schedule of pyrantel pamoate in the masstreatment of ascariasis to reduce the expense of masstreatment.
Clinicopathologic characteristics and outcomes of gastric cancers with the MSI-H phenotype
Seo, Hyung Min,Chang, Yeon Soo,Joo, Sun Hyung,Kim, Youn Wha,Park, Yong-Koo,Hong, Sung Wha,Lee, Suk-Hwan Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of surgical oncology Vol.99 No.3
<B>Objectives</B><P>We examined the correlation between microsatellite instability (MSI) status and the clinicopathological features and prognostic value in gastric cancer and compared the efficacy of immunohistochemical staining for hMLH1 and hMSH2 with a polymerase chain reaction (PCR)-based test.</P><B>Methods</B><P>MSI status was examined in 328 consecutive gastric adenocarcinomas using tissue preserved in paraffin blocks. DNA extracted from tumor sections and the corresponding normal tissue was analyzed using PCR at the five microsatellite loci recommended by the National Cancer Institute (NCI). Immunohistochemical staining for hMLH1 and hMSH2 was performed and the results were compared with the MSI status measured using PCR. The relationship of the clinicopathologic variables to MSI status was analyzed.</P><B>Results</B><P>Of the gastric cancers, 8.2% (n = 27) contained MSI-H and this was associated with older age (>70 years), distal tumor location, tumor size, and intestinal subtype. Lymphatic and vascular invasion were associated with the disease-free survival. On immunohistochemical staining, the loss of expression of hMLH1 or hMSH2 was observed in 11% (n = 36). The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of immunohistochemical staining were 63.0%, 93.7%, 47.2%, 96.6%, and 91.2%, respectively.</P><B>Conclusions</B><P>Gastric cancers with MSI-H have specific clinicopathologic characteristics, such as older age at diagnosis, distal tumor location, increased tumor size, and intestinal histologic type. However, immunohistochemical staining for hMLH1 and hMSH2 is not as accurate as the PCR-based MSI test. J. Surg. Oncol. 2009;99: 143–147. © 2008 Wiley-Liss, Inc.</P>
Optimal culture conditions for the production of pullulan by Aureobasidium pullulans HP-2001
Seo,Hyung Pil,Son,Chang Woo,Kim,Hyun Sook,Kim,Sung Koo,Lee,Jin Woo 한국생명과학회 2001 한국생명과학회 학술발표회 Vol.33 No.-
The production of pullulan by Aureobasidium pullulans HP-2001 was investigated under various ratios of glucose as the carbon source to yeast extract as the nitrogen source. A. pullulans HP-2001 was the UV-induced mutant of A. pullulans ATCC 42023 and showed to overcome catabolite repression against glucose up to 20%(w/v). The highest conversion rate of pullulan from glucose was 36.7% when concentrations of glucose and yeast extract were 5% (w/v) and 0.15% (w/v), respectively. Maximal production of pullulan was 26.6 g/l when concentrations of glucose and yeast extract were 8% (w/v) and 0.25% (w/v), respectively. Optimal pH of medium and concentration of K₂HPO₄for the production of pullulan were 6.0 and 0.2% (w/v), respectively.
Vibration Analysis of a Rotary Compressor
Hyung-Suk Han,Seon-Woong Hwang,Jeong-Seo Koo 한국정밀공학회 2004 International Journal of Precision Engineering and Vol.5 No.3
The vibration of a rolling piston type rotary compressor for air-conditioning use is analyzed numerically and experimentally. Multibody dynamic analysis methods to predict the vibration are given. The compressor is modeled as a multibody system composed of bodies, joints, and force elements. Experimental results are shown to compare with simulation results. A sensitivity study using different variables that affect the compressor vibration is also carried out. It is found that the mass of the weight balancer plays an important role in acceleration.
Seo,Hyung Pil,Kim,Mi Ryung,Kim,Sung Koo,Cho,Young Soo,Chung,Chung Han,Lee,Jin Woo 한국생명과학회 2000 한국생명과학회 학술발표회 Vol.27 No.-
Effect of byproduct from production process for soybean source as the nitrogen source on production of extracellular polysaccharides by Aureobasidum pullulans HP- 2001 was investigated. The byproduct from production process for soybean source were found to be good nitrogen sources. The conversion rate of 2% (w/v) glucose to exopolymer with this nitrogen source was about 50%. Molecular weight of exopolymers also affected by nitrogen sources.