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Ha Seunggyun,O Joo Hyun,Park Chansoo,Boo Sun Ha,Yoo Ie Ryung,Moon Hyong Woo,Chi Dae Yoon,Lee Ji Youl 대한영상의학회 2024 Korean Journal of Radiology Vol.25 No.2
Objective: 177Lutetium [Lu] Ludotadipep is a novel prostate-specific membrane antigen targeting therapeutic agent with an albumin motif added to increase uptake in the tumors. We assessed the biodistribution and dosimetry of [177Lu]Ludotadipep in patients with metastatic castration-resistant prostate cancer (mCRPC). Materials and Methods: Data from 25 patients (median age, 73 years; range, 60–90) with mCRPC from a phase I study with activity escalation design of single administration of [177Lu]Ludotadipep (1.85, 2.78, 3.70, 4.63, and 5.55 GBq) were assessed. Activity in the salivary glands, lungs, liver, kidneys, and spleen was estimated from whole-body scan and abdominal SPECT/CT images acquired at 2, 24, 48, 72, and 168 h after administration of [177Lu]Ludotadipep. Red marrow activity was calculated from blood samples obtained at 3, 10, 30, 60, and 180 min, and at 24, 48, and 72 h after administration. Organand tumor-based absorbed dose calculations were performed using IDAC-Dose 2.1. Results: Absorbed dose coefficient (mean ± standard deviation) of normal organs was 1.17 ± 0.81 Gy/GBq for salivary glands, 0.05 ± 0.02 Gy/GBq for lungs, 0.14 ± 0.06 Gy/GBq for liver, 0.77 ± 0.28 Gy/GBq for kidneys, 0.12 ± 0.06 Gy/GBq for spleen, and 0.07 ± 0.02 Gy/GBq for red marrow. The absorbed dose coefficient of the tumors was 10.43 ± 7.77 Gy/GBq. Conclusion: [177Lu]Ludotadipep is expected to be safe at the dose of 3.7 GBq times 6 cycles planned for a phase II clinical trial with kidneys and bone marrow being the critical organs, and shows a high tumor absorbed dose.
Microwave transmission characteristics of ZnO nanowire
Joon Hyong Cho,Hyong Seo Yoon,Whan Kyun Kim,Juhwan Lim,Ji Yoong Kang,Juyeong Oh,Ryong Ha,Jung Han Choi,Heon-Jin Choi,Seong Chan Jun IET 2012 Electronics letters Vol.48 No.17
<P>Electrical characteristics of single ZnO nanowire with various diameters at the high-frequency range are presented. Transmission characteristics were measured as <I>S</I>-parameter and RLC circuit simulation to deduce passive circuit elements. The result showed that the contact parameters were dominant as frequency increases. This study discovered the parasitic effects supposed to be minimised, contribute significantly to major signal transmission of ZnO nanowire and are crucial in developing such nano-electronic devices.</P>
물오리나무 ( Alnus hirsuta ) 의 칼루스 유도 및 자엽유래 칼루스로부터의 원형질체 배양
김형하(Hyong Ha Kim),안정선(Chung Sun An) 한국식물학회 1990 Journal of Plant Biology Vol.33 No.4
Callus-inducing ability of Alnus hirsuta was examined by culturing various tissues (leaf, hypocotyl, cotyledon and seed) on NT (Nagata & Takebe) medium, supplemented with 2.5 μM 2,4-D. Leaf-orginated callus was cultured on media varying in auxin (IBA and NAA) and cytokinin (BAP) concentrations to examine the effects of auxin and cytokinin on callus growth. Maximum growth was obtained at 10μM IBA + 10μM BAP and 10μM NAA without cytokinin. Cell suspensions established from cotyledon-originated callus yielded viable protoplasts after incubation for 16-18 hours in an enzyme mixture (1% (w/v) Onozuka R-10, 0.5% (w/v) Macerozyme, CPW salts and 13% (w/v) mannitol, pH 5.8). Protoplasts were cultured on NT medium, supplemented with glucose, hormones and coconut milk. After 6 weeks of culture, protoplasts sustained cell divisions to form microcallus, which showed various colors from red to white.
Kim, Hyong-Ha,Song, Nam Woong,Park, Tae Sook,Yoon, Minjoong Elsevier 2006 Chemical physics letters Vol.432 No.1
<P><B>Graphical abstract</B></P><P>The ensemble and single molecule fluorescence spectral properties of Nile Red embedded in polystyrene (PS) films on glasses were investigated. Two distinct environments exist in the thin PS films on glasses: a low polarity environment in PS bulk and a high polarity environment near the PS/glass interface.</P><ce:figure id='figure.0010'></ce:figure> <P><B>Abstract</B></P><P>The ensemble and single molecule (SM) fluorescence properties of Nile Red embedded in polystyrene (PS) films on glasses were investigated. The ensemble spectra showed dual emission bands and SM spectra exhibited distribution with two emission maxima. These results indicate that two distinct environments exist in the thin PS film on a glass: a low polarity environment in the PS bulk and a high polarity environment near the PS/glass interface. It was also found that a PS film of <I>ca.</I> 10nm thick is sufficient to separate fluorophores from the charged species on glass surfaces.</P>
The Design and Arrangement of Coastal Ship′s Bridge on the Basis of Ergonomic Concept
Ha, Weon-Jae,Jong, Jae-Yong,Lee, Hyong-Ki,Park, Young-Soo,Park, Jin-Soo Korean Institute of Navigation and Port Research 2003 한국항해항만학회지 Vol.27 No.6
In this paper, the ergonomic principle and concept will be established and the conceptual bridge design based on the ergonomic studies pertaining to bridge design undertaken by IMO and ISO will be introduced. In particular, this study has looked into the applicability of ergonomic design concept on coastal ships and proposes new bridge design to make good contribution to the prevention of marine accidents in the coastal sea.
Middle School Students` Knowledge State Analysis about Light
( Hyong Jae Lee ),( Ji Seon Ha ),( Sang Tae Park ) 한국과학교육학회 2012 한국과학교육학회지 Vol.32 No.8
In this study, 15 evaluation questions about light were developed and presented to 30 middle school students, and then the theory of knowledge space was used to analyze the status of the middle school students`` knowledge about light. Not only was the state of the students`` knowledge about light intended to be measured by schematizing the knowledge hierarchy obtained; the data obtained were also intended to be used as basic materials to improve the teaching methods used. To achieve the purpose of this study, the evaluation results, the individual knowledge state, and the hierarchy of questions were analyzed. As a result, different knowledge structures were found in the individuals and groups, and it was determined that individuals and groups should be diagnosed differently. In addition, the implication that there is a connection between each question and the individual knowledge state was drawn.
河正基,張判亨 진주농과대학 1969 진주농과대학 연구논문집 Vol.- No.8
本試驗의 供試卵은 晋州鷄卵市場에서 7日間隔으로 구입한 White Leghorn卵 總 523個를 갖이고 本試驗을 實施했으며 그 試驗結果는 다음과 같다. 1. 卵重은 最高가 68.4g, 最下가 39.5g. 平均 52.4g이였다. 2. 卵의 넓이는 最高 49.8mm. 最下 37mm. 平均 40.9mm였다. 3. 卵의 길이는 最高 67.5mm. 最下 47.5mm. 平均 56.2mm였다. 4. 氣室의 지름은 最高 27mm. 最下 8.9mm. 平均 14mm였다. 5. 卵殼의 두께는 鈍端部가 最高 0.40mm. 最下 0.23mm. 平均 0.32mm였고 尖端部는 最高가 0.46mm. 最下 0.22mm. 平均 0.33mm였다. 6. 破殼力은 最高 8kg. 最下 2.3kg. 平均 5.1kg 이였다. 7. 卵黃重量은 最高 23.7kg. 最下 11.5g. 平均 16.3g이였다. 8. 卵의 比重은 最高 1.13. 最下 1.06. 平均 1.09이였다. 9. 卵黃重量과 卵黃係數와의 間에는 Y=0.4918-0.004267X의 回歸直線이 成立되었다. 10. 市販卵의 卵白係數은 0.10∼0.115間이 가장높은 比率로 35%였다. 11. 市販卵의 卵黃係數은 0.41∼0.43間이 가장 높은 比率로 32%였다. 12. 卵白과 卵黃의 量과 卵殼두께間에는 Y=0.2946+0.000857X의 回歸直線이 成立되었다. 13. 卵의 破殼力과 鈍殼部두께間에는 Y=0.4036-0.0737X-0.0127X²의 回歸曲線이 成立되었다. 또 尖端部間에는 Y=0.0369X+0.15722의 回歸直線이 成立되었다. 14. 市販卵의 比重은 1.085∼1.09間이 22.5%로서 가장 많았다. 15. 市販卵의 卵白係數는 最高 0.172. 最下 0.041 平均 0.115였다. 16. 市販卵의 卵黃係數는 最高 0.55 最下 0.20 平均 0.45이였다. Market egg quality was surveyed in the suburbs of Chinju City from January to March, 1968. The eggs sampled were 523 market White Leghorn eggs from Chinju egg market. 1. The average values for the different egg quality for the sampled eggs were as follows: egg weight, 52,4 g; egg width, 40.9 mm; egg length, 56.2 mm; air cell diameter, 18.9 mm; egg shell thickness of blunt end; 0.32 mm. egg shell thickness of point end, 0.33 mm; albumen index, 0.115; yolk index, 045; breaking strength, 5.1 kg; yolk weight, 16.31g; specific gravity, 1.09. 2. Some linear regression equation obtained were as follows: yolk weight on yolk index, Y=0.4918-0.004267 X; albumen plus yolk on shell thickness in both ends, Y=0.2946-0.000857 X; breaking strength on shell thickness in point end. Y=0.0369-0.1572 X. However, a curve linear regression equation was fitted for the breaking strength on the shell thickness in blunt end as Y=0.4030-0.0737 X-0.0127X².