A study on the determination of a Health based Guidance Value of Formaldehyde

Hyeonji Oh,Heeju Choi,Yongmu Kim,Seo Yun Kim,Jae-Hong Park,Haejung Yoon,Yun-Sook Kang 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

Formaldehyde can be exposed through various routes, including the environment such as air and water, food and cosmetics. Therefore, a risk assessment is necessary to identifiy and manage human health effect. This study aims to identify the relationship between formaldehyde exposure and adverse effects as a hazard characterization step in the risk assessment process and to establish and propose a Health based Guidance Value. In order to carry out ther research, we used some online databases to find scientific papers, reports and opinions published by other institutions. Data for dose-response assessment were selected and classified, as properties of toxicity, and then the most appropriate study for establishing Health based Guidance Value was finally decided. Til et al (1989), 2-years carcinogenicity study with rats, was the optimal toxicity data. As the toxicity endpoint, the Health based Guidance Value TDI 0.15 mg/kg bw/day was proposed by applying an uncertainty factor of 100(interspecies difference 10, intraspeices difference 10) to NOAEL 15 mg/kg bw/day for chronic atrophic gastritis, focal ulceration and glandular hyperplasia in the landular forestomach.

사회부과 완벽주의와 전위 공격성의 관계: 분노억제와 사고통제감의 조절된 매개효과

오현지 ( Hyeonji Oh ),박기환 ( Keehwan Park ) 사단법인 아시아문화학술원 2021 인문사회 21 Vol.12 No.6

본 연구에서는 사회부과 완벽주의가 전위 공격성을 유발하는 경로에서 분노억제의 매개효과와 사고통제감의 조절효과를 통합적으로 확인하고자 하였다. 이를 위해, 수도권 소재 대학생 및 대학원생 392명을 대상으로 다차원적 완벽주의 척도(HMPS), 한국판 상태 특성 분노표현 척도(STAXI-K), 사고통제능력 질문지(TCAQ), 한국판 전위 공격성 척도(K-DAQ)를 포함한 자기 보고식 설문을 오프라인으로 시행하고 분석하였다. 분석 결과, 사회부과 완벽주의와 전위 공격성의 관계를 분노억제가 매개하고 이를 다시 사고통제감이 조절하는 조절된 매개효과가 확인되었다. 이러한 결과는 사회부과 완벽주의가 분노억제를 통해 전위 공격성으로 이어지며, 이 과정에서 사고통제감이 완충 역할을 할 수 있음을 시사한다. 치료적 장면에서 사고통제감을 강화함으로써 부적응적 분노표현을 보다 완화시킬 수 있을 것으로 기대된다. The present study aimed to investigate comprehensively the mediating effect of anger-in and the moderating effect of thought control ability in the path that socially prescribed perfectionism induces displaced aggression. For this purpose, 392 university and graduate school students completed self-report questionnaires in offline, including HMPS, STAXI-K, TCAQ, K-DAQ. As a result of the analysis, it was confirmed that Anger-in mediated the relationship between socially prescribed perfectionism and displaced aggression, and thought control ability moderated it. These results suggest that socially prescribed perfectionism leads to displaced aggression through anger-in, and in this process, thought control ability can serve as a buffer. It is expected that maladaptive anger expression can be further alleviated by strengthening the thought control ability in the therapeutic scene.

Fluvoxamine Treatment of Patients with Symptomatic COVID-19 in a Community Treatment Center: A Preliminary Result of Randomized Controlled Trial

Seo Hyeonji,Kim Haein,Bae Seongman,Park Seonghee,Chung Hyemin,Sung Heungsup,Jung Jiwon,Kim Min-Jae,Kim Sung-Han,Lee Sang-Oh,Choi Sang-Ho,Kim Yang Soo,Son Ki Young,Chong Yong Pil 대한감염학회 2022 Infection and Chemotherapy Vol.54 No.1

Background This study aimed to evaluate whether fluvoxamine reduces clinical deterioration in adult patients with mild to moderate coronavirus disease 2019 (COVID-19), and to identify risk factors for clinical deterioration in patients admitted to a community treatment center (CTC). Materials and Methods A randomized, placebo-controlled trial was conducted in a CTC, in Seoul, Korea from January 15, 2021, to February 19, 2021. Symptomatic adult patients with positive results of severe acute respiratory syndrome coronavirus 2 real time-polymerase chain reaction within 3 days of randomization were assigned at random to receive 100 mg of fluvoxamine or placebo twice daily for 10 days. The primary outcome was clinical deterioration defined by any of the following criteria: oxygen requirement to keep oxygen saturation over 94.0%, aggravation of pneumonia with dyspnea, or World Health Organization clinical progression scale 4 or greater. Results Of 52 randomized participants [median (interquartile range) age, 53.5 (43.3 - 60.0) years; 31 (60.0%) men], 44 (85.0%) completed the trial. Clinical deterioration occurred in 2 of 26 patients in each group (P >0.99). There were no serious adverse events in either group. Clinical deterioration occurred in 15 (6.0%) of 271 patients admitted to the CTC, and all of them were transferred to a hospital. In multivariate analysis, age between 55 and 64, fever and pneumonia at admission were independent risk factors for clinical deterioration. Conclusion In this study of adult patients with symptomatic COVID-19 who were admitted to the CTC, there was no significant differences in clinical deterioration between patients treated with fluvoxamine and placebo (ClinicalTrials.gov Identifier: NCT04711863). Background This study aimed to evaluate whether fluvoxamine reduces clinical deterioration in adult patients with mild to moderate coronavirus disease 2019 (COVID-19), and to identify risk factors for clinical deterioration in patients admitted to a community treatment center (CTC). Materials and Methods A randomized, placebo-controlled trial was conducted in a CTC, in Seoul, Korea from January 15, 2021, to February 19, 2021. Symptomatic adult patients with positive results of severe acute respiratory syndrome coronavirus 2 real time-polymerase chain reaction within 3 days of randomization were assigned at random to receive 100 mg of fluvoxamine or placebo twice daily for 10 days. The primary outcome was clinical deterioration defined by any of the following criteria: oxygen requirement to keep oxygen saturation over 94.0%, aggravation of pneumonia with dyspnea, or World Health Organization clinical progression scale 4 or greater. Results Of 52 randomized participants [median (interquartile range) age, 53.5 (43.3 - 60.0) years; 31 (60.0%) men], 44 (85.0%) completed the trial. Clinical deterioration occurred in 2 of 26 patients in each group (P >0.99). There were no serious adverse events in either group. Clinical deterioration occurred in 15 (6.0%) of 271 patients admitted to the CTC, and all of them were transferred to a hospital. In multivariate analysis, age between 55 and 64, fever and pneumonia at admission were independent risk factors for clinical deterioration. Conclusion In this study of adult patients with symptomatic COVID-19 who were admitted to the CTC, there was no significant differences in clinical deterioration between patients treated with fluvoxamine and placebo (ClinicalTrials.gov Identifier: NCT04711863).

가막만 북부해역의 빈산소수괴 발생 특성

정현지(Hyeonji Jung),정희호(Huiho Jeong),정다진(Dajin Jeong),오주혜(Juhye Oh),이강현(Kanghyeon Lee),Mai Duc Hung,조현서(Hyeonseo Cho) 한국해양환경·에너지학회 2018 한국해양환경·에너지학회 학술대회논문집 Vol.2018 No.5

잉여 식재료를 활용한 스마트 도마 개발

김현지(Hyeonji Kim),유세희(Sehui Yoo),윤성우(Seongu Yun),정민욱(Minuk Jeong),오유수(Yoosoo Oh) 한국HCI학회 2022 한국HCI학회 학술대회 Vol.2022 No.2

KoGPT-2 언어 모델을 이용한 유아의 감정에 따른 동화 생성 시스템 설계

김현지(Hyeonji Kim),오유수(Yoosoo Oh) 한국HCI학회 2024 한국HCI학회 학술대회 Vol.2024 No.1

동화는 시공간적 제약을 많이 받는 유아들에게 간접적 삶의 경험을 제공한다. 간접적 삶의 경험은 유아들의 정서 발달에 영향을 끼친다. 본 논문은 유아들을 위한 동화 생성 시스템을 제안한다. 본 논문은 KoGPT-2 언어 모델을 적용하여 동화를 생성하고 영상 인식과 자연어 인식 모델을 적용하여 유아들의 감정을 분석한다. 제안된 시스템은 이미지 기반 영상처리와 언어기반 자연어처리를 통해 감정을 분석한다. 이미지 기반 감정 분석 모듈은 카메라를 통해 유아들의 표정 이미지를 수집하고 CNN+STN(Convolution Neural Network + Spatial Transformer Network) 구축하여 유아 표정 이미지에 대한 감정을 분석한다. 언어기반 감정 분석 모듈은 마이크를 통해 입력된 음성 데이터를 STT(Speech-To-Text)를 통해 변환하여 수집하고 KoBERT 언어 모델을 적용한 후 언어에서 획득 가능한 감정을 분석한다. 제안된 시스템은 이미지와 언어기반 감정 분석 모델을 융합하여 도출된 감정 결과를 기반으로 Fine-Tuning 한 KoGPT-2 언어 모델을 사용하여 동화를 생성한다. 생성된 동화는 TTS(Text-To-Speech)로 유아들에게 음성으로 들려주도록 제공된다.

Risk Factors for Mortality in Patients with Klebsiella pneumoniae Carbapenemase-producing K. pneumoniae and Escherichia coli bacteremia

Seo Hyeonji,Bae Seongman,Kim Min-Jae,Chong Yong Pil,Kim Sung-Han,Lee Sang-Oh,Choi Sang-Ho,Kim Yang Soo,Jung Jiwon 대한감염학회 2021 Infection and Chemotherapy Vol.53 No.3

Background: Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacterales bacteremia is associated with significant mortality; however, no optimal antibiotic strategy is available. We aimed to evaluate the clinical outcomes according to the antibiotic regimens and identify risk factors for mortality in patients with KPC-producing K. pneumoniae and Escherichia coli bacteremia. Materials and Methods: This retrospective cohort study included all adult patients with monomicrobial bacteremia (KPC-producing K. pneumoniae or E. coli) between January 2011 and March 2021 at a 2,700-bed tertiary center. Results: Ninety-two patients were identified; 7 with E. coli bacteremia, and 85 with K. pneumoniae bacteremia. Thirty-day mortality was 38.0% (35/92). Non-survivors were more likely to have had nosocomial infection (88.6% vs. 63.2%, P = 0.01), high APACHE II scores (mean [interquartile range], 22.0 [14.0 - 28.0] vs. 14.0 [11.0 - 20.5], P <0.001), and septic shock (51.4% vs. 26.3%, P <0.001) and less likely to have been admitted to the surgical ward (5.7% vs. 22.8%, P = 0.04), undergone removal of eradicable foci (61.5% vs. 90.6%, P = 0.03), and received appropriate combination treatment (57.1% vs. 78.9%, P = 0.03) than survivors. No significant difference in mortality was observed according to combination regimens including colistin, aminoglycoside, and tigecycline. In multivariable analysis, high APACHE II scores (adjusted odds ratio [aOR], 1.14; 95% confidence interval [CI], 1.06 - 1.23, P <0.001), and appropriate definitive treatment (aOR, 0.25; CI, 0.08 - 0.74, P = 0.01) were independent risk factors for mortality. Conclusion: High APACHE II scores and not receiving appropriate definitive treatment were associated with 30-day mortality. Mortality did not significantly differ according to combination regimens with conventional drugs such as aminoglycoside and colistin.

영광 주변 해역 해양수질환경의 계절적 변동 특성

오주혜(Juhye Oh),이강현(Kanghyeon Lee),정다진(Dajin jeong),정현지(Hyeonji Jeong),Mai Duc Hung,조현서(Hyeonseo Cho) 한국해양환경·에너지학회 2018 한국해양환경공학회 학술대회논문집 Vol.2018 No.5

머신러닝 프로세스의 이미지 및 문자열 데이터 입력에 대한 전처리 방법 추천 시스템 설계

김현지(Kim Hyeonji),오유수(Oh Yoosoo) 한국HCI학회 2022 한국HCI학회 학술대회 Vol.2022 No.2

본 논문은 지식기반 필터링을 사용하여 문자열과 이미지 전처리 방법 추천 시스템을 제안한다. 제안된 알고리즘은 사용자가 사용하고자 하는 이미지 데이터에 대해 분석하고, 분석한 결과를 바탕으로 적절한 전처리 방법을 추천한다. 본 논문은 문자열 데이터 중 식재료 데이터의 특성을 분석하였다. 본 논문은 식재료명 데이터에 TF-IDF 를 적용하여 가중치를 부여한다. 제안된 알고리즘은 가중치 값들의 정규화를 통해 각 레시피 내 식재료의 중요도를 계산하는 전처리 방법 추천이 가능하다.

Non-Saponin Fraction of Korean Red Ginseng Regulates Immunosenescence in 20- to 24-Month-Old C57BL/6J Mice

Hyun-Ji Oh,Heegu Jin,Hyeonji Woo,Eunhye Cho,Boo-Yong Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

The non-saponin fraction (NSF) of Korean Red Ginseng is a powder in which only saponin was removed from red ginseng concentrate through non-saponin fractionation procedure. Young (3-6 months) and old (20-24 months) C57BL/6J mice received oral NSF (50 mg/kg/day or 200 mg/kg/day) daily for 6 weeks. After sacrifice, blood samples were collected, and the concentrations of pro-inflammatory cytokines in serum were measured. Also, flow cytometry was performed to examine the effect of NSF on immune homeostasis in the spleen. Levels of pro-inflammatory cytokines were significantly higher in serum from old mice than in mice serum from young mice, indicating that old mice were in a low-grade chronic inflammation state. However, NSF treatment led to a significant reduction in the serum levels of pro-inflammatory cytokines in old mice. In flow cytometry analysis, NSF showed the effect of maintaining immune homeostasis by regulating the proportion of CD11b+F4/80+ macrophages in old mice. In conclusion, we found that NSF inhibited inflammation as a result of immunosenescence and maintained immune homeostasis in aged C57BL/6J mice.