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Moon, Hyeong-Gon,Han, Wonshik,Ahn, Soo Kyung,Cho, Nariya,Moon, Woo Kyung,Im, Seock-Ah,Park, In Ae,Noh, Dong-Young Lippincott Williams Wilkins, Inc. 2013 Annals of surgery Vol.257 No.1
OBJECTIVE:: To investigate whether the accuracy of magnetic resonance imaging (MRI) after neoadjuvant systemic therapy (NST) is affected by molecular features of primary breast cancer and the use of human epidermal growth factor receptor 2 (HER2)-targeted agents. BACKGROUND:: Improved understanding of factors affecting the accuracy of breast MRI after NST can lead to more tailored use of MRI in deciding surgical extent after NST. METHODS:: We analyzed the imaging and clinicopathological data of 463 patients who underwent NST. We aimed to investigate whether the molecular subtypes, and the use of targeted therapies, were associated with changes in the accuracy of MRI predicting residual tumor extent. RESULTS:: The accuracy of MRI predicting the residual tumor extent was most accurate in triple-negative breast cancer and was least accurate in Luminal A subtype (Pearson correlation coefficient of 0.754 and 0.531, respectively). Multivariate analysis suggested estrogen receptor (ER) status as an independent factor influencing the MRI accuracy. In HER2-amplified tumors, the use of HER2-targeted agents was associated with a less accurate MRI prediction. CONCLUSIONS:: The accuracy of MRI in predicting residual tumor extent was lowest in ER-positive tumors treated with NST. In HER2-positive tumors, the use of HER2-targeted agents resulted in a less accurate MRI after NST. These factors should be considered for deciding the extent of breast conservation after neoadjuvant chemotherapy.
경피적 심낭배액술과 Trastuzumab 단독요법으로 치료한 심낭압전을 동반한 유방암의 심막전이
문형곤(Hyeong-Gon Moon),정은정(Eun-Jung Jung),박순태(Soon-Tae Park),송대현(Dae Hyun Song),하우송(Woo-Song Ha),최상경(Sang-Kyung Choi),홍순찬(Soon-Chan Hong),이영준(Young-Joon Lee),주영태(Young-Tae Joo),정치영(Chi-Young Jeong) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.75 No.2
Although autopsy studies suggest that malignant pericardial effusion is present in up to 15% of the patients suffering with malignancies, symptomatic pericardial effusion presenting as a first manifestation of systemic recurrence in a breast cancer patient is a rare condition. Symptomatic malignant pericardial effusion requires prompt attention and intervention since it can lead to the cardiac tamponade. Treatment of symptomatic pericardial effusion includes pericardial decompression and systemic or intrapericardial chemotherapy. We recently experienced a patient with early breast cancer who developed cardiac tamponade from malignant pericardial effusion as a first manifestation of systemic recurrence 4 years after her initial surgery. The patient was treated with percutaneous pericardiocentesis and she subsequently received systemic trastuzumab. After 6 cycles of trastuzumab, the follow-up CT showed complete disappearance of the pericardial effusion and the mediastinal lymph nodes.
( Moon Jung Kim ),( Hyeong Gon Yu ) 대한안과학회 2010 Korean Journal of Ophthalmology Vol.24 No.2
We report a case of bilateral peripheral retinal neovascularization and chronic idiopathic myelofibrosis in a 69-year-old man. Ophthalmic examination revealed peripheral retinal nonperfusion with retinal neovascularization in both eyes and vitreous hemorrhage in the right eye. Fluorescein angiography of both eyes showed a marked midperipheral and peripheral avascular retina temporally with arteriovenous anastomosis and sea-fan neovascularizations. Blood tests showed pancytopenia and teardrop-shaped red blood cells, and bone marrow examination showed hypocellular marrow with severe fibrosis. The neovascularization was regressed following pars plana vitrectomy in the right eye and scatter laser photocoagulation in the left. The results suggest that peripheral retinal vessel occlusion and neovascularization may be associated with idiopathic myelofibrosis.
Hyeong-Sun Moon,Seung-Gon Lee,Sang-Eun Lee,Changbaig Hyun 한국임상수의학회 2007 한국임상수의학회지 Vol.24 No.2
intolerance, especially after vigorous exercise. Physical examination revealed split S1 and grade III/VI diastolicregurgitant murmur at the left apex and base, respectively. ECG finding was normal sinus rhythm at rest, butsupraventricular tachycardia with bundle branch blocks after exercise. Thoracic radiography revealed dilated ascendingaorta with normal range of cardiac silhouette (VHS 10.2). Echocardiography revealed abnormal valvular structuresjust above the aortic valvular cusps causing aortic regurgitation with a reduction of left ventricular ejection fraction(LVEF). Based on those findings, the case was diagnosed as congenital aortic regurgitation caused by abnormal valvularstructures. The dog was managed with diltiazem and exercise restriction. This is a rare case of aortic deformity in dogs.
Primary Pulmonary Hypertension in a Maltese Dog
Hyeong-Sun Moon,Seung-Gon Lee,Ran Choi,박인철,Changbaig Hyun 한국임상수의학회 2007 한국임상수의학회지 Vol.24 No.4
A 1-year-old castrated male Maltese dog (weighing 2.4 kg) was presented with primary complaints ofocasional coughing, dyspnea and exercise intolerance. Badiastolic regurgitant murmur, marked dilation of pulmonary artery, right ventricular eccentric hypertrophy withthickening of ventricular septum, severe tricuspid and pulmonic regurgitation (5.4 m/sec and 3.4 m/sec, respectively)and the absence of any congenital intracardiac shunting, obstructive pulmonary diseases and systemic diseases associatedwith right ventricular pressure overload or pulmonary hyperperfusion, the case was tentatively diagnosed as primarypulmonary hypertension. The dog was treated with furosemide, aspirin and oxygen supplementation. This case reportdescribed a rare case of primary pulmonary hypertension in a Maltese dog.