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사용자 수술명과 수술분류 code(ICD-9-CM) 일치율 향상에 관한 연구 : 수술실 OCS program 사용 활성화를 통하여
최향하,김미영,김도진,유지원,장정화,박수정,박재성 한국의료QA학회 2005 한국의료질향상학회지 Vol.12 No.1
Background : The necessity of unify and standardize codes used at hospital has been emphasized since OCS (Order Communicating System) was adopted. Therefore, the purpose of this study were to standardize operation code by continuous training of the ICD-9-CM code that is used as standard code in OCS program at operating room. Method : In 400 operation data, operation code entered in OCS program at operating room was compared to operation name recorded in medical record. In addition, a matching rate between input data of operation code by medical record department and computing input data of operation code in 3,710 cases was compared for each department. User operation name and operation code were matched and major diagnosis by operation department and operation name were also matched. Results : User operation name was reflected in operation classification code in detail, and operation code entered on user was registered. Input rate and matching rate of operation code were gradually improved after improvement activity. In particular, a matching rate was high at ophthalmology where operation name is segmented. Plastic surgery and orthopedics with a lot of emergency operation and comprehensive operation name show low input rates. Conclusions : As the medical field makes progress in computerlization, awareness of information exchange and sharing becomes higher. Among codes to classified medical institution, codes related to surgical operation are all different by user of hospital and department. Computerlization and standardization is essential. And when efforts of standardization continue in alliance with individual hospital and institution, initiative of preparing medical policy data at a national level will be accelerated.
Park, Jin-Hee,Kim, Hyoung Kyu,Jung, Hana,Kim, Ki Hyang,Kang, Mi Seon,Hong, Jun Hyuk,Yu, Byeng Chul,Park, Sungjae,Seo, Su-Kil,Choi, Il Whan,Kim, Soon Ha,Kim, Nari,Han, Jin,Park, Sae Gwang Spandidos Publications 2017 International journal of oncology Vol.50 No.1
<P>A major goal of breast cancer research is to prevent the molecular events that lead to tumour metastasis. It is well-established that both cytoplasmic and mitochondrial reactive oxygen species (ROS) play important roles in cell migration and metastasis. Accordingly, this study examined the molecular mechanisms of the anti-metastatic effects of NecroX-5, a mitochondrial ROS scavenger. NecroX-5 inhibited lung cancer metastasis by ameliorating migration in a mouse model. In human cancer cells, the inhibition of migration by NecroX-5 is cell type-dependent. We observed that the effect of NecroX-5 correlated with a reduction in mitochondrial ROS, but mitochondrial ROS reduction by MitoQ did not inhibit cell migration. NecroX-5 decreased intracellular calcium concentration by blocking Ca2+ influx, which mediated the inhibition of cell migration, AKT down regulation and the reduction of mitochondrial ROS levels. However, the reduction of mitochondrial ROS was not associated with supressed migration and AKT downregulation. Our study demonstrates the potential of NecroX-5 as an inhibitor of breast cancer metastasis.</P>
Molecular Interaction between a Bcl_2 Homolog from Kaposi Sarcoma Virus and p53
Ha, Ji-Hyang,Won, Eun-Young,Yoon, Ho-Sup,Kang, Sung-hyun,Bae, Kwang-Hee,Park, Sung-Goo,Park, Byoung-Chu,Choi, Byong-Seok,Lee, Joon-Hwa,Chi, Seung-Wook Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.7
Molecular Mimicry-Based Repositioning of Nutlin-3 to Anti-Apoptotic Bcl-2 Family Proteins
Ha, Ji-Hyang,Won, Eun-Young,Shin, Jae-Sun,Jang, Mi,Ryu, Kyoung-Seok,Bae, Kwang-Hee,Park, Sung Goo,Park, Byoung Chul,Yoon, Ho Sup,Chi, Seung-Wook American Chemical Society 2011 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.133 No.5
Incidence and Characteristics of Scarlet Fever, South Korea, 2008–2015
Park, Duck Woong,Kim, Sun-Hee,Park, Jung Wook,Kim, Min-Ji,Cho, Sun Ju,Park, Hye Jung,Jung, So Hyang,Seo, Mi Hee,Lee, Yong Seok,Kim, Byung Hee,Min, Hyeran,Lee, Su Ya,Ha, Dong Ryong,Kim, Eun Sun,Hong, Y Centers for Disease Control and Prevention 2017 Emerging infectious diseases Vol.23 No.4
<P>The incidence rate for scarlet fever in South Korea is rising. During 2008–2015, we collected group A <I>Streptococcus</I> isolates and performed <I>emm</I> and exotoxin genotyping and disk-diffusion antimicrobial tests. Scarlet fever in South Korea was most closely associated with <I>emm</I> types <I>emm</I>4, <I>emm</I>28, <I>emm</I>1, and <I>emm</I>3. In 2015, tetracycline resistance started increasing.</P>
Hyun Ha Park,Byeong-Hyeon Kim,Seol Hwa Leem,Yong Ho Park,Hyang-Sook Hoe,Yunkwon Nam,Sujin Kim,Soo Jung Shin,Minho Moon 생화학분자생물학회 2023 BMB Reports Vol.56 No.9
Alzheimer’s disease (AD) is a progressive neurodegenerative diseasecharacterized by cognitive decline. Several recent studiesdemonstrated that impaired adult neurogenesis could contributeto AD-related cognitive impairment. Adult subventricularzone (SVZ) neurogenesis, which occurs in the lateral ventricles,plays a crucial role in structural plasticity and neural circuitmaintenance. Alterations in adult SVZ neurogenesis are earlyevents in AD, and impaired adult neurogenesis is influencedby the accumulation of intracellular Aβ. Although Aβ-overexpressingtransgenic 5XFAD mice are an AD animal model wellrepresentative of Aβ-related pathologies in the brain, the characterizationof altered adult SVZ neurogenesis following ADprogression in 5XFAD mice has not been thoroughly examined. Therefore, we validated the characterization of adult SVZ neurogenesischanges with AD progression in 2-, 4-, 8-, and 11-montholdmale 5XFAD mice. We first investigated the Aβ accumulationin the SVZ using the 4G8 antibody. We observed intracellularAβ accumulation in the SVZ of 2-month-old 5XFADmice. In addition, 5XFAD mice exhibited significantly increasedAβ deposition in the SVZ with age. Next, we performed a histologicalanalysis to investigate changes in various phases of adultneurogenesis, such as quiescence, proliferation, and differentiation,in SVZ. Compared to age-matched wild-type (WT) mice,quiescent neural stem cells were reduced in 5XFAD mice from2-11 months of age. Moreover, proliferative neural stem cellswere decreased in 5XFAD mice from 2 to 8 months of age. Furthermore, differentiations of neuroblasts were diminished in5XFAD mice from 2-11 months of age. Intriguingly, we foundthat adult SVZ neurogenesis was reduced with aging in healthymice. Taken together, our results revealed that impairment ofadult SVZ neurogenesis appears with aging or AD progression.
Associations between air pollutant levels and medical care visits for atopic dermatitis
( Se Ha Park ),( Seul Ki Lee ),( Jeong Soo Kim ),( Ha Ryeong Ryu ),( Hee Joo Kim ),( Hyang Joon Park ),( Jin Ok Baek ),( Joo Young Roh ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: The prevalence of Atopic dermatitis (AD) is rising in most industrialized countries, and it causes increased burden and costs in public health systems. Over the past decades, studies for effects of air pollution to human health were conducted and revealed considerable evidences that air pollutants ca Objectives: To estimate the effect of air pollutants on hospital visits of AD in Incheon and analyse the associating factors Methods: The study subjects were any medical care visits for atopic dermatitis in 2012-2015, which were identified by national health insurance claims data in Incheon, Republic of Korea. Air pollutants considered in this study were obtained from the Ministry of Environment Results: When using the pollutant levels of the current day and cumulative models to day 7, higher PM10, O3, and SO<sub>2</sub> significantly increased the risk of medical care visits for atopic dermatitis. In contrast, NO<sub>2</sub> and CO showed an inverse association with medical care visits for atopic dermatitis. There were no remarkable differences across age, gender and insurance groups in the risk for medical visits for atopic dermatitis. Higher risks were shown in those with previous AD diagnosis (PM10 and SO<sub>2</sub>) and those with allergic rhinitis (PM10, O<sub>3</sub>, and SO<sub>2</sub>) Conclusion: This study suggests that exposure to PM10, O3 and SO2 increase the hospital visit of AD in short-term period. Significant variables are underlying disease such as AD and allergic rhinitis
( Se Ha Park ),( Seul Ki Lee ),( Jeong Soo Kim ),( Ha Ryeong Ryu ),( Hee Joo Kim ),( Hyang Joon Park ),( Jin Ok Baek ),( Joo Young Roh ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Although atopic dermatitis (AD) has been characterized by predominant Th2 cytokines, Th1 cells are also involved in AD pathogenesis. Objectives: This study was to identify in vitro cytokine milieu that can accurately reproduce the expression profile of genes important in AD. Methods: mRNA levels of CCL22, CCL17, IL5, IL13, FLG, and LOR were evaluated by qRT-PCR in skin samples from 6 AD patients, 12 healthy controls, and HaCaT cells cultured variously with Th1 (TNF-α, IFN-γ) and/or Th2 (IL-4) cytokines. Cytokine effects on HaCaT cell growth were examined by phase-contrast microscopy and WST-1 assay. Results: Cell viability was not altered by treatment with TNF-α, IFN-γ, or IL-4 alone, or by combination of TNF-α and IL-4. Expression of Th2 genes (CCL22, CCL17, IL5 and IL13) was increased in human AD skin lesions, while cornified cell envelop-related FLG and LOR were reduced. Interestingly, similar HaCaT cell gene expression profiles were observed when stimulated with Th1 cytokines, but not with IL-4, implying that Th1 stimulation is required to reproduce the AD-like features in HaCaT cells. Conclusion: Collectively, Th1 and Th2 cytokines do not seem to function dichotomously, and a complex inflammatory network drives AD-like changes. Further in vitro experiments using HaCaT cells to study AD-related genes would need stimulation with various cytokine combinations not limited to Th2 polarization for optimal gene expression.
[P268] Toxic shock syndrome in a child presented with profuse diarrhea and palmoplantar erythema
( Se Ha Park ),( Seul Ki Lee ),( Jeong Soo Kim ),( Ha Ryeong Ryu ),( Hee Joo Kim ),( Hyang Joon Park ),( Jin Ok Baek ),( Joo Young Roh ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Toxic shock syndrome (TSS) is an acute, multi-system, toxin-mediated illness, often resulting in multi-organ failure. It occurs due to production of TSS Toxin-1 (TSST-1) by Staphylococcus aureus that induces a severe immunologically mediated inflammatory response affecting multiple organ systems. The diagnosis of TSS consists of clinical feature with high fever, hypotension, diffuse erythroderma, and desquamation together with three or more findings of renal or liver dysfunction, coagulopathy, gastrointestinal or central nervous system disorder Wereport a case of 6-year-old boy with bullae and erosive patch on both hand and feet who had watery diarrhea and fever. He had been suffered from profuse watery diarrhea for 10 days. Laboratory studies revealed acute renal failure, thrombocytopenia and anemia accompanied by prolonged prothrombin time. Histopathologicexamination revealed subcorneal separation with bacterial debris and exocytosis with epidermal spongiosis. Diagnosis of TSS was made based upon clinical and laboratory findings. He expired even after intensive care with antibiotic treatment due to multi-organ failure and sepsis. Prompt diagnosis and appropriate management of TSS are critical. This boy with TSS demonstrated the clinical manifestation of fever, profuse diarrhea and palmoplantar desquamation. Profuse watery diarrhea and desquamation of skin can be diagnostic clue of TSS.