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Comparative Genomic Hybridization 기법을 이용한 한국인 원발성 간세포암에서의 염색체 변화에 대한 연구
박훤겸,정풍만,이광수,조율희 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1
Comparative genomic hybridization(CGH) technique is one of the screening tests for DNA sequence copy number changes(losses, deletions, gains, amplifications) in tumor genomes. DNA changes in 23 hepatocellular carcinomas(HCC) associated with hepatitis B virus(HBV) were analyzed by CGH technique. Eighteen of the 23 cases showed genetic alterations. The remaining 5 cases showed no detectagble aberration. The losses of chromosome regions 17p(74%), 4q (57%), 16p (52%), 16q (48%), 8p (43%) and 13q (43%) were detected in the order of decreasing frequency. In cases of multiple losses of chromosomes, a combination of 17p,16p,16q,4q, and 8p losses was found in 5 cases (30%). On the other hand, chromosomal gains occurred on 1q (65%), 8q (52%), 20p (48%) and 20q (43%) in the order of decreasing frequency. And the simultaneous genomic gains of these 4 chromosomes were found in 9 cases (40%). Moreover, the combination of 5 genomic losses (17p, 16p, 16q, 4q, & 8p) and 4 genomic gains (1q, 8q, 20p, & 20q) was observed in 4 case s(23%). The pattern of chromosomal gains and losses in HCC with hepatitis B in Korean patients is very complex and involves virtually every site in the genome. This indicated a high genomic instability. This could possibly be explained either as the result of random chromosomal changes during early development of tumor, or as the highly variable and random pattern of integration of HBV in the HCC. The hepatocarcinogenesis may be the result of cumulative effocts rather than those orders of occurrence of those genomic changes. The sites of cellular DNA at which HBV integrates frequently undergo rearrangements, resulting in translocations, inverted duplications, deletions, and possibly recombinational events. But, CGH only detects changes of chromosomal copy number but could not identify translocations, inversions, and other aberrations of chromosome. The chromosomal analysis of HCC with HBV in Korean patients by CGH technique confirms the presence of complex and sporadic, but nonrandom genetic changes in the chromosome. In the future, more detailed oncogenic study could be carried out on the chromosomes which showed abnormal aberrations through this study.
혈소판 감소증 환자에서 대마비와 전신 상태의 급격한 악화 : 급성 대동맥 혈전증 A Case Report of Acute Aortic Thrombosis 증례 보고
이홍기,박훤겸,백홍규,남영수,김영선,김용수 대한혈관외과학회 2002 Vascular Specialist International Vol.18 No.2
Acute aortic occlusion is rare but poses a high mortality and morbidity. Prompt diagnosis and treatment is essential. Typical presentation is rest pain with bilateral absent femoral pulse. When the non-typical symptoms predominate such as paraplegia, acute abdomen or sudden-onset hypertension, diagnosis may be difficult. We experienced a case of acute aortic thrombosis who suddenly developed paraplegia and rapidly deteriorated within several hours. When the paraplegia developed, he was under treatment with heparin and urokinase, was thrombocytopenic, and the femoral arteries were pulsatile. Spinal cord compression due to bleeding complication had to be ruled out. Duplex sonography and lumbar CT scan were not diagnostic. Aortic thrombosis was diagnosed by abdominal CT scan. This case illustrates the need for high suspicion of acute aortic occlusion presenting with paraplegia especially in patients with associated atherosclerotic disease.
이종석,서교택,황환성,전익균 한국공업화학회 2003 응용화학 Vol.7 No.2
This study is on the whole process of manufacturing functional shoe lining leather from Kip raw skin, which is classified and investigated into raw skin, pelt, wet blue leather, crust leather, and finished leather. Especially it is tried to make the wet blue leather for lining more favorable for environment in the wet blue leather process by the use of vegetable tanning agent. The finished leather for lining is endowed with high hygiene in the finishing process by the use of antibacterial and deodorization agents. It is proved that the lining leather manufactured through these steps has the more improved physical properties of the finished leather than those through other treatments. Also, The insole is endowed with high hygiene by the use of antibacterial and deodorization agents.
이종석,최한희,황환성 한국공업화학회 2004 응용화학 Vol.8 No.1
Effect of processing agents on physical properties of leather has been studied. It is tried to make the wet blue leather for upper more favorable for environment in the wet blue leather process by the use of low chrome and vegetable tanning agent. Surface treatment agents such as urethane binder is used in the finished leather process. The finished leather for upper is endowed with high hygiene in the finishing process by the use of antibacterial and deodorization agents. It is proved that the upper leather manufactured through these steps has the more improved physical properties. Also, The insole is endowed with high hygiene by the use of antibacterial agents. Leather and insole with these treatments are satisfied with the Korean Industrial Standard.
Hwon Ihm 한국정보기술융합학회 2013 JoC Vol.4 No.2
Twitter is one of the most popular social media outlets available and has been expanding over the years in both scope and reach. The growing number of users, and the accessibility to their micro-posts and metadata make Twitter a popular subject for research in various research communities. In this paper, we propose and examine a content analysis method that utilizes the hierarchy of effects model, which has a very long history of use by both practitioners and academics in the field of advertising and marketing. We have judges manually annotate tweets in accordance with one of the five stages of attitudes: Attention, Interest, Desire, Action, or Satisfaction. Next, we examine the tagged corpus to identify general traits and to explore the possibilities for the newly gained information from the tweets. The results suggest that consumer attitude information can be utilized to improve the prediction quality of box-office revenues and possibly better represent movie audience sentiment. These findings can complement other content analysis methods that utilizes Twitter data by providing an additional dimension for the researchers to consider.